Cefotaxime: Semisynthetic broad-spectrum cephalosporin. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 5742673 |
| CHEMBL ID | 1730 |
| CHEBI ID | 204928 |
| SCHEMBL ID | 3731931 |
| MeSH ID | M0003722 |
| Synonym |
|---|
| AC-217 |
| (6r,7r)-3-(acetyloxymethyl)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid |
| BRD-K78364995-236-03-5 |
| LOPAC0_000278 |
| PRESTWICK2_000139 |
| PRESTWICK3_000139 |
| BPBIO1_000240 |
| BSPBIO_000218 |
| cefotaxim hikma (tn) |
| cefotaxime (inn) |
| D07647 |
| cephotaxime |
| claforan (*sodium salt*) |
| 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6r,7r)- |
| (6r,7r)-3-(acetoxymethyl)-7-[[(2z)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| C06885 |
| cefotaxime |
| (6r,7r)-3-acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| (6r,7r,z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| DB00493 |
| (6r,7r)-3-(acetoxymethyl)-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6r,7r)- |
| ru 24662 |
| 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z)))- |
| cephotaxim |
| cefotaxime [inn:ban] |
| (6r,7r)-3-(acetoxymethyl)-7-(()-2-(2-amino-4-thiazolyl)-2-methoxyiminoglyoxylamino)-8-oco-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure |
| cefotaxima [inn-spanish] |
| cefotaximum [inn-latin] |
| einecs 264-299-1 |
| HMS2090M11 |
| (6r,7r)-3-(acetyloxymethyl)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| CHEBI:204928 , |
| CHEMBL1730 |
| cefotaxim hikma |
| (6r,7r)-3-[(acetyl-oxy)methyl]-7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| cefotaximum |
| cefotaxima |
| AKOS015951267 |
| S4720 |
| n2gi8b1gk7 , |
| unii-n2gi8b1gk7 |
| omnatax |
| taxim |
| 3-(acetyloxymethyl)-7-(((2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid |
| (6r,7r)-3-(acetoxymethyl)-7-((2-(2-amino-4-thiazolyl)-2-methoxyiminoglyoxylamino)-8-oco-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure |
| 60846-21-1 |
| 4KOT |
| (6r,7r,z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid |
| cefotaxime [inn] |
| cefotaxime [jan] |
| cefotaxime [vandf] |
| cefotaxime [mi] |
| cefotaxime [who-dd] |
| SCHEMBL3731931 |
| (6r,7r)-3-(acetyloxymethyl)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| DTXSID6022761 , |
| (6r,7r)-3-[(acetyloxy)methyl]-7-[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| CS-0013515 |
| HY-A0088A |
| bdbm50482777 |
| (6r,7r)-3-[(acetyloxy)methyl]-7-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| clo[4.2.0]oct-2-ene-2-carboxylic acid |
| (6r,7r)-3-(acetyloxymethyl)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy |
| mfcd00864971 |
| AS-12690 |
| SDCCGSBI-0050266.P002 |
| Q27262497 |
| e-cefotaxime |
| cefotaxima acid |
| A936301 |
| dtxcid501476108 |
| (6r,7r)-3-acetoxymethyl-7-(2-(2-amino-thiazol-4-yl)-2-((z)-methoxyimino)-acetylamino)-8-oxo-5-thia-1-aza-bicyclo(4.2.0)oct-2-ene-2-carboxylic acid |
| cefotaxima (inn-spanish) |
| cefotaximum (inn-latin) |
| (6r,7r,z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo(4.2.0)oct-2-ene-2-carboxylic acid |
| 3-(acetoxymethyl)-7beta-(((2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-3,4-didehydrocepham-4-carboxylic acid |
| (6r,7r)-3-(acetoxymethyl)-7-(((2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid |
| j01da10 |
| EN300-21702510 |
Third-generation cephalosporins in general have few adverse effects. Adverse reactions occurred in one of 45 ceftizoxime-treated patients. Reversible adverse reactions were the most common reason for withdrawal of cefotaxime.
The pharmacokinetic behaviour of two aminothiazolyl cephalosporins, ceftazidime (CAZ) and cefotaxime (CTX), were compared in three studies. The aim of this study was to build a population pharmacokinetics model for ceftaxime and its metabolite desacetylcefotaxim.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bacteriological, pharmacokinetic and clinical studies on cefdinir (CFDN, FK482), a new oral cephalosporin, 5% and 10% granules, were performed in the field of pediatrics." | ( [Bacteriological, pharmacokinetic and clinical studies of 5% and 10% granules of cefdinir in the pediatric field]. Hatakeyama, K; Hori, M; Nakano, K; Sakaguchi, N; Sugita, M; Toyonaga, Y; Yamazaki, M; Yamori, K, 1992) | 0.28 |
| " With an average elimination half-life of about 1 h, cefotaxime is not considered to be a 'long half-life cephalosporin' like ceftriaxone." | ( Cefotaxime dosage in infants and children. Pharmacokinetic and clinical rationale for an extended dosage interval. Jacobs, RF; Kearns, GL; Young, RA, 1992) | 0.28 |
| " Furthermore, pharmacokinetic analysis of the data obtained from in vivo and in vitro experiments indicated that PCG reduced the permeability of [14C]CDZM across the sinusoidal and bile canalicular membranes to 32% and 40% of the control value, respectively." | ( Effect of benzylpenicillin on the disposition of cefodizime in rats: no net effect on total clearance due to decreased hepatobiliary clearance and increased renal clearance. Hanano, M; Iga, T; Kawaguchi, Y; Matsushita, H; Sawada, Y; Sugiyama, Y; Suzuki, H, 1992) | 0.28 |
| " Pharmacokinetic parameters were estimated by using an extended least-squares modeling program (MKMODEL)." | ( Comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime. LeBel, M; Vallée, F, 1991) | 0.28 |
| " The purpose of the study was to compare cefoxitin, cefotetan, ceftizoxime, cefotaxime (CT), desacetylcefotaxime (DACT), and CT/DACT (1:1 ratio) by integrating their microbiologic activity against clinical isolates of Bacteroides fragilis with their pharmacokinetic properties." | ( Evaluation of cephalosporins/cephamycins with antianaerobic activity by integrating microbiologic and pharmacokinetic properties. Del Bene, VE; Friedrich, LV; Kays, MB; White, RL, ) | 0.13 |
| " As compared with values obtained for anuric patients during the dialysis-free period, the mean serum half-life was nearly doubled (2." | ( [Infection-induced change in the pharmacokinetics of cefotaxime. Dose calculation in multiple organ failure and relevance of score systems]. Hofmann, W; Kroh, U; Lennartz, H, 1991) | 0.28 |
| "Sisomicin (SMN) and cefotaxime (CTX) antimicrobial effect (AME) kinetics were studied under in vitro stimulation the drug monoexponential pharmacokinetic profiles mimicking normal and impaired elimination of SMN or CTX administered in various doses to humans." | ( In vitro simulated pharmacokinetics profiles: forecasting antibiotic optimal dosage. Firsov, AA, 1991) | 0.28 |
| "The pharmacokinetic profile of amikacin was analysed by a two-compartment model in 100 critically-ill adult and paediatric patients with normal renal function." | ( The pharmacokinetic of amikacin in critically ill adult and paediatric patients: comparison of once- versus twice-daily dosing regimens. Havlik, I; Lipman, J; Marik, PE; Monteagudo, FS, 1991) | 0.28 |
| " Both the CTX fraction nonrenally cleared and elimination half-life increased with decreasing renal function." | ( Pharmacokinetics of cefotaxime and its active metabolite in children with renal dysfunction. Hubbard, JW; Mahan, JD; Mentser, MA; Nahata, MC; Paap, CM; Puri, SK, 1991) | 0.28 |
| "A pharmacokinetic study on cefixime (CFIX) 5% granules for pediatric use was performed, and pharmacokinetic parameter were calculated." | ( [Pharmacokinetic studies on oral antibiotics in pediatrics. I. A pharmacokinetic study on cefixime in pediatrics]. Iwai, N; Nakamura, H, 1991) | 0.28 |
| " The following pharmacokinetic indices were estimated after single and repeated (values in brackets) dosing: C0." | ( Pharmacokinetics of cefodizime in the elderly following single and repeated intravenous administration of 1 g. Lenfant, B; Nilsen, OG; Rennemo, F; Rennemo, R, 1990) | 0.28 |
| " Cefodizime concentrations in blood and urine (iv dosage only) sampled up to 12h post dose were measured by microbiological assay and pharmacokinetic parameters were derived on the basis of a two-compartment open model." | ( The pharmacokinetics of cefodizime in children. Boccazzi, A; Careddu, P; Fusi, G; Maretti, M; Mezzopane, AM, 1990) | 0.28 |
| "The pharmacokinetic parameters of cefixime were determined in healthy volunteers following oral administration of 200 mg cefixime as tablet, syrup and dry suspension, respectively." | ( [Pharmacokinetics of cefixime in volunteers and a literature comparison with the new ester prodrug cephalosporins]. Kees, F; Naber, KG, 1990) | 0.28 |
| " Based on these predicted pharmacokinetic parameters, we calculated the plasma concentration profiles of these drugs in humans and found a good agreement between the predicted and observed values." | ( Prediction of the pharmacokinetics of cefodizime and cefotetan in humans from pharmacokinetic parameters in animals. Hanano, M; Iga, T; Kawaguchi, Y; Matsushita, H; Sawada, Y; Sugiyama, Y; Suzuki, H, 1990) | 0.28 |
| " The extent to which Ro 23-9424 acts in vivo as a true dual-action cephalosporin, or acts as a combination of active metabolites, is therefore a function of its pharmacokinetic properties." | ( Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals. Chan, KK; Christenson, JG; Cleeland, R; Dix-Holzknecht, B; Farrish, HH; Patel, IH; Specian, A, 1990) | 0.28 |
| " Following a single intravenous injection, the blood concentration-time curve indicated two compartments open model, with an elimination half-life value (t1/2 beta) of 22." | ( Pharmacokinetic profile of cefotaxime in goats. Afifi, NA; Atef, M; Ramadan, A; Youssef, SA, 1990) | 0.28 |
| " The terminal half-life of cefotaxime increased and total clearance decreased due to an impairment of drug metabolism, mainly in patients with a nonfunctioning allograft and during rejection." | ( Pharmacokinetics of cefotaxime in patients after liver transplantation. Kuse, E; Rosenkranz, B; Vogt, P, ) | 0.13 |
| " A significant inverse relationship was found between gestational age and the elimination half-life of CTX, and the AUC of both CTX and DCTX." | ( Pharmacokinetics of cefotaxime in preterm infants. Chretien, P; Gouyon, JB; Kazmierczak, A; Pechinot, A; Safran, C; Sandre, D, 1990) | 0.28 |
| " Following a single intravenous injection, the blood concentration-time curve indicated a two compartment open model, with an elimination half-life value (t1/2 beta) of 22." | ( Pharmacokinetic profile of cefotaxime in goats. Afifi, NA; Atef, M; Ramadan, A; Youssef, SA, 1990) | 0.28 |
| "The dependence of the antibacterial activity of the two oral cephalosporins cefixime and cefaclor on pharmacokinetic properties was investigated in an in vitro model using strains of enterobacteria and a streptococcal strain." | ( Comparative activity of cefixime and cefaclor in an in vitro model simulating human pharmacokinetics. Nies, BA, 1989) | 0.28 |
| " The elimination half-life varies between 3 and 4 hours." | ( [Pharmacokinetic properties of cefixime]. Barré, J, 1989) | 0.28 |
| " The time for maximum serum concentration was delayed and the cefixime half-life in serum was prolonged, as a reflect of increased volume of distribution resulting from ascites and hypoalbuminemia." | ( [Effect of hepatic failure upon the pharmacokinetics of cefixime]. Gaudin, C; Lebrec, D; Montay, G; Roche, G; Singlas, E; Taburet, AM, 1989) | 0.28 |
| "We have conducted pharmacokinetic and clinical trials of a new cephem derivative, cefodizime (THR-221, CDZM), and obtained the following results." | ( [Pharmacokinetic and clinical studies on cefodizime in the field of obstetrics and gynecology]. Eguchi, K; Kondoh, T; Nakagiri, Y; Niida, K; Nishi, M; Okuda, H; Sanoh, T; Sekiba, K; Suzuki, Y; Yamashita, K, 1989) | 0.28 |
| "A study of the pharmacokinetic parameters of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in newborns was conducted; the former is commonly used for neonatal infections." | ( Pharmacokinetics of cefotaxime and desacetylcefotaxime in the newborn. Aujard, Y; Brion, F; Chretien, P; Criqui, C; Jacqz-Aigrain, E; Kasse, MC; Mathieu, H, ) | 0.13 |
| "Over the past 5 yr, we have conducted two clinical and two pharmacokinetic investigations of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in neonates, infants, and children." | ( Cefotaxime and desacetylcefotaxime in neonates and children: a review of microbiologic, pharmacokinetic, and clinical experience. Jacobs, RF; Kearns, GL, ) | 0.13 |
| "Relationships between concentration and antimicrobial effect (AME) of sisomicin (SMN) and cefotaxime (CTX) were established by simulating their pharmacokinetic profiles in an in vitro dynamic model." | ( [Correlation of dose-antimicrobial effect in modeling in vitro pharmacokinetic profiles of normal and impaired elimination of antibiotics]. Firsov, AA, 1989) | 0.28 |
| " The relationship between half-life (ceftriax-one 6 h, cefotaxime 1 h) and potency was examined by following bacterial kill curves in a single chamber, open-ended perfusion model over an 8-hour period." | ( Potencies of ceftriaxone and cefotaxime in a single chamber pharmacokinetic system simulating their in vivo half-lives. Patel, IH; Sattler, J; Unowsky, J, 1989) | 0.28 |
| "Examining serum level values and urinary concentrations taken from nonpregnant control persons and pregnant women suffering from urinary tract infections (UTI) during the third trimenon, the pharmacokinetic dates after single application of 1 g cefotaxime have been evaluated." | ( [Pharmacokinetics of cefotaxime during late pregnancy]. Bierwisch, I; Michels, W; Schröder, S; Voigt, R, ) | 0.13 |
| " In both the pharmacokinetic and meningitis studies, the safety profile for cefotaxime was excellent with no adverse reactions." | ( Cefotaxime pharmacokinetics and treatment of meningitis in neonates. Jacobs, RF; Kearns, GL, ) | 0.13 |
| "The pharmacokinetic disposition of cefotaxime, desacetyl cefotaxime, and mezlocillin after the administration of each drug singly and in combination was examined in eight healthy volunteers and in five anuric patients with end-stage renal disease (ESRD)." | ( Influence of coadministration on the pharmacokinetics of mezlocillin and cefotaxime in healthy volunteers and in patients with renal failure. Barriere, SL; Flaherty, JF; Gambertoglio, JG; Rodondi, LC; Schoenfeld, P, 1989) | 0.28 |
| " The beta-elimination half-life was 17 min with Cls of 13." | ( Disposition of cefotaxime and its metabolite, desacetylcefotaxime, in rat: application of a pharmacokinetic-protein binding model. Bourne, DW; Hakim, L; Triggs, EJ, 1989) | 0.28 |
| " The relevant pharmacokinetic parameters of the single substances were essentially unchanged when administered in combination." | ( Studies on the synergism of sulbactam and beta-lactam antibiotics under in vitro conditions and in healthy volunteers after intravenous administration. Antibacterial activity in vitro, compatibility and pharmacokinetics of the drugs in combination. Eibel, G; Pfaff, G; Räder, K; Schmalreck, A; Wildfeuer, A, 1989) | 0.28 |
| " The pharmacokinetic profile and protein binding parameters of ceftriaxone were determined in rat, and compared with those of cefotaxime." | ( Disposition of ceftriaxone in rat: application of a pharmacokinetic-protein binding model and comparison with cefotaxime. Bourne, DW; Hakim, L; Triggs, EJ, 1989) | 0.28 |
| " Pharmacokinetic data showed that ciprofloxacin was eliminated more slowly than cefotaxime." | ( [Ciprofloxacin and cefotaxim: pharmacokinetic and therapeutic effectiveness in E. coli pyelonephritis in rats]. Boness, J; Marre, R; Schulz, E; Tietgen, K, 1986) | 0.27 |
| " In patients with ascites, the drug elimination half-life was significantly more prolonged (7." | ( [Pharmacokinetics of cefotaxime in cirrhotic patients with or without ascites]. Colombel, JF; Husson, MO; Izard, D; Leclerc, H; Paris, JC; Vincent, P, 1988) | 0.27 |
| "05) the area under the curve in tissue-cage fluid of ceftriaxone and cefotiam-treated animals, and the terminal half-life of ceftriaxone in their sera (3." | ( Enhancement of the therapeutic effect of cephalosporins in experimental endocarditis by altering their pharmacokinetics with diclofenac. Brion, N; Carbon, C; Joly, V; Pangon, B; Vallois, JM, 1988) | 0.27 |
| " There was a small but significantly longer (approximately 1 h) time to peak concentration when the drug was given with food." | ( The pharmacokinetics of cefixime in the fasted and fed state. Bohaychuk, W; Desjardins, RE; Faulkner, RD; Haynes, JD; Silber, BM; Yacobi, A, 1988) | 0.27 |
| " After dosing cefotaxime and its metabolite by high performance liquid chromatography, the pharmacokinetic parameters were calculated, especially: plasma and renal clearance, volume of distribution at steady state, area under the curve, and elimination half-life." | ( [Influence of fever on cefotaxime pharmacokinetics]. Albin, H; Aubertin, J; Demotes-Mainard, F; Gin, H; Ragnaud, JM; Vincon, G, 1988) | 0.27 |
| "To determine the influence of in vitro activity, pharmacokinetic properties, and therapeutic regimen on the antibacterial effect in vivo, we compared three cephalosporins, cefotiam, cefmenoxime, and ceftriaxone, in a rabbit model of experimental Escherichia coli endocarditis after 4 days of treatment." | ( Comparative efficacy of cefotiam, cefmenoxime, and ceftriaxone in experimental endocarditis and correlation with pharmacokinetics and in vitro efficacy. Abel, L; Brion, N; Buré, A; Carbon, C; Contrepois, A; Joly, V; Pangon, B; Vallois, JM, 1987) | 0.27 |
| " Comparison (ANOVA) of serum and urinary excretion pharmacokinetic parameters for cefixime on days 1, 8, and 15 found no significant (P greater than ." | ( Pharmacokinetics of cefixime after once-a-day and twice-a-day dosing to steady state. Bohaychuk, W; Desjardins, RE; Faulkner, RD; Haynes, JD; Look, ZM; Silber, BM; Weiss, AI, 1987) | 0.27 |
| "The pharmacokinetic properties of SCE-1141, an anti stereoisomer of cefmenoxime, were compared with those of cefmenoxime." | ( Pharmacokinetics of SCE-1141, a stereoisomer of cefmenoxime, in rats. Imada, A; Itakura, K; Kita, Y; Tsuchiya, K, 1986) | 0.27 |
| "The pharmacokinetic analysis was enriched, during the last several years, with the method of statistical moment (MSM)--an alternative for the classical compartment approach, presumed as model-non-dependent." | ( [Noncompartment (model-independent) pharmacokinetic analysis. 1. The method of statistical moments in evaluating the pharmacokinetic characteristics of cefotiam following its intravenous administration]. Terzinvanov, D, 1986) | 0.27 |
| " In 2 cases of 2 day-old neonates given CTM 20 mg/kg by 30-minute intravenous drip infusion, the mean peak concentration at the termination of the infusion was 25." | ( [Pharmacokinetic and clinical studies of cefotiam in mature neonates]. Nishimura, T; Tabuki, K; Takashima, T, 1986) | 0.27 |
| " At the same time, pharmacokinetic analysis was done to study the maternal fetal transfer." | ( [Pharmacokinetic and clinical studies of cefotiam in the perinatal period]. Chan, C; Hanabayashi, T; Hayasaki, M; Iida, M; Ito, K; Noda, K; Osugi, S; Ri, J; Takada, Y; Yamada, Y, 1986) | 0.27 |
| "The pharmacokinetic behaviour of cephalosporin antibiotic, second generation after intravenous administration to patients during the early post-operative period was characterized as well as after cholecystectomy." | ( [Pharmacokinetics of the cephalosporin antibiotic cefotiam following its intravenous administration to patients after cholecystectomy]. Gerova, Z; Terziivanov, D; Vlakhov, V, 1986) | 0.27 |
| "A pharmacokinetic study of Cefmenoxime (CMX) has been carried out in 17 patients, 60 to 90 years old, following IV injection of 1 gram." | ( [Pharmacokinetics of cefmenoxime in the aged subject (60 to 90 years of age) after an intravenous injection of 1 g]. Boquet, A; Bryskier, A; Fourtillan, JB; Modai, J; Veyssier, P, 1986) | 0.27 |
| " The mean respective pharmacokinetic parameters obtained after the two intravenous infusions (6." | ( Pharmacokinetics of cefixime after oral and intravenous doses in dogs: bioavailability assessment for a drug showing nonlinear serum protein binding. Bialer, M; Look, ZM; Silber, BM; Wu, WH; Yacobi, A, 1987) | 0.27 |
| " Pharmacokinetic parameters were determined by iterative non-linear least squares regression analysis of plasma and dialysis fluid drug concentration curves." | ( Cefotaxime disposition pharmacokinetics during peritoneal dialysis. Fugleberg, S; Løkkegaard, N; Nielsen-Kudsk, F; Overgaard, S; Scrøder, S, 1987) | 0.27 |
| "The pharmacokinetic and chemotherapeutic properties of the new penem antibiotic HRE 664 (Fig." | ( HRE 664, a new parenteral penem. II. Evaluation of the pharmacokinetic behavior and the chemotherapeutic activity in animals. Isert, D; Johnson, C; Klesel, N; Limbert, M; Schrinner, E; Seibert, G, 1987) | 0.27 |
| "The aim of the study was to investigate the pharmacokinetic modelling of Cefotaxime (CTX) and its main metabolite Desacetyl Cefotaxime (DCTX) which has a less antibacterial activity than the CTX." | ( Pharmacokinetics of cefotaxime and its desacetyl metabolite in plasma and in cerebrospinal fluid. Aiache, JM; Beyssac, E; Cardot, JM; Colnet, G; Sirot, J, ) | 0.13 |
| " In general the half-life of the drug is about 3 to 4 hours and is not dependent on dose." | ( Pharmacokinetic profile of cefixime in man. Barone, JS; Faulkner, RD; Kaplan, SA; Silber, BM; Yacobi, A, 1987) | 0.27 |
| " The pharmacokinetic study in nine elderly patients showed a prolonged plasma half life of aztreonam (2." | ( Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. Dette, GA; Grobecker, H; Kees, F; Knothe, H; Naber, KG, 1986) | 0.27 |
| " Most pharmacokinetic parameters were also significantly altered early in the puerperium relative to those obtained 4 months later." | ( Pharmacokinetics of cefotaxime, moxalactam, and cefoperazone in the early puerperium. Charles, D; Larsen, B, 1986) | 0.27 |
| " The plasma concentrations (Cp) and pharmacokinetic data obtained after cefotaxime in the oily suspension was injected IM and SC were compared with data from the same animals after they were given an aqueous solution of cefotaxime by the same routes." | ( Pharmacokinetic evaluation of a slow-release cefotaxime suspension in the dog and in sheep. Bourne, DW; English, PB; Filippich, LJ; Guerrini, VH; Schneider, J, 1986) | 0.27 |
| " Apparent total body, renal, and apparent nondialysis-nonrenal clearances and protein binding declined and elimination half-life increased with decreasing creatinine clearance." | ( Pharmacokinetics of cefixime (CL 284,635; FK 027) in healthy subjects and patients with renal insufficiency. Brown, GR; Guay, DR; Harding, GK; Meatherall, RC, 1986) | 0.27 |
| " Patients with impaired renal function showed increased values for the area under the curve and half-life in both serum and tissue fluid." | ( Pharmacokinetics of intravenous antibiotics in acutely ill elderly patients. Jonsson, M; Walder, M, 1986) | 0.27 |
| " The pharmacokinetic parameters were obtained using an open two-compartment model." | ( Pharmacokinetics of cefotaxime after a single intravenous dose in patients with impaired renal function. Moukhtar, I; Nawishy, S; Sabbour, M, 1987) | 0.27 |
| " After intramuscular administration of 1 g of cefotiam to three healthy volunteers, a mean (+/- standard deviation) peak concentration of 16." | ( Pharmacokinetics of cefotiam in humans. Guibert, J; Lecaillon, JB; Modai, J; Rouan, MC; Schoeller, JP, 1985) | 0.27 |
| "Cefmenoxime (1 g) was intravenously administered by one shot to investigate its pharmacokinetic profile with respect to transfer into the kidney, vesical wall and prostatic adenoma." | ( [Pharmacokinetic study of cefmenoxime concerning its transfer into tissues]. Hirao, N; Iwase, Y; Sakagami, H; Tsugaya, M; Washida, H, 1985) | 0.27 |
| "Ceftizoxime pharmacokinetic parameters from mice, rats, monkeys, and dogs were scaled allometrically and used to predict the value of each parameter in a 70-kg human." | ( Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data. Mordenti, J, 1985) | 0.27 |
| "05) between the half-life for biliary excretion and the volume of the biliary flow support that presumption." | ( [Characterization of the pathways of cefotiam elimination by clearance approaches in patients following cholecystectomy]. Gerova, Z; Terziivanov, D; Vlakhov, V, 1985) | 0.27 |
| " This antibiotic displays two major characteristics: a very long serum half-life and a good tissue penetration." | ( [Pharmacokinetics and tissue penetration of ceftriaxone]. Bergan, T, 1985) | 0.27 |
| " This review addresses the clinical pharmacokinetic aspects of drug therapy in patients undergoing peritoneal dialysis and considers: the efficiency of the peritoneal membrane as a dialysing membrane; the effects of peritoneal dialysis on the pharmacokinetics of drugs; the pharmacokinetic models and estimation methods for peritoneal dialysis clearance and the effects of peritoneal dialysis on drug elimination; the influence of the pharmacokinetic parameters of drugs on drug dialysability; and the application of pharmacokinetic principles to the adjustment of drug dosage regimens in peritoneal dialysis patients." | ( Drug therapy in patients undergoing peritoneal dialysis. Clinical pharmacokinetic considerations. Cornish, WR; Hardy, BG; Manuel, MA; Paton, TW, ) | 0.13 |
| " The pharmacokinetic data were described using a nonlinear least-squares computer program." | ( Pharmacokinetics of ceftriaxone in subjects with renal insufficiency. Echols, RM; Kowalsky, SF; Parker, MA, ) | 0.13 |
| " Pharmacokinetic variables were studied in 11 patients." | ( Ceftriaxone: pharmacokinetics and effect on the intestinal microflora in patients with acute bacterial infections. Nilsson-Ehle, I; Nord, CE; Ursing, B, 1985) | 0.27 |
| " Model-dependent and noncompartmental pharmacokinetic parameters were determined and were found to be congruous." | ( Cefotaxime and desacetylcefotaxime pharmacokinetics in infants and children with meningitis. Brown, AL; Jacobs, RF; Kearns, GL; Kluza, RB; Trang, JM; Underwood, FL; Wells, TG, 1985) | 0.27 |
| "A scarcity of pharmacokinetic data are available on cefotaxime in the obstetric patient." | ( Pharmacokinetics of cefotaxime in the postpartum patient. Cleary, TG; Cotton, DB; Feldman, S; Gonik, B; Pickering, LK, 1985) | 0.27 |
| "Simultaneous administration by the intravenous route of 1 g of cefotiam and 1 g of cefsulodin does not alter the pharmacokinetic parameters of either compound." | ( [Pharmacokinetic behavior of cefsulodin and cefotiam alone or in combination after intravenous injection of 1 gram]. Bryskier, A; Fourtillan, JB; Ingrand, I; Lefebvre, MA, 1984) | 0.27 |
| "The pharmacokinetic properties of cefodizime, a new aminothiazolyliminomethoxycephalosporin, were studied in laboratory animals and compared with the pharmacokinetics of another long-acting cephalosporin, ceftriaxone." | ( Cefodizime, an aminothiazolylcephalosporin. II. Comparative studies on the pharmacokinetic behavior in laboratory animals. Klesel, N; Limbert, M; Schrinner, E; Seeger, K; Seibert, G; Winkler, I, 1984) | 0.27 |
| "In human subjects, ceftriaxone exhibits an exceptionally long elimination half-life (5." | ( Pharmacokinetic profile of ceftriaxone in man. Kaplan, SA; Patel, IH, 1984) | 0.27 |
| " Minor increases in the biologic half-life (12 hours versus normal of 8 hours) of ceftriaxone have been seen in (functionally) anephric patients with normal extrarenal clearance mechanisms." | ( Pharmacokinetics of ceftriaxone in patients with renal and liver insufficiency and correlations with a physiologic nonlinear protein binding model. Koup, JR; Stoeckel, K, 1984) | 0.27 |
| "The pharmacokinetic behavior of ceftriaxone was studied in 60 patients with severe community- or hospital-acquired infections." | ( Variability of ceftriaxone pharmacokinetics in hospitalized patients with severe infections. Joos, B; Luethy, R; Muehlen, E; Siegenthaler, W, 1984) | 0.27 |
| " The average values of the pharmacokinetic parameters obtained after such administration to the control rabbits, with normal biliary excretion, expressed in accordance with a two-compartment open kinetic model were: alpha = 15." | ( Influence of experimentally induced cholestasis on the pharmacokinetics of cefotiam. Alonso, IG; Dominguez-Gil, A; Mariño, EL, 1984) | 0.27 |
| " The results indicate that reduced renal mass increased the plasma half-life for cefotaxime as well as increasing its diffusion into tissue." | ( Pharmacokinetics of cefotaxime and probenecid in sheep with normal and reduced renal function. Bourne, DW; Cao, GR; English, PB; Filippich, LJ; Guerrini, VH, 1984) | 0.27 |
| " Pharmacokinetic data in 18 patients were determined from serum profiles." | ( Cefmenoxime efficacy, safety, and pharmacokinetics in critical care patients with nosocomial pneumonia. Cumbo, TJ; Reitberg, DP; Schentag, JJ, 1984) | 0.27 |
| " No significant differences were observed with respect to the terminal half-life (1 h) and the area under the curve versus the dose." | ( Pharmacokinetics of cefotiam administered intravenously and intramuscularly to healthy adults. Brisson, AM; Bryskier, A; Fourtillan, JB; Millerioux, L, 1984) | 0.27 |
| " Patients with impairment of renal function were excluded from this pharmacokinetic study." | ( [Clinical and pharmacokinetic evaluation of ceftriaxone in children]. Fujita, K; Maruyama, S; Murono, K; Sakata, H; Sanae, N; Yoshioka, H, 1984) | 0.27 |
| "In 48 patients undergoing elective gynecological, urological and otorhinolaryngological surgery a pharmacokinetic study after 1 g dose of ceftriaxone or cefotaxime was done." | ( Comparative pharmacokinetic evaluation of ceftriaxone and cefotaxime in coincidence for short-term antimicrobial prophylaxis in surgery. Alaimo, E; Costantini, A; Finistorchi, O; Gasparri, F; Mazzei, T; Nicoletti, P; Periti, P; Rizzo, M; Scarselli, G, 1984) | 0.27 |
| " In addition to manual methods, a computer program was used to determine six pharmacokinetic variables." | ( The safety and pharmacokinetics of cefotaxime in the treatment of neonates. de Louvois, J; Hurley, R; Mulhall, A, 1982) | 0.26 |
| " Pharmacokinetic constants were calculated using a modified two compartment model." | ( [Availability of cefotaxime. Pharmacokinetic studies on the distribution in central and various peripheral compartments (author's transl)]. Schassan, HH; Seidel, H; Welter, J; Wittmann, DH, 1980) | 0.26 |
| " The decline of serum concentrations was biphasic in all patients, and the data were fitted to the pharmacokinetic two-compartment model." | ( Cefotaxime pharmacokinetics following a single intravenous dose to patients with varying renal function. Bundtzen, RW; Craig, WA; Madsen, PO; Nielsen, OS; Toothaker, RD; Welling, PG, 1980) | 0.26 |
| " bolus injection of a single 15 mg/kg dose, pharmacokinetic data were calculated using a two compartment model." | ( [Pharmacokinetics of cefotaxime in patients with chronic renal impairment (author's transl)]. Fillastre, JP; Godin, M; Humbert, G; Ings, RM; Leroy, A, 1981) | 0.26 |
| " In rabbit CSF, moxalactam had the greatest concentration and penetration, but rocephin had the longest half-life and duration of bactericidal activity." | ( Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis. Loock, CA; McCracken, GH; Schaad, UB; Thomas, ML, 1981) | 0.26 |
| " Pharmacokinetic parameters were determined using a two-compartment linear model." | ( Pharmacokinetics of intravenous cefotaxime in patients undergoing chronic hemodialysis. Chodos, J; Francke, EL; Neu, HC; Saltzman, M, 1981) | 0.26 |
| " The 6-h elimination half-life of ceftriaxone was 2- to 10-fold longer than those reported for marketed and other known investigational cephalosporins." | ( Pharmacokinetics of ceftriaxone in humans. Brooks, MA; Chen, S; Hackman, MR; Kaplan, SA; Konikoff, J; Parsonnet, M; Patel, IH, 1981) | 0.26 |
| " No major pharmacokinetic differences were observed between the two populations." | ( Single-dose pharmacokinetics of ceftriaxone in infants and young children. Schaad, UB; Stoeckel, K, 1982) | 0.26 |
| " In uremic patients, the half-life for the terminal phase increased with renal failure with the microbioassay, but it is demonstrated that deacetyl cefotaxime has only a prolonged half - life with a more specific assay = HPLC method." | ( [Pharmacokinetics of cefotaxime and metabolites in uremic patients (author's transl)]. Fillastre, JP; Godin, M; Humbert, G; Ings, RM; Leroy, A, 1982) | 0.26 |
| "The pharmacokinetic parameters of total (bound and unbound) and free (unbound) ceftriaxone in six healthy volunteers after intravenous injection of 39 were compared with low-dose data from a previous study." | ( Pharmacokinetics of ceftriaxone following intravenous administration of a 3 g dose. McNamara, PJ; Stoeckel, K; Ziegler, WH, 1982) | 0.26 |
| " Pharmacokinetic parameters after single and multiple doses were investigated." | ( Clinical pharmacokinetics of cefotaxime and penetration in sputum, bone, and prostatic tissue. Apicella, F; Braga, PC; Cedrini, C; Fraschini, F; Gagliardi, V; Manganelli, V; Paiola, G; Pozzato, C; Scaglione, F; Scarpazza, G, 1982) | 0.26 |
| " Results of studies showed that in healthy subjects the levels of desacetylcefotaxime are low relative to those of cefotaxime and that either a bioassay or HPLC is adequately specific for determination of pharmacokinetic parameters." | ( Clinical pharmacokinetics of cefotaxime in patients with normal and reduced renal function. Doluisio, JT, ) | 0.13 |
| "The pharmacokinetic parameters of moxalactam were compared with those of cefoperazone and cefotaxime in normal volunteers in a crossover manner." | ( Comparative pharmacokinetics of moxalactam, cefoperazone, and cefotaxime in normal volunteers. Drusano, GL; McNamee, WB; Ryan, PA; Schimpff, SC; Standiford, HC; Tatem, B, ) | 0.13 |
