Proteins > Sodium/glucose cotransporter 2

Page last updated: 2024-08-07 16:28:47

Sodium/glucose cotransporter 2

A sodium/glucose cotransporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31639]

Synonyms

Na(+)/glucose cotransporter 2;
Low affinity sodium-glucose cotransporter;
Solute carrier family 5 member 2

Research

Bioassay Publications (48)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (14.58)	29.6817
2010's	35 (72.92)	24.3611
2020's	6 (12.50)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phloretin	Homo sapiens (human)	IC50	18.3000	1	1
phlorhizin	Homo sapiens (human)	IC50	7.7955	13	13
phlorhizin	Homo sapiens (human)	Ki	0.0186	1	1
vexibinol	Homo sapiens (human)	IC50	4.1000	1	1
2',4',6'-Trihydroxydihydrochalcone	Homo sapiens (human)	IC50	14.7000	1	1
2',4',6'-trihydroxychalcone	Homo sapiens (human)	IC50	33.3000	1	1
sergliflozin etabonate	Homo sapiens (human)	IC50	0.2600	1	1
sergliflozin etabonate	Homo sapiens (human)	Ki	0.1510	1	1
remogliflozin etabonate	Homo sapiens (human)	IC50	2.5300	2	2
dapagliflozin	Homo sapiens (human)	IC50	0.0022	29	29
ipragliflozin	Homo sapiens (human)	IC50	0.0076	4	4
empagliflozin	Homo sapiens (human)	IC50	0.0031	2	2
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	Homo sapiens (human)	IC50	0.0023	4	4
nothofagin	Homo sapiens (human)	IC50	0.0119	1	1
canagliflozin	Homo sapiens (human)	IC50	0.0039	4	4
pf 04971729	Homo sapiens (human)	IC50	0.0014	3	3
deberza	Homo sapiens (human)	IC50	0.0033	3	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phlorhizin	Homo sapiens (human)	EC50	0.1018	9	10
dapagliflozin	Homo sapiens (human)	EC50	0.1752	7	8
ipragliflozin	Homo sapiens (human)	EC50	0.0074	1	1
empagliflozin	Homo sapiens (human)	EC50	0.0030	1	1
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	Homo sapiens (human)	EC50	0.0023	1	1
canagliflozin	Homo sapiens (human)	EC50	0.0022	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
low-affinity glucose:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [TC:2.A.21.3.-]
glucose:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
alpha-glucoside transmembrane transporter activity	molecular function	Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]
D-glucose transmembrane transporter activity	molecular function	Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:jid, GOC:jsg, GOC:mah]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
alpha-glucoside transport	biological process	The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, ISBN:0198506732, PMID:9919658]
carbohydrate metabolic process	biological process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]
hexose transmembrane transport	biological process	The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. [GOC:vw]
renal glucose absorption	biological process	A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:yaf, PMID:11269503]
glucose import across plasma membrane	biological process	The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
sodium ion import across plasma membrane	biological process	The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
sodium ion transport	biological process	The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]