A transient receptor potential cation channel TRPM8 that is encoded in the genome of rat. [OMA:Q8R455, PRO:DNx]
Cold menthol receptor 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cannabinol | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| thymol | Rattus norvegicus (Norway rat) | IC50 | 241.8500 | 2 | 2 |
| citronellol | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| citronellyl acetate | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| ag 3-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0580 | 1 | 1 |
| geraniol | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| benzylidenephthalide | Rattus norvegicus (Norway rat) | IC50 | 9.2500 | 2 | 2 |
| butylidenephthalide | Rattus norvegicus (Norway rat) | IC50 | 147.0000 | 2 | 2 |
| nerol | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| cannabidiol | Rattus norvegicus (Norway rat) | IC50 | 2.8000 | 1 | 1 |
| 3-(2-methoxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one | Rattus norvegicus (Norway rat) | IC50 | 8.3000 | 1 | 1 |
| geranyl acetate | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 4-[4-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| cannabigerol | Rattus norvegicus (Norway rat) | IC50 | 0.1600 | 1 | 1 |
| n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 0.4750 | 1 | 1 |
| cannabidivarin | Rattus norvegicus (Norway rat) | IC50 | 0.9000 | 1 | 1 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| menthol | Rattus norvegicus (Norway rat) | EC50 | 75.0000 | 1 | 1 |
| thymol | Rattus norvegicus (Norway rat) | EC50 | 52.2000 | 1 | 1 |
| ag 3-5 | Rattus norvegicus (Norway rat) | EC50 | 0.1500 | 2 | 2 |
| 3-(2-methoxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one | Rattus norvegicus (Norway rat) | EC50 | 1.1000 | 1 | 1 |