| ", the peak levels, the peak-to-trough fluctuations, and the half-life were comparable." | ( Comparison study of the kinetics of ceftizoxime penetration into extravascular spaces with known surface area/volume ratio in vitro and in vivo in rabbits. Fasching, CE; Gerding, DN; Peterson, LR; Van Etta, LL, 1983) | 0.27 |
| "The pharmacokinetic and antibacterial properties of cefotaxime were determined in normal adult volunteers." | ( Cefotaxime: pharmacokinetics and in vitro antibacterial activity of serum and urine in normal human volunteers. Bernstein, B; Fass, RJ; Ho, I; Perkins, RL; Plouffe, JF; Prior, RB, 1983) | 0.27 |
| " This bacteriological and pharmacokinetic study was therefore performed in order to evaluate the potency of cefmenoxime in the treatment of respiratory infections." | ( Laboratory evaluation of cefmenoxime: a new cephalosporin. In vitro and in vivo antibacterial activities and pharmacokinetic properties. Harada, T; Matsumoto, K; Nagatake, T; Rikitomi, N; Uzuka, Y, 1983) | 0.27 |
| " By a combination of gentamicin plus ampicillin pharmacokinetic parameters are not influenced; while if gentamicin is combined with cefotaxim the apparent elimination halflife of gentamicin (beta-slope) is significantly reduced." | ( [Pharmacokinetics of combined antibiotic therapy in the newborn infant]. Bergt, U; Heimann, G; Schug, S, 1983) | 0.27 |
| " Relevant pharmacokinetic parameters were calculated, using two- and three-compartment models." | ( Comparative pharmacokinetics of cefoperazone, cefotaxime, and moxalactam. Belmega, G; Borner, K; Jendroschek, T; Kemmerich, B; Koeppe, P; Lode, H, 1983) | 0.27 |
| " Therefore a simple half-life cannot be given." | ( Pharmacokinetics of Cefmenoxime in normal and impaired renal function. Höffler, D; Koeppe, P, 1983) | 0.27 |
| " The half-life of ceftizoxime was 136 +/- 36 min." | ( Pharmacokinetics of multiple doses of ceftizoxime and their influence on fecal flora. Kemmerich, B; Knothe, H; Koeppe, P; Lode, H; Warns, H, 1983) | 0.27 |
| " The data were fit by iterative nonlinear regression procedures to a two-compartment open pharmacokinetic model, with elimination from the central compartment." | ( Effect of probenecid on the pharmacokinetics of cefmenoxime. Quinn, D; Rollins, DE; Sennello, LT; Sonders, RC; Tolman, KG, 1983) | 0.27 |
| "We have theoretically examined the influence of plasma protein binding (specifically the fraction unbound, fp) on the pharmacokinetic parameters following rapid injection of a drug undergoing concentration-dependent binding." | ( Volume of distribution terms for a drug (ceftriaxone) exhibiting concentration-dependent protein binding. I. Theoretical considerations. Gibaldi, M; McNamara, PJ; Stoeckel, K, 1983) | 0.27 |
| "The pharmacokinetic parameters of ceftriaxone in eight patients with end-stage renal disease were determined during dialysis and during the interdialysis period." | ( Pharmacokinetics of ceftriaxone in patients with renal failure and in those undergoing hemodialysis. Appel, GB; Cohen, D; Neu, HC; Scully, B, 1983) | 0.27 |
| " The elimination half-life (group mean ranged from 11." | ( Ceftriaxone pharmacokinetics in patients with various degrees of renal impairment. Berman, SJ; Patel, IH; Siemsen, AW; Sugihara, JG; Weinfeld, RE; Wong, EG, 1984) | 0.27 |
| " Besides an adequate choice of antibiotics, the special pharmacokinetic properties of the cerebrospinal membranes should not be neglected in the concept of the antibiotic therapy of meningitis." | ( Pharmacokinetics of antimicrobial drugs in the cerebrospinal fluid. Heimann, G; Skopnik, H, 1983) | 0.27 |
| "To compare the pharmacokinetic and pharmacodynamic activity of three drug regimens: cefotaxime plus metronidazole, cefoxitin, and ampicillin-sulbactam against two organisms frequently isolated in intraabdominal infection, Escherichia coli and Bacteroides fragilis." | ( Comparison of the pharmacodynamic activity of cefotaxime plus metronidazole with cefoxitin and ampicillin plus sulbactam. Nightingale, CH; Quintiliani, R; Sullivan, MC; Sweeney, KR, ) | 0.13 |
| " The main pharmacokinetic parameters of the two groups were calculated with computer." | ( [The pharmacokinetics and pharmacodynamics of cefotaxime in experimental diabetic rats]. Li, QZ; Zhang, CL, 1995) | 0.29 |
| " Its pharmacokinetic property includes a small volume of distribution with low protein binding." | ( Pharmacokinetics of cefotaxime in healthy volunteers and patients. Nicolau, DP; Nightingale, CH; Patel, KB; Quintiliani, R, ) | 0.13 |
| " Application of pharmacodynamics requires an integration of the pharmacokinetic and in vitro properties of the agent." | ( Pharmacodynamic (kinetic) considerations in the treatment of moderately severe infections with cefotaxime. Turnidge, JD, ) | 0.13 |
| " When the impact of development on CTX and dCTX disposition is considered, it is apparent that age-appropriate pharmacokinetic data can be used to individualize CTX dosing regimens according to age." | ( Pharmacokinetics of cefotaxime and desacetylcefotaxime in the young. Kearns, GL; Young, RA, ) | 0.13 |
| "A physiologically based pharmacokinetic model was established to describe the hepatobiliary excretion process for ligands which are excreted into the bile without metabolic conversion." | ( Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion. Hanano, M; Sathirakul, K; Sugiyama, Y; Suzuki, H; Yasuda, K, 1993) | 0.29 |
| "5 liters), terminal elimination half-life (3." | ( Pharmacokinetics of cefodizime following single doses of 0.5, 1.0, 2.0, and 3.0 grams administered intravenously to healthy volunteers. Bryskier, A; Coussediere, D; Lenfant, B; Logeais, C; Namour, F; Rivault, O; Surjus, A, 1995) | 0.29 |
| " Plasma and urine concentrations of cefixime were determined using a reversed phase HPLC assay and pertinent pharmacokinetic parameters were estimated by model-independent standard methods." | ( Pharmacokinetics of cefixime in children with urinary tract infections after a single oral dose. Kasteridou, N; Mamzoridi, K; Niopas, I; Peonides, A, 1996) | 0.29 |
| " These pharmacokinetic data can be used as a basis to compare the four oral cephalosporins; however, comparative susceptibility data must also be considered." | ( Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers. Affrime, MB; Hyatt, JM; Nix, DE; Reidenberg, P; Symonds, WT; Teal, MA; Wilton, JH, ) | 0.13 |
| " In addition neonate renal excretory function is low and the hepatic enzyme system is immature, thus the half-life of drugs is prolonged." | ( Pharmacokinetics of antibiotics in neonates. Sato, Y, 1997) | 0.3 |
| " Knowledge of the pharmacokinetic and pharmacodynamic properties of cefotaxime supports the view that low dose (1-2 g), low frequency (12-hourly) dosage regimens are applicable to many mild-to-moderately severe infections, including community-acquired pneumonia, caused by susceptible organisms." | ( The use of cefotaxime for the treatment of common infections: in vitro, pharmacokinetic and clinical considerations. Bouza, E; Lode, H; Mouton, Y; Wilson, WR, 1997) | 0.3 |
| " Pharmacokinetic interactions between these two classes of drugs have been described in experimental models, and exceptionally in humans." | ( Pharmacokinetic parameters and killing rates in serum of volunteers receiving amoxicillin, cefadroxil or cefixime alone or associated with niflumic acid or paracetamol. Bernard, E; Carsenti-Etesse, H; De Salvador, F; Dellamonica, P; Durant, J; Farinotti, R; Roger, PM; Rouveix, B, ) | 0.13 |
| " The following pharmacokinetic parameters were calculated: maximum plasma concentration (C5 min), area under the plasma concentration-time curve (AUC), terminal half-life (T1/2), terminal rate constant (lambda-z), total clearance (Clt), volume of distribution (Vd), mean residence time (MRT), urine data-derived terminal half-life (T1/2 r), renal clearance (Clr)." | ( Pharmacokinetics of cefodizime in patients with various degrees of renal failure. Amorena, M; Calderaro, V; Contaldi, C; Lampa, E; Loffreda, A; Lucarelli, C; Rossi, F, ) | 0.13 |
| "Serum concentration profiles were simulated from mean cefotaxime pharmacokinetic parameters that have been published for children and for adults using widely available spreadsheet software." | ( Limiting cefotaxime pediatric dosing to adult standards: a pharmacokinetic simulation study. Dulaney Lopez, AM; Estes, KS; Lopez-Samblas, AM; Rodriguez, JC, 1999) | 0.3 |
| "The duration of time that serum levels are above the minimum inhibitory concentration (MIC; T >MIC) seems to be an important pharmacodynamic parameter for beta-lactams." | ( Comparative activity of cefodizime and ceftriaxone against respiratory pathogens in an in vitro pharmacodynamic model simulating concentration-time curves. Blandino, G; Milazzo, I; Musumeci, R; Nicoletti, G; Nicolosi, VM; Speciale, A, 2000) | 0.31 |
| " This in vivo combined pharmacodynamic effect offers possibilities that can be used to address penicillin resistance." | ( Effects of specific antibodies against Streptococcus pneumoniae on pharmacodynamic parameters of beta-lactams in a mouse sepsis model. Aguilar, L; Casal, J; Fenoll, A; Giménez, MJ; Jado, I; Prieto, J; Yuste, J, 2002) | 0.31 |
| " dose of fosphenytoin alters the t1/2,z but not the other pharmacokinetic parameters or clinical effects of phenytoin in African children with severe malaria." | ( Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO, 2002) | 0.31 |
| " The improved bioavailability is reflected in various pharmacokinetic parameters viz." | ( Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Dhuley, JN; Hiwale, AR; Naik, SR, 2002) | 0.31 |
| " The stability and predictive performance of the final population pharmacokinetic model was assessed using 200 bootstrap samples of the original data." | ( Pharmacokinetic modelling of cefotaxime and desacetylcefotaxime--a population study in 25 elderly patients. Barre, J; Bouvier D'yvoire, M; Druguet, M; Laurent, N; Maire, P; Urien, S, 2004) | 0.32 |
| " The pharmacokinetic variables were calculated in both cases." | ( Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats. Chakraborty, AK; Debnath, SC; Dutta, BP; Mandal, TK, 2004) | 0.32 |
| " The pharmacokinetic profile of cefodizime was evaluated in rabbits after intraduodenal administration with and without an absorption enhancer." | ( Influence of enhancers on the absorption and on the pharmacokinetics of cefodizime using in-vitro and in-vivo models. Brandsch, M; Bretschneider, B; Härtl, A; Mrestani, Y; Neubert, RH, 2004) | 0.32 |
| " Pharmacokinetic variables were defined for doses of 10 mg/kg, and 20 mg/kg, utilising a quantitative bacteriological analysis." | ( Pharmacokinetics and clinical efficacy of cefotaxime for the treatment of septicaemia in dogs. Gutierrez, L; Ocampo, L; Sumano, H, 2004) | 0.32 |
| " Cefotaxime (CTX), used as perioperative prophylaxis, demonstrates time-dependent killing and therefore continuous infusion might have pharmacodynamic advantages." | ( Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients. Bruining, HA; Buijk, SE; Groenland, TH; Gyssens, IC; Metselaar, HJ; Mouton, JW; Verbrugh, HA, 2004) | 0.32 |
| " A mathematical model was developed that described the selection of preexisting and newborn mutants and the post-MIC effect (PME) as functions of pharmacokinetic parameters." | ( Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli. Andersson, DI; Cars, O; Geli, P; Olofsson, SK, 2005) | 0.33 |
| " Pharmacokinetic characteristics of cefodizime were assessed in 13 critically ill elderly patients (median age 73+/-6 years)." | ( Single-dose pharmacokinetics of cefodizime in critically ill elderly patients. Bojic, A; Locker, G; Meyer, B; Schmid, R; Thalhammer, F; Traunmueller, F; Winkler, S, 2006) | 0.33 |
| " Pediatric pharmacokinetic data were derived from the literature." | ( Pharmacodynamic evaluation of meropenem and cefotaxime for pediatric meningitis: a report from the OPTAMA program. Ellis, JM; Kuti, JL; Nicolau, DP, 2006) | 0.33 |
| " The pharmacokinetic profiles fitted one-compartment open model." | ( Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis). Sharma, SK; Srivastava, AK, 2006) | 0.33 |
| " pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data." | ( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008) | 0.35 |
| "Rational dosing of antibiotics in neonates should be based on pharmacokinetic (PK) parameters assessed in specific populations." | ( Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. Ahsman, MJ; Mathot, RA; Tibboel, D; Wildschut, ED, 2009) | 0.35 |
| "The pharmacokinetic behaviour of two aminothiazolyl cephalosporins, ceftazidime (CAZ) and cefotaxime (CTX), were compared in three studies." | ( The comparative pharmacokinetics of ceftazidime and cefotaxime in healthy volunteers. Ayrton, J; Harding, SM; Hogg, MI; Monro, AJ; Thornton, JE, 1981) | 0.26 |
| "Extracorporeal membrane oxygenation (ECMO) is used to temporarily sustain cardiac and respiratory function in critically ill infants but can cause pharmacokinetic changes necessitating dose modifications." | ( Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. Ahsman, MJ; Mathot, RA; Tibboel, D; Wildschut, ED, 2010) | 0.36 |
| "The objective of this study was to evaluate whether pharmacokinetic parameters (clearance and volume of distribution of the central compartment) from a sparse sampling population pharmacokinetic study can be obtained with a very small sample size." | ( Population pharmacokinetics with a very small sample size. Duan, J; Mahmood, I, 2009) | 0.35 |
| "We developed a detailed, whole-body physiologically based pharmacokinetic (PBPK) modeling tool for calculating the distribution of pharmaceutical agents in the various tissues and organs of a human or animal as a function of time." | ( BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems. Graf, JF; Scholz, BJ; Zavodszky, MI, 2012) | 0.38 |
| " With respect to pentoxifylline and ciprofloxacin, which are less hydrophilic, the effect of pharmacokinetic interference was either weaker or absent." | ( [Influence of perftoran on pharmacokinetics of hydrophilic drugs]. Pshenkina, NN, 2011) | 0.37 |
| " The objective of the present study was to conduct a population pharmacokinetic study of cefotaxime in neonates and young infants in order to evaluate and optimize the dosing regimen." | ( A Population and Developmental Pharmacokinetic Analysis To Evaluate and Optimize Cefotaxime Dosing Regimen in Neonates and Young Infants. Biran, V; Gouyon, JB; Jacqz-Aigrain, E; Leroux, S; Roué, JM; Zhao, W; Zheng, H, 2016) | 0.43 |
| " Modifications of pharmacokinetic parameters could lead to low drug concentrations and therefore, insufficient therapeutic levels." | ( Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children. Aboura, R; Benaboud, S; Béranger, A; Genuini, M; Heilbronner, C; Hirt, D; Oualha, M; Renolleau, S; Toubiana, J; Tréluyer, JM; Urien, S, 2018) | 0.48 |
| "The aim of this study was to build a population pharmacokinetic model for cefotaxime and its metabolite desacetylcefotaxime in order to optimize individual dosing regimens for critically ill children." | ( Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children. Aboura, R; Benaboud, S; Béranger, A; Genuini, M; Heilbronner, C; Hirt, D; Oualha, M; Renolleau, S; Toubiana, J; Tréluyer, JM; Urien, S, 2018) | 0.48 |
| "The pharmacokinetic profile of most drugs is dependent on the patient's covariates and may be influenced by the disease." | ( Population Pharmacokinetics of Cefotaxime and Dosage Recommendations in Children with Sickle Cell Disease. Benkerrou, M; Facchin, A; Faye, A; Ha, P; Jacqz-Aigrain, E; Kaguelidou, F; Koehl, B; Lorrot, M; Maksoud, E; Mariani, P; Zhao, W, 2018) | 0.48 |
| " In total, 263 cefotaxime samples were included in the population pharmacokinetic analysis." | ( Population pharmacokinetics of cefotaxime in intensive care patients. Furebring, M; Jönsson, S; Lipcsey, M; Nielsen, EI; Smekal, AK; Swartling, M, 2022) | 0.72 |
| "A population pharmacokinetic model was developed to describe cefotaxime pharmacokinetics and associated variability in adult ICU patients." | ( Population pharmacokinetics of cefotaxime in intensive care patients. Furebring, M; Jönsson, S; Lipcsey, M; Nielsen, EI; Smekal, AK; Swartling, M, 2022) | 0.72 |
| "Cefotaxime is frequently used in critically ill children, however pharmacokinetic (PK) studies to support adequate dosing in this patient population are limited." | ( Population pharmacokinetics of intravenous cefotaxime indicates that higher doses are required for critically ill children. Brüggemann, RJ; de Wildt, SN; Hartman, SJF; Knibbe, CA; Mathôt, RAA; Schreuder, MF; Upadhyay, PJ; van der Flier, M, 2022) | 0.72 |
| " The purpose of performing this review is to thoroughly evaluate the pharmacokinetic (PK) data on cefiximeFive databases were systematically searched to identify studies on the PK of cefixime." | ( Clinical pharmacokinetics of cefixime: a systematic review. Ajmal, M; Alqahtani, F; Aziz, M; Imran, I; Majeed, A; Rasool, MF; Rehman, AU; Saeed, H; Zamir, A, 2023) | 0.91 |
Cefotaxime (CTX) alone and in combination with its metabolite, desacetylcefotaxim (dCTX), demonstrated in vitro antimicrobial activity against Staphylococcus aureus. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefataxime essentially showed indifference.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The minimal inhibitory concentrations of piperacillin (PIP) or cefotaxime (CTX) alone or in combination with tazobactam (TAZ) were determined against 168 anaerobes." | ( [Strict anaerobic bacteria: comparative study of various beta-lactam antibiotics in combination with tazobactam or sulbactam]. Dubreuil, L; Sedallian, A, 1991) | 0.28 |
| "05 mg/g) alone or in combination with one dose of dexamethasone (0." | ( Effect of dexamethasone or HWA-138 in combination with antibiotics in experimental Haemophilus influenzae type b infection. Hawkins, EP; Kaplan, SL; Mason, EO; Rodriguez, AF, 1991) | 0.28 |
| "The in vitro antimicrobial activity of ticarcillin (TICAR), mezlocillin (MEZLO), piperacillin (PIPER), cefoperazone (CPZ), cefotaxime (CTX) and ceftazidime (CAZ), alone and in combination with 8 micrograms/ml of sulbactam (SULB), was studied by agar dilution against TICAR resistant strains isolated in 8 hospitals over a period of 3 months in 1989 (747 enterobacteria, 110 Ps." | ( [In vitro activity of beta-lactam antibiotics in combination with sulbactam against enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter. Results of a multicenter study]. Acar, JF; Denis, F; Drugeon, H; Fleurette, J; Kazmierczak, A; Siebor, E; Sirot, J; Soussy, CJ; Thabaut, A, 1991) | 0.28 |
| "An open multicenter study on inpatients of 12 german hospitals was performed to investigate efficacy and safety of sulbactam in combination with mezlocillin, piperacillin or cefotaxim in severe bacterial infections." | ( [Sulbactam in combination with mezlocillin, piperacillin or cefotaxime. Clinical and bacteriological results in the treatment of severe bacterial infections]. Heizmann, WR; Manncke, K; Sonntag, HG; Springsklee, M, 1991) | 0.28 |
| " In comparison with the antibiotic alone, the most marked reductions in the number of resistant strains on combination with sulbactam were as follows (the percentage of reduction is shown in brackets): for SUL + AMP and Acine-tobacter spp." | ( In vitro activity against clinically important gram-positive and gram-negative bacteria of sulbactam, alone and in combination with ampicillin, cefotaxime, mezlocillin, and piperacillin. Schmalreck, AF; Wildfeuer, A, 1990) | 0.28 |
| "We evaluated cefotaxime (CTX) alone and in combination with its metabolite, desacetylcefotaxime (dCTX) against strains of Staphylococcus aureus that produce the four recognized variants of staphylococcal beta-lactamase and a beta-lactamase-producing isolate characterized by the expression of borderline resistance to methicillin." | ( Evaluation of cefotaxime alone and in combination with desacetylcefotaxime against strains of Staphylococcus aureus that produce variants of staphylococcal beta-lactamase. Eades, SC; Kernodle, DS; Stratton, CW; Weeks, LS, ) | 0.13 |
| " Thus the physicochemical and pharmacological properties of sulbactam apparently permit flexible dosage in combination with different penicillins or cephalosporins and sulbactam can be administered as non-fixed combination in the clinical treatment of bacterial infections." | ( Studies on the synergism of sulbactam and beta-lactam antibiotics under in vitro conditions and in healthy volunteers after intravenous administration. Antibacterial activity in vitro, compatibility and pharmacokinetics of the drugs in combination. Eibel, G; Pfaff, G; Räder, K; Schmalreck, A; Wildfeuer, A, 1989) | 0.28 |
| "A study was done on cefodizime (THR-221, CDZM) in combination with ampicillin (ABPC) for its transferability to cerebrospinal fluid (CSF) of rabbits with experimental meningitis caused by Staphylococcus aureus." | ( [Experimental study on transferability to cerebrospinal fluid of cefodizime in combination with ampicillin]. Haruta, T; Kobayashi, Y; Okura, K, 1989) | 0.28 |
| "In a randomised and coordinated multicentre study, 143 patients with severe infections received treatment with either imipenem/cilastatin (72; I/C group) or cefotaxime combined with metronidazole and optional cloxacillin (71; CX/M/CL group)." | ( Imipenem/cilastatin as monotherapy in severe infections: comparison with cefotaxime in combination with metronidazole and cloxacillin. Report from a Norwegian Study Group. , 1987) | 0.27 |
| "The objectives of this study were to investigate the bactericidal activity in serum of cefotaxime alone or in combination with tobramycin against clinical strains and to determine the influence of tobramycin on the pharmacokinetics of cefotaxime." | ( Comparative study of serum bactericidal activity of cefotaxime alone or in combination with tobramycin. Bergeron, MG; Charest, A; Forcier, JF; LeBel, M; Morin, J; Vallée, F, 1986) | 0.27 |
| "Emergence of bacterial resistance to antimicrobial agents was studied during a period of 30 months of continuous use of parenteral cefotaxime combined with oral non-absorbable polymyxin E and tobramycin (selective decontamination) in a surgical intensive care unit (ICU)." | ( Cefotaxime combined with selective decontamination in long term intensive care unit patients. Virtual absence of emergence of resistance. Stoutenbeek, CP; van Saene, HK; Zandstra, DF, 1988) | 0.27 |
| " In a preliminary in vitro checkerboard study the bactericidal effect of various cephalosporins (cephalothin, cefamandole, cefotaxime and cefoperazone) in combination with other antibiotics (netilmicin, amikacin, vancomycin and fosfomycin) was studied on ten M-R staphylococcal strains." | ( Cefotaxime in combination with other antibiotics for the treatment of severe methicillin-resistant staphylococcal infections. Chavanet, P; Duez, JM; Kazmierczak, A; Lucht, F; Portier, H; Tremeaux, JC, 1985) | 0.27 |
| " Fifty-one patients were administered CTM in combination with aminoglycoside or (and) penicillin." | ( [Clinical investigation of cefotiam in combination with aminoglycoside or (and) penicillin against complicated infections with hematopoietic disorders]. Kageyama, S; Kamio, N; Kataoka, Y; Katayama, N; Koh, T; Minami, N; Ono, T; Ota, C; Tanaka, I; Uno, N, 1984) | 0.27 |
| "The in vitro bactericidal interactions of penicillin G, cefotaxime, or vancomycin in combination with gentamicin were compared against 20 group G streptococci by the timed kill curve method." | ( In vitro bactericidal synergy of gentamicin combined with penicillin G, vancomycin, or cefotaxime against group G streptococci. Bayer, AS; Lam, K, 1984) | 0.27 |
| "The activities of moxalactam and cefotaxime, alone and combined with ampicillin or penicillin, against 40 isolates of group B streptococci were assessed by using the microtiter broth dilution, checkerboard, and time-kill techniques." | ( Activity of moxalactam and cefotaxime alone and in combination with ampicillin or penicillin against group B streptococci. Cherubin, CE; Corrado, ML; Landesman, SH; Sierra, MF, 1981) | 0.26 |
| "A broth dilution checkerboard synergy assay was used to assess the activity of cefoperazone, cefotaxime, moxalactam, and carbenicillin, in combination with tobramycin, against 38 strains of Pseudomonas aeruginosa." | ( Comparative synergistic activity of cefoperazone, cefotaxime, moxalactam, and carbenicillin, combined with tobramycin, against Pseudomonas aeruginosa. Drew, WL; Mintz, L, 1981) | 0.26 |
| "We investigated the antibacterial activity of ceftriaxone at concentrations of 1/4 X minimum inhibition concentration (MIC), 1 X MIC and 4 X MIC against a serum-resistant Pseudomonas aeruginosa and a serum-resistant STaphylococcus aureus strain in broth, serum, and in combination with leukocytes." | ( Effect of ceftriaxone on Pseudomonas aeruginosa and Staphylococcus aureus in broth, serum, and in combination with human polymorphonuclear leukocytes. Bassler, M; Blaschke, H; Daschner, FD; Just, M, 1982) | 0.26 |
| " This observation suggests that a new and extremely active cephalosporin is as effective in vivo when used alone as when given in combination with an aminoglucoside and provides rationale for testing the use of single antibiotic therapy for clinical situations for which combinations of antibiotics are currently recommended." | ( Treatment of experimental ascending Escherichia coli pyelonephritis with ceftriaxone alone and in combination with gentamicin. Glauser, MP, 1982) | 0.26 |
| "The in vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against 50 Pseudomonas aeruginosa strains was studied by the broth dilution method and the time-kill curve method." | ( In vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa. Watanakunakorn, C, 1983) | 0.27 |
| "The in-vitro activity of ticarcillin in combination with clavulanic acid was compared with that of ticarcillin alone, piperacillin, cefotaxime and, where appropriate, other beta-lactams against a total of 301 recent clinical isolates and characterized beta-lactamase producers." | ( Clavulanic acid in combination with ticarcillin: an in-vitro comparison with other beta-lactams. Clarke, AM; Zemcov, SJ, 1984) | 0.27 |
| "The in vitro bactericidal interactions of three new extended-spectrum cephalosporins (ceftriaxone, ceftizoxime, or ceftazidime) in combination with gentamicin or amikacin were compared against 40 recent nosocomial bloodstream Enterobacteriaceae isolates by the timed-kill curve technique." | ( Enhanced in vitro bactericidal activity of amikacin or gentamicin combined with three new extended-spectrum cephalosporins against cephalothin-resistant members of the family Enterobacteriaceae. Bayer, AS; Eisenstadt, R; Morrison, JO, 1984) | 0.27 |
| " Data are also presented for cefotaxime 2 g every 8 h alone and in combination with ofloxacin." | ( Role of pharmacokinetics and pharmacodynamics in the design of dosage schedules for 12-h cefotaxime alone and in combination with other antibiotics. Nix, DE; Schentag, JJ, ) | 0.13 |
| "In vivo synergistic effects of cefodizime (CDZM) were investigated in combination with aminoglycosides (AGs), sisomicin (SISO) or dibekacin (DKB) against Pseudomonas aeruginosa in immunocompromised tumour bearing mice." | ( [Therapeutic efficacy of cefodizime in combination with aminoglycosides against systemic infections caused by Pseudomonas aeruginosa in immunocompromised tumour bearing mice]. Deguchi, K; Furukawa, T; Hyodo, A; Miyake, Y; Uji, T, 1993) | 0.29 |
| " However, strains expressing class A beta-lactamase were susceptible to cefodizime in combination with clavulanic acid." | ( In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors. Amicosante, G; Franceschini, N; Oratore, A; Perilli, M; Segatore, B; Setacci, D, 1993) | 0.29 |
| "The in vivo synergistic effect of cefodizime (CDZM) in combination with minocycline (MINO) against methicillin-resistant Staphylococcus aureus (MRSA) was investigated." | ( [Therapeutic efficacy of cefodizime in combination with minocycline against systemic infection caused by methicillin-resistant Staphylococcus aureus in immunocompromised tumour bearing mice]. Deguchi, K; Furukawa, T; Hyodo, A; Miyake, Y; Shimizu, C; Uji, T, 1993) | 0.29 |
| " This finding, along with the abscess sterilization results, indicates that cefotaxime in combination with metronidazole is a highly effective treatment but is associated with a high frequency of reversible side effects." | ( Efficacy and safety of cefotaxime in combination with metronidazole for empirical treatment of brain abscess in clinical practice: a retrospective study of 66 consecutive cases. Enblad, P; Jansson, AK; Sjölin, J, 2004) | 0.32 |
| " We also evaluated the inhibitory activity of cefazolin or cefotaxime combined with minocycline." | ( In vitro antimicrobial effect of cefazolin and cefotaxime combined with minocycline against Vibrio cholerae non-O1 non-O139. Chuang, YC; Ko, WC; Liu, CY; Liu, YC; Su, BA; Tang, HJ; Wang, YY, 2005) | 0.33 |
| "Our objective is to determine in vitro efficiency of moxifloxacin (MXF) alone or in combination with cefotaxime (CTX) on Group B streptococcus (GBS)." | ( [In vitro activity of moxifloxacin (8-methoxyquinolone) alone or in combination with cefotaxime against group B streptococci]. Collignon, A; Cruaud, P; Gaudelus, J; Jacquier, H; Lachassinne, E; Poilane, I, 2007) | 0.34 |
| "To explore the curative effects of vancomycin and cefotaxime combined with gamma globulin respectively in neonatal septicemia and their influences on PCT, CRP, and hs-CRP, so as to provide references for clinical treatment." | ( Curative effects of vancomycin and cefotaxime combined with gamma globulin respectively in neonatal septicemia and their influences on PCT, CRP and hs-CRP. Ouyang, Y; Xu, YB; Zhao, D, 2020) | 0.56 |
| " Patients treated with vancomycin combined with gamma globulin were selected as group A (96 cases) and those treated with cefotaxime combined with gamma globulin were selected as group B (85 cases)." | ( Curative effects of vancomycin and cefotaxime combined with gamma globulin respectively in neonatal septicemia and their influences on PCT, CRP and hs-CRP. Ouyang, Y; Xu, YB; Zhao, D, 2020) | 0.56 |
| "Cefotaxime combined with gamma globulin in the treatment of patients with neonatal septicemia has short improvement time in clinical symptoms, high total effective rate of drugs, low mortality, fewer adverse reactions and complications, and can significantly reduce levels of serum CRP, PCT, and hs-CRP, which is worthy of further promotion and application in clinical practice." | ( Curative effects of vancomycin and cefotaxime combined with gamma globulin respectively in neonatal septicemia and their influences on PCT, CRP and hs-CRP. Ouyang, Y; Xu, YB; Zhao, D, 2020) | 0.56 |
| " This experiment carried out to analyze the efficacy of cefotaxime combined with gamma globulins on neonatal sepsis and the effect on CRP and PCT." | ( Efficacy of cefotaxime combined with gamma globulins on C-reactive protein and procalcitonin in neonatal sepsis. Zhang, F, 2020) | 0.56 |
| "Reduced doses of antibiotics, bacterial morphological alterations, efflux pump down regulation, porin over expression and beta-lactamase gene inhibition of ESBL-QR bacteria by EG alone or in combination with CTX/CIP might have reversed antibiotic resistance profile of ESBL-QR bacteria." | ( The use of eugenol in combination with cefotaxime and ciprofloxacin to combat ESBL-producing quinolone-resistant pathogenic Enterobacteriaceae. Dhara, L; Tripathi, A, 2020) | 0.56 |
| "A total of 29 MRSA, including 6 VISA, 14 hVISA, and 9 VSSA isolates, were subjected to a microbroth dilu- tion-minimum inhibitory concentration (MIC) checkerboard using vancomycin combined with cefotaxime, imipenem, or meropenem." | ( Synergistic effect of vancomycin combined with cefotaxime, imipenem, or meropenem against Staphylococcus aureus with reduced susceptibility to vancomycin Booncharoen, S; Chaiyapoke, C; Chanawong, A; Lulitanond, A; Srisrattakarn, A; Tavichakorntrakool, R; Tippayawat, P; Wongthong, S, 2021) | 0.62 |
| " Using time-kill assay, the vancomycin combined with either imipenem or cefotaxime demonstrated synergism against both VISA and hVISA isolates, while the synergistic effect with meropenem was obtained only in the VISA isolates." | ( Synergistic effect of vancomycin combined with cefotaxime, imipenem, or meropenem against Staphylococcus aureus with reduced susceptibility to vancomycin Booncharoen, S; Chaiyapoke, C; Chanawong, A; Lulitanond, A; Srisrattakarn, A; Tavichakorntrakool, R; Tippayawat, P; Wongthong, S, 2021) | 0.62 |
| "Synergistic effects of phages in combination with antibiotics have received increasing attention." | ( Synergistic Antibacterial Effect of Phage pB3074 in Combination with Antibiotics Targeting Cell Wall against Multidrug-Resistant Acinetobacter baumannii Fan, J; Jin, J; Li, Q; Liu, M; Luo, C; Luo, J; Wang, P; Xie, L; Yang, M, 2023) | 0.91 |
| " The time-kill kinetic assay was performed to evaluate the dynamic bactericidal activity of eugenol alone and in combination with cefotaxime." | ( Synergistic Effect and Time-Kill Evaluation of Eugenol Combined with Cefotaxime Against Staphylococcus aureus. Lady, J; Nurcahyanti, ADR; Tjoa, E, 2023) | 0.91 |
In-vivo evaluation was carried out on eight Sprague-Dawley rats in a two-way crossover study. Cefotaxime administered intramuscularly was well absorbed from the injection site (91% +/- 19%) and produced maximal levels of 25.
