perfluorododecanoic acid: a synthetic perfluorinated chemical containing 12 carbons, has broad industrial applications and has been detected in sera from humans and other animals [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
perfluorododecanoic acid : A fluoroalkanoic acid that is dodecanoic acid in which all of the hydrogens attached to carbon atoms are replaced by fluorines. It is a highly persistent, bioaccumulative breakdown product of stain- and grease-proof coatings on food packaging, soft furnishings and carpets. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 67545 |
| CHEBI ID | 90633 |
| SCHEMBL ID | 108127 |
| MeSH ID | M0512988 |
| Synonym |
|---|
| tricosafluorododecanoic acid, 95% |
| 307-55-1 |
| tricosafluorododecanoic acid |
| perfluorododecanoic acid (pfdoa) |
| einecs 206-203-2 |
| dodecanoic acid, tricosafluoro- |
| perfluorododecanoic acid |
| tricosafluorolauric acid |
| T2492 |
| perfluorolauric acid |
| 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluorododecanoic acid |
| pfdoa, c12 |
| pfdoda |
| pfdoa |
| pfdoa cpd |
| dodecanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluoro- |
| perfluoro-n-dodecanoic acid |
| p6g1j7nm2d , |
| unii-p6g1j7nm2d |
| n-perfluorododecanoic acid |
| FT-0676234 |
| AKOS015852633 |
| SCHEMBL108127 |
| perfluorododecanoicacid |
| 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluorododecanoic acid # |
| tricosafluorododecanoic acid, analytical standard |
| 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-tricosafluorododecanoic acid |
| CHEBI:90633 |
| c11f23co2h |
| n-c11f23cooh |
| n-c11f23co2h |
| c11f23cooh |
| DTXSID8031861 |
| mfcd00198081 |
| AS-74021 |
| dodecanoic acid, tricosafluoro- (6ci,7ci,8ci,9ci); 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluorododecanoic acid; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-tricosafluorododecanoic acid; pfdoda; pfc |
| J-018128 |
| Q27162640 |
| perfluoro-n-dodecanoic acid 50 microg/ml in methanol/water |
| benzene, 1-chloro-4-(1-propyn-1-yl)- |
| D78405 |
| perfluoro-n-dodecanoic acid 50 microg/ml in methanol/water |
| CS-0320465 |
| 1ST9507 |
Perfluorododecanoic acid is an endocrine-damaging compound in contaminated food and water. It has been detected in human sera and has adverse effects on testicular function in animal models.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Perfluorododecanoic acid (PFDoA) has been used as a surfactant and may have reproductive toxicity. " | ( Perfluorododecanoic Acid Blocks Rat Leydig Cell Development during Prepuberty. Chen, X; Chen, Y; Ge, F; Ge, RS; Guo, X; Li, H; Li, X; Ma, L; Mo, J; Wu, K; Zhao, J, 2019) | 3.4 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Perfluoroalkyl carboxylic acids (PFCAs) are a series of environmental contaminants that have received attention because of their possible adverse effects on wildlife and human health." | ( Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats. Fujii, S; Hirata-Koizumi, M; Hirose, A; Kato, H; Matsumoto, M; Ono, A; Takahashi, M, 2015) | 0.66 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Male rats were orally dosed for 14 days with 1, 5, or 10 mg PFDoA/kg/day or with vehicle." | ( Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Dai, J; Liu, Y; Shi, Z; Xu, M; Zhang, H, 2007) | 0.56 |
| " To determine the hepatotoxicity of PFDoA, male rats were orally dosed by gavage for 14 days with 0, 1, 5, or 10 mg PFDoA/kg/day." | ( Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid. Dai, J; Liu, Y; Shi, Z; Wei, Y; Zhang, H, 2008) | 0.58 |
| "5 mg dosed group, while homocitrulline, α-aminoadipic acid, β-alanine, and cystathionine decreased." | ( Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies. Chen, H; Dai, J; Ding, L; Fang, X; Shi, Z; Yan, X; Zhang, H; Zhang, Y, 2011) | 0.68 |
| Role | Description |
|---|---|
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| fluoroalkanoic acid | Any organofluorine compound that is the perfluorinated derivative of any alkanoic acid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 26 (61.90) | 24.3611 |
| 2020's | 5 (11.90) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (37.64) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 42 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||