Page last updated: 2024-08-07 18:32:37
Beta-lactamase
[no definition available]
Synonyms
EC 3.5.2.6;
Cephalosporinase
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (18)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tazobactam | Pseudomonas aeruginosa PAO1 | IC50 | 10.8825 | 4 | 4 |
| sulbactam | Pseudomonas aeruginosa PAO1 | IC50 | 27.0000 | 1 | 1 |
| clavulanic acid | Pseudomonas aeruginosa PAO1 | IC50 | 50.4000 | 2 | 2 |
| avibactam | Pseudomonas aeruginosa PAO1 | IC50 | 0.1280 | 1 | 1 |
Drugs with Other Measurements
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Extended-spectrum cephalosporinases in Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:5, 2009
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Extended-spectrum cephalosporinases in Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:5, 2009
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:12, 2010
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:12, 2010
Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Extended-spectrum cephalosporinases in Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:5, 2009
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007