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| "We studied the action of nifedipine on the bioavailability of cefixime, a molecule absorbed via the gut wall dipeptide carrier system in the rat, and on the bioavailability of D-xylose, which is absorbed via a pH (and Na(+)-)-dependent transporter." | ( Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system. Bouten, A; Carbon, C; Deslandes, A; Duverne, C; Farinotti, R; Trouvin, JH; Westphal, JF, 1992) | 0.28 |
| " Concomitant administration of lidocaine did not alter either bioavailability or pharmacokinetic characteristics." | ( Pharmacokinetic profile of cefodizime. Brockmeier, D; Dagrosa, EE, 1992) | 0.28 |
| "Cefotaxime was well absorbed and therapeutic serum concentrations were achieved after intraperitoneal administration." | ( Cefotaxime and metabolite disposition in two pediatric continuous ambulatory peritoneal dialysis patients. Hubbard, JA; Mahan, JD; Mentser, MA; Nahata, MC; Paap, CM; Puri, SK, 1992) | 0.28 |
| "The relative bioavailability of cefixime was studied in 24 healthy male volunteers, with each subject receiving a single 400mg dose of cefixime administered as an aqueous solution, a 400mg tablet and two 200mg tablets, in a randomised crossover sequence." | ( Comparative bioavailability study of cefixime administered as tablets or aqueous solution. Chassard, D; Frydman, A; Le Liboux, A; Le Roux, Y; Masala, F; Montay, G; Roche, G; Thebault, JJ; Uhlrich, J, 1991) | 0.28 |
| " However, these cephems were not well absorbed orally." | ( Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. I. Kim, H; Kim, WJ; Ko, KY; Oh, J, 1991) | 0.28 |
| " The absolute bioavailability im is almost 100%." | ( Pharmacokinetics of cefodizime: a review of the data on file. Barré, J, 1990) | 0.28 |
| " The best bioavailability was obtained with the dry suspension followed by the tablet and the syrup." | ( [Pharmacokinetics of cefixime in volunteers and a literature comparison with the new ester prodrug cephalosporins]. Kees, F; Naber, KG, 1990) | 0.28 |
| "Three galenic formulations of cefixime (tablet, syrup and dry suspension) containing 200 mg each were compared with respect to their relative bioavailability in twelve healthy volunteers." | ( Relative bioavailability of three cefixime formulations. Grobecker, H; Kees, F; Naber, KG; Sigl, G; Ungethüm, W, 1990) | 0.28 |
| "After a 200 mg intravenous or oral dose, the absolute bioavailability of cefixime, evaluated by comparison of areas under the serum concentration-time curve values, is 50 per cent." | ( [Pharmacokinetic properties of cefixime]. Barré, J, 1989) | 0.28 |
| "The advances achieved in the field of oral cephalosporins consist of improved bioavailability and enhanced intrinsic activity of the compounds." | ( [Structure-activity relationship of oral cephalosporins]. Bingen, E; Lambert-Zechovsky, N, 1989) | 0.28 |
| "Interaction studies in dogs have indicated that antacids significantly decrease the oral bioavailability of cefixime." | ( Influence of an antacid containing aluminum and magnesium on the pharmacokinetics of cefixime. Healy, DP; Racht, EM; Sahai, JV; Sterling, LP, 1989) | 0.28 |
| "In a four-way cross-over study, the absolute bioavailability of cefixime was determined in 16 healthy volunteers." | ( Absolute bioavailability of cefixime in man. Falkowski, AJ; Faulkner, RD; Fernandez, P; Lawrence, G; Sia, LL; Silber, BM; Weiss, AI; Yacobi, A, 1988) | 0.27 |
| "In a separate study on the orally active acyloxymethyl esters (1) of 7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl) - 1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acid (cefotiam, CTM), we have shown, by quantitative structure-oral bioavailability (BA) relation analysis, that the R2 group in the acyl group R2CO must have both an adequate lipophilicity (Hansch's lipophilic parameter, pi) and steric hindrance (Taft's Es value)." | ( Preparation of 1-acyloxyethyl esters of 7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoe thy l)-1H-tetrazol-5-yl]thio]-methyl]ceph-3-em-4-carboxylic acid (cefotiam) and their oral absorption in mice. Hamaguchi, N; Yashiki, T; Yoshimura, Y, 1986) | 0.27 |
| " The syntheses and oral bioavailability (BA) in mice are described." | ( Orally active 1-(cyclohexyloxycarbonyloxy)alkyl ester prodrugs of cefotiam. Hamaguchi, N; Hirai, S; Miyake, A; Nishimura, T; Numata, M; Takanohashi, K; Yamaoka, M; Yashiki, T; Yoshimura, Y, 1987) | 0.27 |
| " The absolute bioavailability, based on comparisons of area under the serum concentration-time curve values after 200-mg intravenous, 200-mg oral solution, and 200- and 400-mg capsule doses, ranged from 40 to 52%, showing a comparable bioavailability for cefixime at single 200- and 400-mg oral doses." | ( Pharmacokinetic profile of cefixime in man. Barone, JS; Faulkner, RD; Kaplan, SA; Silber, BM; Yacobi, A, 1987) | 0.27 |
| " The average bioavailability of cefotaxime given by intramuscular injection was 86." | ( Pharmacokinetics of cefotaxime in the dog. Bourne, DW; English, PB; Filippich, LJ; Guerrini, VH; Schneider, J, 1986) | 0.27 |
| " Cross-over comparison with intramuscular CZX in a child showed approximately one-third bioavailability of the suppository against intramuscular injection." | ( [Clinical and pharmacokinetic evaluations of ceftizoxime suppositories in children]. Fujii, R; Mashiko, J; Meguro, H; Shinozaki, T, 1985) | 0.27 |
| " CZX-S was well absorbed in children." | ( [Fundamental and clinical studies of ceftizoxime rectal suppositories in the field of pediatrics]. Chikaoka, H; Nakada, Y; Nakazawa, S; Narita, A; Oka, S; Sato, H; Suzuki, H; Tazoe, K, 1985) | 0.27 |
| " In 2 animals, the bioavailability of an IM injection was 98." | ( Pharmacokinetics of cefotaxime in the domestic cat. Clark, CH; McElroy, D; Ravis, WR, 1986) | 0.27 |
| " injection, probenecid and cefotaxime were well tolerated and cefotaxime was well absorbed (101 +/- 45%)." | ( Effect of probenecid on the pharmacokinetics of cefotaxime in sheep. Bourne, DW; Cao, GR; English, PB; Filippich, LJ; Guerrini, VH, 1985) | 0.27 |
| " The pharmacokinetic data suggested that 1% lidocaine does not alter either the elimination parameters or the bioavailability of intramuscularly administered ceftriaxone." | ( Pharmacokinetics and tolerance of ceftriaxone in humans after single-dose intramuscular administration in water and lidocaine diluents. Konikoff, J; Parsonnet, M; Patel, IH; Weinfeld, RE, 1982) | 0.26 |
| " Cefotaxime administered intramuscularly was well absorbed from the injection site (91% +/- 19%) and produced maximal levels of 25." | ( The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal function. Fillastre, JP; Godin, M; Humbert, G; Ings, RM; Leroy, A, ) | 0.13 |
| "The oral bioavailability of new formulations of ceftizoxime sodium was investigated in animals and humans." | ( Effect of ethyl cellulose in a medium-chain triglyceride on the bioavailability of ceftizoxime. Kozatani, J; Shimojo, F; Ueda, I, 1983) | 0.27 |
| " Oral absorption was comparatively slow and bioavailability values for single 5 mg/kg doses were 20." | ( Clinical pharmacology of cefixime in unweaned calves. Glickman, A; Lavy, E; Winkler, M; Ziv, G, 1995) | 0.29 |
| "Betalactams, mainly when orally administered, may lead to intestinal flora modifications related to their spectrum of activity, rate of absorption and degradation." | ( Betalactam therapy and intestinal flora. Cassetta, MI; Conti, S; Dei, R; Fallani, S; Mazzei, T; Novelli, A, 1995) | 0.29 |
| " enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats." | ( Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Dhuley, JN; Hiwale, AR; Naik, SR, 2002) | 0.31 |
| " Because of the obvious drawbacks of drug delivery by injection, the development of alternatives with enhanced oral bioavailability has received much attention in pharmaceutical research." | ( Influence of enhancers on the absorption and on the pharmacokinetics of cefodizime using in-vitro and in-vivo models. Brandsch, M; Bretschneider, B; Härtl, A; Mrestani, Y; Neubert, RH, 2004) | 0.32 |
| "The utilization of the membrane transport protein PEPT1 as a drug delivery system is a promising strategy to enhance the oral bioavailability of drugs." | ( Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. Biegel, A; Brandsch, M; Gebauer, S; Hartrodt, B; Neubert, K; Thondorf, I, 2005) | 0.33 |
| " These additives increased intestinal permeability (P(app)) and absorption rate constant (K(a)) up to two and fourfold, respectively." | ( In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Chawla, HP; Panchagnula, R; Sharma, P; Varma, MV, ) | 0.13 |
| "A liposome system was evaluated for oral delivery of a poorly bioavailable hydrophilic drug." | ( Enhanced oral bioavailability and intestinal lymphatic transport of a hydrophilic drug using liposomes. Barker, SA; Khan, NA; Ling, SS; Magosso, E; Yuen, KH, 2006) | 0.33 |
| " For "selective intestinal decontamination", poorly absorbed oral norfloxacin is the preferred schedule." | ( [Bacterial infections in liver cirrhosis]. Farkas, A; Papp, M; Tornai, I; Udvardy, M, 2007) | 0.34 |
| "A liposome preparation that is amenable to receptor-mediated endocytosis has been developed to enhance the oral bioavailability of poorly absorbable peptidomimetic drugs by use of folic acid as the mediator of liposomal uptake." | ( Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats. Barker, SA; Ling, SS; Magosso, E; Yuen, KH, 2009) | 0.35 |
| " In-vivo evaluation was carried out on eight Sprague-Dawley rats in a two-way crossover study to compare the oral bioavailability of cefotaxime loaded in folic acid-free liposomes and folic acid-coupled liposomes." | ( Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats. Barker, SA; Ling, SS; Magosso, E; Yuen, KH, 2009) | 0.35 |
| "Enhanced oral bioavailability (AUC(0-infinity)) of cefotaxime was observed when administered via folic acid-coupled liposomes." | ( Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats. Barker, SA; Ling, SS; Magosso, E; Yuen, KH, 2009) | 0.35 |
| " CEF oral bioavailability was increased twofold when coadministered with MKC and when encapsulated in microvesicles and ninefold when encapsulated in MKC microvesicles compared to the same CEF dose administered orally as saline solution." | ( Cefotaxime pharmacokinetics after oral application in the form of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate microvesicles in rat. Arafat, M; Golocorbin-Kon, S; Lepojevic, Z; Mikov, I; Mikov, M; Sahman-Zaimovic, M; Tomic, Z, ) | 0.13 |
| " Very low bioavailability (2." | ( Microemulsion and mixed micelle for oral administration as new drug formulations for highly hydrophilic drugs. Behbood, L; Härtl, A; Mrestani, Y; Neubert, RH, 2010) | 0.36 |
| " The oral bioavailability and pharmacokinetics of cefotaxime was assessed in rats (n = 6 per group) after single dose of drug-encapsulated in liposomes containing bile salt, drug in conventional liposomes, and cefotaxime solution (oral and intravenous)." | ( Nanosized Liposomes Containing Bile Salt: A Vesicular Nanocarrier for Enhancing Oral Bioavailability of BCS Class III Drug. Arafat, M; Kirchhoefer, C; Löbenberg, R; Mikov, M; Sarfraz, M, 2017) | 0.46 |
| " The total oral bioavailability of cefotaxime in liposomes containing bile salt was found to be 5-times higher compared to cefotaxime solution and twice as much as in conventional liposomes." | ( Nanosized Liposomes Containing Bile Salt: A Vesicular Nanocarrier for Enhancing Oral Bioavailability of BCS Class III Drug. Arafat, M; Kirchhoefer, C; Löbenberg, R; Mikov, M; Sarfraz, M, 2017) | 0.46 |
| " The nano-sized liposomes containing sodium deoxycholate were able to reduce the leakage of encapsulated cefotaxime in the gut due to the improved vesicle stability and to enhance the oral bioavailability of acid-labile drugs up to 5-fold." | ( Nanosized Liposomes Containing Bile Salt: A Vesicular Nanocarrier for Enhancing Oral Bioavailability of BCS Class III Drug. Arafat, M; Kirchhoefer, C; Löbenberg, R; Mikov, M; Sarfraz, M, 2017) | 0.46 |
Cefotaxime at a dosage of 3 gm intravenously every eight hours was administered to 80 patients with hematological malignancies and suspected septicemia. The slower elimination of cefataxime in patients over 80 years of age may allow reduction in the dose without jeopardizing the efficacy of therapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A comparative study of cefixime (CFIX), a new oral cephem antibiotic, was carried out at the Department of Urology, Nagoya University Hospital and its four affiliated hospitals to evaluate the clinical efficacy and safety of two dosage regimens of CFIX, given either in twice daily doses (BID group) or once daily dose (UID group), in the treatment of acute uncomplicated cystitis." | ( [Clinical evaluation of usefulness of cefixime (200 mg administered once daily) in the treatment of acute uncomplicated cystitis]. Hattori, R; Ito, Y; Kinukawa, T; Miyake, K; Narushima, M; Obata, K; Otani, T; Sakata, T; Takita, T, 1992) | 0.28 |
| " Both these antimicrobials seem appropriate for the treatment of meningitis caused by penicillin G-resistant pneumococci provided their dosage is adjusted to achieve adequate drug levels in the cerebrospinal fluid." | ( [Bacteriostatic activity and killing curves of eight antibiotics against seven strains of penicillin G-resistant pneumococci]. Barakett, V; Burghoffer, B; Delisle, F; Guidet, B; Lesage, D; Offenstadt, G; Petit, JC; Richard, G; Vergez, P, 1992) | 0.28 |
| " The dosage of 1 x 2 g CDZ is recommended for the treatment of UUTI and complicated LUTI." | ( Cefodizime given once daily for the treatment of upper urinary tract infections and complicated lower urinary tract infections. Hofstetter, AG, 1992) | 0.28 |
| " No great differences were found between the clinical and microbiological results in the various dosage groups, and no corresponding improvement was noted with the highest dosages studied." | ( Clinical and bacteriological experience with cefodizime in acute purulent exacerbations of chronic bronchitis. Costongs, RJ; Davies, BI; Geraedts, WH; Gubbelmans, HL; Maesen, FP; Meek, JC; van den Bergh, JJ, 1992) | 0.28 |
| " No significant differences in clinical and bacteriological outcome were detected when the various CDZ dosage regimens were compared." | ( Review of effectiveness of cefodizime in the treatment of lower respiratory tract infections with parenchymal involvement. Pauwels, RA, 1992) | 0.28 |
| " It is concluded that a usual CDZ dosage regimen stimulates depressed phagocytosis in haemodialysis patients, and that this stimulatory effect persists for at least two weeks after the end of treatment." | ( Cefodizime: enhancement of depressed phagocytosis-associated respiratory burst activity in chronic uremic patients. Ringoir, S; Vanholder, R, 1992) | 0.28 |
| " Further studies are needed to establish appropriate intraperitoneal dosing guidelines of cefotaxime in pediatric CAPD patients." | ( Cefotaxime and metabolite disposition in two pediatric continuous ambulatory peritoneal dialysis patients. Hubbard, JA; Mahan, JD; Mentser, MA; Nahata, MC; Paap, CM; Puri, SK, 1992) | 0.28 |
| "The optimal antibiotic dosage in serious chest infections is not established and commonly used regimens may well be excessive." | ( Efficacy of a low dose of cefotaxime in serious chest infections. Cade, JF; Keighley, C; Presneill, J; Sinickas, V, 1992) | 0.28 |
| "7 hours) supports the clinical evaluation of a 400mg once-daily dosage regimen for cefixime." | ( Comparative bioavailability study of cefixime administered as tablets or aqueous solution. Chassard, D; Frydman, A; Le Liboux, A; Le Roux, Y; Masala, F; Montay, G; Roche, G; Thebault, JJ; Uhlrich, J, 1991) | 0.28 |
| " Our analysis indicates that cefotaxime therapy may be less costly than ceftriaxone therapy in the dosage schedules used in these clinical studies and routine clinical practice." | ( Evaluating the cost-effectiveness of treatment with third-generation cephalosporins. Gladen, HE, 1992) | 0.28 |
| " three times daily with dosage adjustment according to renal function and body weight (group 2)." | ( Empiric treatment of serious infections in patients with cancer: randomised comparison of two combinations. Maiche, AG; Teerenhovi, L, 1991) | 0.28 |
| " CAT identifies Escherichia coli and Bacteroides fragilis as the most important pathogens for intraabdominal infections and determines the most effective antibiotics at the tissue breakpoint, which is defined as the minimal concentration maintained for more than 90% of the dosage interval period at the infected tissues." | ( Calculated empiric antimicrobial therapy for mixed surgical infections. Bergstein, JM; Frantzides, C; Wittmann, DH, 1991) | 0.28 |
| " As estimates of pharmacodynamic activity, time below the MIC (T less than MIC) and percentage of the dosing interval below the MIC (% INT less than MIC) were calculated for individual isolates using total and unbound serum concentrations." | ( Evaluation of cephalosporins/cephamycins with antianaerobic activity by integrating microbiologic and pharmacokinetic properties. Del Bene, VE; Friedrich, LV; Kays, MB; White, RL, ) | 0.13 |
| " With increasing time following cefotaxime dosing there was a significant increase in the abscess:plasma concentration ratio of desacetylcefotaxime." | ( Penetration of cefotaxime and desacetylcefotaxime into brain abscesses in humans. Arneborn, P; Cars, O; Eriksson, N; Sjölin, J, 1991) | 0.28 |
| " Thus, it is possible to adjust reliably individual dosage in multiple-organ failure and to reduce the frequency of drug monitoring required." | ( [Infection-induced change in the pharmacokinetics of cefotaxime. Dose calculation in multiple organ failure and relevance of score systems]. Hofmann, W; Kroh, U; Lennartz, H, 1991) | 0.28 |
| " In addition the serum amikacin levels in 200 patients randomized to receive a once- or twice-daily dosing regimen are reported." | ( The pharmacokinetic of amikacin in critically ill adult and paediatric patients: comparison of once- versus twice-daily dosing regimens. Havlik, I; Lipman, J; Marik, PE; Monteagudo, FS, 1991) | 0.28 |
| " In summary, a once-daily dosing regimen of amikacin 15 mg/kg is practical and probably efficacious and safe in severely infected patients." | ( Clinical and bacteriological efficacy, and practical aspects of amikacin given once daily for severe infections. Beaucaire, G; Beuscart, C; Caillaux, M; Chidiac, C; Karp, P; Leroy, O, 1991) | 0.28 |
| " This antibiotic was used in 25 diabetic patients with osteomyelitis at a dosage of 2 gr." | ( [Cefotaxime treatment of osteomyelitis of the foot in the diabetic]. Alguacil, R; Barberán, J; Gomis, M; Herranz, A; Pastor, JM, 1991) | 0.28 |
| " Modest accumulation of cefotaxime in patients with severe hepatic impairment is unlikely to produce toxicity because of its high therapeutic index, and dosing modifications may not be required." | ( Pharmacokinetics of cefotaxime and desacetylcefotaxime in patients with liver disease. Akriviadis, E; Appleman, M; Cohen, JL; Ko, RJ; Koda, RT; Nichols, S; Runyon, B; Sattler, FR, 1991) | 0.28 |
| " The results of this study indicate that dosage adjustment may be necessary for CTX in children with renal dysfunction." | ( Pharmacokinetics of cefotaxime and its active metabolite in children with renal dysfunction. Hubbard, JW; Mahan, JD; Mentser, MA; Nahata, MC; Paap, CM; Puri, SK, 1991) | 0.28 |
| " A daily dosage of 3-6 mg/kg/day was given divided into 2 to 3 times daily for 3-15 days." | ( [Clinical evaluation of cefixime in pediatric respiratory tract infections]. Iwai, N; Kasai, K; Maki, T; Matsui, Y; Nakamura, H; Ozaki, T; Taneda, Y; Tauchi, N; Yamaguchi, H, 1991) | 0.28 |
| "Serum levels achieved within 90 minutes of equivalent intraosseous (IO) and IV bolus dosing of ceftriaxone, cefotaxime, and a combination of ampicillin and gentamicin were compared in the weanling pig." | ( Intraosseous administration of antibiotics: same-dose comparison with intravenous administration in the weanling pig. Parks, BR; Pender, ES; Pollack, CV; Woodall, BN, 1991) | 0.28 |
| " Serum levels of ceftriaxone after IO administration paralleled those after IV dosing but remained significantly lower at all time intervals." | ( Intraosseous administration of antibiotics: same-dose comparison with intravenous administration in the weanling pig. Parks, BR; Pender, ES; Pollack, CV; Woodall, BN, 1991) | 0.28 |
| " A dosage regimen of 1 g every 12 h seems to be the most suitable schedule for the treatment of LRTI while 1 g every 12 h or 2 g every 24 h can equally well be adopted for treatment of UTI." | ( Cefodizime in clinical use: a review of the clinical trial reports. Grassi, GG, 1990) | 0.28 |
| " These results demonstrate a lack of accumulation and no changes in the pharmacokinetic profile of cefodizime during repeated dosing in the elderly." | ( Pharmacokinetics of cefodizime in the elderly following single and repeated intravenous administration of 1 g. Lenfant, B; Nilsen, OG; Rennemo, F; Rennemo, R, 1990) | 0.28 |
| " Cefodizime concentrations in blood and urine (iv dosage only) sampled up to 12h post dose were measured by microbiological assay and pharmacokinetic parameters were derived on the basis of a two-compartment open model." | ( The pharmacokinetics of cefodizime in children. Boccazzi, A; Careddu, P; Fusi, G; Maretti, M; Mezzopane, AM, 1990) | 0.28 |
| " The total clearance is about 20% less in elderly subjects than in young adults, but no dosing adjustment is needed in the elderly." | ( Pharmacokinetics of cefodizime: a review of the data on file. Barré, J, 1990) | 0.28 |
| " The dosage was 200 mg bid." | ( [Cefixime therapy in sinusitis]. Jorde, W; Schata, M, 1990) | 0.28 |
| " The dosage was 2 x 4 mg/kg body weight daily for a period of seven to 11 days." | ( [Therapy of pediatric infections with cefixime]. Helwig, H, 1990) | 0.28 |
| " The study presented here was designed to compare cefotaxime at a dosage of 2 x 3 g/day with penicillin G at a dosage of 2 x 10 megaunits/day, for ten days in a prospective randomized trial." | ( Cefotaxime versus penicillin in the late stage of Lyme disease--prospective, randomized therapeutic study. Hassler, D; Haude, M; Heinrich, F; Hufnagel, HD; Sonntag, HG; Zöller, L, ) | 0.13 |
| " Mean dosage per application: 20." | ( [Experimental and clinical studies on cefodizime in pediatrics]. Aramaki, M; Kawakami, A; Koga, T; Motohiro, T; Oda, K; Okabayashi, S; Sakata, Y; Takajo, N; Tanaka, K; Yamashita, F, 1990) | 0.28 |
| " In the present study, the 6-h concentration time course was plotted of the total and free concentrations of cefotaxime and ceftriaxone in serum and pleural exudate in 12 patients per group, after iv dosing with 1 g of either cefotaxime or ceftriaxone." | ( Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate. Fraschini, F; Raichi, M; Scaglione, F, 1990) | 0.28 |
| " The pharmacokinetic profile of cefixime is significantly altered in patients with marked renal impairment (creatinine clearance less than 20 ml/min), and in such cases dosage should be reduced from 400 to 200 mg/day." | ( [Pharmacokinetic properties of cefixime]. Barré, J, 1989) | 0.28 |
| " Modifications of cefixime kinetics resulting from impaired hepatic function were modest and did not require specific dosage adjustment." | ( [Effect of hepatic failure upon the pharmacokinetics of cefixime]. Gaudin, C; Lebrec, D; Montay, G; Roche, G; Singlas, E; Taburet, AM, 1989) | 0.28 |
| " When administering combinations of antibiotics non-simultaneous dosing is superior to simultaneous administration." | ( [The kinetics of bacterial killing by fluctuating concentrations of antibiotics]. Allerberger, F; Bonatti, H; Dierich, MP; Guggenbichler, JP; Semenitz, E, 1989) | 0.28 |
| "In 43 ICU patients undergoing continuous volume constant hemofiltration (CVHF), the pharmacokinetics of 12 drugs were investigated to ensure correct dosage adjustments." | ( [Dosage adjustment of drugs during continuous hemofiltration. Results and practical consequences of a prospective clinical study]. Dehne, M; el Abed, K; Hofmann, W; Kroh, U; Lennartz, H, 1989) | 0.28 |
| " Diarrhoea occurred in rabbits and monkeys dosed with imipenem or meropenem." | ( Safety evaluation of meropenem in animals: studies on the kidney. Goonetilleke, UR; Jones, DV; Murgatroyd, LB; Topham, JC; Wright, J, 1989) | 0.28 |
| " The results discussed with the dates given by literature allow us to state that it is not necessary to change dosage and application interval of cefotaxime during pregnancy." | ( [Pharmacokinetics of cefotaxime during late pregnancy]. Bierwisch, I; Michels, W; Schröder, S; Voigt, R, ) | 0.13 |
| " In a non-comparative prospective clinical trail, 22 infants (one week - three months) were treated for gram-negative enteric bacillary meningitis with cefotaxime at a dosage of 50 mg/kg/day." | ( Cefotaxime pharmacokinetics and treatment of meningitis in neonates. Jacobs, RF; Kearns, GL, ) | 0.13 |
| " We conducted a study in children older than one year to compare the efficacy and tolerance of two treatment regimens for urinary tract infection with tissue penetration: cefotaxime 100 mg/kg/d in four divided iv doses for 14 days (group I) and amoxycillin/clavulanate 100 mg/kg/d in four divided iv doses for seven days with conversion to the oral route at a dosage of 50 mg/kg/d for seven days (group II)." | ( Urinary tract infections with tissue penetration in children: cefotaxime compared with amoxycillin/clavulanate. Fischbach, M; Geisert, J; Janin, A; Jehl, F; Mengus, L; Monteil, H; Simeoni, U, 1989) | 0.28 |
| " ABPC was discontinued, gentamicin was administered for 2 days, CTX was continued at the same dosage level and an administration of prednisolone 40 mg daily was begun." | ( [Klebsiella pneumoniae meningitis associated with liver abscess: a case report]. Kataoka, K; Kobayashi, Y; Maruyama, H; Nakamura, H; Saruta, T; Takei, I; Yanagawa, T, 1989) | 0.28 |
| " Ceftriaxone administered at a dosage of 1 g (i." | ( Study on the relationship between pharmacokinetics and antibacterial activity: comparison between ceftriaxone and cefotaxime within the respiratory tract. Fraschini, F; Scaglione, F, 1989) | 0.28 |
| " Thus the physicochemical and pharmacological properties of sulbactam apparently permit flexible dosage in combination with different penicillins or cephalosporins and sulbactam can be administered as non-fixed combination in the clinical treatment of bacterial infections." | ( Studies on the synergism of sulbactam and beta-lactam antibiotics under in vitro conditions and in healthy volunteers after intravenous administration. Antibacterial activity in vitro, compatibility and pharmacokinetics of the drugs in combination. Eibel, G; Pfaff, G; Räder, K; Schmalreck, A; Wildfeuer, A, 1989) | 0.28 |
| "2 micrograms/ml for 40 mg/kg, thus a dose-response was observed." | ( [Study on cefodizime, a new cephem antibiotic, in the field of pediatrics]. Matsumoto, K; Nakanishi, Y; Nakazawa, S; Narita, A; Niino, K; Sato, H; Suzuki, H, 1989) | 0.28 |
| " Results of these trials demonstrate that cefixime at a dosage of 400 mg once daily is an effective and safe oral antibiotic for the treatment of acute respiratory tract infections." | ( Comparative, multicenter studies of cefixime and amoxicillin in the treatment of respiratory tract infections. Johnson, D; Kiani, R; Nelson, B, 1988) | 0.27 |
| " reactive protein dosage was performed in each patient." | ( [Choice of first-line antibiotic therapy in the treatment of bone and joint infections in children]. Badelon, O; Bensahel, H; Bingen, E; de Ribier, A; Lambert-Zechovsky, N; Sauzeau, C, 1988) | 0.27 |
| "To evaluate the cost-effectiveness of cefotaxime sodium at a dosage of 12 g/day vs nafcillin sodium and tobramycin sulfate for the treatment of serious infection, the hospital and physician charges of patients enrolled in a prospective, randomized, clinical trial were analyzed." | ( Cefotaxime vs nafcillin and tobramycin for the treatment of serious infection. Comparative cost-effectiveness. Holloway, JJ; Lietman, PS; Moore, RD; Smith, CR, 1986) | 0.27 |
| "The minimum dosage of antibiotics which reduced mortality in rats intraperitoneally inoculated with an Escherichia coli isolate was determined." | ( In vivo significance of the inoculum effect of antibiotics on Escherichia coli. Castilla, C; Fernández-Roblas, R; Ponte, C; Santamaría, M; Soriano, F, 1988) | 0.27 |
| "In continuation of our clinical observations on perioperative prophylaxis by application of Halospor and Gentamicin the dosage of Halospor has been reduced to 2 grams once only." | ( [Once again: the perioperative antibiotic prophylaxis in cesarean section]. Bellée, H; Fiedler, FB; Link, M, 1988) | 0.27 |
| " Major changes in general conditions observed in mice and rats were decreased spontaneous activity, lying prone, respiratory changes, staggering gait, clonic or clonic-tonic convulsions, and cyanosis, and in the animals dosed orally, diarrhea or salivation was also noted." | ( [Acute toxicity study of cefodizime sodium]. Inazu, M; Kobayashi, T; Kuwata, M; Miyamoto, M; Morioka, H; Nakano, S; Sakaguchi, T; Wada, N; Yada, H, 1988) | 0.27 |
| " The males were dosed for 9 weeks prior to mating and through the mating period, and the females were treated from 2 weeks before mating through day 6 of gestation." | ( [Fertility study of cefodizime sodium in mice--intravenous administration from pre-conceptional period through early period of gestation]. Akaike, M; Kitatani, T; Kobayashi, T; Takayama, K, 1988) | 0.27 |
| " Each drug was administered single and consecutive 14-day dosage with its alone or in combination with either furosemide or gentamicin." | ( [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988) | 0.27 |
| "6 h) was slightly longer than that observed after dosing in the fasting condition (3." | ( The pharmacokinetics of cefixime in the fasted and fed state. Bohaychuk, W; Desjardins, RE; Faulkner, RD; Haynes, JD; Silber, BM; Yacobi, A, 1988) | 0.27 |
| " This antibiotic offers a broad spectrum of antimicrobial activity with little resistance, few side effects, evidence of penetration into the infected tissues and prolonged dosing intervals, which allow substantial cost savings as well as efficacious treatment of acute pelvic inflammatory disease." | ( Pelvic inflammatory disease. Decision making in the pharmacy and therapeutics committee. Mercer, LJ, 1988) | 0.27 |
| " After dosing cefotaxime and its metabolite by high performance liquid chromatography, the pharmacokinetic parameters were calculated, especially: plasma and renal clearance, volume of distribution at steady state, area under the curve, and elimination half-life." | ( [Influence of fever on cefotaxime pharmacokinetics]. Albin, H; Aubertin, J; Demotes-Mainard, F; Gin, H; Ragnaud, JM; Vincon, G, 1988) | 0.27 |
| " The purpose of this paper is to discuss the rationale for determination of the optimal dosage and of adequate modes of administration." | ( Cefotaxime optimal dosage in adult patients. A reappraisal. Carbon, C; d'Aubrac, CA; Safran, C; Simon, A, 1988) | 0.27 |
| " They also demonstrate that, provided that the dose is sufficient, a long-acting broad-spectrum cephalosporin may be effective in severe gram-negative infections, even when given at relatively long dosing intervals, in contrast with a rapidly cleared drug with the same intrinsic activity." | ( Comparative efficacy of cefotiam, cefmenoxime, and ceftriaxone in experimental endocarditis and correlation with pharmacokinetics and in vitro efficacy. Abel, L; Brion, N; Buré, A; Carbon, C; Contrepois, A; Joly, V; Pangon, B; Vallois, JM, 1987) | 0.27 |
| " The slower elimination of cefotaxime in patients over 80 years of age may allow reduction in the dose without jeopardizing the efficacy of therapy, whereas in patients under 80 years of age the normal dosage is required." | ( Pharmacokinetics of cefotaxime and desacetylcefotaxime in elderly patients. Csiba, A; Graber, H; Ludwig, E; Székely, E, 1988) | 0.27 |
| " Overall, there is no need for any dosage adjustment of the drug in the elderly." | ( Pharmacokinetics of cefixime in the young and elderly. Bohaychuk, W; Desjardins, RE; Faulkner, RD; Haynes, JD; Lanc, RA; Silber, BM; Yacobi, A, 1988) | 0.27 |
| "The pharmacokinetics of cefixime (CL 284,635; FK027), a new orally active broad-spectrum cephalosporin, were determined in 26 healthy volunteers, after multiple 200-mg twice-a-day (group 1; N = 13) or 400-mg once-a-day (group 2; N = 13) dosing for 15 days." | ( Pharmacokinetics of cefixime after once-a-day and twice-a-day dosing to steady state. Bohaychuk, W; Desjardins, RE; Faulkner, RD; Haynes, JD; Look, ZM; Silber, BM; Weiss, AI, 1987) | 0.27 |
| " A linear response to dosage was shown (coefficient of correlation r = ." | ( Dose linearity and other pharmacokinetics of cefodizime after single-dose intravenous administration. Dagrosa, EE; de Looze, S; Grötsch, H; Hajdú, P; Malerczyk, V; Seeger, K, 1987) | 0.27 |
| " A crossover analysis of concentrations of CMX in bile of patients given doses of 1 g and 2 g revealed a dose-response relationship." | ( [Clinical studies on the transference of cephem-type antibiotics into bile and gallbladder tissues with special reference to cefotiam and cefmenoxime]. Aeba, S; Hasegawa, S; Iijima, K; Kusaba, T; Matsumoto, H; Mishima, T; Okano, A; Shiozaki, H; Totsuka, S; Usui, R, 1986) | 0.27 |
| " It appeared, therefore, that this dosage regimen was useful for the treatment of refractory complicated urinary tract infection." | ( [Concomitant therapy with cefmenoxime and cefsulodin for refractory complicated urinary tract infection (especially caused by Pseudomonas aeruginosa)]. Arakawa, S; Fujii, A; Harada, M; Ishigami, J; Kamidono, S; Kataoka, N; Kawabata, G; Miyazaki, S; Takasaki, N; Umezu, K, 1986) | 0.27 |
| "The selection of dosage regimens for different animal species requires the establishment of pharmacokinetic equivalency between species." | ( Dosage regimen design for pharmaceutical studies conducted in animals. Mordenti, J, 1986) | 0.27 |
| " A dose-response relationship was observed." | ( [Pharmacokinetic and clinical studies of cefotiam in mature neonates]. Nishimura, T; Tabuki, K; Takashima, T, 1986) | 0.27 |
| " Recommendations for dosage adjustment in patients with renal insufficiency are proposed based on the data obtained in this study." | ( Pharmacokinetics of cefmenoxime in patients with impaired renal function and in those undergoing hemodialysis. Konishi, K, 1986) | 0.27 |
| " Ceftriaxone was administered at a once-a-day dose of either 1 or 2 g (in 13 and 14 patients, respectively) and cefotaxime at a 2 g twice daily dosing regimen (27 patients), both antibiotics being given for 7-12 days." | ( Treatment of lower respiratory tract infections with ceftriaxone and cefotaxime. A comparative study. Abbate, GF; Alagia, I; Altucci, P; Caputi, M; Catena, E; Giaquinto, E; Guarino, C; Leonessa, V; Micillo, E; Savioli, L, 1986) | 0.27 |
| " The rate of bacterial killing (delta log10 CFU/ml per h) did not change over a dosage range of 1 to 15 mg/kg per h (-0." | ( Evaluation of pefloxacin in experimental Escherichia coli meningitis. Hackbarth, CJ; Sande, MA; Shibl, AM, 1986) | 0.27 |
| " These children were divided into 2 dosage groups (suppository, 35; injection, 32) with matching pretreatment background factors." | ( [A comparative, well-controlled study of ceftizoxime suppository against ceftizoxime intravenous injection in infantile acute pneumonia]. Arimasu, O; Fujii, R; Hiruma, F; Hori, M; Iwai, N; Kuno, K; Meguro, H; Sugita, M; Tamura, K; Toyonaga, Y, 1986) | 0.27 |
| " In spite of kinetics modifications, it seems that it is not necessary to modify the dosage regimen in elderly." | ( [Pharmacokinetics of cefmenoxime in the aged subject (60 to 90 years of age) after an intravenous injection of 1 g]. Boquet, A; Bryskier, A; Fourtillan, JB; Modai, J; Veyssier, P, 1986) | 0.27 |
| " In the case of cefixime, single daily doses of 400 mg were taken; with cefaclor, the dosage was 250 mg three times daily." | ( Bowel flora changes in humans receiving cefixime (CL 284,635) or cefaclor. Edelstein, MA; Finegold, SM; Gee, R; Ingram-Drake, L; MacDonald, K; Reinhardt, J; Wexler, H, 1987) | 0.27 |
| "25 and 25 mg/kg (each given over 2 hours), approximating the rate of appearance of the drug also given after oral dosing (12." | ( Pharmacokinetics of cefixime after oral and intravenous doses in dogs: bioavailability assessment for a drug showing nonlinear serum protein binding. Bialer, M; Look, ZM; Silber, BM; Wu, WH; Yacobi, A, 1987) | 0.27 |
| " We conclude that the dosage of cefotaxime to uraemic patients adjusted to the renal function needs no further adjustment during peritoneal dialysis." | ( Cefotaxime disposition pharmacokinetics during peritoneal dialysis. Fugleberg, S; Løkkegaard, N; Nielsen-Kudsk, F; Overgaard, S; Scrøder, S, 1987) | 0.27 |
| " If dosage of netilmicin is closely monitored by measuring serum concentrations, toxicity is minimal." | ( A prospective randomised comparison of cefotaxime vs. netilmicin vs. cefotaxime plus netilmicin in the treatment of hospitalised patients with serious sepsis. Nazareth, B; Noone, P; Sage, R, 1987) | 0.27 |
