Proteins > Neuropeptide Y receptor type 2
Page last updated: 2024-08-07 16:45:07
Neuropeptide Y receptor type 2
A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146]
Synonyms
NPY2-R;
NPY-Y2 receptor;
Y2 receptor
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bms 193885 | Homo sapiens (human) | Kb | 1.0000 | 1 | 1 |
Ligands of the neuropeptide Y Y2 receptor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Ligands of the neuropeptide Y Y2 receptor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Ligands of the neuropeptide Y Y2 receptor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Ligands of the neuropeptide Y Y2 receptor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Novel non-peptidic neuropeptide Y Y2 receptor antagonists.Bioorganic & medicinal chemistry letters, , Mar-08, Volume: 14, Issue:5, 2004
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.Journal of medicinal chemistry, , May-28, Volume: 58, Issue:10, 2015
Ligands of the neuropeptide Y Y2 receptor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 17, Issue:7, 2007
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008
Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine.Journal of medicinal chemistry, , Sep-07, Volume: 43, Issue:18, 2000
Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Ligands of the neuropeptide Y Y2 receptor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| peptide YY receptor activity | molecular function | Combining with gut peptide YY to initiate a change in cell activity. [PMID:9315606] |
| neuropeptide Y receptor activity | molecular function | Combining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606] |
| calcium channel regulator activity | molecular function | Modulates the activity of a calcium channel. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cilium | cellular component | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] |
| non-motile cilium | cellular component | A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| outflow tract morphogenesis | biological process | The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145] |
| cardiac left ventricle morphogenesis | biological process | The process in which the left cardiac ventricle is generated and organized. [GOC:mtg_heart] |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| neuropeptide signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194] |
| locomotory behavior | biological process | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph] |