chlortetracycline and Necrosis

Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Cholelithiasis; Cholestasis; Erythromycin; Halothane; Heart Valve Prosthesis; Hepatitis A; Humans; Hypoxia; Isoniazid; Jaundice; Liver; Liver Diseases; Methoxyflurane; Necrosis; Pancreatitis; Postoperative Complications; Sulfonamides; Transfusion Reaction

Severe necro-purulent lesions were induced in mice following parenteral inoculation of Sphaerophorus necrophorus. Gross and histological changes observed in the lung, liver, and foot pad of infected mice were similar to those occurring naturally in cattle. The lesions could be prevented, cured or significantly reduced by the administration of chemotherapeutic agents such as sulfonamides, potentiated sulfonamide and antibiotics. The application of this novel laboratory model infection in the primary evaluation of potential antibacterial agents is discussed.

Topics: Animals; Chlortetracycline; Foot; Fusobacterium Infections; Fusobacterium necrophorum; Injections; Injections, Subcutaneous; Leucomycins; Liver; Lung; Male; Mice; Microbial Sensitivity Tests; Necrosis; Neomycin; Oxytetracycline; Penicillins; Pyrimidines; Skin; Sulfadimethoxine; Sulfamethoxazole; Thorax

Topics: Cell Line; Chlortetracycline; Demeclocycline; Liver; Necrosis; Oxytetracycline; Technetium; Tetracycline

Topics: Adult; Black or African American; Black People; Brain Abscess; Brain Diseases; Carotid Arteries; Central Nervous System Diseases; Chlortetracycline; Cryptococcosis; Electroencephalography; Female; Humans; Macrophages; Male; Meninges; Mycoses; Necrosis; Nocardia asteroides; Nocardia Infections; Radiography; Senegal; Sulfadiazine

Topics: Angiography; Animals; Chlortetracycline; Hepatic Artery; Liver Circulation; Liver Diseases; Necrosis; Postoperative Complications; Swine; Swine Diseases

Topics: Animals; Chlortetracycline; Edema; Female; Hemorrhage; Hyperemia; Lip; Male; Mice; Necrosis; Radiation Effects; Radiation Injuries, Experimental; Radiation-Protective Agents; Streptomycin; Water

Topics: Animals; Cecum; Chlortetracycline; Colon, Sigmoid; Cricetinae; Diarrhea; Drug Hypersensitivity; Epithelium; Intestine, Large; Necrosis; Oxytetracycline; Tetracycline; Vascular Diseases

Topics: Chlortetracycline; Enteritis; Gangrene; Humans; Ileum; Jejunum; Mesenteric Vascular Occlusion; Necrosis; Penicillins; Streptomycin; Surgical Procedures, Operative; Thrombosis

Topics: Animals; Chlortetracycline; Diet; Intestines; Necrosis; Penicillins; Rats

Topics: Acids; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chlortetracycline; Diet; Dietary Supplements; Ether; Necrosis; Penicillins; Rats; Urine