Compounds > irinotecan
Page last updated: 2024-08-24

irinotecan and Necrosis

irinotecan has been researched along with Necrosis in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (25.00)29.6817
2010's16 (66.67)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Branco de Barros, AL; Cassali, GD; de Aguiar Ferreira, C; de Alcântara Lemos, J; de Oliveira Silva, J; Fernandes, RS; Miranda, SEM; Nunes, SS; Oliveira, MC; Townsend, DM1
Dreher, MR; Gates, VL; Gordon, AC; Harris, KR; Huang, X; Larson, AC; Lewandowski, RJ; Lyu, T; Omary, RA; Procissi, D; Salem, R; White, SB; Yang, Y; Zhang, Z1
Albares, MP; del Carmen Leiva-Salinas, M; Frances, L; Guijarro, J; Ramon, R1
Jakubczak, M; Kontek, R; Matlawska-Wasowska, K1
Gilbert, CW; Hukuoka, Y; Kichikawa, K; Masada, T; Nishiofuku, H; Obayashi, C; Sato, T; Takano, M; Tanaka, T1
Kaku, Y; Kanno, T; Nishizaki, T; Tsuchiya, A1
Gruenberger, B; Gruenberger, T; Singh, J; Starlinger, P; Stift, J; Stremitzer, S; Tamandl, D1
Almeida, GS; deSouza, NM; Jamin, Y; Papaevangelou, E; Robinson, SP1
Ghegediban, SH; Laurent, A; Maeda, N; Namur, J; Osuga, K; Paci, A; Pascale, F; Reb, P; Seck, A; Sterba, M; Verret, V; Wassef, M1
Abrey, LE; Aftab, DT; Cloughesy, TF; Ellingson, BM; Harris, RJ; Hessel, C; Lai, A; Leu, K; Mason, WP; Nghiemphu, PL; Pope, WB; Sahebjam, S; Schwab, GM; Wen, PY; Woodworth, DC; Zaw, O1
Fukuoka, Y; Kichikawa, K; Masada, T; Matsushima, S; Nishiofuku, H; Ohbayashi, C; Sato, T; Sho, M; Takano, M; Tanaka, T; Tatsumoto, S; Yamato, I; Yasuda, S1
Amano, F; Kanai-Mori, A; Koike, A; Morishige, Y; Tamaki, R; Yanagihara, K1
Brugge, W; Cizginer, S; Kambadakone, A; Karaca, C; Konuk, Y; Macfarlane, C; Mino-Kenudson, M; Sahani, DV; Turner, BG1
Azzariti, A; Cantore, M; Cassano, G; Colabufo, NA; Gasparre, G; Iannelli, G; Panaro, MA; Paradiso, A; Porcelli, L; Quatrale, AE; Tommasi, S1
Brinker, T; Glage, S; Hedrich, HJ; Held, N; Lewis, AL1
Fourcade, S; Gaudy-Marqueste, C; Grob, JJ; Richard, MA; Tasei, AM1
Allen, PJ; Bao, F; D'Angelica, MI; DeMatteo, RP; Fong, Y; Hernandez-Boussard, T; Jarnagin, WR; Kemeny, NE; Klimstra, DS; Poultsides, GA; Saltz, LB; Servais, EL; Shia, J1
Herbst, RS; Isobe, T; Itasaka, S; Jacoby, JJ; Koo, PJ; Morgensztern, D; O'Reilly, MS; Onn, A; Shibuya, K; Shintani, T; Wu, W1
Carano, RA; Koeppen, H; Ross, AL; Ross, J; Schwall, RH; Van Bruggen, N; Williams, SP1
Bhonde, MR; Daniel, PT; Gillissen, BF; Hanski, C; Hanski, ML; Notter, M; Zeitz, M1
Biasco, G; Brandi, G; Bridonneau, C; Dabard, J; De Vivo, A; Di Battista, M; Morselli Labate, AM; Pantaleo, MA; Pisi, AM; Raibaud, P1
Berrocal, DH; Gelpi, RJ; González, GE; Grinfeld, LR; Morales, C1
Bar-Eli, M; Fan, D; Fidler, IJ; Kerbel, RS; Kim, SJ; Kuwai, T; Nakamura, T; Sasaki, T; Villares, GJ; Wang, H; Zigler, M1
Barbier, M; Boutonnat, J; Grunwald, D; Mousseau, M; Muirhead, K; Ronot, X; Seigneurin, D1

