Baculoviral IAP repeat-containing protein 5

A baculoviral IAP repeat-containing protein 5 that is encoded in the genome of human. [PMID:12719470, PMID:15917996, PMID:20929775, PRO:KER]

Synonyms

Apoptosis inhibitor 4;
Apoptosis inhibitor survivin

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benziodarone	Homo sapiens (human)	Kd	8.0000	1	1
3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone	Homo sapiens (human)	Kd	5.3500	2	2

Enables

This protein enables 8 target(s):

Target	Category	Definition
cysteine-type endopeptidase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. [GOC:dph, GOC:tb]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
microtubule binding	molecular function	Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
protein-folding chaperone binding	molecular function	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
nuclear chromosome	cellular component	A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. [GOC:dph, GOC:mah]
chromosome, centromeric region	cellular component	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
kinetochore	cellular component	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:elh]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
spindle	cellular component	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
microtubule	cellular component	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]
microtubule cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172]
midbody	cellular component	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
chromosome passenger complex	cellular component	A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. [GOC:vw, PMID:16824200, PMID:19570910]
survivin complex	cellular component	A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC). [GOC:bhm, PMID:10949038]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
mitotic cell cycle	biological process	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]
mitotic cytokinesis	biological process	A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
sensory perception of sound	biological process	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
protein-containing complex localization	biological process	A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. [GOC:mah]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
mitotic spindle midzone assembly	biological process	The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]
positive regulation of mitotic cell cycle spindle assembly checkpoint	biological process	Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. [GOC:mah, GOC:vw]
mitotic spindle assembly	biological process	Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. [GOC:tb, GOC:vw]
positive regulation of mitotic sister chromatid separation	biological process	Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. [GOC:TermGenie, PMID:1846086]
positive regulation of attachment of mitotic spindle microtubules to kinetochore	biological process	Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. [GOC:TermGenie, PMID:22065639]
positive regulation of mitotic cytokinesis	biological process	Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis. [GO_REF:0000058, GOC:TermGenie, PMID:24920823]