Compounds > tris(2,3-dibromopropyl)isocyanurate
Page last updated: 2024-11-07

tris(2,3-dibromopropyl)isocyanurate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tris(2,3-dibromopropyl)isocyanurate, also known as TDBPI, is a brominated flame retardant that has been widely used in various materials, including polymers, textiles, and electronics. It is synthesized through the reaction of cyanuric chloride with 2,3-dibromopropanol. TDBPI is highly effective in preventing the spread of flames due to its ability to release bromine radicals during combustion, which interrupt the chain reaction of the flame. However, concerns have arisen regarding its potential toxicity and environmental persistence. Studies have shown that TDBPI can accumulate in the environment and potentially pose risks to human health and wildlife. Its persistence and potential bioaccumulation have led to its phase-out or restriction in many countries. Research on TDBPI focuses on its environmental fate and transport, toxicity to various organisms, and alternative flame retardants. The study of TDBPI is crucial to understand its environmental impact, develop safer alternatives, and protect human health and ecosystems.'

tris(2,3-dibromopropyl)isocyanurate: Flame Retardant; RN, structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID103634
SCHEMBL ID26874
MeSH IDM0537035

Synonyms (28)

Synonym
tris(2,3-dibromopropyl) isocyanurate, 97%
einecs 257-913-4
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazinane-2,4,6-trione
52434-90-9
I0355
isocyanuric acid tris(2,3-dibromopropyl) ester
tris(2,3-dibromopropyl) isocyanurate
FT-0640069
tris-(2,3-dibromopropyl)isocyanurate
1,3,5-triazine-2,4,6(1h,3h,5h)-trione, 1,3,5-tris(2,3-dibromopropyl)-
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1h,3h,5h)-trione
tris(2,3-dibromopropyl)isocyanurate
AKOS015901131
hexahydro-1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6-trione
SCHEMBL26874
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazinane-2,4,6-trione #
NZUPFZNVGSWLQC-UHFFFAOYSA-N
DTXSID9052713
tri(2,3-dibromopropyl) isocyanate
W-105826
mfcd00010290
tris-dibromopropyisocyanate
SB73273
tris(2,3-dibromopropyl)-s-triazine-2,4,6-trione
BS-49290
CS-0327079
F71233
tris-dibromopropylisocyanurate

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Our results also indicated that mitochondria are one of the major target cytoplasmic organelles for TBC, suggesting that damage in mitochondria is one of the pathways that led to toxic effects in the liver and lung of TBC-treated groups."( Toxicity of new emerging pollutant tris-(2,3-dibromopropyl) isocyanurate on BALB/c mice.
Bao, J; Li, J; Liang, Y; Liu, Y; Zhang, A; Zhang, J; Zhang, X, 2015)		0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's17 (94.44)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.88 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index5.53 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
corticosterone
[no description available]		2.111011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
tetrabromobisphenol a
tetrabromobisphenol A: a brominated flame retardant. 3,3',5,5'-tetrabromobisphenol A : A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.		2.110brominated flame retardant;
bromobisphenol
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		2.110biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.1110
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.		02.5220
Encephalopathy, Toxic
[description not available]		02.1110
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.1110