A serine racemase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZT4]
EC 5.1.1.18;
D-serine ammonia-lyase;
D-serine dehydratase;
4.3.1.18;
L-serine ammonia-lyase;
L-serine dehydratase;
4.3.1.17
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzoic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| glycine | Homo sapiens (human) | Ki | 366.0000 | 1 | 1 |
| malonic acid | Homo sapiens (human) | IC50 | 667.4500 | 2 | 2 |
| malonic acid | Homo sapiens (human) | Ki | 52.6667 | 3 | 3 |
| thiophene-3-carboxylic acid | Homo sapiens (human) | IC50 | 8,213.0000 | 1 | 1 |
| 3-hydroxy-1-benzopyran-2-one | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| tricarballylic acid | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| crotonic acid | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 3-coumaric acid | Homo sapiens (human) | IC50 | 8,386.0000 | 1 | 1 |
| sun | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 13 target(s):
| Target | Category | Definition |
|---|---|---|
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| L-serine ammonia-lyase activity | molecular function | Catalysis of the reaction: L-serine = pyruvate + NH3. [EC:4.3.1.17] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| D-serine ammonia-lyase activity | molecular function | Catalysis of the reaction: D-serine = pyruvate + NH3. [EC:4.3.1.18] |
| glycine binding | molecular function | Binding to glycine, aminoethanoic acid. [GOC:ai] |
| threonine racemase activity | molecular function | Catalysis of the reaction: L-threonine = D-threonine. [EC:5.1.1.6, RHEA:13913] |
| PDZ domain binding | molecular function | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| serine racemase activity | molecular function | Catalysis of the synthesis of free D-serine from L-serine. [GOC:kd] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| apical part of cell | cellular component | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| L-serine metabolic process | biological process | The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg] |
| serine family amino acid metabolic process | biological process | The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. [GOC:ai] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to organic cyclic compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef] |
| response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464] |
| pyruvate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. [GOC:go_curators] |
| D-serine metabolic process | biological process | The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. [CHEBI:16523, GOC:jsg, GOC:mah] |
| D-serine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine. [CHEBI:16523, GOC:jsg, GOC:mah] |