| " To control the development of aminoglycoside resistance in hospitals, it may be necessary to restrict the use of more than the one drug to which resistance is developing; to use the antibiotic at the right dosage and, when necessary, in a combination that may prevent the emergence of resistant organisms and plasmids; and to develop measures to control bacterial and R factor transmission." | ( Strategies in aminoglycoside use and impact upon resistance. Acar, JF; Bleriot, JP; Goldstein, FW; Menard, R, 1986) | 0.27 |
| " The dosage was 4 g/day, adapted to renal function as appropriate." | ( Hemostasis in patients with normal and impaired renal function under treatment with cefodizime. Andrassy, K; Iwand, A; Jähnchen, E; Koderisch, J; Trenk, D, 1987) | 0.27 |
| " In the repeated-dose study, there were mild and transient subjective symptoms such as soft stools, diarrhea, and anorexia, which disappeared without additional treatment during the dosing period." | ( Phase I study of cefixime, a new oral cephalosporin. Kanamaru, M; Nakashima, M; Takiguchi, Y; Uematsu, T, ) | 0.13 |
| " Upon multiple dosing for 2 weeks on a 400-mg daily or 200-mg twice a day regimen, serum concentrations and urinary recovery of unchanged drug were similar for each group, and there was no drug accumulation." | ( Pharmacokinetic profile of cefixime in man. Barone, JS; Faulkner, RD; Kaplan, SA; Silber, BM; Yacobi, A, 1987) | 0.27 |
| " Cefixime was administered daily or twice daily and because results on the two dosage regimens did not differ, data were combined for analysis." | ( Bacteriologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Howie, VM; Owen, MJ, 1987) | 0.27 |
| " Dosing of the drug was studied." | ( [Clinical effectiveness and pharmacokinetic characteristics of cefotaxime in premature infants with pneumonia]. Parshina, NV, 1986) | 0.27 |
| " When older patients are treated, adjustments in dosing should be based on estimates of kidney function." | ( Management of sepsis in the elderly. Holloway, WJ, 1986) | 0.27 |
| "86 hours and urinary excretions rates up to 12 hours after dosing were 16." | ( [Clinical studies of cefixime granules in pediatrics]. Chikaoka, H; Kamigaki, M; Koido, R; Matsumoto, K; Nakazawa, S; Narita, A; Niino, K; Sato, H; Suzuki, H, 1986) | 0.27 |
| " Thus, this study clearly illustrates that the twice-daily dosage regimen used was quite adequate in elderly patients." | ( Pharmacokinetics of intravenous antibiotics in acutely ill elderly patients. Jonsson, M; Walder, M, 1986) | 0.27 |
| "Cefotaxime at a dosage of 3 gm intravenously every eight hours was administered to 80 patients with hematological malignancies and suspected septicemia." | ( Cefotaxime monotherapy in septicemic patients with hematological malignancies. Friis, H; Hansen, MM; Nissen, NI; Plesner, AM, 1986) | 0.27 |
| " The usual dosage regimen was given 2 approximately 4 g/day of CMX by intravenous drip infusion over 1 hour." | ( [Clinical evaluation of cefmenoxime in chronic complicated urinary tract infection]. Ashiki, A; Hamada, W; Kusumi, Y; Sudo, Y; Suzuki, T; Tsukui, A; Yamato, K, 1985) | 0.27 |
| " The antibiotic dosage was calculated so that the serum level remained constant for a given period of time." | ( [Intraocular penetration of systemically administered cephalosporins under steady-state conditions in animal experiments]. Mendel, N; Mester, U; Völker, B, 1985) | 0.27 |
| "Serum and renal tissue concentrations of ceftizoxime (CZX) after intravenous dosing with 1 g were determined in 15 patients with renal disease." | ( [Transfer of ceftizoxime to renal tissues]. Endoh, H; Miyagi, T; Ohtsuka, K; Yamashiro, Y, 1985) | 0.27 |
| " The recommended dosage regimens (i." | ( Clinical evaluation of cefotiam and cefamandole in respiratory tract infections. Beumer, HM; Kahn, M; Olislagers, WP; van Hamersveld, JD, 1985) | 0.27 |
| "In 45 patients in whom typhoid fever was confirmed by culture of a blood sample, cefotaxime (1 gm BID) was administered intravenously for four days; if defervescence did not occur by day 5, the dosage was increased to 2 gm BID until defervescence, when it was reduced to 1 gm BID until discharge." | ( Clinical trial of cefotaxime in patients with typhoid fever. Choi, HR; Choi, HS; Kim, SY; Kim, TW; Lee, CH; Lee, MA; Park, CH; Park, SC; Seok, SE; Won, JS, 1985) | 0.27 |
| " Cefmenoxime was given as single drug therapy in all patients but one, in a daily dosage of 2 g divided into two intramuscular injections, for 3 to 28 days (average 22 days)." | ( [Clinical evaluation of cefmenoxime in urinary tract and prostatic infections]. Acar, JF; Bryskier, A; Destree, D; Guibert, J, 1985) | 0.27 |
| " The need for adjustment of drug dosage in patients with endstage renal disease and the need for supplemental dosages following haemodialysis are well recognised." | ( Drug therapy in patients undergoing peritoneal dialysis. Clinical pharmacokinetic considerations. Cornish, WR; Hardy, BG; Manuel, MA; Paton, TW, ) | 0.13 |
| " Cefotaxime in a dosage of 150 mg/kg/day divided every 6 hours intravenously seems safe and effective therapy for neonatal Gram-negative bacillary meningitis." | ( Cefotaxime therapy of neonatal gram-negative bacillary meningitis. Dunkle, LM; Maxwell, MA; Naqvi, SH, ) | 0.13 |
| "0 micrograms/ml at 15-30 minutes after dosing and decreased with time." | ( [Fundamental and clinical studies of ceftizoxime suppositories in the pediatric field]. Akita, H; Ihara, M; Iwata, S; Murai, T; Oikawa, T; Osano, M; Sato, Y, 1985) | 0.27 |
| "A clinical trial of ceftizoxime suppositories (CZX-S) was conducted in children whose chemotherapy was considered to be best performed in this dosage form at the physician's discretion." | ( [Clinical effects of ceftizoxime suppositories in pediatric infections]. Furukawa, S; Okada, T, 1985) | 0.27 |
| " More frequent (6 to 8 h) or higher (greater than or equal to 2 g) dosing appears to be necessary to achieve prolonged serum bactericidal activity against less susceptible isolates (MBC, greater than or equal to 2 to 8 micrograms/ml)." | ( Assessment of serum bactericidal activity after administration of cefoperazone, cefotaxime, ceftizoxime, and moxalactam to healthy subjects. Barriere, SL; Mordenti, J; Ozasa, DC, 1985) | 0.27 |
| " The mean predicted plasma concentration of cefotaxime in 6 cats at 0 time after a single IV dosage of 10 mg/kg of body weight was 88." | ( Pharmacokinetics of cefotaxime in the domestic cat. Clark, CH; McElroy, D; Ravis, WR, 1986) | 0.27 |
| " Once a day dosing of ceftriaxone in pediatric patients provides greater ease of administration combined with efficacy equal to that achieved with a divided dosage schedule." | ( Ceftriaxone administered once or twice a day for treatment of bacterial infections of childhood. Cunningham, FM; Higham, M; Teele, DW, ) | 0.13 |
| " Thus, ceftriaxone may be administered to treat Chinese patients without any major modification in the standard dosing regimen." | ( Single-dose pharmacokinetics of ceftriaxone in healthy Chinese adults. Arnold, K; Chan, YP; Sun, M; Zhou, HH, 1985) | 0.27 |
| " Dosage regimens for the use of cefotaxime in patients with renal impairment are proposed." | ( Cefotaxime and desacetyl cefotaxime kinetics in renal impairment. Abraham, PA; Halstenson, CE; Keane, WF; Matzke, GR, 1985) | 0.27 |
| " The free plasma and blister fluid ceftriaxone concentrations observed at the end of the dosing interval of the 2 g q24h regimen were higher than the MIC for 90% of the susceptible microorganisms and justified the once-a-day use of ceftriaxone." | ( Difference in blister fluid penetration after single and multiple doses of ceftriaxone. Bergeron, MG; Caron, M; Grégoire, S; LeBel, M, 1985) | 0.27 |
| "The serum kinetics of intravenous cefotaxime was studied in 13 neonates and 5 infants presenting with bacterial infections in order to establish the dosage and route of administration." | ( [Pharmacokinetic study of cefotaxime in newborn infants and infants]. Bégué, P; Martin, C; Quinet, B; Safran, C; Sarlangue, J, ) | 0.13 |
| "5 micrograms/ml for the 1- and 2-gm dosage regimens, respectively." | ( Pharmacokinetics of cefotaxime in the postpartum patient. Cleary, TG; Cotton, DB; Feldman, S; Gonik, B; Pickering, LK, 1985) | 0.27 |
| " It is possible that the major advance of CTX and CTZ pertains to their ability to kill many organisms at extremely low concentrations, allowing for monotherapy with low and infrequent dosing, which is very cost-effective in comparison with high and more frequent dosing required by older agents or with antibiotic combinations." | ( Comparative pharmacokinetics of cefotaxime and ceftizoxime and the role of desacetylcefotaxime in the antibacterial activity of cefotaxime. Nightingale, CH; Quintiliani, R; Tilton, R, 1984) | 0.27 |
| " Cefmenoxime was given as monotherapy to 63 patients in a mean daily dosage of 3 g (range: 1 to 6 g)." | ( [Bacteriologic, clinical and kinetic evaluation of cefmenoxime (SCE 1365) in the treatment of 68 cases of septicemia. A multicenter trial]. Bleichner, G; Bryskier, A; Canton, P; Dureux, JB; Guerin, JM; Lallement, PY; Mottin, J; Segrestaa, JM; Sollet, JP; Veyssier, P, 1984) | 0.27 |
| "Clinical trials with cefotaxime have demonstrated that this antibiotic is effective and safe in a wide range of dosage schedules." | ( Effect of frequency of administration on therapeutic efficacy of cefotaxime. Parker, RH, 1984) | 0.27 |
| " The dosage schedule for cefotiam in patients with normal renal function can be used in the presence of renal failure when the creatinine clearance is equal to or greater than 1 l/h (16." | ( Pharmacokinetics and dosage adjustment of cefotiam in renal impaired patients. Bammatter, F; Binswanger, U; Guibert, J; Rouan, MC; Schoeller, JP; Theobald, W, 1984) | 0.27 |
| " Ceftizoxime at a dosage of 1 gm twice daily proved to be at least as effective as 1 gm of cefamandole given four times daily." | ( Ceftizoxime treatment of cutaneous and subcutaneous tissue infections. Layne, PP; Parish, LC; Parks, DB; Uri, JV, 1984) | 0.27 |
| " The once or twice daily dosing possible with ceftriaxone was particularly advantageous for permitting highly cost-effective at home therapy for 42 of the 76 patients." | ( Combined ceftriaxone and surgical therapy for osteomyelitis in hospital and outpatient settings. Eron, LJ; Goldenberg, RI; Poretz, DM, 1984) | 0.27 |
| " We conclude that single agent treatment with ceftriaxone is preferable because of the greater safety and the longer dosing intervals." | ( Ceftriaxone versus combined gentamicin and clindamycin for polymicrobial surgical sepsis. Bourneuf, AA; Geheber, CE; Mullins, RJ; Stone, HH; Strom, PR, 1984) | 0.27 |
| " Thus, the chosen dosage regimens considered apt for gonorrhea led to high initial as well as long-standing drug levels." | ( Plasma and skin blister fluid levels of cefotiam and cefmenoxime after single intramuscular application of 1 g in gonorrhea. Korting, HC, 1984) | 0.27 |
| " The frequency of adverse effects for the once-daily and twice-daily dosing regimens was comparable, except for a statistically significant increase in local reactions when ceftriaxone was administered twice daily." | ( Clinical adverse effects during ceftriaxone therapy. Moskovitz, BL, 1984) | 0.27 |
| " Cefotaxime would appear to provide adequate perioperative prophylactic cover in the dosage regimen used." | ( Serum and tissue concentrations of intravenous cefotaxime during aortic surgery. Kharsany, A; Robbs, JV, 1984) | 0.27 |
| " These results differ from earlier findings that the concentration of ampicillin in the CSF of rabbits was significantly lower in animals concomitantly dosed with latamoxef (moxalactam) and ampicillin than in a group dosed only with ampicillin." | ( Cerebrospinal fluid penetration after combined administration of cefotaxime and ampicillin to rabbits with staphylococcal meningitis. Haruta, T; Kobayashi, Y; Okura, K, 1984) | 0.27 |
| " It is concluded that single-dose genitourinary surgical prophylaxis with cefotaxime may be more effective than a longer dosing schedule with cefoxitin in the prevention of post-operative urinary tract infections, and that a single-dose regimen may represent significant cost containment advantages for hospitals." | ( Antibiotic prophylaxis in elective genitourinary tract surgery: a comparison of single-dose pre-operative cefotaxime and multiple-dose cefoxitin. Childs, SJ; deBessonet, DA; Merlin, AS, 1984) | 0.27 |
| " Patients received either cefoperazone (14) intravenously or intramuscularly in a dose range from 2 to 8 g/day or cefotaxime (15) 1 to 2 g intravenous or intramusculary at dosing intervals of 6 to 8 h (total 3 to 8 g/day), depending on the severity of the disease." | ( A comparison of cefotaxime and cefoperazone in respiratory tract infections. Garcia-Rodriguez, JA; Gomez-Garcia, AC, 1984) | 0.27 |
| " Using this classification, the effectiveness of cefotaxime was examined in three dosage regimens." | ( Cefotaxime in the treatment of urinary tract infections. Porpaczy, P, 1984) | 0.27 |
| " A positive reaction for protein induced by vitamin K absence or antagonism (PIVKA II) occurred in 25 to 63% of the subjects administered cephems possessing a methylthiotetrazole group, but not in those dosed with cefotaxime or ceftazidime." | ( The influence of cefotaxime on intestinal flora and bleeding diathesis in infants and neonates, compared with other beta-lactams. Akita, H; Iwata, S; Sato, Y; Sunakawa, K, 1984) | 0.27 |
| " Dosage recommendations for subjects with renal insufficiency are proposed." | ( Cefmenoxime pharmacokinetics in patients with renal insufficiency. Baggett, JW; Kerkering, TM; Kline, BJ; Patterson, PM; Polk, RE; Sica, DA, 1984) | 0.27 |
| " These results suggest that the pharmacokinetics of the two drugs are not modified by their simultaneous administration and that the dosing schedule previously proposed for administration of the two cephalosporins alone in the presence of renal insufficiency can be applied without modification when they are given together." | ( Pharmacokinetics of cefotiam and cefsulodin after simultaneous administration to patients with impaired renal function. Binswanger, U; Guibert, J; Lecaillon, JB; Rouan, MC; Schoeller, JP, 1984) | 0.27 |
| " The antibiotic dosage given to mice was calculated on a body weight basis from the doses recommended for humans." | ( Effects of cefotaxime, clindamycin, mezlocillin, and piperacillin on mouse sarcoma L-1 tumor. Jeljaszewicz, J; Ko, HL; Pulverer, G; Roszkowski, K; Roszkowski, W, 1984) | 0.27 |
| " The dosage of cefmenoxime was 2 g per day (n = 30) or 1 g per day (n = 10)." | ( Clinical results and concentrations of cefmenoxime in serum, amniotic fluid, mother's milk, and umbilical cord. Adams, D; Gutschow, K; Luehr, HG; Peters-Welte, C; Weissenbacher, ER, 1984) | 0.27 |
| " The same determinations were made in 18 patients prospectively treated, except that dosage was optimized on the basis of previous mathematical relations to achieve bacterial eradication in four days." | ( Role for dual individualization with cefmenoxime. DeAngelis, C; Fracasso, JE; Schentag, JJ; Smith, IL; Swanson, DJ; Vance, JW; Vari, A, 1984) | 0.27 |
| " Over the above dosing range and routes of administration, cefotiam pharmacokinetics were essentially linear, with plasma clearances varying from 19." | ( Pharmacokinetics of cefotiam administered intravenously and intramuscularly to healthy adults. Brisson, AM; Bryskier, A; Fourtillan, JB; Millerioux, L, 1984) | 0.27 |
| " We give recommendations for dosage adjustment in patients with renal insufficiency." | ( Pharmacokinetics of cefotiam in patients with impaired renal function and in those undergoing hemodialysis. Konishi, K; Ozawa, Y, 1984) | 0.27 |
| " Cefmenoxine dosage should be reduced in proportion to the decline in creatinine clearance." | ( Cefmenoxime pharmacokinetics in healthy volunteers and subjects with renal insufficiency and on hemodialysis. Alexander, DP; Barriere, SL; Gambertoglio, JG, 1984) | 0.27 |
| " Forty-one patients, aged 2 months to 10 years, were treated with an intravenous dosage of 10 to 58 mg/kg CTRX every 12 hours for 2 to 29 days." | ( [Ceftriaxone therapy for pediatric infections]. Abe, K; Miyanosita, A; Nagamatsu, I, 1984) | 0.27 |
| " The comparison of the serum level by 1 hour intravenous drip infusion between the dosage groups of 20 mg/kg and 40 mg/kg revealed that the former group reached a peak of 85." | ( [Fundamental and clinical evaluation on ceftriaxone in the pediatric field]. Hori, M; Kawamura, K; Kurosu, Y; Nakamura, H; Okabe, T; Seo, K; Sugita, M; Takahashi, T; Toyonaga, Y; Uekusa, T, 1984) | 0.27 |
| " The half-life time was over 6 hours in most cases, but the multiple intravenous dosage did not cause any elevation of the blood level." | ( [Evaluation on ceftriaxone in the pediatric field]. Chikaoka, H; Hirama, Y; Nakazawa, S; Narita, A; Niino, K; Satoh, H; Suzuki, H; Tazoe, K, 1984) | 0.27 |
| " As for purulent meningitis, the administration dosage and frequency will have to be further examined based on the intravenous injection with 50 mg/kg twice daily." | ( [Clinical evaluation on ceftriaxone in the field of pediatrics]. Haruta, T; Kobayashi, Y; Kuroki, S; Matsuo, H; Mayumi, M; Ohkura, K, 1984) | 0.27 |
| " This fact suggests that CTRX exhibits sufficient efficacy when administered intravenously even in a small dosage of 1 g in the present study." | ( [Fundamental and clinical evaluation of ceftriaxone in the field of obstetrics and gynecology]. Kuwabara, M; Matsui, K, 1984) | 0.27 |
| " These facts suggest that CTRX is effective against infections and that the dosage and frequency of administration could be reduced." | ( [Fundamental and clinical study on ceftriaxone in the field of obstetrics and gynecology]. Ichijo, M; Itoh, K; Moriyama, I; Tsuji, Y, 1984) | 0.27 |
| "The excretory pathway for the elimination of 14C-cefotaxime (14C-HR 756) was found to be the same for rat, dog and man with elimination into the urine being the most important route, accounting for greater than 80% of the dosed radioactivity." | ( Disposition of cefotaxime in rat, dog and man. Chamberlain, J; Coombes, JD; Dell, D; Fromson, JM; Macdonald, CM; McDonald, A, 1984) | 0.27 |
| " There was no evidence to show that retention of radioactivity in pigmented tissues had occurred nor was there any suggestion of accumulation of radioactivity in any organ or tissue as a consequence of multiple dosing with 14C-cefotaxime." | ( Whole body autoradiographic and quantitative tissue distribution studies with 14C-cefotaxime in the rat. Coombes, JD; Fromson, JM; Ings, RM; Stevens, LA, 1984) | 0.27 |
| " These metabolites are found in the urine of man and dogs dosed with cefotaxime." | ( Cefotaxime: sites and pathway of metabolic conversion. Coombes, JD; Fromson, JM; Macdonald, CM; McDonald, A, 1984) | 0.27 |
| " However, in experimental infections with the same pathogens the superior efficacy of ceftriaxone over all comparative cephems and penicillins, expressed in low 50% effective doses after multiple and particularly after single dosage schedules, and caused by a longer maintenance of blood and tissue levels can be demonstrated." | ( Comparative experimental antibacterial activity of ceftriaxone (Ro 13-9904). Böhni, E, 1984) | 0.27 |
| " Groups of ten patients each received either 2 g cefotaxime or 1 mg/kg body weight tobramycin or cefotaxime and tobramycin in the same dosage every eight hours intravenously for at least seven days." | ( Tobramycin nephrotoxicity: failure of cefotaxime to potentiate renal toxicity. Grötsch, H; Kuhlmann, J; Seidel, G, 1982) | 0.26 |
| " Urine levels were greater than the minimum inhibitory concentrations for susceptible organisms for at least eight hours after dosing in all individuals who produced urine." | ( Cefotaxime pharmacokinetics following a single intravenous dose to patients with varying renal function. Bundtzen, RW; Craig, WA; Madsen, PO; Nielsen, OS; Toothaker, RD; Welling, PG, 1980) | 0.26 |
| " The mean dosage was 45 mg/kg/day." | ( [Clinical experience of cefotaxime (author's transl)]. Boussougant, Y; Carbon, C; Destaing, F; Portier, H, 1981) | 0.26 |
| " A dosage schedule for the use of intravenously administered cefotaxime in patients undergoing hemodialysis is presented." | ( Pharmacokinetics of intravenous cefotaxime in patients undergoing chronic hemodialysis. Chodos, J; Francke, EL; Neu, HC; Saltzman, M, 1981) | 0.26 |
| " Only fosfomycin was effective in both models even at the low dosage of 100 mg/kg/d." | ( [Chemotherapy with fosfomycin, cefoxitin, and cefotaxime in experimental E. coli-pleuropneumonia (author's transl)]. Henkel, W; Krüger, C; Marre, R, 1981) | 0.26 |
| " In the present study, modification of the dosage is probably unnecessary in patients with creatinine clearance of more than 30 ml/min; however, dose reduction or prolongation of dosage interval, or both, may be appropriate in patients with severe renal dysfunction." | ( Doses of antibiotic in patients with renal insufficiency. Kuroda, K; Ohkawa, M, 1981) | 0.26 |
| " We recommend dosing as follows, using a dose of 25 mg/kg: every 12 hours for preterm infants less than one week of age, every 8 hours for preterm infants one to four and term infants less than one week of age, and every 6 hours for term infants more than one week of age." | ( Treatment of severe neonatal infections with cefotaxime. Efficacy and pharmacokinetics. Brater, DC; Dellagrammaticas, H; Kafetzis, DA; Kapiki, AN; Papadatos, CJ; Papas, CV, 1982) | 0.26 |
| " Urinary excretion was measured in 2 cases with normal renal function after dosing with 750 mg (35 mg/kg) and 350 mg (17 mg/kg) of ceftizoxime by intravenous injections." | ( [Clinical studies on ceftizoxime in pediatric field (author's transl)]. Matsuda, H; Yoshida, T, 1982) | 0.26 |
| " Plasma clearance of the drug was dosage level and route independent, averaging 254 ml/min; thus, there was an excellent linear relationship between the area under the plasma level curve and the dose." | ( Intramuscular and intravenous pharmacokinetics of cefmenoxime, a new broad-spectrum cephalosporin, in healthy subjects. Granneman, GR; Sennello, LT; Sonders, RC; Steinberg, FJ, 1982) | 0.26 |
| " A dosage schedule for cefotaxime in newborn infants is presented." | ( Pharmacokinetics of cefotaxime in newborn infants. McCracken, GH; Thomas, ML; Threlkeld, NE, 1982) | 0.26 |
| " We conclude that the percent penetration of CTM into CSF increases in the presence of the inflamed meninges and that prophylactic dosage of CTM for postoperative meningitis will be intravenous administration of 2 g of CTM in adults." | ( [Penetration of cefotiam dihydrochloride into cerebrospinal fluid (author's transl)]. Furuno, M; Kojima, T; Morikawa, A; Okada, M; Shimizu, T; Waga, S, 1982) | 0.26 |
| " At a dosage regimen of 1 g every 12 h the peak and trough serum antibiotic concentrations were well above the minimal inhibitory concentrations of most pathogens." | ( Efficacy of ceftriaxone in serious bacterial infections. Epstein, JS; Hasselquist, SM; Simon, GL, 1982) | 0.26 |
| " Cefotiam was given intramuscularly in monotherapy, at the daily dosage of 1 and 2 g in two injections during 7 to 28 days." | ( [Clinical evaluation of cefotiam in adults urinary tract infections (author's transl)]. Coppens, H; Guibert, J; Yvelin, C, 1982) | 0.26 |
| " Ceftriaxone mean peak plasma concentrations, determined by high-power liquid chromatography, were 267 and 184 microgram/ml for the 75 and 50 mg/kg dosage groups, respectively." | ( Single-dose ceftriaxone pharmacokinetics in pediatric patients with central nervous system infections. Chadwick, EG; Patel, IH; Shulman, ST; Weinfeld, RE; Yogev, R, 1983) | 0.27 |
| " In the present study, cefotaxime was administered at a dosage level of 20 mg/kg by intravenous drip infusion over a 30-minute period." | ( [Study of intravenous cefotaxime therapy in neonates]. Chikaoka, H; Hirama, Y; Nakazawa, S; Sato, H, 1982) | 0.26 |
| " Recommendations are made for the adjustment of dosing schedules in patients with renal failure." | ( The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal function. Fillastre, JP; Godin, M; Humbert, G; Ings, RM; Leroy, A, ) | 0.13 |
| " The dosage was 50 mg of ceftriaxone per kg." | ( Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis. Chrane, D; Del Rio, M; McCracken, GH; Nelson, JD; Shelton, S, 1982) | 0.26 |
| " Dosage for ceftizoxime was 1 gm." | ( Ceftizoxime in the treatment of urinary tract infections. Crawford, ED; Plimpton, HW, 1982) | 0.26 |
| "The efficacies of several dosage schedules of cefazolin, cefotaxime, and ceftazidime, started 12 or 36 h after infection, were examined in experimental pneumonia caused by Klebsiella pneumoniae in rats." | ( Therapeutic activities of cefazolin, cefotaxime, and ceftazidime against experimentally induced Klebsiella pneumoniae pneumonia in rats. Bakker-Woudenberg, IA; Michel, MF; van den Berg, JC, 1982) | 0.26 |
| " These results indicate group B streptococci to be sensitive to ceftriazone in vitro and that, in the low dosage used, ceftriaxone effectively eradicates group B streptococcal bacteraemia and meningitis in infant rats." | ( Ceftriaxone therapy of group B streptococcal bacteraemia and meningitis in infant rats. Delaplane, D; Shulman, ST; Yogev, R, 1983) | 0.27 |
| " A dosage schedule of 50 mg/kg every 12 h for bacterial meningitis caused by susceptible organisms is suggested for pediatric patients over 7 days of age." | ( Pharmacokinetics of ceftriaxone in pediatric patients with meningitis. Bradsher, RW; Eyre, LB; Patel, IH; Spicehandler, J; Steele, RW; Weinfeld, RE, 1983) | 0.27 |
| " A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants." | ( Ceftriaxone pharmacokinetics in newborn infants. McCracken, GH; Siegel, JD; Thomas, M; Threlkeld, N, 1983) | 0.27 |
| " These patients would require no dose adjustments in their dosing regimen." | ( Single-dose ceftriaxone kinetics in functionally anephric patients. Blumberg, A; Hoppe-Seyler, G; Keller, E; McNamara, PJ; Stoeckel, K, 1983) | 0.27 |
| " The dosage of the drug was 30 to 200 mg/kg/day; 103 mg/kg/day and under in 21 cases, 150 mg/kg/day and 200 mg/kg/day in 1 case each." | ( [Therapeutic effects of cefmenoxime in the treatment of various infections on infants and children]. Hamawaki, M; Kitamura, I; Kurashige, T; Nishibayashi, Y; Ozaki, H; Wakiguchi, H, 1982) | 0.26 |
| " The daily dosage administered in meningitis, pyothorax and brain abscess ranged from 145-311 mg/kg/day, from 43-88 mg/kg/day in other bacterial infections." | ( [Clinical trial of cefmenoxime in children]. Furukawa, S; Okada, T, 1982) | 0.26 |
| " But in some patients a dosage of 5-7 mg/kg/d of gentamicin is too low, while others show concentrations near to the toxic levels." | ( [Pharmacokinetics of combined antibiotic therapy in the newborn infant]. Bergt, U; Heimann, G; Schug, S, 1983) | 0.27 |
| "Ceftriaxone, a new broad spectrum cephalosporin with a long biological half-life has been used on a single intravenous daily dosage regimen over a five day period to treat complicated urinary tract infection." | ( Treatment of complicated urinary tract infections with the long acting cephalosporin, ceftriaxone. Bremner, DA; Rothwell, DL; Taylor, KM, 1983) | 0.27 |
| " This agent was administered to children at a dosage of 50 to 75 mg/kg/day intravenously in two divided doses." | ( Ceftriaxone for the treatment of serious infections. Bradsher, RW; Steele, RW, 1983) | 0.27 |
| " A 3-g intravenous dose of ceftizoxime given every 48 h would result in adequate activity against most susceptible organisms, but more frequent dosing may be necessary for less susceptible organisms." | ( Pharmacokinetics of ceftizoxime in patients undergoing continuous ambulatory peritoneal dialysis. Blair, AD; Burgess, ED, 1983) | 0.27 |
| " All of these changes disappeared within a few days after the dosing period." | ( Nephrotoxicity of cefotiam in rats. Chiba, S; Miyajima, H; Nakai, Y; Suhara, I; Takano, K; Yamazaki, M, ) | 0.13 |
| " Since the age-related changes in kinetics were relatively small, it is concluded that dosage adjustment is probably not necessary for elderly subjects requiring ceftriaxone." | ( Age and ceftriaxone kinetics. Durkin, J; Luderer, JR; Patel, IH; Schneck, DW, 1984) | 0.27 |
| " Despite varying renal function in patients, mean cefmenoxime serum concentration-time curves for all three dosing regimens were closely aligned, reflecting successful empiric dosage adjustment." | ( Effect of protein binding on cefmenoxime steady-state kinetics in critical patients. Cumbo, TJ; Reitberg, DP; Schentag, JJ; Smith, IL, 1984) | 0.27 |
| " These data support a 12-hour dosage interval, but clinical studies are needed to evaluate efficacy of the drug at both 12-hour and 24-hour dosage regimens." | ( Single-dose plasma and cerebrospinal fluid pharmacokinetics of ceftriaxone in infants and children. Aronoff, SC; Blumer, JL; Myers, CM; Reed, MD; Rekate, HL, ) | 0.13 |
| " Therefore, there is no need to relate the timing of blood (and urine) sampling for creatinine assay to dosage of these antibiotics." | ( Lack of interference of five new beta-lactam antibiotics with serum creatinine determination. LeBel, M; Lewis, GP; Paone, RP, 1983) | 0.27 |
| " On the basis of these findings, CTX dosage adjustment is recommended only in patients with a glomerular filtration rate (GFR) below 20 ml/min." | ( Kinetic interactions between azlocillin, cefotaxime, and cefotaxime metabolites in normal and impaired renal function. Borner, K; Kampf, D; Kessel, M; Möller, M, 1984) | 0.27 |
| " After a 12- or 24-h dose regimen, predicted trough concentrations of ceftriaxone in plasma at steady state derived from kinetic data generated from the study and assuming linear pharmacokinetic behavior were well above the minimum inhibitory concentrations of most sensitive bacteria, suggesting the feasibility of a once-a-day dosage regimen especially for patients with severe renal insufficiency." | ( Kinetic disposition of intravenous ceftriaxone in normal subjects and patients with renal failure on hemodialysis or peritoneal dialysis. East, DS; Fortin, L; Kreeft, JH; Ogilvie, RI; Somerville, PJ; Ti, TY, 1984) | 0.27 |
| " The method described presents the following advantages: a fast extraction and efficient deproteinization of serum samples are achieved with Sep-Pak cartridges; the mobile phase is a mixture of methanol - bidistilled water - acetic acid which permits the simultaneous dosage of Ctx and D-Ctx under the same chromatographic process." | ( [Technic for assaying cefotaxime and desacetylcefotaxime in serum by high performance liquid chromatography]. Boyer, M; Cluzel, R; Sirot, J, 1984) | 0.27 |
| " Since these changes are moderate, adjustment in the dosage regimen of ceftriaxone for patients with impaired renal function should not be necessary when ceftriaxone dosage is 2 g or less per day (2 g every 24 h or 1 g every 12 h)." | ( Ceftriaxone pharmacokinetics in patients with various degrees of renal impairment. Berman, SJ; Patel, IH; Siemsen, AW; Sugihara, JG; Weinfeld, RE; Wong, EG, 1984) | 0.27 |
| " The results suggest a twice daily dosage regimen." | ( The pharmacokinetics of ceftriaxone in serum, skin blister and thread fluid. Bergan, T; Digranes, A; Kalager, T; Solberg, CO, 1984) | 0.27 |
| " The concentrations of both the parent compound and the metabolite 3 h after the infusion suggest that, considering the activity and half life of both the dosing might be spaced at 6-8 h intervals." | ( Concentrations of cefotaxime and the desacetyl metabolite in serum and CSF of patients with meningitis. Cherubin, CE; Humbert, G; Leroy, A; Nair, SR, 1984) | 0.27 |
| " To investigate the influence of the dosage regimen on the kinetic profile of antibiotics in the CSF, chloramphenicol and cefotaxim were measured using high pressure liquid chromatography (HPLC)-techniques." | ( Pharmacokinetics of antimicrobial drugs in the cerebrospinal fluid. Heimann, G; Skopnik, H, 1983) | 0.27 |
| " Both the duration of time cefotaxime was above the MIC90 for the Enterobacteriaceae and the area under the concentration-time curve were significantly less because of its short elimination half-life, results indicating the need for more frequent dosing with cefotaxime than with moxalactam." | ( Integration of selected pharmacologic and microbiologic properties of three new beta-lactam antibiotics: a hypothesis for rational comparison. Drusano, GL; Moody, MR; Ryan, PA; Schimpff, SC; Standiford, HC, ) | 0.13 |
| " We conclude that cefodizime 1 g IM once daily is an effective dosing regimen in the treatment of patients with community-acquired pneumonia." | ( Single daily dose of cefodizime in patients with community-acquired pneumonia: an open-label, controlled, randomized study. The Italian Multicentre Community-Acquired Pneumonia Group. Canepa, G; Cantone, V; De Palma, M; Peri, A; Rocchi, D, ) | 0.13 |
| " It is likely that selected monomicrobic infections in immunocompetent hospitalized patients due to such highly susceptible organisms could be treated with lower dosages of cefotaxime or with longer dosing intervals (e." | ( The in vitro activity of cefotaxime versus bacteria involved in selected infections of hospitalized patients outside of the intensive care unit. Doern, GV, ) | 0.13 |
| "A retrospective analysis of the clinical and economic outcome of a regimen of cefotaxime 1 g given every 12 h was conducted following the introduction of an institutional policy recommending this new dosing strategy." | ( Retrospective analysis of the clinical and economic outcomes of twice-daily dosing of cefotaxime in a Canadian tertiary care institution. Conly, JM; Pitre, M; Tin, LY, ) | 0.13 |
| " Subsequent publications showed that a dosage of 2 g every 6 h was also adequate in this infection." | ( Experience with cefotaxime in the treatment of spontaneous bacterial peritonitis in cirrhosis. Arroyo, V; Navasa, M; Rimola, A, ) | 0.13 |
| " In the recent past, however, an effort has been made, both in the United States and in Europe to reevaluate the dosage of cefotaxime." | ( Review and reassessment of dosing schedules for cefotaxime in selected medical indications. Young, LS, ) | 0.13 |
| " Patients treated with cefotaxime twice or three times a day as monotherapy (excluding metronidazole) for at least 1 day (240 cases) were analyzed in terms of clinical and bacteriologic outcome, these results were correlated with the dosing regimen." | ( Retrospective analysis of the efficacy of cefotaxime sodium dosed twice daily. The Swedish experience. Ahlquist, G; Bergquist, SO; Eriksson, I; Eriksson, S; Lönnbro, N; Runehagen, A; Styrud, J, ) | 0.13 |
| "A retrospective, matched cohort study was performed to determine the cost outcomes among 495 hospitalized patients who received twice-daily dosing of cefotaxime and 3949 matched cohorts who received other antibiotics." | ( A retrospective analysis of twice-daily cefotaxime compared to conventional therapy for the treatment of infections in a USA hospital. Burke, JP; Classen, DC; Lloyd, JF; Pestotnik, SL, ) | 0.13 |
| " The high activity of cefotaxime alone and the contributions of desacetylcefotaxime to the drug's total antimicrobial value must be considered in reestablishing correct dosing of this "third-generation" cephalosporin." | ( Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review. Jones, RN, ) | 0.13 |
| " Of the 88 patients without serious underlying diseases who received the 1-g 12-h dosage regimen, all were considered to be clinically cured, and all 54 isolated pathogens were eradicated or presumed to be eradicated." | ( Study of cefotaxime twice daily for the therapy of postoperative pneumonia. The German Cefotaxime Study Group. Bruch, HP; Kujath, P, ) | 0.13 |
| " The half-life of cefotaxime and its metabolite is altered in patients with severe renal dysfunction requiring dosage adjustment." | ( Pharmacokinetics of cefotaxime in healthy volunteers and patients. Nicolau, DP; Nightingale, CH; Patel, KB; Quintiliani, R, ) | 0.13 |
| " For bacteria to have no postantibiotic effect, plasma levels need to exceed the MIC for the whole of the dosing interval to achieve maximum killing at the site of infection." | ( Pharmacodynamic (kinetic) considerations in the treatment of moderately severe infections with cefotaxime. Turnidge, JD, ) | 0.13 |
| " However, the area under the inhibitory serum concentration time-curve (AUIC) may be superior when appropriate dosing intervals are selected." | ( Role of pharmacokinetics and pharmacodynamics in the design of dosage schedules for 12-h cefotaxime alone and in combination with other antibiotics. Nix, DE; Schentag, JJ, ) | 0.13 |
| " Although cefotaxime levels cannot be maintained above the bacterial minimum inhibitory concentration (MIC) for all infecting pathogens with extended dosing intervals, concentrations of desacetyl-cefotaxime remain above the effective concentration for a variety of organisms throughout the extended interval." | ( Therapeutic options for cefotaxime in the management of bacterial infections. Ostergaard, BE; Raddatz, JK; Rotschafer, JC, ) | 0.13 |