Trials

2 trial(s) available for irinotecan and Necrosis

ArticleYear
Histological response, pattern of tumor destruction and clinical outcome after neoadjuvant chemotherapy including bevacizumab or cetuximab in patients undergoing liver resection for colorectal liver metastases.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2015, Volume: 41, Issue:7

    Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Hepatectomy; Humans; Irinotecan; Kaplan-Meier Estimate; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Necrosis; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Proportional Hazards Models; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Tomography, X-Ray Computed; Treatment Outcome

2015
Baseline pretreatment contrast enhancing tumor volume including central necrosis is a prognostic factor in recurrent glioblastoma: evidence from single and multicenter trials.
    Neuro-oncology, 2017, Volume: 19, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Camptothecin; Contrast Media; Female; Follow-Up Studies; Glioblastoma; Humans; Irinotecan; Male; Middle Aged; Molecular Imaging; Necrosis; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate; Tumor Burden

2017

Other Studies

22 other study(ies) available for irinotecan and Necrosis

ArticleYear
pH-responsive and folate-coated liposomes encapsulating irinotecan as an alternative to improve efficacy of colorectal cancer treatment.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144

    Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Delayed-Action Preparations; Drug Compounding; Drug Liberation; Folic Acid; Hydrogen-Ion Concentration; Irinotecan; Lipids; Liposomes; Mice, Inbred BALB C; Necrosis; Time Factors; Topoisomerase I Inhibitors; Tumor Burden

2021
Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model.
    Cardiovascular and interventional radiology, 2020, Volume: 43, Issue:10

    Topics: Animals; Antineoplastic Agents; Chemoembolization, Therapeutic; Disease Models, Animal; Dose-Response Relationship, Drug; Feasibility Studies; Irinotecan; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Microspheres; Necrosis; Rabbits; Yttrium Radioisotopes

2020
Localized skin necrosis by bevacizumab.
    European journal of dermatology : EJD, 2013, Apr-01, Volume: 23, Issue:2

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Brain Neoplasms; Camptothecin; Drug Eruptions; Humans; Irinotecan; Male; Middle Aged; Necrosis; Skin

2013
The antioxidants, vitamin A and E but not vitamin C and melatonin enhance the proapoptotic effects of irinotecan in cancer cells in vitro.
    Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Ascorbic Acid; Camptothecin; Cell Line, Tumor; Coloring Agents; Flow Cytometry; HT29 Cells; Humans; In Situ Nick-End Labeling; Irinotecan; Melatonin; Necrosis; Vitamin A; Vitamin E

2014
Pharmacokinetics and antitumor efficacy of chemoembolization using 40 µm irinotecan-loaded microspheres in a rabbit liver tumor model.
    Journal of vascular and interventional radiology : JVIR, 2014, Volume: 25, Issue:7

    Topics: Alkaline Phosphatase; Animals; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Camptothecin; Chemistry, Pharmaceutical; Chemoembolization, Therapeutic; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Monitoring; Irinotecan; Liver Neoplasms, Experimental; Microspheres; Necrosis; Particle Size; Rabbits

2014
Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.
    Pharmacology, 2015, Volume: 95, Issue:3-4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caco-2 Cells; Camptothecin; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Irinotecan; Male; Mice, Nude; Necrosis; Neoplasms; Tumor Burden

2015
Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy.
    British journal of cancer, 2015, Apr-28, Volume: 112, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Proliferation; Colorectal Neoplasms; Diffusion Magnetic Resonance Imaging; Dipeptides; Female; Humans; Immunoenzyme Techniques; Indoles; Irinotecan; Lymphatic Metastasis; Mice; Mice, Nude; Necrosis; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2015
Safety and efficacy compared between irinotecan-loaded microspheres HepaSphere and DC bead in a model of VX2 liver metastases in the rabbit.
    Journal of vascular and interventional radiology : JVIR, 2015, Volume: 26, Issue:7

    Topics: Activation, Metabolic; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chemoembolization, Therapeutic; Drug Carriers; Gene Expression Regulation, Neoplastic; Hepatic Artery; Injections, Intra-Arterial; Irinotecan; Liver Neoplasms, Experimental; Male; Microspheres; Necrosis; Particle Size; Rabbits; Tissue Distribution

2015
Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model.
    Journal of vascular and interventional radiology : JVIR, 2017, Volume: 28, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Area Under Curve; Camptothecin; Drug Carriers; Drug Compounding; Female; Femoral Vein; Hepatic Artery; Infusions, Intra-Arterial; Infusions, Intravenous; Irinotecan; Liver Neoplasms, Experimental; Micelles; Nanoparticles; Necrosis; Rabbits; Tissue Distribution

2017
Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line.
    Oncology reports, 2017, Volume: 37, Issue:4

