Proteins > Tyrosine-protein kinase Srms
Page last updated: 2024-08-08 00:14:59

Tyrosine-protein kinase Srms

A tyrosine-protein kinase Srms that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3Y6]

Synonyms

EC 2.7.10.2

Research

Bioassay Publications (5)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Compounds (75)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC506.500022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000022
staurosporineHomo sapiens (human)Kd0.740022
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.820022
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd6.700022
birb 796Homo sapiens (human)Kd10.000022
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd10.000022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd9.800033
pd 173955Homo sapiens (human)Kd0.600011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd10.000033
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd0.013022
zd 6474Homo sapiens (human)Kd1.900022
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd1.400022
bosutinibHomo sapiens (human)Kd0.100011
su 11248Homo sapiens (human)Kd10.000033
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd10.000022
ekb 569Homo sapiens (human)Kd10.000011
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd10.000033
ki 20227Homo sapiens (human)Kd0.400011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd2.500022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd0.062022
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.610011
brivanibHomo sapiens (human)Kd10.000011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.072022
kw 2449Homo sapiens (human)Kd2.700011
abt 869Homo sapiens (human)Kd10.000022
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd10.000011
chir-265Homo sapiens (human)Kd10.000022
motesanibHomo sapiens (human)Kd10.000022
mln8054Homo sapiens (human)Kd10.000022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd7.900022
nvp-tae684Homo sapiens (human)Kd0.160011
fedratinibHomo sapiens (human)Kd5.000011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd0.021011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd10.000022
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.018011
chir 258Homo sapiens (human)Kd10.000022
nintedanibHomo sapiens (human)Kd10.000011
pp242Homo sapiens (human)Kd10.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
non-membrane spanning protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]
signaling receptor bindingmolecular functionBinding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
negative regulation of signal transductionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. [GOC:sm]
peptidyl-tyrosine phosphorylationbiological processThe phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
peptidyl-tyrosine autophosphorylationbiological processThe phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. [PMID:10037737, PMID:10068444, PMID:10940390]
positive regulation of TORC1 signalingbiological processAny process that activates or increases the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
cell surface receptor protein tyrosine kinase signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]