| " It was concluded that the dosage of cefotaxime, adjusted for renal function, would require no further adjustment during peritoneal dialysis or hemofiltration." | ( Pharmacokinetics of cefotaxime in dialysis patients. Andrassy, K, ) | 0.13 |
| " When the impact of development on CTX and dCTX disposition is considered, it is apparent that age-appropriate pharmacokinetic data can be used to individualize CTX dosing regimens according to age." | ( Pharmacokinetics of cefotaxime and desacetylcefotaxime in the young. Kearns, GL; Young, RA, ) | 0.13 |
| "3% after dosing an aqueous solution of cefixime and 35." | ( Clinical pharmacology of cefixime in unweaned calves. Glickman, A; Lavy, E; Winkler, M; Ziv, G, 1995) | 0.29 |
| " Cefixime was administered orally in 2 phases at a standard dosage of 5 mg/kg of body weight to clinically normal adult male and female dogs." | ( Clinical pharmacologic aspects of cefixime in dogs. Aroch, I; Glickman, A; Lavy, E; Ziv, G, 1995) | 0.29 |
| "The disposition kinetics and dosage regimen of cefotaxime were investigated in cross-bred calves following a single intravenous administration of cefotaxime (10 mg/kg)." | ( Disposition kinetics and dosage regimen of cefotaxime in cross-bred male calves. Bal, MS; Sharma, SK; Srivastava, AK, 1995) | 0.29 |
| " A satisfactory intramuscular dosage regimen for cefotaxime in calves would be 11 mg/kg followed by 10 mg/kg at 7 h intervals." | ( Pharmacokinetics and dosage regimen of cefotaxime in cross-bred calves following single intramuscular administration. Sharma, SK; Srivastava, AK, 1994) | 0.29 |
| " In vitro, antibiotics improve the susceptibility of microorganisms to antimicrobial activity of leukocytes, suggesting that this effect may contribute to determine the antimicrobial therapy and safe dosing intervals." | ( Enhancement of the susceptibility of Staphylococcus aureus to phagocytosis after treatment with fosfomycin compared with other antimicrobial agents. Gómez-Lus, ML; Herrera, I; Martínez, P; Pérez Fernández, P; Prieto, J, ) | 0.13 |
| " In individuals with more severe renal impairment or those requiring chronic hemodialysis, dosage adjustment would be required." | ( Pharmacokinetics of cefodizime in volunteers with normal or impaired renal function. Conte, JE, 1994) | 0.29 |
| " In two trials, 891 pediatric patients were enrolled to either cefprozil or amoxicillin-clavulanate dosage regimens." | ( Multi-investigator evaluation of the efficacy and safety of cefprozil, amoxicillin-clavulanate, cefixime and cefaclor in the treatment of acute otitis media. Kafetzis, DA, 1994) | 0.29 |
| "Concentrations of cefotaxime in serum and tissue fluid were studied in the bovine after intravenous and intramuscular administration at a dosage of 10 mg." | ( Pharmacokinetics and penetration into tissue fluid of cefotaxime in bovines. Buschiazzo, H; de Buschiazzo, P; Quiroga, G; Rubio, M; Rule, R, ) | 0.13 |
| " Oral doxycycline in higher dosage (three times 100 mg daily for 20 days) failed to prevent generalization of the infection with rigor, head and neck aches, myalgia, fatigue and subfebrile temperatures." | ( [Reinfection with Borrelia burgdorferi in an immunocompetent patient]. Hassler, D; Maiwald, M, 1994) | 0.29 |
| " The virtual peak levels which had been determined by pharmacokinetic dosage calculation were compared with the serum concentrations obtained directly after the administration as well as after 15, 30, 60 and 180 min." | ( Studies on drug monitoring in thrice and once daily treatment with aminoglycosides. Georgieff, M; Konrad, F; Neumeister, B; Rommel, H; Wagner, R, 1993) | 0.29 |
| " During od dosing the trough level was extremely important in drug monitoring, whereas determination of the high peak level was of doubtful value." | ( Studies on drug monitoring in thrice and once daily treatment with aminoglycosides. Georgieff, M; Konrad, F; Neumeister, B; Rommel, H; Wagner, R, 1993) | 0.29 |
| " Dosage of 40 mg/kg of body weight given IV every 4 to 6 hours for neonatal foals with gram-negative septicemia and every 2 hours for foals with meningitis is recommended for further study." | ( Pharmacokinetics of cefotaxime in neonatal pony foals. Divers, TJ; Gardner, SY; Sweeney, RW, 1993) | 0.29 |
| " Twice daily dosage was preferred with adults (60." | ( Safety and efficacy of cefixime in treatment of respiratory tract infections in Germany. Hausen, T; Schmitt, J; Weidlich, G, 1995) | 0.29 |
| " It is therefore possible to follow the pharmacokinetics of CTX in urine within a 12 h dosing interval." | ( NONMEM analysis in determining the tri-exponential disposition of cefotaxime: a method of evaluating serum and urinary phase I data. Harnisch, L; Mendes, P; Rokitta, C; Weber, W; Zimmer, M, 1995) | 0.29 |
| " Simulated pediatric dosage regimens and target peak concentrations in the central compartment were as follows: penicillin V-potassium, 26 mg/kg of body weight every 6 h (q6h) and 14 micrograms/ml; cefaclor, 13." | ( Bactericidal activities of cefprozil, penicillin, cefaclor, cefixime, and loracarbef against penicillin-susceptible and -resistant Streptococcus pneumoniae in an in vitro pharmacodynamic infection model. Cappelletty, DM; Rybak, MJ, 1996) | 0.29 |
| "01 mg/L) the minimum dosage tested achieving significant cure was 2 mg/kg for amoxycillin, co-amoxiclav and cefotaxime." | ( Correlation of in-vitro activity and pharmacokinetic parameters with in-vivo effect of amoxycillin, co-amoxiclav and cefotaxime in a murine model of pneumococcal pneumonia. Nieto, E; Parra, A; Ponte, C; Soriano, F, 1996) | 0.29 |
| " To date, apart from anecdotal case reports or studies involving a very limited number of patients, few data regarding the dosing and usage of medications in neonates and paediatric patients are available in the literature." | ( [Development of a practical guide for utilization of injectable drugs in neonatology and in pediatrics]. Bressolle, F; Courrege, C; Kinowski, JM; Poujol, H; Veillet, B, ) | 0.13 |
| "An in-vitro dialysis model was employed to assess the feasibility of once-daily dosing of cefodizime in the treatment of infections caused by various Enterobacteriaceae: Escherichia coli, Klebsiella pneumoniae, Morganella morganii, Serratia marcescens, Providencia stuartii and Enterobacter cloacae." | ( Bactericidal activity of cefodizime on Enterobacteriaceae in an in-vitro model simulating plasma pharmacokinetics in humans. Bryskier, A; Duez, JM; Kazmierczak, A; Neuwirth, C; Péchinot, A, 1997) | 0.3 |
| " Retrospective and post-marketing studies also reveal the similar efficacy of cefotaxime administered twice and 3 times daily, and pharmacoeconomic studies suggest that total direct costs of treatment with cefotaxime compared is similar to that with other third generation cephalosporins in currently used dosage regimens." | ( Cefotaxime. A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections. Brogden, RN; Spencer, CM, 1997) | 0.3 |
| " Therefore, the same dose per unit time as that for children (including infants) needs to be administered to neonates at dosing intervals that may be prolonged according to renal function." | ( Pharmacokinetics of antibiotics in neonates. Sato, Y, 1997) | 0.3 |
| " This novel information may be useful for the rational development of dosage schedules and may improve predictions regarding therapeutic outcome." | ( Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Agneter, E; Burgdorff, T; Eichler, HG; Georgopoulos, A; Haag, O; Jansen, B; Müller, M; Pehamberger, H; Stanek, G; Weninger, W, 1996) | 0.29 |
| " The duration of SBTs and T > MIC for both antimicrobial agents exceeded 50% of the dosing interval for all isolates." | ( Comparative serum bactericidal activities of ceftizoxime and cefotaxime against intermediately penicillin-resistant Streptococcus pneumoniae. Nicolau, DP; Nightingale, CH; Patel, KB; Quintiliani, R, 1996) | 0.29 |
| " With CTX, a high dosage of 400 mg/kg (dose/MIC ratio, 100 or 50) administered every 8 h (TID) was needed to protect 66 and 75% of the animals, respectively, with no statistically significant differences versus CRO." | ( Efficacies of cefotaxime and ceftriaxone in a mouse model of pneumonia induced by two penicillin- and cephalosporin-resistant strains of Streptococcus pneumoniae. Azoulay-Dupuis, E; Bédos, JP; Carbon, C; Darras-Joly, C; Moine, P; Rieux, V; Sauve, C, 1996) | 0.29 |
| " Both drugs were administered twice at a dosage of 40 mg/kg of body weight (pre- and intraoperative)." | ( Prospective randomized comparison of cefodizime versus cefuroxime for perioperative prophylaxis in patients undergoing coronary artery bypass grafting. Bartunek, A; Graninger, W; Hiesmayr, M; Parschalk, B; Pernerstorfer, T; Wenisch, C; Zedtwitz-Liebenstein, K, 1997) | 0.3 |
| " Knowledge of the pharmacokinetic and pharmacodynamic properties of cefotaxime supports the view that low dose (1-2 g), low frequency (12-hourly) dosage regimens are applicable to many mild-to-moderately severe infections, including community-acquired pneumonia, caused by susceptible organisms." | ( The use of cefotaxime for the treatment of common infections: in vitro, pharmacokinetic and clinical considerations. Bouza, E; Lode, H; Mouton, Y; Wilson, WR, 1997) | 0.3 |
| " All the data have been calculated for the highest recommended oral dosage in France." | ( Choice of an oral beta-lactam antibiotic for infections due to penicillin-resistant Streptococcus pneumoniae. Goldstein, FW, 1997) | 0.3 |
| "Growth and development were monitored for up to 42 months in nine neonates to whom ciprofloxacin, a fluoroquinolone, was given in the neonatal period at a dosage of 20 mg/kg/day." | ( The effects of a fluoroquinolone on the growth and development of infants. Balkan, E; Doğruyol, H; Gürpinar, AN; Kiliç, N; Kiriştioğlu, I, ) | 0.13 |
| " A HPLC method was developed for determination of both antibiotics in ocular aqueous humor and plasma in order to optimize dosage for safe surpassing minimal inhibitory concentration in the humor compartment." | ( Simultaneous quantification of cefotaxime, desacetylcefotaxime, ofloxacine and ciprofloxacine in ocular aqueous humor and in plasma by high-performance liquid chromatography. Breithaupt, A; Breithaupt, H; Gehrke, R; Kraemer, HJ, 1997) | 0.3 |
| " Group A (n = 41) received cefixime at a dosage of 10 mg/kg to 12 mg/kg per day in two divided doses." | ( Cefixime: an oral option for the treatment of multidrug-resistant enteric fever in children. Billoo, AG; Memon, HI; Memon, IA, 1997) | 0.3 |
| "This study compared the efficacy and tolerability of once-daily dosing with either roxithromycin or cefixime in previously healthy adult patients aged between 18 and 60 with markers of uncomplicated community-acquired pneumonia (CAP) in three outpatient clinics in an open, randomized study." | ( Comparison of roxithromycin with cefixime in the treatment of adults with community-acquired pneumonia. Fachinelli, H; Kijanczuk, S; Mingrone, H; Salvarezza, CR, 1998) | 0.3 |
| " The method was found to be reproducible and convenient for quantitative analysis of ceftriaxone, cefixime and cefotaxime in their raw materials and their dosage forms." | ( HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms. Agbaba, D; Eric-Jovanovic, S; Vladimirov, S; Zivanov-Stakic, D, 1998) | 0.3 |
| " The spectrophotometric and the atomic absorption spectrometric procedures hold well their accuracy and precision when applied to the analysis of cefotaxime sodium and cefuroxime sodium dosage forms." | ( Spectrophotometric and atomic absorption spectrometric determination of certain cephalosporins. Abdellatef, HE; Ayad, MM; Elsaid, HM; Shalaby, AA, 1999) | 0.3 |
| " To gain further evidence using this updated dosing schedule, 258 pediatric patients with lower respiratory tract infections were treated with cefotaxime 100 mg/kg/day, administered as a twice daily or three times daily regimen." | ( Clinical and pharmacological evaluation of a modified cefotaxime bid regimen versus traditional tid in pediatric lower respiratory tract infections. Bellosta, C; Boccazzi, A; Careddu, P; Tonelli, P, 1998) | 0.3 |
| " Although cefotaxime was traditionally administered at 6- or 8-hourly intervals, evaluations of twice daily regimens have demonstrated the feasibility of using this extended dosage interval in selected patients." | ( Cefotaxime. A pharmacoeconomic review of its use in the treatment of infections. Benfield, P; Foster, RH; Plosker, GL, 1998) | 0.3 |
| " Middle ear fluid was extracted by tympanocentesis 4, 12 and 24 h after dosing and divided into two fractions: with cells (as collected) (C+) and cell-free (C-)." | ( Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin. Arcidiacono, MM; Demartini, G; Dugnani, S; Fraschini, F; Pintucci, JP; Scaglione, F, 1999) | 0.3 |
| " The model was used to predict serum concentrations using dosage regimens of 1 g or 50 mg/kg administered every six or eight hours in pediatric patients of various weights with pediatric pharmacokinetic parameters and 1 g every six or eight hours for adult patients with adult pharmacokinetic parameters." | ( Limiting cefotaxime pediatric dosing to adult standards: a pharmacokinetic simulation study. Dulaney Lopez, AM; Estes, KS; Lopez-Samblas, AM; Rodriguez, JC, 1999) | 0.3 |
| "The 50 mg/kg pediatric dosing regimens administered every 8 hours (q8h) or every 6 hours (q6h) consistently produced peak serum concentrations and area under the concentration versus time curve (AUC) values higher than those in adults." | ( Limiting cefotaxime pediatric dosing to adult standards: a pharmacokinetic simulation study. Dulaney Lopez, AM; Estes, KS; Lopez-Samblas, AM; Rodriguez, JC, 1999) | 0.3 |
| "The results support the concept of limiting cefotaxime dosage regimens to 1 g administered every 6 or 8 hours for mild to moderate infections in children weighing more than 20 kg." | ( Limiting cefotaxime pediatric dosing to adult standards: a pharmacokinetic simulation study. Dulaney Lopez, AM; Estes, KS; Lopez-Samblas, AM; Rodriguez, JC, 1999) | 0.3 |
| "Overall, 94% of orders in the intervention group met cefotaxime dosage criteria compared with 86% in the control group (p = ." | ( A randomized trial to measure the optimal role of the pharmacist in promoting evidence-based antibiotic use in acute care hospitals. Dranitsaris, G; McGeer, A; Pitre, M; Spizzirri, D, 2001) | 0.31 |
| "The pharmacist as a vehicle for promoting the appropriate use of broad-spectrum antibiotics in the acute care hospital setting can improve the dosing of such agents." | ( A randomized trial to measure the optimal role of the pharmacist in promoting evidence-based antibiotic use in acute care hospitals. Dranitsaris, G; McGeer, A; Pitre, M; Spizzirri, D, 2001) | 0.31 |
| "Afer twenty years of commercial availability of cefotaxime, the objective of this study was to know the reasons and modes of use, administration dosage as well as its effectiveness and tolerance in critically ill patients admitted to Intensive Care Units (ICU) in our country." | ( [Cefotaxime, twenty years later. Observational study in critically ill patients]. Alvarez-Lerma, F; Cerda, E; Olaechea, P; Palomar, M; Sierra, R, 2001) | 0.31 |
| " These doses produced times that the levels in serum remained above the MIC (deltaT > MICs) approximately 30% of the dosing interval." | ( Effects of specific antibodies against Streptococcus pneumoniae on pharmacodynamic parameters of beta-lactams in a mouse sepsis model. Aguilar, L; Casal, J; Fenoll, A; Giménez, MJ; Jado, I; Prieto, J; Yuste, J, 2002) | 0.31 |
| " To be able to optimize the dosing it is necessary to characterize the pharmacokinetics of cefuroxime which requires a selective and sensitive analytical method for cefuroxime in plasma or serum." | ( Determination of cefuroxime in human serum or plasma by liquid chromatography with electrospray tandem mass spectrometry. Jansson, B; Sandström, M; Viberg, A, 2004) | 0.32 |
| " Target serum concentrations of > or =4 mg/L were reached for 100% of the dosing interval during CI and approximately 60% during BI." | ( Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients. Bruining, HA; Buijk, SE; Groenland, TH; Gyssens, IC; Metselaar, HJ; Mouton, JW; Verbrugh, HA, 2004) | 0.32 |
| "Although an intermittent bolus infusion of CTX 1000 mg produces t > target concentration for 60% of the dosing interval during liver transplantation, serum concentrations may be insufficient during the reperfusion phase." | ( Perioperative pharmacokinetics of cefotaxime in serum and bile during continuous and intermittent infusion in liver transplant patients. Bruining, HA; Buijk, SE; Groenland, TH; Gyssens, IC; Metselaar, HJ; Mouton, JW; Verbrugh, HA, 2004) | 0.32 |
| "Antibiotic dosing regimens may vary in their capacity to select mutants." | ( Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli. Andersson, DI; Cars, O; Geli, P; Olofsson, SK, 2005) | 0.33 |
| " Chief among these are drug, dose, and the dosing interval." | ( Monte Carlo simulation in the evaluation of susceptibility breakpoints: predicting the future: insights from the society of infectious diseases pharmacists. Ambrose, PG, 2006) | 0.33 |
| "The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration (10 mg/kg) were investigated in buffalo calves." | ( Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis). Sharma, SK; Srivastava, AK, 2006) | 0.33 |
| " Cefotaxime and vancomycin assays were carried out with a high-performance liquid chromatography (HPLC)/UV method, whereas gentamicin was dosed using fluorescence polarization immunoassay (FPIA)." | ( Development of a ready-to-use antibiotic conservation solution for arterio-venous grafts. Augé, C; Gourdier, B; Reiter-Chenel, V; Rey, JB, ) | 0.13 |
| "This case emphasizes the importance of adequately dosed antibiotic therapy, also for unusual bacteria such as species of Aeromonas." | ( [Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria]. Bomke, AK; Feyerherd, P; Podbielski, A, 2006) | 0.33 |
| " Dexamethasone can, therefore, be used without fear of impeding vancomycin penetration into the CSF of patients with pneumococcal meningitis, provided that vancomycin dosage is adequate." | ( Levels of vancomycin in cerebrospinal fluid of adult patients receiving adjunctive corticosteroids to treat pneumococcal meningitis: a prospective multicenter observational study. Barnaud, G; Bouadma, L; Chevrel, G; Dreyfuss, D; Hidri, N; Lacherade, JC; Mourvillier, B; Ricard, JD; Wolff, M, 2007) | 0.34 |
| " It was concluded that plasmid-borne bla(SHV) greatly facilitates the selection of ESBL expression, even when the same gene is on the chromosome, and that gene dosage effects are likely to contribute to this phenomenon." | ( Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. Bell, J; Giffard, PM; Hammond, DS; Harris, T; Turnidge, J, 2008) | 0.35 |
| " We report a child presenting with ileus, hypothermia and lethargy after receiving supratherapeutic dosing of phenytoin after a concentration miscalculation." | ( Unusual presentation of iatrogenic phenytoin toxicity in a newborn. DeGreeff, J; Lowry, JA; Scalzo, AJ; Vandover, JC, 2005) | 0.33 |
| " Physicians must be aware of inaccuracies in reference manuals that may result in dosing errors." | ( Unusual presentation of iatrogenic phenytoin toxicity in a newborn. DeGreeff, J; Lowry, JA; Scalzo, AJ; Vandover, JC, 2005) | 0.33 |
| " pneumoniae MIC for 100% of the dosing interval at 12 hours." | ( Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Boatwright, DW; Camblin, M; Gums, JG; Halstead, DC; Jones, ME; Sanderson, R, 2008) | 0.35 |
| "Patients receiving a dosage of 100 mg/kg/day had a mean cefotaxime concentration of 24." | ( Serum concentrations of cefotaxime and its metabolite desacetyl-cefotaxime in infants and children during continuous infusion. Bertels, RA; Gerrits, GP; Mouton, JW; Semmekrot, BA, 2008) | 0.35 |
| " This phenomenon of continued inhibition of bacterial growth even after removal of the antibiotic from the growth medium is of high relevance in the context of optimizing dosing regimens." | ( A multi-type branching model with varying environment for bacterial dynamics with postantibiotic effect. Andersson, DI; Andersson, M; Geli, P; Svensson, A, 2009) | 0.35 |
| "Rational dosing of antibiotics in neonates should be based on pharmacokinetic (PK) parameters assessed in specific populations." | ( Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. Ahsman, MJ; Mathot, RA; Tibboel, D; Wildschut, ED, 2009) | 0.35 |
| " So more attention should be paid to reducing the frequency, times and dosage of antimicrobials, especially third or fourth cephalosporins." | ( Transconjugation and genotyping of the plasmid-mediated AmpC beta-lactamase and extended-spectrum beta-lactamase genes in Klebsiella pneumoniae. Qin, JP; Shi, WF; Zhou, J, 2009) | 0.35 |
| " Given a range of built-in features and its inherent flexibility to customization, the model can be used to study a variety of pharmacokinetic and pharmacodynamic problems such as the effects of inter-individual differences and disease-states on drug pharmacokinetics and pharmacodynamics, dosing optimization, and inter-species scaling." | ( BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems. Graf, JF; Scholz, BJ; Zavodszky, MI, 2012) | 0.38 |
| " The proposed method was successfully applied for the determination of these compounds in their dosage forms." | ( Spectrophotometric complexation of cephalosporins with palladium (II) chloride in aqueous and non-aqueous solvents. Bagheri Gh, A; Rezvani, M; Roshanzamir, S; Yosefi rad, A, 2012) | 0.38 |
| " Results support continuous drug infusion over bolus dosing in the treatment for neonatal foal septicemia to optimize time that cefotaxime concentration exceeds the minimum inhibitory concentration of common equine pathogens." | ( Comparison of continuous infusion with intermittent bolus administration of cefotaxime on blood and cavity fluid drug concentrations in neonatal foals. Arroyo, LG; del Castillo, JR; Diaz-Mendez, A; Gu, Y; Hewson, J; Johnson, R; Ruiz-López, JA, 2013) | 0.39 |
| " Unbound brain concentrations were then simulated at two dosing regimens (4 g every 6 h or 8 h), and the time over the MICs (T>MIC) was estimated for breakpoints of susceptible and resistant Streptococcus pneumoniae strains." | ( Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury. Adier, C; Couet, W; Dahyot-Fizelier, C; Debaene, B; Frasca, D; Grégoire, N; Marchand, S; Mimoz, O, 2013) | 0.39 |
| " A dosing regimen of 1,000 mg of CTX given four times daily is likely to achieve adequate plasma levels in patients with AKI treated with CVVH." | ( Pilot Study of the Pharmacokinetics of Cefotaxime in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy. Koedijk, JB; Mulder, PG; Rijpstra, TA; Touw, DJ; Valk-Swinkels, CG; van 't Veer, NE; van der Meer, NJ; van der Voort, PH, 2016) | 0.43 |
| " Dose-response relationships between antibiotic exposure and extended-spectrum-beta-lactamase-producing or AmpC-producing isolates were not demonstrated." | ( Previous Antibiotic Exposure Increases Risk of Infection with Extended-Spectrum-β-Lactamase- and AmpC-Producing Escherichia coli and Klebsiella pneumoniae in Pediatric Patients. Adler, AL; Elward, A; Haaland, W; Kronman, MP; Miles-Jay, A; Newland, JG; Qin, X; Weissman, SJ; Zaoutis, T; Zerr, DM; Zhou, C, 2016) | 0.43 |
| " However, the dosing regimens routinely used in clinical practice vary considerably." | ( A Population and Developmental Pharmacokinetic Analysis To Evaluate and Optimize Cefotaxime Dosing Regimen in Neonates and Young Infants. Biran, V; Gouyon, JB; Jacqz-Aigrain, E; Leroux, S; Roué, JM; Zhao, W; Zheng, H, 2016) | 0.43 |
| " The detailed analysis of PAP revealed prophylactic cefuroxim doses about 30 mg/kg instead of 50 mg/kg and no repeated dosing in operations lasting longer than 4 h." | ( Clinical practice audit concerning antimicrobial prophylaxis in paediatric neurosurgery: results from a German paediatric oncology unit. Graf, N; Linsler, S; Oertel, J; Schöpe, J; Simon, A; Weiss, K, 2017) | 0.46 |
| "The aim of this study was to build a population pharmacokinetic model for cefotaxime and its metabolite desacetylcefotaxime in order to optimize individual dosing regimens for critically ill children." | ( Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children. Aboura, R; Benaboud, S; Béranger, A; Genuini, M; Heilbronner, C; Hirt, D; Oualha, M; Renolleau, S; Toubiana, J; Tréluyer, JM; Urien, S, 2018) | 0.48 |
| "Standard intermittent cefotaxime dosing regimens in critically ill children are not adequate to reach the target." | ( Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children. Aboura, R; Benaboud, S; Béranger, A; Genuini, M; Heilbronner, C; Hirt, D; Oualha, M; Renolleau, S; Toubiana, J; Tréluyer, JM; Urien, S, 2018) | 0.48 |
| " Dosing optimization, performed using EUCAST MIC susceptibility breakpoints, showed that a dose of 100 mg/kg/6 h should be used, depending on the patient's characteristics and clinical presentation, in order to reach a value of the percentage of time that the drug concentration exceeded the MIC under steady-state pharmacokinetic conditions of 80% in 80% of the patients when targeting sensitive Gram-positive cocci and Gram-negative bacilli with MICs of 1 mg/liter or below." | ( Population Pharmacokinetics of Cefotaxime and Dosage Recommendations in Children with Sickle Cell Disease. Benkerrou, M; Facchin, A; Faye, A; Ha, P; Jacqz-Aigrain, E; Kaguelidou, F; Koehl, B; Lorrot, M; Maksoud, E; Mariani, P; Zhao, W, 2018) | 0.48 |
| "In older adults, few studies confirm that adequate concentrations of antibiotics are achieved using current dosage regimens of intravenous β-lactam antibiotics." | ( Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection-a prospective observational study. Hatti, M; Odenholt, I; Resman, F; Solomonidi, N; Tham, J, 2018) | 0.48 |
| "9% of hypothetical neonates treated with 50 mg/kg of body weight three times a day (TID) would reach the pharmacodynamic target (the percentage of the dosing interval that the free antimicrobial drug concentration remains above the MIC, 70%) using the standard EUCAST MIC susceptibility breakpoints of 2 mg/liter and 4 mg/liter, respectively." | ( Penetration of Cefotaxime into Cerebrospinal Fluid in Neonates and Young Infants. Chen, XK; Huang, X; Jacqz-Aigrain, E; Leroux, S; Li, Y; Shi, HY; Xu, HY; Zhao, W; Zheng, Y; Zhou, Y, 2018) | 0.48 |
| " Conventional intermittent dosing frequently yields inadequate drug concentrations, while continuous dosing might result in better target attainment." | ( Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations. Aardema, H; Alffenaar, JC; Bult, W; Dieperink, W; Touw, DJ; van Hateren, K; Zijlstra, JG, 2020) | 0.56 |
| "To assess total and unbound serum levels of cefotaxime and an active metabolite, desacetylcefotaxime, in critically ill patients treated with either continuously or intermittently dosed cefotaxime." | ( Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations. Aardema, H; Alffenaar, JC; Bult, W; Dieperink, W; Touw, DJ; van Hateren, K; Zijlstra, JG, 2020) | 0.56 |
| "Adult critical care patients with indication for treatment with cefotaxime were randomized to treatment with either intermittent dosing (1 g every 6 h) or continuous dosing (4 g/24 h, after a loading dose of 1 g)." | ( Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations. Aardema, H; Alffenaar, JC; Bult, W; Dieperink, W; Touw, DJ; van Hateren, K; Zijlstra, JG, 2020) | 0.56 |
| "Twenty-nine and 30 patients, respectively, were included in the continuous dosing group and the intermittent dosing group." | ( Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations. Aardema, H; Alffenaar, JC; Bult, W; Dieperink, W; Touw, DJ; van Hateren, K; Zijlstra, JG, 2020) | 0.56 |
| "These results support the application of a continuous dosing strategy of β-lactams in critical care patients and the practice of therapeutic drug monitoring in a subset of patients with higher renal clearance and need for prolonged treatment for further optimization, where using total cefotaxime concentrations should suffice." | ( Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations. Aardema, H; Alffenaar, JC; Bult, W; Dieperink, W; Touw, DJ; van Hateren, K; Zijlstra, JG, 2020) | 0.56 |
| " The bioanalytical method was applied for the quantification of cefotaxime and its metabolite to 20 capillary microsamples collected at five time points in one dosing interval from five critically ill children." | ( Development and validation of a UHPLC-MS/MS method to measure cefotaxime and metabolite desacetylcefotaxime in blood plasma: a pilot study suitable for capillary microsampling in critically ill children. Coulthard, MG; Dorofaeff, T; Guerra Valero, YC; Lipman, J; Parker, SL; Roberts, JA; Sparkes, L; Wallis, SC, 2021) | 0.62 |
| " Median (IQR) cefotaxime daily dosage was 15 g (12-19), corresponding to 200 mg/kg (150-280)." | ( CSF concentration of cefotaxime in adult patients with pneumococcal meningitis: a multicentre retrospective study. Duval, X; El Helali, N; Gregoire, M; Guilhaumou, R; Le Turnier, P; Lemaitre, F; Leroy, AG; Pilmis, B; Revest, M; Velly, LJ, 2021) | 0.62 |
| "Cefotaxime is frequently used in critically ill children, however pharmacokinetic (PK) studies to support adequate dosing in this patient population are limited." | ( Population pharmacokinetics of intravenous cefotaxime indicates that higher doses are required for critically ill children. Brüggemann, RJ; de Wildt, SN; Hartman, SJF; Knibbe, CA; Mathôt, RAA; Schreuder, MF; Upadhyay, PJ; van der Flier, M, 2022) | 0.72 |
| "To characterize cefotaxime PK in critically ill children and evaluate exposures achieved by current and alternative dosing regimens." | ( Population pharmacokinetics of intravenous cefotaxime indicates that higher doses are required for critically ill children. Brüggemann, RJ; de Wildt, SN; Hartman, SJF; Knibbe, CA; Mathôt, RAA; Schreuder, MF; Upadhyay, PJ; van der Flier, M, 2022) | 0.72 |
| "To describe the population pharmacokinetics of cefotaxime and desacetylcefotaxime in critically ill paediatric patients and provide dosing recommendations." | ( Optimal dosing of cefotaxime and desacetylcefotaxime for critically ill paediatric patients. Can we use microsampling? Coulthard, MG; Dorofaeff, T; Guerra Valero, YC; Lipman, J; Parker, SL; Roberts, JA; Sparkes, L; Wallis, SC, 2022) | 0.72 |
| " Monte Carlo dosing simulations were tested using a range of estimated glomerular filtration rates (60, 100, 170 and 200 mL/min/1." | ( Optimal dosing of cefotaxime and desacetylcefotaxime for critically ill paediatric patients. Can we use microsampling? Coulthard, MG; Dorofaeff, T; Guerra Valero, YC; Lipman, J; Parker, SL; Roberts, JA; Sparkes, L; Wallis, SC, 2022) | 0.72 |
| " Standard dosing of 50 mg/kg q6h was only able to achieve the PK/PD target of 100% ƒT>MIC in patients >10 kg and with impaired renal function or patients of 40 kg with normal renal function." | ( Optimal dosing of cefotaxime and desacetylcefotaxime for critically ill paediatric patients. Can we use microsampling? Coulthard, MG; Dorofaeff, T; Guerra Valero, YC; Lipman, J; Parker, SL; Roberts, JA; Sparkes, L; Wallis, SC, 2022) | 0.72 |
| " The 1000 mg four times daily dosage is recommended in patients undergoing CKRT with partially preserved renal function to achieve the target." | ( Target attainment and pharmacokinetics of cefotaxime in critically ill patients undergoing continuous kidney replacement therapy. Abdulla, A; Dijkstra, A; Haringman, JJ; Koch, BCP; Ter Horst, PGJ; Wagenvoort, GHJ; Wieringa, A, 2022) | 0.72 |
| " TDM could identify patients that need individual higher dosing regimens already on the first day of treatment." | ( Low attainment to PK/PD-targets for β-lactams in a multi-center study on the first 72 h of treatment in ICU patients. Eliasson, E; Furebring, M; Lipcsey, M; Smekal, AK, 2022) | 0.72 |
| " Four different dosing regimens were simulated: intermittent infusion in 30 min, prolonged infusion in 4 h, continuous infusion, and continuous infusion with a loading dose." | ( Optimization of β-Lactam Dosing Regimens in Neonatal Infections: Continuous and Extended Administration versus Intermittent Administration. de Grauw, AM; Kruizinga, MD; Leegwater, E; Storm, BN; van Veen, M; Wewerinke, L, 2023) | 0.91 |
| "For all antibiotics except cefotaxime, continuous infusion with a loading dose resulted in a higher PTA compared with other dosing regimens." | ( Optimization of β-Lactam Dosing Regimens in Neonatal Infections: Continuous and Extended Administration versus Intermittent Administration. de Grauw, AM; Kruizinga, MD; Leegwater, E; Storm, BN; van Veen, M; Wewerinke, L, 2023) | 0.91 |
| Role | Description |
|---|---|
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| drug allergen | Any drug which causes the onset of an allergic reaction. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| cephalosporin | A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy. |
| 1,3-thiazoles | |
| oxime O-ether | O-organyl oximes R2C=NOR' (R' =/= H). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Acinetobacter baumannii | Ki | 0.5000 | 0.0070 | 0.2023 | 0.5000 | AID567279 |
| Beta-lactamase | Acinetobacter baumannii | Ki | 2.5000 | 0.5000 | 2.0000 | 3.0000 | AID567280 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 2,000.0000 | 0.5000 | 0.5000 | 0.5000 | AID681363 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | Ki | 30,000.0000 | 0.1800 | 3.3933 | 9.8000 | AID238858; AID681115 |
| Solute carrier family 15 member 2 | Homo sapiens (human) | Ki | 19,976.2998 | 0.7943 | 4.2210 | 8.0000 | AID612540 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | Ki | 3.1300 | 0.0300 | 3.2043 | 7.8200 | AID681377 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 20,000.0000 | 3.0000 | 6.4778 | 8.5000 | AID681114 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 0.2900 | 0.0400 | 4.2297 | 9.0000 | AID681373 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | Ki | 6.1500 | 0.2000 | 2.5771 | 6.1500 | AID681569 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 800.0000 | 6.0300 | 6.0300 | 6.0300 | AID681344 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Albumin | Homo sapiens (human) | Kd | 12.0000 | 0.0893 | 3.3135 | 8.0000 | AID557095 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Citrobacter freundii | Km | 46.0000 | 5.0000 | 7.0000 | 9.0000 | AID405084 |
| Beta-lactamase | Citrobacter gillenii | Km | 714.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| Beta-lactamase | Escherichia coli | Km | 9.4000 | 1.1000 | 4.7667 | 9.4000 | AID394487 |
| Beta-lactamase | Aeromonas caviae | Km | 61.0000 | 7.0000 | 7.0000 | 7.0000 | AID374363 |
| Beta-lactamase | Shouchella clausii | Km | 790.0000 | 0.0100 | 3.0050 | 6.0000 | AID373209 |
| Beta-lactamase | Burkholderia cenocepacia | Km | 150.0000 | 10.0000 | 10.0000 | 10.0000 | AID541022 |
| Metallo-beta-lactamase type 2 | Klebsiella pneumoniae | Km | 10.0000 | 8.0000 | 9.3333 | 10.0000 | AID563972 |
| Metallo-beta-lactamase VIM-11 | Pseudomonas aeruginosa | Km | 11.4000 | 4.5000 | 7.0000 | 9.4000 | AID520385 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 130.0000 | 3.2000 | 5.8250 | 10.0000 | AID562754 |
| Metallo-beta-lactamase VIM-2 | Pseudomonas aeruginosa | Km | 13.4000 | 5.5000 | 7.8750 | 9.9000 | AID520386 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 0.4500 | 0.3000 | 2.0063 | 8.0000 | AID495661 |
| Beta-lactamase | Aeromonas allosaccharophila | Km | 900.0000 | 1.5000 | 6.3000 | 10.0000 | AID584846 |
| Metallo-beta-lactamase | Stutzerimonas stutzeri | Km | 3.5000 | 3.5000 | 4.7500 | 6.0000 | AID518728 |
| Beta-lactamase SHV-1 | Klebsiella pneumoniae | Km | 257.0000 | 4.2000 | 4.2500 | 4.3000 | AID519983 |
| Beta-lactamase | Pseudomonas aeruginosa PAO1 | Km | 6.0000 | 0.5000 | 4.2444 | 8.0000 | AID546426 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Km | 714.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| B2 metallo-beta-lactamase | Chryseobacterium indologenes | Km | 33.0000 | 3.0000 | 3.0000 | 3.0000 | AID562337 |
| Beta-lactamase | Acinetobacter pittii | Km | 0.0800 | 0.0200 | 2.1814 | 6.7300 | AID555223 |
| Beta-lactamase | Acinetobacter pittii | Km | 0.3200 | 0.1800 | 1.3683 | 3.8500 | AID555225 |
| Beta-lactamase | Acinetobacter pittii | Km | 0.2000 | 0.1300 | 1.5250 | 4.5400 | AID555227 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 26.0000 | 8.7000 | 8.7000 | 8.7000 | AID562755 |
| Beta-lactamase | Salmonella enterica subsp. enterica serovar Westhampton | Km | 180.0000 | 10.0000 | 10.0000 | 10.0000 | AID556340 |
| Metallo-beta-lactamase VIM-2 | Klebsiella pneumoniae | Km | 32.0000 | 5.0000 | 7.5000 | 10.0000 | AID563976 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 21.0000 | 5.0000 | 7.1667 | 10.0000 | AID519982 |
| Metallo-beta-lactamase | Escherichia coli | Km | 31.5000 | 2.0000 | 6.8571 | 10.0000 | AID583083; AID583084; AID583085; AID583094 |
| Beta-lactamase | Pseudomonas luteola | Km | 86.0000 | 7.0000 | 7.5000 | 8.0000 | AID495635 |
| BlaVIM-1 | Escherichia coli | Km | 250.0000 | 1.5000 | 1.5000 | 1.5000 | AID495914 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 5.0000 | 0.5000 | 2.7500 | 5.0000 | AID546429 |
| Beta-lactamase | Escherichia coli | Km | 26.0000 | 7.1000 | 8.1667 | 8.7000 | AID368492 |
| Carbapenem-hydrolyzing beta-lactamase KPC | Klebsiella pneumoniae | Km | 183.5000 | 1.6000 | 3.8000 | 6.0000 | AID374025; AID548044 |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | Km | 12.0000 | 2.0000 | 6.6500 | 9.4000 | AID531315 |
| Beta-lactamase VIM-1 | Pseudomonas aeruginosa | Km | 285.0000 | 4.0000 | 4.0000 | 4.0000 | AID530340 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID523046 | Antimicrobial activity against Moraxella catarrhalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID510503 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M2AC9-31 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID542060 | Antibacterial activity against Klebsiella pneumoniae expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID342024 | Antibacterial activity against Klebsiella pneumoniae NK29 assessed as inhibition zone diameter by CLSI disk diffusion confirmatory test | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID558536 | Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P854 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID163779 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 27853 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID495904 | Antimicrobial activity in Klebsiella pneumoniae DIH-2 clinical isolate expressing beta-lactamase VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID495324 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID587977 | Antibacterial activity against Escherichia coli AS226 carrying pBSD-H2 after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID519660 | Antimicrobial activity against Escherichia coli EPI300 harboring GM2995 pCC1 carrying beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID559696 | Antibacterial activity against Escherichia coli 3963 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. |
| AID543956 | Antibacterial activity against chloramphenicol, tetracycline-resistant Staphylococcus aureus COL-S carrying SSpbpD/mecI-mecR1 plasmid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID68182 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Enterobacter cloacae P99 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID544953 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID405308 | Antibacterial activity against beta-lactamase positive ampicillin resistant Haemophilus influenzae isolate assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID405307 | Antibacterial activity against beta-lactamase positive ampicillin resistant Haemophilus influenzae isolate assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID544959 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID323689 | Antibacterial activity against Acinetobacter baumannii by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. |
| AID373217 | Ratio of Kcat for Bacillus clausii NR beta-lactamase BCL1 to Kcat for Bacillus cereus beta lactamase BcI | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID323037 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Escherichia coli isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID557092 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 50% human serum | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID423765 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate 110 having upstream IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID287371 | Antibacterial activity against Escherichia coli after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID520880 | Antibacterial activity against Achromobacter xylosoxidans TB1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID567312 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2203 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID131715 | Effective dose against mouse infected with Pseudomonas aeruginosa 8780 (LDs-240) | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID150909 | The compound was tested in vitro for minimum inhibitory concentration against Pseudomonas aeruginosa 18S/H | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID373058 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID563971 | Antibacterial activity against Escherichia coli NF-NDM-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID372626 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-12 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID583015 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID1056850 | Antibacterial activity against TEM-1/SHV-12 expressing Klebsiella pneumoniae isolate 303 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID520979 | Antibacterial activity against Pseudomonas aeruginosa KG2505 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID498842 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae CY75 deficient in SHV-11, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID523040 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID69605 | Antibacterial activity against Escherichia coli EC14 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID495518 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4676 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID543792 | Antimicrobial activity against Acinetobacter baumannii VT 126 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID499066 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ88 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID555208 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID197866 | Minimum inhibitory concentration against Staphylococcus aureus A4 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID519007 | Antimicrobial activity against Escherichia coli HB101 expressing plasmid encoded TEM-149 T182M mutant by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID530346 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M plasmid carrying blaCTX-M-15 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID368750 | Antimicrobial activity against Klebsiella pneumoniae Kp2 expressing TEM-15 TEM-17 TEM-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID520973 | Antibacterial activity against Klebsiella pneumoniae KN2303 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID564533 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID585179 | Activity of Beta-lactamase GES-6 K104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID535898 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JS33 harboring GyrA T83I mutant, wild-type ParC, GyrB, qnrA and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID560125 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG3 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID587972 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 D240S mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID560053 | Antibacterial activity against Acinetobacter baumannii A9844 infected in Galleria mellonella caterpillar assessed as prolonged survival rate at 150 mg/kg administered as single dose | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. |
| AID544535 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8133 expressing bla TEM-55 gene by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID523516 | Antimicrobial activity against Pseudomonas aeruginosa isolate 13120 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID559699 | Antimicrobial activity against Micrococcus luteus AB93113 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID524570 | Antimicrobial activity against Shigella sonnei isolate AM22855 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID587976 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 G232A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID395357 | Antibacterial activity against Micrococcus luteus La 2971 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID1056875 | Antibacterial activity against Escherichia coli FNSST 982 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID678797 | TP_TRANSPORTER: inhibition of PGF2alpha in OAT2-S2 cells | 2003 | European journal of pharmacology, Mar-28, Volume: 465, Issue:1-2 | Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. |
| AID554991 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 67 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID285270 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM36 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID541022 | Activity at Burkholderia cenocepacia 07-34 beta-lactamase PenB1 expressed in Escherichia coli Top10 by UV-spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID585176 | Activity of Beta-lactamase GES-7 K104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID577713 | Antibacterial activity against 10'5 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a after 16 hrs by by two fold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics. |
| AID524932 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A and Q38R mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID285266 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM151 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID544978 | Antimicrobial activity against Klebsiella pneumoniae 52OmpA2 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. |
| AID542065 | Antibacterial activity against Klebsiella pneumoniae A expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID395737 | Antimicrobial activity against imipenem-susceptible Haemophilus influenzae Rd by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID524050 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID405314 | Antibacterial activity against Haemophilus influenzae group IIa isolates with ftsI gene mutation by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID495328 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Gly490Glu, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID542616 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID495813 | Antimicrobial activity against Escherichia coli 138 expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID495633 | Antimicrobial activity against Escherichia coli DH10B transfected with pBK-L3 expressing blaLUT-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID325161 | Antimicrobial activity against Haemophilus parasuis BB 1026 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID535883 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132T harboring qnrB gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID342025 | Antibacterial activity against plasmid pK29 transconjugant Escherichia coli J53 assessed as inhibition zone diameter by CLSI disk diffusion confirmatory test | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID535718 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-B2 S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID544958 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID521992 | Antimicrobial activity against Escherichia coli isolate J53 harboring pA-1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID535865 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ47T harboring qnrB gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID584847 | Ratio of Kcat to Km for Aeromonas allosaccharophila AL-1 beta-lactamase PER6 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID522379 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID532206 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99T harboring qnrB gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID495753 | Antimicrobial activity against Escherichia coli J5 transconjugants expressing beta lactamase CTX-M-9 isolated from human flora associated C3H rat infected with Salmonella enterica serotype Virchow and treated with Cefixime-cluvulanic acid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. |
| AID558535 | Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P843 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID295111 | Antibacterial activity against Bacillus cereus ATCC 7064 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID524435 | Antimicrobial activity against Shigella isolate DH-13291 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID326272 | Activity of Escherichia coli K12 beta-lactamase TEM1 relative to penicillin G | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID585447 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAK harboring pZY0901 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID495654 | Antimicrobial activity against Pseudomonas aeruginosa 531 expressing beta-lactamase BEL-2 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID499046 | Antimicrobial activity against Klebsiella pneumoniae ZJ68T expressing CTX-M-15 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID521997 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp4A expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID405080 | Antimicrobial activity against Citrobacter freundii 33587 isolate by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID540947 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c36 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID326270 | Activity of Escherichia coli beta-lactamase SCO1 relative to penicillin G | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID528741 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X V405A mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID562750 | Antimicrobial activity against Escherichia coli K-12 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID701875 | Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID95736 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Klebsiella oxytoca 1082 E | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID561111 | Antibacterial activity against Pasteurella multocida BB1045 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID524062 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID583017 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli ECB-1 plasmid carrying ACC-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID373752 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab3 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID540945 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pH205 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID471596 | Antibacterial activity against Escherichia coli ATCC 9637 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID542719 | Antimicrobial activity against ESBL-producing Klebsiella pneumoniae clinical isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases. |
| AID499064 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae GX56 deficient in ompC and expressing low levels of ompF DE by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID164241 | Antibacterial activity against Pseudomonas aeruginosa PS18 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID156279 | Concentration required for 90% inhibition against 66 kDa penicillin-binding protein 2 binding using [14C]-Pen G as the radioligand. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID64081 | The compound was tested in vitro for minimum inhibitory concentration against Escherichia coli 257 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID373060 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID1129349 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii clinical isolate E2-1228625 after 18 hrs by microdilution broth method | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7 | Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli. |
| AID285439 | Antimicrobial activity against Citrobacter gillenii CIP 106783 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID324360 | Antibacterial activity against Acinetobacter johnsonii 7037 expressing SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID562334 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid pBC-SK after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID573516 | Antibacterial activity against Serratia marcescens isolate Sm201 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID546426 | Activity at Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID543954 | Antibacterial activity against chloramphenicol-resistant Staphylococcus aureus COL carrying mecI-mecR1 plasmid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID495645 | Antimicrobial activity against Pseudomonas luteola LAM expressing blaLUT-1 by Etest method in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID583027 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli ECB-1 plasmid carrying ACC-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID1056858 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID523049 | Antimicrobial activity against beta-lactamase positive Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID534167 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid VOG1 expressing RmtB, TEM-1, and QepA gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID523047 | Antimicrobial activity against Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID587727 | Antimicrobial activity against Escherichia coli DH5alpha carrying Pseudomonas aeruginosa strain PS 297 IMP-18-pLBII after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID545446 | Antimicrobial activity against extended-spectrum beta-lactamase-negative Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID523038 | Antimicrobial activity against streptococcal sp. by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID544420 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID326266 | Antibacterial activity against Escherichia coli K12 carrying pR3521 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID373057 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID549347 | Antimicrobial activity against Escherichia coli isolate 32 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID405302 | Antibacterial activity against beta-lactamase positive ampicillin resistant Haemophilus influenzae isolate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID373210 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID531062 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC243 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID523039 | Antimicrobial activity against Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID520392 | Antibacterial activity against mef and erm(B) positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID573541 | Antibacterial activity against Klebsiella pneumoniae Kp38045 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID535755 | Antimicrobial activity against community-acquired Escherichia coli obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID530512 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607-03 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID519066 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID519734 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID544955 | Antimicrobial activity against Klebsiella pneumoniae extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID573544 | Antibacterial activity against Enterobacter cloacae El3799 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID340725 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-1 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID545434 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID613258 | Antibacterial activity against Bacillus subtilis ATCC 33712 after 24 hrs by NCCLS M7-A6 broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. |
| AID555219 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID518730 | Antimicrobial activity against Pseudomonas stutzeri clinical isolate expressing beta-lactamase DIM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID584560 | Antimicrobial activity against Acinetobacter lwoffii isolate G expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID278597 | Inhibitory activity against azide-resistant Escherichia coli J53 T12-1183 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID324361 | Activity of Acinetobacter johnsonii SCO1 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID562573 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID326267 | Antibacterial activity against Escherichia coli DH5-alpha carrying pSCO1 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID541007 | Antimicrobial activity against Burkholderia cenocepacia 09-54 expressing beta-lactamase PenB2 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID549334 | Antimicrobial activity against Escherichia coli isolate 100 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID330971 | Antimicrobial activity against ampD deficient Escherichia coli transfected with pCF1 by agar diffusion assay | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID544562 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8130 expressing bla SHV-1 gene by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID560490 | Antibacterial activity against 5 x 10'5 CFU/ml Escherichia coli MC4100 harboring plasmid ACYC184 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID209864 | In vivo activity in murine against Streptococcus pneumoniae 6301 infection after sc administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID544437 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID583084 | Activity of Escherichia coli BL21(DE3) VIM-2 W87F mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID524925 | Antimicrobial activity against Escherichia coli MI1443 harboring A77V mutation in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID544956 | Antimicrobial activity against Proteus mirabilis extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID542769 | Antimicrobial activity against Escherichia coli J53 transformed with pHND1 carrying DHA-1 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID534764 | Antimicrobial activity against Escherichia coli CSH-2 conjugant of strain 08-607 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID535635 | Antimicrobial activity against Group B streptococcus serotype VI R5 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID519640 | Antimicrobial activity against Escherichia coli AB14156 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID521350 | Antimicrobial activity against Streptococcus pneumoniae isolate 40 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID657433 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID528532 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B68 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID209628 | In vitro minimum inhibitory concentration was measured against Streptococcus pyogenes 4 strain.; ( | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID423755 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate M1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID544509 | Metabolic stability in Escherichia coli TOP10 harboring beta-lactamase KPC-2 assessed as hydrolysis rate per mg of extracts at 100 uM after 5 mins by spectrophotometric analysis | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID543270 | Antimicrobial activity against Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID519647 | Antimicrobial activity against Escherichia coli AB14156 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID495907 | Antimicrobial activity in Escherichia coli TOP10 strain harbouring recombinant plasmid VIM-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID535356 | Antimicrobial activity against Streptococcus pyogenes clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID374022 | Activity of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGE | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. |
| AID531061 | Antimicrobial activity against CMY-2,CTX-M-14,TEM-2-like beta-lactamase producing Klebsiella pneumoniae isolate CUMCK2 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID467613 | Volume of distribution at steady state in human | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID543276 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID562812 | Antimicrobial activity against Escherichia coli DH5[alpha] | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID576274 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18260 by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID368503 | Ratio of Kcat to Km of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID529893 | Antimicrobial activity against Leptospira interrogans serovar Bataviae isolate 1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID557097 | Protein binding in serum | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID543808 | Bactericidal activity against Klebsiella pneumoniae VT 1367 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID544966 | Antimicrobial activity against Proteus mirabilis expressing extended-spectrum beta-lactamase by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID531316 | Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID530514 | Antimicrobial activity against group B Streptococcus sp. 'group B' isolate 4214-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID372615 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-12 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID558783 | Antimicrobial activity against Enterobacter aerogenes assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID405082 | Antimicrobial activity against Escherichia coli 33587-TC9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID285441 | Antimicrobial activity against Escherichia coli DH10B after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID519737 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID559920 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID583093 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pBC-SK plasmid by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID200682 | In Vitro minimal inhibitory concentration against Salmonella typhi (O-901) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID523030 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID520810 | Antimicrobial activity against SHV-5 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype D by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID372606 | Antibacterial activity against rifampin-resistant Escherichia coli C600 transconjugant producing beta-lactamase of pI 5.2 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID544489 | Antibacterial activity against Enterobacter cancerogenus E624 harboring beta-lactamase KPC-4 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID587986 | Antibacterial activity against Escherichia coli AS226 after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID555214 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 243 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID531313 | Activity of Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID1056877 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID544967 | Antimicrobial activity against Proteus mirabilis expressing beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID164883 | In Vitro minimal inhibitory concentration against Pseudomonas aeruginosa (1101-75) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID521348 | Antimicrobial activity against Streptococcus pneumoniae isolate 187 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID1126582 | Antibacterial activity against methicillin-resistant Staphylococcus aureus at 37 degC after 24 hrs by agar well diffusion assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, structure-activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives. |
| AID1329363 | Antibacterial activity against Escherichia coli ATCC 11775 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID519643 | Antimicrobial activity against Escherichia coli EPI300 transformant harboring pCC1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID1230844 | Antimicrobial activity against wild type Escherichia coli DH10B by agar dilution method | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14 | Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors. |
| AID523042 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID531966 | Antibacterial activity against Klebsiella pneumoniae urine isolate A28009 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID68185 | In vitro antibacterial activity against Enterobacter cloacae P99 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID206118 | In vitro antibacterial activity against Staphylococcus aureus Smith(MS) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID278596 | Inhibitory activity against Klebsiella pneumoniae 12-1183 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID372613 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-158 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID521490 | Antibacterial activity against Escherichia coli harboring pCOL plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID341969 | Antimicrobial activity against Escherichia coli AJE0508 isolate carrying ISCR1 element related blaCTX-M-14 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene. |
| AID532167 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii PU55 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB, qnrA genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID519747 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-72 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID584317 | Antimicrobial activity against azide-resistant Escherichia coli J53 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Outbreak of meropenem-resistant Serratia marcescens comediated by chromosomal AmpC beta-lactamase overproduction and outer membrane protein loss. |
| AID587967 | Activity of Escherichia coli beta-lactamase Toho-1 G232A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID405303 | Antibacterial activity against beta-lactamase nonproducing ampicillin resistant Haemophilus influenzae isolate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID521436 | Ratio of induction of xylE gene expression in Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene to induction of xylE gene expression in Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene assessed as catec | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID523032 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID547996 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237C mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID559708 | Antimicrobial activity against penicillin-resistant Staphylococcus epidermidis P1389 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID520775 | Antibacterial activity against beta-lactamase KPC-2 producing Klebsiella pneumoniae isolate K1 to K9 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID529460 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID573724 | Antibacterial activity against Serratia marcescens Sm265 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID373212 | Activity of Bacillus anthracis beta-lactamase Bla1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID438298 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID529663 | Activity of Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID558786 | Antimicrobial activity against Citrobacter freundii assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID559687 | Antibacterial activity against ESBL-positive Escherichia coli Top10 harboring plasmid AT517 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID529578 | Ratio of Kcat to Km for Chryseobacterium meningosepticum beta-Lactamase GOB-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID573331 | Antibacterial activity against Klebsiella pneumoniae isolate Kp1945 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 and dfrA12-orfF-aadA2 arrays by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID548040 | Antimicrobial activity against Escherichia coli DH10B harboring plasmid pBK SK(+) by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID573495 | Antibacterial activity against Citrobacter amalonaticus isolate Ca3927 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID495750 | Antimicrobial activity against Escherichia coli J5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID521292 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype F by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID562341 | Ratio of Kcat to Km for Chryseobacterium meningosepticum CCUG 4310 beta-lactamase BlaB1 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID681363 | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | 2002 | Life sciences, Mar-08, Volume: 70, Issue:16 | Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. |
| AID532169 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii PU55T harboring wild-type GyrA, ParC, GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID325158 | Antimicrobial activity against Haemophilus parasuis BB 1025 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID587612 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID529655 | Activity of Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID585674 | Antimicrobial activity against ampGh1 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID330968 | Antimicrobial activity against ampD deficient Escherichia coli transfected with pCF1 in medium containing EtbuPUG by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID567271 | Ratio of Kcat to Ki for Acinetobacter baumannii ADC-33 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID559276 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID583020 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Enterobacter asburiae CIP 105006 plasmid carrying ACT-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID524744 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R mutations in beta lactamase CTX-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID207356 | In vitro minimum inhibitory concentration was measured against Staphylococcus aureus 753 (Methicillin resistant) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID532187 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26T harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID523494 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1530c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID586085 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from human assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID499067 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ89 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID285158 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID498843 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae XJ81 deficient in TEM-1, SHV-12, DHA-1, aac(6')-Ib, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID520985 | Antibacterial activity against Klebsiella pneumoniae 633 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID545443 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID667374 | Antibacterial activity against Pseudomonas aeruginosa ATCC 49189 after 24 hrs by microtiter broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives. |
| AID544951 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase CTX by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID534755 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 06-607 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID524035 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 3413 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID544949 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC and extended-spectrum beta-lactamase by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID543262 | Antimicrobial activity against Streptococcus pneumoniae R6 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID558792 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Klebsiella pneumoniae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID573547 | Antibacterial activity against Klebsiella oxytoca Ko1156 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID558328 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P286 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID567323 | Antimicrobial activity against Escherichia coli TUM4670 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID519627 | Antimicrobial activity against Brachyspira pilosicoli 80.10 without producing beta-lactamase OXA-63 by disc diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID521296 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype J by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID530523 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607 expressing multiple copies of wild-type pbp2x by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID524041 | Antibacterial activity against methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID559903 | Antimicrobial activity against Escherichia coli TF-KO281 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID523506 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1712c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID499062 | Antimicrobial activity against carbapenem-resistant Escherichia coli HX74 deficient in TEM-1, CTX-M-14, CTX-M-3, aac(6')-Ibcr, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID405317 | Antibacterial activity against Haemophilus influenzae group IId isolates with ftsI gene mutation by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID558338 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1730 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID48764 | Minimum inhibitory concentration for prevention of visible growth of Candida albicans | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID584836 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER6 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID325155 | Antimicrobial activity against Haemophilus parasuis BB 1022 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID373758 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab1254 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID1056845 | Antibacterial activity against TEM-1/SHV-12 expressing Enterobacter cloacae isolate 306 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID520779 | Antibacterial activity against Escherichia coli EC600 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID1209734 | Inhibition of mouse OAT1 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID285156 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID520808 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype B by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID496593 | Activity at Escherichia coli DH10B beta-lactamase KPC-2 by diode array spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. |
| AID535360 | Antimicrobial activity against Haemophilus influenzae clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID529576 | Ratio of Kcat to Km for Erwinia carotovora subsp. atroseptica DSM 30184 beta-Lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID405309 | Antibacterial activity against beta-lactamase nonproducing ampicillin resistant Haemophilus influenzae isolate assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID542063 | Antibacterial activity against Klebsiella pneumoniae B expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID373054 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID495662 | Ratio of Kcat to Km for Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID342026 | Antibacterial activity against Escherichia coli J53 assessed as inhibition zone diameter by CLSI disk diffusion confirmatory test | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID531653 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC223 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID586086 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from animals and food assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID529574 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid BC-SK after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID560115 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG3 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID584839 | Antimicrobial activity against Escherichia coli DH10B by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID565197 | Antimicrobial activity against Klebsiella pneumoniae isolate H-1406 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID584486 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae ATCC 138821 by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID372605 | Antibacterial activity against Escherichia coli BER1 producing beta-lactamase pI 5.2 and pI 5.4 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID520394 | Antibacterial activity against mef(E)-positive Streptococcus pneumoniae isolate Spain 9V-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID295099 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID567464 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080048Ty transconjugant harboring bla CTX-M-15 gene by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID524929 | Antimicrobial activity against Escherichia coli MI1443 harboring N106S and P167S mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID368492 | Activity of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID374135 | Antimicrobial activity Enterobacter cloacae 63 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID368496 | Activity of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID532675 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID498362 | Antimicrobial activity against rifampin resistant Klebsiella pneumoniae 52deltaacrR containing isogenic acrR knockout assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. |
| AID524070 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID528534 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B503 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID555212 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 128 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID207357 | In vitro minimum inhibitory concentration was measured against Staphylococcus aureus smith strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID608337 | Antibacterial activity against 1 x 10'4 cfu/mL Bacillus subtilis ATCC 33712 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID567471 | Antimicrobial activity against gLow-BLNAR Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID521345 | Antimicrobial activity against Streptococcus pneumoniae isolate k-637 obtained from CSF of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID520388 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID521487 | Antibacterial activity against Pseudomonas aeruginosa 2404 plasmid by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID573525 | Antibacterial activity against Klebsiella oxytoca isolate Ko238 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID560122 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG4 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID423763 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 108 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID523045 | Antimicrobial activity against Listeria monocytogenes by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID1765578 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID532179 | Antimicrobial activity against aac(6')-Ib-cr-negative Klebsiella pneumoniae SY22 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID584564 | Antimicrobial activity against Acinetobacter lwoffii isolate K expressing beta-lactamase OXA-58 isolated from blood culture of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID542742 | Antimicrobial activity against Citrobacter freundii D26 expressing qnrB6 and CTX-M-9G genes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID522003 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp7A expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID33698 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Alcaligenes | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID520805 | Antimicrobial activity against Escherichia coli str. K-12 substr. DH10B harboring plasmid CTX-M-59 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID523048 | Antimicrobial activity against beta-lactamase negative Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID583092 | Activity of Escherichia coli XL1-Blue VIM-2 A64W mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID555221 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 109 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID510506 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-6 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID529577 | Ratio of Kcat to Km for Pseudomonas maltophilia ULA-511 beta-Lactamase L-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID498814 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae FZ47 deficient in IMP-8, TEM-1, SHV-11, CTX-M-14, qnrB2, aac(6')-Ib, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID523029 | Antimicrobial activity against Staphylococcus sp. by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID147162 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Neisseria perfl. | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID325153 | Antimicrobial activity against Haemophilus parasuis BB 1020 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID532182 | Antimicrobial activity against aac(6')-Ib-cr-negative Klebsiella pneumoniae SY22T harboring qnrS gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535856 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID522389 | Activity of Aeromonas caviae Beta-lactamase CAV1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID325154 | Antimicrobial activity against Haemophilus parasuis BB 1021 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID544564 | Antimicrobial activity against Escherichia coli ATCC 25922 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID533874 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID535752 | Antimicrobial activity against hospital-acquired Klebsiella pneumoniae obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID368734 | Antimicrobial activity against Enterobacter aerogenes Ea1 expressing TEM-24b gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID495751 | Antimicrobial activity against Escherichia coli J5 transconjugants expressing beta lactamase CTX-M-9 isolated from human flora associated C3H rat infected with Salmonella enterica serotype Virchow by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. |
| AID531075 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC190 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID422499 | Activity of Carnobacterium divergens BM4489 penicillinase Cad-1 at 1 uM enzyme concentration assessed as initial rate of hydrolysis by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID340729 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-14 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID1879068 | Antibacterial activity against NDM-1 positive Escherichia coli ZC-YN3 isolates assessed as inhibition of bacterial growth incubated for 18 to 24 hrs by CLSI based broth microdilution method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli. |
| AID495752 | Antimicrobial activity against Escherichia coli J5 transconjugants expressing beta lactamase CTX-M-9 isolated from human flora associated C3H rat infected with Salmonella enterica serotype Virchow and treated with Cefixime by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. |
| AID558323 | Antibacterial activity against Campylobacter jejuni isolate P270 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID238858 | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13 | Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. |
| AID1056834 | Antibacterial activity against GIM-1 expressing Pseudomonas aeruginosa isolate 197 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID498819 | Antimicrobial activity against Klebsiella pneumoniae GZ64T expressing IMP-4 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID529658 | Ratio of Kcat to Km for Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID279183 | Antibacterial activity against Escherichia coli DH10B expressing recombinant beta lactamase LAP1 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID585628 | Antimicrobial activity against tetracycline resistant Escherichia coli SNO301-1 harboring pEC1C carrying ampC, ampR from Enterobacter cloacae after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID548016 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237D mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID529456 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID531682 | Antimicrobial activity against Acinetobacter baumannii Ab290 containing plasmid harboring OXA-58-4 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID521828 | Antimicrobial activity against Streptococcus pneumoniae in meningitis patients by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID562755 | Activity of Klebsiella pneumoniae AH27 CTX-M-15 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID499049 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU104 deficient in TEM-1, SHV-11, CTX-M-15, qnrS1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID528600 | Antimicrobial activity against Escherichia coli TOP10 harboring blaKPC-2 and blaTEM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID575417 | Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e at 30 ug after 16 hrs by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID495517 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4675 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID521827 | Antimicrobial activity against Streptococcus pneumoniae isolated from cerebrospinal fluid of patient with bacterial infection by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID540949 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBCSK plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID1056853 | Antibacterial activity against Aeromonas hydrophila FNSST 014 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID372603 | Antibacterial activity against Escherichia coli BER1 producing beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1056878 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID587983 | Antibacterial activity against Escherichia coli AS226 carrying pBSDC69A mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID573545 | Antibacterial activity against Klebsiella pneumoniae Kp3799 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID660262 | Ratio of MIC for wild type Escherichia coli TG1 to MIC for acrB-deficient Escherichia coli KAM3 by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID423758 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 102 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID524198 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID70760 | In vitro antibacterial activity against Escherichia coli 257 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID373766 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh14 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID543806 | Bactericidal activity against Acinetobacter baumannii VT 126 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID205951 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Staphylococcus aureus SG511 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID545464 | Antimicrobial activity against Pseudomonas fluorescens assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID528783 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID543281 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID523043 | Antimicrobial activity against Streptococcus viridans by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID373756 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab20 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID428292 | Antimicrobial activity against Acinetobacter baumannii BM4579 expressing deltaadeIJK genes isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID70595 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Escherichia coli 1507E | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID535694 | Antimicrobial activity against Azide-resistant Escherichia coli J53 transconjugant harboring Escherichia coli DH5alpha-5825 qnrB2 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID543283 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID562474 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 transconjugant expressing beta-lactamase SHV-12 by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID520970 | Antibacterial activity against Escherichia coli harboring pNGR plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID405315 | Antibacterial activity against Haemophilus influenzae group IIb isolates with ftsI gene mutation by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID587975 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 F160T mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID523037 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID559859 | Antimicrobial activity against Streptococcus agalactiae clinical isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. |
| AID529902 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 12 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID542614 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338P mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID561320 | Antimicrobial activity against Escherichia coli isolate 17 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID567313 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2204 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID546433 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1329365 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID372604 | Antibacterial activity against Escherichia coli BER1 producing TEM-158 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID573535 | Antibacterial activity against Enterobacter cloacae El1573 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID584566 | Antimicrobial activity against Acinetobacter lwoffii isolate M expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID495322 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-resistant Haemophilus influenzae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID562765 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID564532 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid with entire blaAmpC gene with alanine residue deletion at 215 position by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID542064 | Antibacterial activity against Klebsiella pneumoniae C expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID585185 | Ratio of Kcat to Km for Beta-lactamase GES-6 K104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID395731 | Antimicrobial activity against imipenem-resistant invasive nontypeable Haemophilus influenzae isolate 184 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID535886 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID162748 | Minimum inhibitory concentration against Proteus mirabilis 90 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID562223 | Antimicrobial activity against Desulfovibrio desulfuricans MB by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID395353 | Antibacterial activity against Proteus vulgaris ATCC 8427 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID521998 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp5A expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1230846 | Antimicrobial activity against wild type Escherichia coli DH10B producing beta-lactamase P99 by agar dilution method | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14 | Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors. |
| AID533881 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID21640 | In vitro plasma protein binding was evaluated using Sprauge-Dawley rat at 20 ug/mL | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID585197 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-13 K104, N170 mutant by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID523034 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID544431 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1056837 | Antibacterial activity against TEM-1/SHV-12 expressing Escherichia coli isolate 237 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID210205 | In vitro antibacterial activity against Streptococcus pneumoniae 6301 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID1295314 | Antimicrobial activity against Aspergillus flavus ATCC 23554 at 1 mg/ml incubated for 24 hrs by cup diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID548012 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237S mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID499071 | Antimicrobial activity against Klebsiella pneumoniae WH97 expressing SHV-33, aac(6')-Ib, ompK35 DE by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID528525 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B6 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID529895 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID156245 | Affinity for penicillin binding protein 3 of Escherichia coli UB1005 (DC0) was evaluated.; ( | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID495336 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Ile449Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID542059 | Antibacterial activity against Klebsiella pneumoniae B expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID70750 | In Vitro minimal inhibitory concentration against Escherichia coli (ATCC 39188) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID548259 | Activity of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 T237S mutant by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID1379750 | Antimicrobial activity against Escherichia coli incubated for 24 hrs by serial dilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs. |
| AID534088 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID541010 | Antimicrobial activity against Burkholderia cenocepacia 212 expressing beta-lactamase PenB3 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID524927 | Antimicrobial activity against Escherichia coli MI1443 harboring A77V and D240G mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID532027 | Antimicrobial activity against Kluyvera georgiana 14751 expressing beta-lactamase CTX-M-78 obtained from bloodstream of patient by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID287378 | Antibacterial activity against Listeria monocytogenes after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID533879 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID559707 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus P1369 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID584495 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae KPBj3 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID531067 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC241 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID374025 | Activity of Klebsiella pneumoniae KPC-1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. |
| AID405313 | Antibacterial activity against Haemophilus influenzae group I isolates with ftsI gene mutation by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID523510 | Antimicrobial activity against Pseudomonas aeruginosa isolate 16008 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID530499 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 3047-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID535632 | Antimicrobial activity against Group B streptococcus R8 harboring T77I, S353F and A514V in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and G527V in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID559264 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID1295317 | Antimicrobial activity against Streptococcus lactis ATCC 14591 incubated for 24 hrs by CLSI/NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID368501 | Activity of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID518521 | Antimicrobial activity against Capnocytophaga sputigena CRBIP 17.39 after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID535638 | Antimicrobial activity against Group B streptococcus serotype VI R2 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID584846 | Activity at Aeromonas allosaccharophila AL-1 beta-lactamase PER6 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID542046 | Antibacterial activity against Escherichia coli TrC A expressing Klebsiella pneumoniae A blaCTX-M beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID584558 | Antimicrobial activity against Acinetobacter lwoffii isolate E expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID530508 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 7037-99 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID567472 | Antimicrobial activity against gBLNAR Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID524741 | Antimicrobial activity against beta lactamase CTX-M-10 producing Escherichia coli GB20 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535904 | Antimicrobial activity against aac(6')-Ib-cr-negative Escherichia coli PU12 harboring GyrA S83L mutant, wild-type GyrB, ParC and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID374112 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr expressing Escherichia coli J53 qnrA1 bearing pHS6 transconjugant from Escherichia coli 650 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID423769 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 116 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID562739 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBC-CTX-M-71 plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID562753 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID369227 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID535494 | Antimicrobial activity against beta-lactamase positive, ampicillin-clavulanic acid resistant Haemophilus influenzae expressing fst1 mutant gene assessed as resistant isolates by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID1056879 | Antibacterial activity against Bacillus cereus ATCC 11778 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID373984 | Antimicrobial activity Escherichia coli 650 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID520981 | Antibacterial activity against Escherichia coli harboring pNYC plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID525550 | Antimicrobial activity against ampicillin resistant serotype-e Haemophilus influenzae isolate BB1053 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID544954 | Antimicrobial activity against Escherichia coli extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID498802 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ18 deficient in KPC-2, SHV-28, DHA-1, ompK35 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID285262 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-1 and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID576068 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 69036 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID447075 | Antibacterial activity against Micrococcus luteus La 2971 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID535643 | Antimicrobial activity against Group B streptococcus serotype III N3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID585452 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampG deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID543431 | Activity at Shigella sonnei UIH-1 beta-lactamase CTX-M-64 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID534396 | Ratio of Kcat to Km for Escherichia coli JM109 harboring recombinant pKHM-1 Beta-lactamase KHM-1 assessed as compound hydrolysis by UV-visible spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID209100 | In vivo activity in murine against Streptococcus pyogenes 4 infection after sc administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID573546 | Antibacterial activity against Klebsiella oxytoca Ko0426 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID520389 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 over Kcat to Km for Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID529161 | FIC index, ratio of MIC for Pseudomonas aeruginosa 100609 in presence of 250 ug/ml polyethylenimine to MIC for Pseudomonas aeruginosa 100609 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID68524 | Minimum inhibitory concentration against Enterobacter cloacae (EB5) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID278603 | Inhibitory activity against azide-resistant Escherichia coli J53 T03-222 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID368752 | Antimicrobial activity against Klebsiella pneumoniae Kp4 expressing SHV-12 SHV-1 and plasmid-mediated cephalosporinase CMY-4 | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID545661 | Antimicrobial activity against Enterobacteriaceae Extended-Spectrum beta-lactamase positive assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID528527 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B8 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID587527 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID495909 | Antimicrobial activity in Escherichia coli J53 transconjugate with Escherichia coli DIH-1 expressing natural plasmid containing beta-lactamase VIM-19 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID509866 | Antibacterial activity against Acinetobacter baumannii isolate 510 isolated from human sputum | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID522571 | Antimicrobial activity against Escherichia coli isolate 7010738 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID524217 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID544442 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID559267 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID573549 | Antibacterial activity against Klebsiella pneumoniae Kp149 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID285442 | Activity of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID559268 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Providencia stuartii Ps5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID1435415 | Anti-bacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 measured after 24 hrs by microtiter broth dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives. |
| AID521303 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype G by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID511288 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-13 plasmid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID583083 | Activity of Escherichia coli BL21(DE3) VIM-2 W87A mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID520980 | Antibacterial activity against Klebsiella pneumoniae YC by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID721641 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 isolated from cystic fibrosis patient assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Monocyclic β-lactams as antibacterial agents: facing antioxidant activity of N-methylthio-azetidinones. |
| AID519663 | Antimicrobial activity against Escherichia coli Irk1224 harboring beta-lactamase CTX-M-3 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID573548 | Antibacterial activity against Escherichia coli Ec158 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID559706 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus P1374 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID535640 | Antimicrobial activity against Group B streptococcus serotype Ib C2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID279813 | Antimicrobial activity against Escherichia coli DH5-alpha pYW1 transformants expressing KPC2 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID583025 | Antimicrobial activity against Escherichia coli TOP10 transformed by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID585832 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAK harboring pUCP24 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID325444 | Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID511290 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID1379752 | Antimicrobial activity against Staphylococcus aureus incubated for 24 hrs by serial dilution method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs. |
| AID495343 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Ala502Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID521344 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-343 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID373761 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii ab1265 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID521831 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent resistant isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID534763 | Antimicrobial activity against Escherichia coli CSH-2 conjugant of strain 08-642 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID326268 | Antibacterial activity against Escherichia coli DH5-alpha by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID285688 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA2404 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID70951 | Antibacterial activity against Escherichia coli TEM | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID529581 | Ratio of Kcat to Km for Janthinobacterium lividum THIN-B | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID64042 | Minimum inhibitory concentration against Enterobacter cloacae P99 (inoculum, 10e4 cfu per spot)(type I lactamase producer) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID555228 | Ratio of Kcat to Km for Acinetobacter genomosp. 3 isolate 195 ADC-18 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID156278 | Evaluated for concentration required for 90 % inhibition of [14C]- penicillin G binding to PBP's of Escherichia coli UB 1005 as penicillin-binding protein 2 66 kDa | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID559277 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID583018 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli pGLK-1 plasmid carrying FOX-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID562340 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-2 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID522386 | Antimicrobial activity against Escherichia coli NI540 carrying cloned class C beta-lactamase TRU-1 gene | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID68523 | Minimum inhibitory concentration against Enterobacter cloacae (265A beta-lactamase containing) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID405316 | Antibacterial activity against Haemophilus influenzae group IIc isolates with ftsI gene mutation by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID544952 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX and SHV by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID198158 | Minimum inhibitory concentration against Serratia marcescens A16 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID543274 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2b, pbp1a and murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID95918 | Antibacterial activity against Klebsiella pneumoniae X26 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID330970 | Antimicrobial activity against wild type Escherichia coli transfected with pCF1 in medium containing EtbuPUG by agar diffusion assay | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID495551 | Antimicrobial activity against Haemophilus influenzae isolate by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID164887 | In vitro antibacterial activity against Pseudomonas aeruginosa 5712 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID372612 | Antibacterial activity against rifampin-resistant Escherichia coli C600 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID540946 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c31 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID209888 | Bacterial challenge for systemic murine infection against Streptococcus pneumoniae 6301 | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID604025 | Unbound CSF to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID368745 | Antimicrobial activity against Escherichia coli Ec8 expressing TEM-21 AmpC gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID524065 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID519748 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID373763 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh9 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID70733 | Evaluated for its antibacterial activity against Escherichia coli UC 6674 | 2001 | Bioorganic & medicinal chemistry letters, Nov-19, Volume: 11, Issue:22 | Enols as potent antibacterial agents. |
| AID200343 | Minimum inhibitory concentration against Salmonella (X514) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID520806 | Antimicrobial activity against Escherichia coli str. K-12 substr. DH10B harboring plasmid CTX-M-59 in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID523508 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1726 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID543818 | Bactericidal activity against Escherichia coli ATCC 25922 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID542618 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID530340 | Activity of Pseudomonas aeruginosa VIM-1 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID1126589 | Antibacterial activity against Escherichia coli at 30 ug/disc at 37 degC after 24 hrs by agar well diffusion assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, structure-activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives. |