    Topics: Adenocarcinoma, Scirrhous; Apoptosis; Camptothecin; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Necrosis; Reactive Oxygen Species; Stomach Neoplasms

2017
Feasibility of EUS-guided injection of irinotecan-loaded microspheres into the swine pancreas.
    Gastrointestinal endoscopy, 2011, Volume: 73, Issue:3

    Topics: Animals; Camptothecin; Feasibility Studies; Injections; Irinotecan; Microspheres; Necrosis; Pancreas; Swine; Tomography, X-Ray Computed; Topoisomerase I Inhibitors; Ultrasonography, Interventional

2011
MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment.
    European journal of pharmacology, 2011, Nov-16, Volume: 670, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biphenyl Compounds; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Genomics; Humans; Irinotecan; Kinetics; Multidrug Resistance-Associated Proteins; Necrosis; Neoplasm Proteins; Signal Transduction; Tetrahydroisoquinolines; Topotecan

2011
A safety and toxicity assessment of the administration of multiple intracerebral injections of irinotecan or doxorubicin drug-eluting beads.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2011, Volume: 13, Issue:10

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Cats; Doxorubicin; Female; Glioma; Infusion Pumps, Implantable; Injections, Intraventricular; Irinotecan; Male; Microspheres; Necrosis; Safety; Treatment Outcome

2011
Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy.
    Archives of dermatology, 2011, Volume: 147, Issue:10

    Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Camptothecin; Chemoradiotherapy; Fatal Outcome; Glioblastoma; Humans; Irinotecan; Male; Methylprednisolone Hemisuccinate; Necrosis; Skin; Striae Distensae

2011
Pathologic response to preoperative chemotherapy in colorectal liver metastases: fibrosis, not necrosis, predicts outcome.
    Annals of surgical oncology, 2012, Volume: 19, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fibrosis; Hepatectomy; Humans; Irinotecan; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Mucins; Multivariate Analysis; Necrosis; Organoplatinum Compounds; Oxaliplatin; Preoperative Care; Prognosis; Retrospective Studies; Single-Blind Method

2012
Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2013, Volume: 8, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Proliferation; Cisplatin; Etoposide; Humans; Irinotecan; Lung Neoplasms; Mice; Mice, Nude; Necrosis; Paclitaxel; Small Cell Lung Carcinoma; Tumor Cells, Cultured

2013
Quantification of tumor tissue populations by multispectral analysis.
    Magnetic resonance in medicine, 2004, Volume: 51, Issue:3

    Topics: Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; fas Receptor; Female; Humans; Irinotecan; Ligands; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Nude; Necrosis; Neoplasm Transplantation; Remission Induction; Skin Neoplasms; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Necrosis Factor-alpha

2004
Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.
    Oncogene, 2006, Jan-12, Volume: 25, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; DNA Damage; Female; Flow Cytometry; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Necrosis; Ploidies; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2006
Intestinal microflora and digestive toxicity of irinotecan in mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-15, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cecum; Colon; Diarrhea; Dose-Response Relationship, Drug; Ileum; Intestinal Mucosa; Intestines; Irinotecan; Jejunum; Mice; Mice, Inbred C3H; Microscopy, Electron, Scanning; Necrosis; Specific Pathogen-Free Organisms; Survival Analysis; Time Factors

2006
Irinotecan-eluting stents inhibited neointimal proliferation in hypercholesterolemic rabbit aortas.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2006, Volume: 68, Issue:1

    Topics: Animals; Aorta, Abdominal; Atherosclerosis; Camptothecin; Cell Proliferation; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Hypercholesterolemia; Inflammation; Irinotecan; Necrosis; Phosphorylcholine; Rabbits; Research Design; Stents; Tunica Intima

2006
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:5

    Topics: Animals; Apoptosis; Blotting, Western; Camptothecin; Cecum; Cell Proliferation; Colonic Neoplasms; Drug Therapy, Combination; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Irinotecan; Lymphatic Metastasis; Male; Mice; Mice, Nude; Necrosis; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; RNA, Small Interfering; Topoisomerase I Inhibitors; Transforming Growth Factor alpha

2008
Response of chemosensitive and chemoresistant leukemic cell lines to drug therapy: simultaneous assessment of proliferation, apoptosis, and necrosis.
    Cytometry, 2000, Feb-15, Volume: 42, Issue:1

    Topics: Annexin A5; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Camptothecin; Cell Division; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Irinotecan; Leukemia, Myeloid; Necrosis; Propidium; Tranexamic Acid; Tumor Cells, Cultured; Vincristine

2000