A sodium channel protein type 3 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NY46]
Sodium channel protein brain III subunit alpha;
Sodium channel protein type III subunit alpha;
Voltage-gated sodium channel subtype III;
Voltage-gated sodium channel subunit alpha Nav1.3
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| phenytoin | Homo sapiens (human) | IC50 | 18.5000 | 1 | 1 |
| amiodarone | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| amitriptyline | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| lidocaine | Homo sapiens (human) | IC50 | 10.5000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| lamotrigine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| mexiletine | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| phenobarbital | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| tetracaine | Homo sapiens (human) | IC50 | 0.7400 | 1 | 1 |
| naphthazarin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| tedisamil | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| n-methylpiperidin-4-yl propionate | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cns 5161 | Homo sapiens (human) | IC50 | 1.7500 | 1 | 1 |
| senicapoc | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| ica-121431 | Homo sapiens (human) | IC50 | 0.0185 | 2 | 2 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 0.0176 | 2 | 2 |
| a 803467 | Homo sapiens (human) | IC50 | 5.5533 | 3 | 3 |
| cnv1014802 | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| saxitoxin | Homo sapiens (human) | IC50 | 0.0130 | 1 | 1 |
| ajmaline | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
This protein enables 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| sarcoplasm | cellular component | The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. [ISBN:0198547684] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| behavioral response to pain | biological process | Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |