Page last updated: 2024-08-07 18:43:39
Solute carrier family 22 member 6
A solute carrier family 22 member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q4U2R8]
Synonyms
Organic anion transporter 1;
hOAT1;
PAH transporter;
hPAHT;
Renal organic anion transporter 1;
hROAT1
Research
Bioassay Publications (31)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 19 (61.29) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
Compounds (59)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| salicylic acid | Homo sapiens (human) | IC50 | 280.0000 | 1 | 1 |
| octanoic acid | Homo sapiens (human) | Ki | 5.4100 | 1 | 1 |
| hippuric acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| hippuric acid | Homo sapiens (human) | Ki | 66.0000 | 1 | 1 |
| glutaric acid | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| p-aminohippuric acid | Homo sapiens (human) | IC50 | 67.9000 | 2 | 2 |
| p-aminohippuric acid | Homo sapiens (human) | Ki | 6.0200 | 2 | 2 |
| benzbromarone | Homo sapiens (human) | IC50 | 4.6000 | 1 | 1 |
| cimetidine | Homo sapiens (human) | IC50 | 492.0000 | 1 | 1 |
| diclofenac | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| diflunisal | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
| etodolac | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| flurbiprofen | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| ibuprofen | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| indomethacin | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| ketoprofen | Homo sapiens (human) | IC50 | 1.3500 | 2 | 2 |
| phenacetin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| probenecid | Homo sapiens (human) | IC50 | 10.1200 | 5 | 5 |
| probenecid | Homo sapiens (human) | Ki | 6.9367 | 3 | 3 |
| cephaloridine | Homo sapiens (human) | IC50 | 1,250.0000 | 1 | 1 |
| cephaloridine | Homo sapiens (human) | Ki | 0.7400 | 1 | 1 |
| cephalothin | Homo sapiens (human) | Ki | 0.2200 | 1 | 1 |
| salicylurate | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| indican | Homo sapiens (human) | IC50 | 83.0000 | 1 | 1 |
| indican | Homo sapiens (human) | Ki | 22.8500 | 2 | 2 |
| 2,2-dimethylbutyric acid | Homo sapiens (human) | IC50 | 3,862.0000 | 1 | 1 |
| indoxyl acetate | Homo sapiens (human) | IC50 | 83.0000 | 1 | 1 |
| cefazolin | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| cephradine | Homo sapiens (human) | IC50 | 1,600.0000 | 1 | 1 |
| cefoperazone | Homo sapiens (human) | Ki | 0.2100 | 1 | 1 |
| cefadroxil anhydrous | Homo sapiens (human) | Ki | 6.1400 | 1 | 1 |
| pravastatin | Homo sapiens (human) | IC50 | 408.0000 | 1 | 1 |
| adefovir | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| cidofovir anhydrous | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| adefovir dipivoxil | Homo sapiens (human) | IC50 | 13.5000 | 1 | 1 |
| rolofylline | Homo sapiens (human) | Ki | 7.8200 | 1 | 1 |
| betamipron | Homo sapiens (human) | IC50 | 22.5000 | 2 | 2 |
| betamipron | Homo sapiens (human) | Ki | 23.6000 | 2 | 2 |
| effusol | Homo sapiens (human) | IC50 | 23.3000 | 1 | 1 |
| s-(2-benzothiazolyl)cysteine | Homo sapiens (human) | IC50 | 9.9000 | 1 | 1 |
| cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine | Homo sapiens (human) | IC50 | 1,100.0000 | 1 | 1 |
| ym 872 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| 4-hydroxyhippuric acid | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| naproxen | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| 3-hydroxyglutaric acid | Homo sapiens (human) | Ki | 98.0000 | 1 | 1 |
| gs 4071 | Homo sapiens (human) | Ki | 45,100.0000 | 1 | 1 |
| cefamandole | Homo sapiens (human) | Ki | 0.0300 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| fosbretabulin | Homo sapiens (human) | IC50 | 41.3600 | 1 | 1 |
| ceftriaxone | Homo sapiens (human) | Ki | 0.2300 | 1 | 1 |
| cefotaxime | Homo sapiens (human) | Ki | 3.1300 | 1 | 1 |
| cilastatin | Homo sapiens (human) | IC50 | 2,550.0000 | 1 | 1 |
| cilastatin | Homo sapiens (human) | Ki | 1,470.0000 | 1 | 1 |
| piroxicam | Homo sapiens (human) | IC50 | 20.5000 | 1 | 1 |
| piroxicam | Homo sapiens (human) | Ki | 19.8000 | 1 | 1 |
| citrinin | Homo sapiens (human) | Ki | 3,080.0000 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| hippuric acid | Homo sapiens (human) | Km | 24.0000 | 1 | 1 |
| glutaric acid | Homo sapiens (human) | Km | 10.7000 | 1 | 1 |
| uric acid | Homo sapiens (human) | Km | 947.0000 | 1 | 1 |
| p-aminohippuric acid | Homo sapiens (human) | Km | 10.7778 | 9 | 9 |
| indican | Homo sapiens (human) | Km | 21.0000 | 1 | 1 |
| indoxyl acetate | Homo sapiens (human) | Km | 14.0000 | 1 | 1 |
| zidovudine | Homo sapiens (human) | Km | 45.9000 | 1 | 1 |
| adefovir | Homo sapiens (human) | Km | 25.8667 | 3 | 3 |
| cidofovir anhydrous | Homo sapiens (human) | Km | 54.0000 | 3 | 3 |
| cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine | Homo sapiens (human) | Km | 309.0000 | 1 | 1 |
| 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid | Homo sapiens (human) | Km | 141.0000 | 1 | 1 |
| methotrexate | Homo sapiens (human) | Km | 553.8000 | 1 | 1 |
| ochratoxin a | Homo sapiens (human) | Km | 0.4200 | 1 | 1 |
| tenofovir | Homo sapiens (human) | Km | 33.8000 | 1 | 1 |
| dinoprostone | Homo sapiens (human) | Km | 0.9700 | 1 | 1 |
| dinoprost | Homo sapiens (human) | Km | 0.5750 | 1 | 1 |
| gs-9148 | Homo sapiens (human) | Km | 259.0000 | 1 | 1 |
| acyclovir | Homo sapiens (human) | Km | 590.6500 | 2 | 2 |
| ganciclovir | Homo sapiens (human) | Km | 895.5000 | 1 | 1 |
Enables
This protein enables 11 target(s):
| Target | Category | Definition |
|---|---|---|
| solute:inorganic anion antiporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai] |
| prostaglandin transmembrane transporter activity | molecular function | Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai] |
| alpha-ketoglutarate transmembrane transporter activity | molecular function | Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684] |
| antiporter activity | molecular function | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] |
| transmembrane transporter activity | molecular function | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729] |
| chloride ion binding | molecular function | Binding to a chloride ion (Cl-). [GOC:mah] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| xenobiotic transmembrane transporter activity | molecular function | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| sodium-independent organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| caveola | cellular component | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198] |
| basal plasma membrane | cellular component | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| monoatomic anion transport | biological process | The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:ai] |
| response to organic cyclic compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef] |
| inorganic anion transport | biological process | The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:krc] |
| organic anion transport | biological process | The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc] |
| prostaglandin transport | biological process | The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| alpha-ketoglutarate transport | biological process | The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| xenobiotic transport | biological process | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| sodium-independent organic anion transport | biological process | The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| metanephric proximal tubule development | biological process | The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10] |
| renal tubular secretion | biological process | The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion] |