Mineralocorticoid receptor

A mineralocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08235]

Synonyms

MR;
Nuclear receptor subfamily 3 group C member 2

Research

Bioassay Publications (59)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	4 (6.78)	18.2507
2000's	18 (30.51)	29.6817
2010's	34 (57.63)	24.3611
2020's	3 (5.08)	2.80

Compounds (22)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mifepristone	Homo sapiens (human)	Potency	1.0000	1	1
onapristone	Homo sapiens (human)	Potency	1.0000	1	1

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
prednisolone	Homo sapiens (human)	IC50	0.0322	5	5
prednisolone	Homo sapiens (human)	Ki	0.0186	2	2
spironolactone	Homo sapiens (human)	IC50	0.0315	13	13
spironolactone	Homo sapiens (human)	Ki	0.0037	2	2
aldosterone	Homo sapiens (human)	IC50	0.0048	2	2
medroxyprogesterone acetate	Homo sapiens (human)	IC50	1.1970	3	3
dihydrotestosterone	Homo sapiens (human)	IC50	0.3600	1	1
mifepristone	Homo sapiens (human)	IC50	2.5337	10	13
mifepristone	Homo sapiens (human)	Ki	3.8303	3	3
metribolone	Homo sapiens (human)	Ki	0.0005	1	1
eplerenone	Homo sapiens (human)	IC50	0.6680	16	16
eplerenone	Homo sapiens (human)	Ki	0.1259	1	1
fluticasone propionate	Homo sapiens (human)	IC50	0.1490	1	1
pulmicort	Homo sapiens (human)	IC50	0.0140	1	1
onapristone	Homo sapiens (human)	IC50	0.8233	3	3
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	IC50	0.6600	2	2
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	Ki	0.0390	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	IC50	1.8800	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	Ki	0.0370	1	1
asoprisnil	Homo sapiens (human)	IC50	1.6000	2	2
zk 216348	Homo sapiens (human)	IC50	0.0587	2	2
fluticasone furoate	Homo sapiens (human)	IC50	0.1660	1	1
way-362450	Homo sapiens (human)	IC50	10.0000	1	1
mebudipine	Homo sapiens (human)	IC50	0.1260	2	2
lgd 2226	Homo sapiens (human)	Ki	1.0000	1	1
pf-03882845	Homo sapiens (human)	IC50	0.0120	3	4
bay 94-8862	Homo sapiens (human)	IC50	0.0275	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
corticosterone	Homo sapiens (human)	Kd	0.0005	1	1
prednisolone	Homo sapiens (human)	EC50	0.0010	2	2
aldosterone	Homo sapiens (human)	EC50	0.0012	5	5
aldosterone	Homo sapiens (human)	Kd	0.0005	1	1
mifepristone	Homo sapiens (human)	EC50	10.0000	1	1
eplerenone	Homo sapiens (human)	EC50	0.1000	1	1
pulmicort	Homo sapiens (human)	EC50	0.0048	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	EC50	100.0000	1	1
fluticasone furoate	Homo sapiens (human)	EC50	3.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
spironolactone	Homo sapiens (human)	Kb	0.0177	1	1
mifepristone	Homo sapiens (human)	Kif	0.0100	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity	molecular function	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
nuclear steroid receptor activity	molecular function	Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
TBP-class protein binding	molecular function	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]
sequence-specific double-stranded DNA binding	molecular function	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
nuclear receptor activity	molecular function	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
estrogen response element binding	molecular function	Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 4 target(s):

Target	Category	Definition
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
positive regulation of non-canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade. [GOC:TermGenie]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
intracellular steroid hormone receptor signaling pathway	biological process	The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling]