Solute carrier family 22 member 6

A solute carrier family 22 member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q4U2R8]

Synonyms

Organic anion transporter 1;
hOAT1;
PAH transporter;
hPAHT;
Renal organic anion transporter 1;
hROAT1

Research

Bioassay Publications (31)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (9.68)	18.2507
2000's	19 (61.29)	29.6817
2010's	8 (25.81)	24.3611
2020's	1 (3.23)	2.80

Compounds (59)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
salicylic acid	Homo sapiens (human)	IC50	280.0000	1	1
octanoic acid	Homo sapiens (human)	Ki	5.4100	1	1
hippuric acid	Homo sapiens (human)	IC50	20.0000	1	1
hippuric acid	Homo sapiens (human)	Ki	66.0000	1	1
glutaric acid	Homo sapiens (human)	IC50	4.9000	1	1
p-aminohippuric acid	Homo sapiens (human)	IC50	67.9000	2	2
p-aminohippuric acid	Homo sapiens (human)	Ki	6.0200	2	2
benzbromarone	Homo sapiens (human)	IC50	4.6000	1	1
cimetidine	Homo sapiens (human)	IC50	492.0000	1	1
diclofenac	Homo sapiens (human)	IC50	4.0000	1	1
diflunisal	Homo sapiens (human)	IC50	0.8500	1	1
etodolac	Homo sapiens (human)	IC50	50.0000	1	1
flurbiprofen	Homo sapiens (human)	IC50	1.5000	1	1
ibuprofen	Homo sapiens (human)	IC50	8.0000	1	1
indomethacin	Homo sapiens (human)	IC50	3.0000	1	1
ketoprofen	Homo sapiens (human)	IC50	1.3500	2	2
phenacetin	Homo sapiens (human)	IC50	200.0000	1	1
probenecid	Homo sapiens (human)	IC50	10.1200	5	5
probenecid	Homo sapiens (human)	Ki	6.9367	3	3
cephaloridine	Homo sapiens (human)	IC50	1,250.0000	1	1
cephaloridine	Homo sapiens (human)	Ki	0.7400	1	1
cephalothin	Homo sapiens (human)	Ki	0.2200	1	1
salicylurate	Homo sapiens (human)	IC50	27.0000	1	1
indican	Homo sapiens (human)	IC50	83.0000	1	1
indican	Homo sapiens (human)	Ki	22.8500	2	2
2,2-dimethylbutyric acid	Homo sapiens (human)	IC50	3,862.0000	1	1
indoxyl acetate	Homo sapiens (human)	IC50	83.0000	1	1
cefazolin	Homo sapiens (human)	Ki	0.1800	1	1
cephradine	Homo sapiens (human)	IC50	1,600.0000	1	1
cefoperazone	Homo sapiens (human)	Ki	0.2100	1	1
cefadroxil anhydrous	Homo sapiens (human)	Ki	6.1400	1	1
pravastatin	Homo sapiens (human)	IC50	408.0000	1	1
adefovir	Homo sapiens (human)	IC50	28.0000	1	1
cidofovir anhydrous	Homo sapiens (human)	IC50	60.0000	1	1
adefovir dipivoxil	Homo sapiens (human)	IC50	13.5000	1	1
rolofylline	Homo sapiens (human)	Ki	7.8200	1	1
betamipron	Homo sapiens (human)	IC50	22.5000	2	2
betamipron	Homo sapiens (human)	Ki	23.6000	2	2
effusol	Homo sapiens (human)	IC50	23.3000	1	1
s-(2-benzothiazolyl)cysteine	Homo sapiens (human)	IC50	9.9000	1	1
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine	Homo sapiens (human)	IC50	1,100.0000	1	1
ym 872	Homo sapiens (human)	IC50	3.0000	1	1
4-hydroxyhippuric acid	Homo sapiens (human)	IC50	25.0000	1	1
naproxen	Homo sapiens (human)	IC50	5.8000	1	1
3-hydroxyglutaric acid	Homo sapiens (human)	Ki	98.0000	1	1
gs 4071	Homo sapiens (human)	Ki	45,100.0000	1	1
cefamandole	Homo sapiens (human)	Ki	0.0300	1	1
ellagic acid	Homo sapiens (human)	IC50	0.2700	1	1
fosbretabulin	Homo sapiens (human)	IC50	41.3600	1	1
ceftriaxone	Homo sapiens (human)	Ki	0.2300	1	1
cefotaxime	Homo sapiens (human)	Ki	3.1300	1	1
cilastatin	Homo sapiens (human)	IC50	2,550.0000	1	1
cilastatin	Homo sapiens (human)	Ki	1,470.0000	1	1
piroxicam	Homo sapiens (human)	IC50	20.5000	1	1
piroxicam	Homo sapiens (human)	Ki	19.8000	1	1
citrinin	Homo sapiens (human)	Ki	3,080.0000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
hippuric acid	Homo sapiens (human)	Km	24.0000	1	1
glutaric acid	Homo sapiens (human)	Km	10.7000	1	1
uric acid	Homo sapiens (human)	Km	947.0000	1	1
p-aminohippuric acid	Homo sapiens (human)	Km	10.7778	9	9
indican	Homo sapiens (human)	Km	21.0000	1	1
indoxyl acetate	Homo sapiens (human)	Km	14.0000	1	1
zidovudine	Homo sapiens (human)	Km	45.9000	1	1
adefovir	Homo sapiens (human)	Km	25.8667	3	3
cidofovir anhydrous	Homo sapiens (human)	Km	54.0000	3	3
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine	Homo sapiens (human)	Km	309.0000	1	1
3-carboxy-4-methyl-5-propyl-2-furanpropionic acid	Homo sapiens (human)	Km	141.0000	1	1
methotrexate	Homo sapiens (human)	Km	553.8000	1	1
ochratoxin a	Homo sapiens (human)	Km	0.4200	1	1
tenofovir	Homo sapiens (human)	Km	33.8000	1	1
dinoprostone	Homo sapiens (human)	Km	0.9700	1	1
dinoprost	Homo sapiens (human)	Km	0.5750	1	1
gs-9148	Homo sapiens (human)	Km	259.0000	1	1
acyclovir	Homo sapiens (human)	Km	590.6500	2	2
ganciclovir	Homo sapiens (human)	Km	895.5000	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
solute:inorganic anion antiporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]
prostaglandin transmembrane transporter activity	molecular function	Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai]
alpha-ketoglutarate transmembrane transporter activity	molecular function	Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684]
antiporter activity	molecular function	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
transmembrane transporter activity	molecular function	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
chloride ion binding	molecular function	Binding to a chloride ion (Cl-). [GOC:mah]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
xenobiotic transmembrane transporter activity	molecular function	Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
sodium-independent organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
caveola	cellular component	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
monoatomic anion transport	biological process	The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:ai]
response to organic cyclic compound	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]
inorganic anion transport	biological process	The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:krc]
organic anion transport	biological process	The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]
prostaglandin transport	biological process	The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
alpha-ketoglutarate transport	biological process	The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
xenobiotic transport	biological process	The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
sodium-independent organic anion transport	biological process	The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
metanephric proximal tubule development	biological process	The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]
renal tubular secretion	biological process	The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion]