Page last updated: 2024-11-08

nivalenol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

nivalenol: RN given refers to 3alpha,4beta,7alpha-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID440908
CHEBI ID7599
SCHEMBL ID15520333
MeSH IDM0115619

Synonyms (9)

Synonym
nivalenol
C06080
23282-20-4
niv
CHEBI:7599
SCHEMBL15520333
(1's,2r,2'r,3's,7'r,9'r,10'r,11's)-3',10',11'-trihydroxy-2'-(hydroxymethyl)-1',5'-dimethyl-8'-oxaspiro[oxirane-2,12'-tricyclo[7.2.1.0^{2,7}]dodecan]-5'-en-4'-one
Q27107536
F82394

Research Excerpts

Overview

Nivalenol is a secondary metabolite of type B trichothecene mycotoxin produced by Fusarium genera. It is widely found in contaminated food and crops such as corn, wheat and peanuts.

ExcerptReferenceRelevance
"Nivalenol (NIV) is a secondary metabolite of type B trichothecene mycotoxin produced by Fusarium genera, which is widely found in contaminated food and crops such as corn, wheat and peanuts. "( Nivalenol affects Cyclin B1 level and activates SAC for cell cycle progression in mouse oocyte meiosis.
Jiao, L; Lu, PS; Sun, SC; Wang, Y, 2022
)
3.61
"Deoxynivalenol is a food borne mycotoxin belonging to the trichothecenes family that may cause severe injuries in human and animals. "( In silico analysis sheds light on the structural basis underlying the ribotoxicity of trichothecenes-A tool for supporting the hazard identification process.
Dall'Asta, C; Dellafiora, L; Galaverna, G, 2017
)
0.97
"Nivalenol is a mycotoxin produced by certain fungi that are pathogenic to important cereal crops, in particular maize, wheat, and barley. "( Production and characterization of a monoclonal antibody that cross-reacts with the mycotoxins nivalenol and 4-deoxynivalenol.
Busman, M; Maragos, C; Sugita-Konishi, Y, 2006
)
2
"Nivalenol (NIV) is a toxic Fusarium secondary trichothecene metabolite occurring naturally in cereal grains. "( Effect of subacute oral doses of nivalenol on immune and metabolic defence systems in mice.
Dedieux, G; Galinier, A; Galtier, P; Gouze, ME; Laffitte, J; Loiseau, N; Oswald, IP; Pinton, P; Thouvenot, JP,
)
1.86
"Nivalenol is a toxic trichothecene metabolite which is produced by a number of different Fusarium species. "( Preparation of the Fusarium toxin, nivalenol, by oxidation of the putative biosynthetic precursor, 7-deoxynivalenol.
Ehrlich, KC, 1989
)
2
"Nivalenol (NIV) is an important Fusarium mycotoxin shown to occur naturally in grains from several countries. "( Determination of nivalenol and deoxynivalenol in cereals by electron-capture gas chromatography.
Kanhere, SR; Scott, PM; Tarter, EJ,
)
1.91

Effects

Nivalenol has been reported to induce hyperproduction of IgA. Whether IgE production, which is under the regulation of Th2 cells, is induced by this compound remains largely unknown.

ExcerptReferenceRelevance
"Nivalenol has been analysed in Swedish cereals between 1987 and 1990 and it was found in oats (35% of all samples), barley (13%) and wheat (4%), with a high yearly variation. "( Nivalenol in Swedish cereals--occurrence, production and toxicity towards chickens.
Elwinger, K; Engström, B; Fossum, O; Hedman, R; Pettersson, H,
)
3.02
"Nivalenol (NIV) has been reported to induce hyperproduction of IgA, which is regulated by T-helper 2 cells (Th2); however, whether IgE production, which is under the regulation of Th2 cells, is induced by this compound remains largely unknown. "( Nivalenol inhibits total and antigen-specific IgE production in mice.
Choi, CY; Kaminogawa, S; Nakajima-Adachi, H; Sugita-Konishi, Y, 2000
)
3.19

Treatment

ExcerptReferenceRelevance
"Treatment with nivalenol decreased the secretion of these chemokines."( Opposite effects of two trichothecene mycotoxins, deoxynivalenol and nivalenol, on the levels of macrophage inflammatory protein (MIP)-1α and MIP-1β in HL60 cells.
Kushiro, M; Nagashima, H; Nakagawa, H, 2012
)
0.97

Toxicity

Nivalenol (NIV) is a potent toxic trichothecene from Fusarium nivale. Feeding the drug to chicks produced no toxic effects at concentrations below 5 mg/kg and only small effects at 6 and 12mg/kg.

ExcerptReferenceRelevance
" Feeding nivalenol to chicks produced no toxic effects at concentrations below 5 mg/kg and only small effects at 6 and 12 mg/kg."( Nivalenol in Swedish cereals--occurrence, production and toxicity towards chickens.
Elwinger, K; Engström, B; Fossum, O; Hedman, R; Pettersson, H,
)
1.99
"We tested the genotoxicity of nivalenol (NIV), a potent toxic trichothecene from Fusarium nivale, in cultured CHO cells and in several mouse organs and tissues (liver, kidney, thymus, bone marrow and mucosa of stomach, jejunum, and colon) using the alkaline single-cell gel electrophoresis (SCG, or Comet) assay."( Detection of nivalenol genotoxicity in cultured cells and multiple mouse organs by the alkaline single-cell gel electrophoresis assay.
Kosaka, Y; Matsuo, H; Matsusaka, N; Murakami, M; Sasaki, YF; Taniguchi, K; Tsuda, S, 1998
)
0.96
" At the same toxin concentrations used in the BrdU bioassay, only T-2 and HT-2 were toxic enough to obtain IC50 values using the MTT bioassay."( Cytotoxicity of four trichothecenes evaluated by three colorimetric bioassays.
Lindberg, JE; Lundh, T; Pettersson, H; Widestrand, J, 1999
)
0.3
" 3-AcDON was less toxic than DON and 15-AcDON."( Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites.
Lundh, T; Pettersson, H; Sundstøl Eriksen, G, 2004
)
0.6
" After 48 h of exposure, the MTT and trypan blue dye-exclusion tests indicated that NIV was significantly more toxic than DON, and both were significantly more toxic than FB1."( Cytotoxicity induced by nivalenol, deoxynivalenol, and fumonisin B1 in the SF-9 insect cell line.
Fornelli, F; Minervini, F; Mulè, G,
)
0.44
"Tricothecene mycotoxins, such as nivalenol, are toxic to leukocytes."( Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells.
Kushiro, M; Nagashima, H; Nakagawa, H, 2011
)
0.92
" These results indicate that the simultaneous presence of low doses of mycotoxins in food commodities and diet may be more toxic than predicted from the mycotoxins alone."( New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic.
Abiola, FA; Abrami, R; Alassane-Kpembi, I; Gauthier, T; Kolf-Clauw, M; Oswald, IP; Puel, O, 2013
)
0.39
"Since humans are exposed to different mycotoxins through daily intake, there is increasing concern about the adverse effects of the interactions between them."( Cytotoxic effects of individual and combined sterigmatocystin and nivalenol on liver hepatocellular carcinoma cells.
Fedeli, C; Fernández-Franzón, M; Ruiz, MJ; Zingales, V, 2020
)
0.8
" DON has ribotoxic, pro-inflammatory, and cytotoxic potential and induces multiple toxic effects in humans and animals."( A novel toxic effect of foodborne trichothecenes: The exacerbation of genotoxicity.
Garofalo, M; Nougayrède, JP; Oswald, E; Oswald, IP; Payros, D; Penary, M, 2023
)
0.91

Compound-Compound Interactions

ExcerptReferenceRelevance
" The purpose of the present study was to investigate the effects of DON alone and in combination with NIV and ZEA on several parameters including weight gain and histological aspects of pigs submitted to chronic intoxication."( Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs.
Bracarense, AP; Callu, P; Gerez, JR; Grosjean, F; Oswald, IP; Pinton, P, 2015
)
0.93

Bioavailability

ExcerptReferenceRelevance
" The elimination rate constant (kel) was higher in broilers than in ducks, whereas the oral bioavailability of FX was higher in ducks than in broilers."( Fate of fusarenon-X in broilers and ducks.
Imsilp, K; Itoh, Y; Kumagai, S; Poapolathep, A; Poapolathep, S; Sinthusing, C; Sugita-Konishi, Y; Tassanawat, T, 2008
)
0.35
" These glucoside conjugates are converted back to the parent toxins during human digestion, but studies to confirm their bioavailability are lacking."( Risk Assessment Considering the Bioavailability of 3-β-d-Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea.
Cho, S; Chun, HS; Hwang, M; Lee, SY; Woo, SY, 2023
)
1.14

Dosage Studied

ExcerptRelevanceReference
" Dose-response curves for each mycotoxin were generated."( Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation.
De Luna, R; Luongo, D; Russo, R; Severino, L, 2008
)
0.58
" To investigate the toxicokinetics of FX and its metabolite nivalenol (NIV), FX was then administered intravenously or orally to piglets at a dosage of 1mg/kg body weight."( Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets.
Ikenaka, Y; Isariyodom, S; Ishizuka, M; Poapolathep, A; Poapolathep, S; Saengtienchai, T, 2014
)
0.88
" While emesis induced by intraperitoneally dosed to DON in the mink has been related to plasma up-grading of 5-hydroxytryptamine (5-HT) and neurotransmitters peptide YY (PYY), the impact of oral dosing with DON or its four congeners on secretion of these chemical substances have not been established."( Emesis to trichothecene deoxynivalenol and its congeners correspond to secretion of peptide YY and 5-HT.
Guo, X; Kuca, K; Qin, Z; Wei, B; Wu, Q; Wu, W; Xiao, H; Xu, B, 2023
)
1.2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
trichotheceneAny one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (272)

TimeframeStudies, This Drug (%)All Drugs %
pre-199018 (6.62)18.7374
1990's34 (12.50)18.2507
2000's78 (28.68)29.6817
2010's104 (38.24)24.3611
2020's38 (13.97)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.60 (24.57)
Research Supply Index5.70 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index49.01 (26.88)
Search Engine Supply Index1.95 (0.95)

This Compound (35.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.34%)5.53%
Reviews9 (3.02%)6.00%
Case Studies1 (0.34%)4.05%
Observational0 (0.00%)0.25%
Other287 (96.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]