| AID285691 | Antimicrobial susceptibility of Citrobacter freundii CF6010 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID395354 | Antibacterial activity against Bacillus cereus ATCC 7064 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID423767 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 114 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID394493 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID528536 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B514 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID576286 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17049 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID163053 | Minimum inhibitory concentration against Proteus rettgeri (C24) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID531604 | Activity of Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID523050 | Antimicrobial activity against ampicillin-nonsusceptible beta-lactamase negative Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID535901 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JS33T harboring qnrA gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID495915 | Ratio of Kcat to Km for beta-lactamase VIM-1 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID203596 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Staphylococcus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID523487 | Antimicrobial activity against Pseudomonas aeruginosa M1251 by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID373768 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh18 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID68856 | In vitro minimum inhibitory concentration was measured against Escherichia coli ATCC 25922 strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID520984 | Antibacterial activity against Escherichia coli harboring pNGR plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID522572 | Antimicrobial activity against Escherichia coli isolate 7014517 with AmpC beta-lactamase 295 Ins LAA mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID587531 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 4 ug/ml Tazobactam beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID554990 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 65 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID575420 | Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e assessed as growth inhibition after 16 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID67540 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Enterobacter | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID582764 | Antimicrobial activity against eaeA negative verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID93995 | In vitro antimicrobial activity against Klebsiella X26 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID529572 | Antimicrobial activity against Erwinia carotovora subsp. atroseptica DSM 30184 after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID523036 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID322313 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID562220 | Antimicrobial activity against Desulfovibrio sp. by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID368497 | Activity of Klebsiella oxytoca beta-lactamase K1assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID395735 | Antimicrobial activity against imipenem-susceptible invasive nontypeable Haemophilus influenzae isolate 251 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID573503 | Antibacterial activity against Escherichia coli isolate Ec9381 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID325447 | Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID278598 | Inhibitory activity against Klebsiella pneumoniae 35 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID285440 | Antimicrobial activity against Escherichia coli DH10B expressing GIL1 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID573504 | Antibacterial activity against Morganella morganii isolate Mm1229 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID587730 | Activity of Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-18 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID322316 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID495655 | Antimicrobial activity against Pseudomonas aeruginosa 51170 expressing beta-lactamase BEL-1 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID577714 | Ratio of MIC wild-type Listeria monocytogenes EGD-e Serovar 1/2a to MIC for telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics. |
| AID495825 | Antimicrobial activity against Providencia stuartii 6858 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID205971 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 29213 (inducible, low level beta-lactamase producer) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID530510 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 6138-03 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID521996 | Antimicrobial activity against Escherichia coli isolate J53 harboring p3A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID548024 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237H mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID535720 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-A | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID530602 | Antibacterial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID564531 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid with entire blaAmpC gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID156272 | Concentration required for 90% inhibition against 90 kDa penicillin-binding protein 1a binding using [14C]-Pen G as the radioligand. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID534170 | Antimicrobial activity against armA positive Escherichia coli TOP10 harboring plasmid COP1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID495843 | Ratio of Kcat to Km for Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID542057 | Antibacterial activity against Klebsiella pneumoniae D expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID326271 | Activity of Escherichia coli K12 beta-lactamase CARB1 relative to penicillin G | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID564213 | Antimicrobial activity against Acinetobacter baumannii ATCC 135040 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID576271 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18567 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID583026 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli EC-6 plasmid carrying AmpC-B2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID559711 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus P1386 at 200 ug/ml after 9 hrs by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID523515 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1253 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID498835 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU4 deficient in SHV-1, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID583024 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli ECB2 plasmid carrying CMY-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID373055 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID567459 | Antimicrobial activity against Escherichia coli W3110 transformant harboring bla CTX-M-15 gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID495661 | Activity at Pseudomonas aeruginosa 531 beta-lactamase BEL-2 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID545458 | Antimicrobial activity against Serratia marcescens assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID584496 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae KPBj3 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID373771 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh29 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID523044 | Antimicrobial activity against Corynebacterium jeikeium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID532203 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99 harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID701869 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID555223 | Activity of Acinetobacter genomosp. 3 isolate 65 ADC-14 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID530814 | Antibacterial activity against Klebsiella pneumoniae 11978 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID573515 | Antibacterial activity against Serratia marcescens isolate Sm220 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID519661 | Antimicrobial activity against Escherichia coli EPI300 harboring GM2995 pCC1 carrying beta-lactamase CTX-M-3 Ser167 mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID524047 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID535903 | Antimicrobial activity against aac(6')-Ib-cr-negative Escherichia coli PU12 harboring GyrA S83L mutant, wild-type GyrB, ParC and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID554988 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 56 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID530520 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 9171-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID558325 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P850 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID558326 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1962 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID373059 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID285267 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM29 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID203147 | In vitro minimum inhibitory concentration was measured against Serratia marcescens 1071(beta lactamase producer) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID405304 | Antibacterial activity against beta-lactamase producing amoxicillin-clavulanic acid-resistant Haemophilus influenzae isolate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID64388 | In vitro evaluation of antimicrobial activity against Enterobacter cloacae EB5 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID285256 | Antimicrobial activity against Escherichia coli DH5-alpha CF1295 isolate expressing CMT and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID587974 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 C69A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID498832 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae CY1 deficient in SHV-11, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID406622 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID531602 | Antimicrobial activity against Escherichia coli JM109 harboring pE1MD plasmid expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID583030 | Antimicrobial activity against Escherichia coli TOP10 transformed with Enterobacter asburiae CIP 105006 plasmid carrying ACT-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID340726 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-15 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID64225 | Minimum inhibitory concentration against Escherichia coli DCO (inoculum, 10e4 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID394494 | Antimicrobial activity against Escherichia coli MC4100 harboring pACYC184 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID535868 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ51 harboring qnrA gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID558802 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Klebsiella oxytoca assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID405301 | Antibacterial activity against beta-lactamase nonproducing ampicillin susceptible Haemophilus influenzae isolate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID535895 | Antimicrobial activity against aac(6')-Ib-cr-negative Citrobacter freundii JN64T harboring qnrA gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID564216 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 harboring plasmid PH98 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID544962 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV and CTX by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID495635 | Activity of Pseudomonas luteola LAM Beta-lactamase LUT-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID561444 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK carrying beta-lactamase CMY-33 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID323039 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Klebsiella pneumoniae isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID547769 | Antimicrobial activity against Escherichia coli DH10B harboring plasmid pBC SK(+) carrying wild type beta-lactamase KPC-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID499059 | Antimicrobial activity against carbapenem-resistant Enterobacter aerogenes PU41 deficient in CTX-M-14, DHA-1, qnrS1, ompC DEc, ompF by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID95908 | Bacterial challenge for systemic murine infection against Klebsiella pneumoniae A | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID560703 | Ratio of Kcat to Km for Escherichia coli MC4100 Beta-Lactamase CMY-2 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID524044 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID558534 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1699 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID395734 | Antimicrobial activity against imipenem-susceptible invasive nontypeable Haemophilus influenzae isolate 248 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID520976 | Antibacterial activity against Pseudomonas aeruginosa KG2505 harboring pCOL plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID396032 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID543482 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 murM, pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID524221 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID532677 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as intermediate resistant isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID368748 | Antimicrobial activity against Klebsiella pneumoniae Kp1 expressing SHV-4 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID497691 | Antimicrobial activity against colistin-resistant Klebsiella pneumoniae isolated from bacteremia patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. |
| AID1056840 | Antibacterial activity against CTX-15 expressing Aeromonas caviae isolate 258 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID573513 | Antibacterial activity against Escherichia coli isolate Ec158 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID499065 | Antimicrobial activity against carbapenem-resistant Enterobacter aerogenes WH85 deficient in TEM-1, CTX-M-3, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID555222 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 195 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID597608 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID523028 | Antimicrobial activity against Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID495803 | Antimicrobial activity against Escherichia coli 2603 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID498825 | Antimicrobial activity against Citrobacter freundii SZ62T expressing IMP-4, qnrS1by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID544440 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID423762 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 107 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID1762807 | Antibacterial activity against against Escherichia coli 24 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID155827 | Concentration required for 90% inhibition against 60 kDa penicillin-binding protein 3 binding using [14C]-Pen G as the radioligand. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID531090 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC244 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID562775 | Antimicrobial activity against Escherichia coli DH10B by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID495822 | Antimicrobial activity against Klebsiella pneumoniae 6828 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID330966 | Antimicrobial activity against ampD deficient Escherichia coli in medium containing EtbuPUG by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID394486 | Ratio of Kcat to Km for Escherichia coli beta-lactamase ACC4 by UV spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID559709 | Antimicrobial activity against penicillin-sensitive Staphylococcus epidermidis P1111 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID567475 | Antimicrobial activity against gBLPACR-2 Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID395349 | Antibacterial activity against Escherichia coli ATCC 11230 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID40190 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Bacillus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID522387 | Antimicrobial activity against Escherichia coli TOP10 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID548036 | Antimicrobial activity against Escherichia coli DH10B by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID519006 | Antimicrobial activity against Escherichia coli HB101 harboring empty vector pBK-SK by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID567462 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080048Ty by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID423760 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 105 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID532194 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii TJ15T harboring wild-type GyrA, ParC, GyrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID542047 | Antibacterial activity against Escherichia coli TrC A expressing Klebsiella pneumoniae A blaCTX-M beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID519630 | Antimicrobial activity against Escherichia coli JM83 harboring beta-lactamase OXA-63 after 3 days by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID495807 | Antimicrobial activity against Escherichia coli C600 2878 transconjugate expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID520393 | Antibacterial activity against mef-positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID681373 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3 | Interaction of human organic anion transporters with various cephalosporin antibiotics. |
| AID530509 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 3789-04 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID545144 | Activity of CMY-2 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID547777 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237G mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID529649 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-16 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID495346 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Ser357Asp, Ala437Ser, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID372610 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-1 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID521825 | Antimicrobial activity against beta-lactam resistant Streptococcus pneumoniae clinical isolate by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID567458 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080048Ty by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID163942 | The compound was tested in vitro for minimum inhibitory concentration against Pseudomonas aeruginosa 8780 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID585673 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID524924 | Antimicrobial activity against beta lactamase CTX-M-10 producing Escherichia coli MI1443 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID1209735 | Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID533205 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as susceptible isolates by PK/PD technique | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID374023 | Activity of Enterobacter cloacae IMI1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. |
| AID613257 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 after 24 hrs by NCCLS M7-A6 broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. |
| AID495321 | Antimicrobial activity against beta-lactamase-negative, ampicillin-sensitive Haemophilus influenzae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID198322 | The compound was tested in vitro for minimum inhibitory concentration against Streptococcus pyogenes | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID535879 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID529656 | Ratio of Kcat to Km for Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID495808 | Antimicrobial activity against Escherichia coli DH5alpha 2878 transformant expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID534761 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 03-287 harboring glpT gene with 405[5-bp duplication]411 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID1129350 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 18 hrs by microdilution broth method | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7 | Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli. |
| AID1765577 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID585178 | Activity of Beta-lactamase GES-5 E104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1435413 | Anti-bacterial activity against Escherichia coli ATCC 11303 measured after 24 hrs by microtiter broth dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID531607 | Ratio of Kcat to Km for Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID210248 | Antibacterial activity against Streptococcus pyogenes | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID521300 | Antimicrobial activity against SHV-5 producing Klebsiella pneumoniae with PFGE pulsotype D by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID279182 | Antibacterial activity against Enterobacter cloacae S3 isolate by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID542061 | Antibacterial activity against Klebsiella pneumoniae A expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID657439 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID535713 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID585835 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampGh1 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID604023 | Ratio of total drug level in brain to plasma in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID573532 | Antibacterial activity against Klebsiella pneumoniae Kp2730 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 and dfrA12-orfF-aadA2 arrays by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID544435 | Antimicrobial activity against Escherichia coli MC4100A harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID701873 | Antibacterial activity against multidrug resistant NDM-1 producing Escherichia coli isolate after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID520809 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype C by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID156274 | Evaluated for concentration required for 90 % inhibition of [14C]- penicillin G binding to PBP's of Escherichia coli UB 1005 as penicillin-binding protein 1b 90 kDa | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID542627 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID523026 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID561317 | Antimicrobial activity against Enterobacter cloacae isolate 153 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID573500 | Antibacterial activity against Klebsiella pneumoniae isolate Kp38009 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID519008 | Activity of Beta-lactamase TEM-149 expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID544443 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID447076 | Antibacterial activity against Proteus vulgaris ATCC 8427 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID585199 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-5 E104, S170 mutant by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID559261 | Antimicrobial activity against Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID525547 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1050 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID295105 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID544539 | Antimicrobial activity against Escherichia coli DH5[alpha] by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID1661686 | Antimicrobial activity against Escherichia coli ATCC 8739 assessed as inhibition of microbial growth incubated for 24 hrs | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Tailoring the Physicochemical Properties of Antimicrobial Peptides onto a Thiazole-Based γ-Peptide Foldamer. |
| AID564535 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position and R210P substitution by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID530347 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M carrying blaCTX-M-15 and pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID559683 | Antibacterial activity against Acinetobacter baumannii BM4674 isolated from the tibia fracture of a patient by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID561327 | Antimicrobial activity against Klebsiella pneumoniae isolate 202 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID524189 | Clearance in infant during extracorporeal membrane oxygenation at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID555218 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 65 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID495841 | Ratio of Kcat to Km for beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID562337 | Activity at Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID374138 | Antimicrobial activity against CTX-M ESBL producing isolate of Escherichia coli at 30 ug by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system. |
| AID558538 | Antibacterial activity against bla-positive and beta-lactamase-weakly positive Campylobacter coli isolate P1627 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID583098 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID252635 | Bacterial susceptibility induced by D121 mutation in Escherichia coli OmpF | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID495797 | Activity at Pseudomonas fluorescens PF-1 beta-lactamase BIC-1 expressed in Escherichia coli DH10B carrying pSau1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID558327 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P285 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID531676 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid containing OXA-58-3 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID519642 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID560131 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID520395 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Sweden 15A-25 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID65048 | In vivo protective dose was determined in infected swiss mice (120/strain) infected ip with Escherichia coli ISM with an inoculum size-0.5 mL of 10 E6 CFU/mL of suspension. Activity value range is 0.118-0.615 | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID395730 | Antimicrobial activity against imipenem-resistant invasive nontypeable Haemophilus influenzae isolate 183 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID523027 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID556340 | Activity of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID584561 | Antimicrobial activity against Acinetobacter lwoffii isolate H expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID373207 | Antimicrobial activity against Bacillus clausii ATCC 21536 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID164871 | Evaluated for its antibacterial activity against Pseudomonas aeruginosa UC 6676 | 2001 | Bioorganic & medicinal chemistry letters, Nov-19, Volume: 11, Issue:22 | Enols as potent antibacterial agents. |
| AID495329 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Ala502Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID498828 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae SZ92 deficient in IMP-4, TEM-1, CTX-M-14, DHA-1, qnrB10/B4-like, aac(6')-Ib, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID534765 | Antimicrobial activity against Escherichia coli CSH-2 conjugant of strain C316 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID534756 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 05-244 harboring glpT gene with 328[14-bp duplication]343, uhpT gene with 1173[96-bp deletion]1270 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID547773 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237A mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID544569 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 7668 expressing bla SHV-48 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID555224 | Ratio of Kcat to Km for Acinetobacter genomosp. 3 isolate 65 ADC-14 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID529904 | Antimicrobial activity against Leptospira interrogans serovar Canicola isolate 11 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID535679 | Antimicrobial activity against beta-lactamase negative Haemophilus influenzae expressing fst1 gene assessed as resistant isolates by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID531317 | Activity of Escherichia coli beta-lactamase VIM-1 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID495912 | Hydrolytic activity of beta-lactamase VIM-19 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID406621 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID524931 | Antimicrobial activity against Escherichia coli MI1443 harboring P167S and D240G mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID495331 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Gly490Glu, Ala502Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID156118 | Affinity for penicillin binding protein 1a of Escherichia coli UB1005 (DC0) was evaluated. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID373767 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh17 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID324362 | Ratio of kcat to Km for Acinetobacter johnsonii SCO1 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID521349 | Antimicrobial activity against Streptococcus pneumoniae isolate 909 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1765575 | Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID511289 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-1 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID521994 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBb containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID585446 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAK harboring pUCP24 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID544961 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase CTX by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID521285 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype I by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID535669 | Antimicrobial activity against beta-lactamase positive, ampicillin-clavulanic acid resistant Haemophilus influenzae expressing fst1 mutant gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID585439 | Antimicrobial activity against ampGh1 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID1295318 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by CLSI/NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID524934 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, A77V and D240G mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID528784 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID535681 | Antimicrobial activity against beta-lactamase negative Haemophilus influenzae expressing fst1 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID131717 | Effective dose against mouse infected with Streptococcus pneumoniae 6301(LDs-5623) | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID520384 | Antimicrobial activity Escherichia coli DH5alpha expressing beta lactamase VIM-2 by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID524328 | Clearance in infant weighing 2 to 6.2 kg weight after extracorporeal membrane oxygenation at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose measured after 72 hrs | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID96241 | In Vitro minimal inhibitory concentration against Klebsiella pneumoniae (NCTC 418) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID164738 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Pseudomonas aeruginosa 1771 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID522385 | Antimicrobial activity against Aeromonas enteropelogenes M1 hyperproducing beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID560497 | Activity of Escherichia coli MC4100 Beta-Lactamase CMY-30 harboring Val211?Gly211 mutation | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID585453 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampG deficient Pseudomonas aeruginosa PAO1 harboring pZY0901 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID524923 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, A77V, N114D, A140S, D240G, D288N mutations in beta lactamase CTX-M-32 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID535864 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ47T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID278601 | Inhibitory activity against azide-resistant Escherichia coli J53 T07-006 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID531969 | Antibacterial activity against Klebsiella pneumoniae blood isolate A28008 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID531974 | Antibacterial activity against Escherichia coli DH10B by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID562574 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID563970 | Antibacterial activity against Escherichia coli J53 harboring beta-lactamase NDM-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID530330 | Antimicrobial activity against Escherichia coli XL1-Blue by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID573494 | Antibacterial activity against Enterobacter cloacae isolate El3518 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID524247 | Antimicrobial activity against Escherichia coli INSRA4590 expressing SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID535359 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID557799 | Antimicrobial activity against Escherichia coli J53 by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. |
| AID368502 | Activity of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID1056838 | Antibacterial activity against CTX-15 expressing Escherichia coli isolate 4024 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID368494 | Ratio of Kcat to Km of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495339 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Ser357Asp, Met377Ile, Ser385Thr, Arg517His substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID532031 | Antimicrobial activity against Escherichia coli TOP10F' by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID548262 | Ratio of Kcat/Km for Klebsiella pneumoniae 1534 beta-lactamase KPC-2 T237A mutant by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID524218 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524208 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID498817 | Antimicrobial activity against Klebsiella pneumoniae FZ49T expressing IMP-8, TEM-1, CTX-M-14, qnrB2, aac(6')-Ib by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535719 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-B2 S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID510512 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate W2AC8-S10 expressing OXA-51 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID499073 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae SZ93 deficient in ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID524045 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524935 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, N106S mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID531087 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC204 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID155826 | Evaluated for concentration required for 90 % inhibition of [14C]- penicillin G binding to PBP's of Escherichia coli UB 1005 as penicillin-binding protein 3 60 kDa | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID585642 | Antimicrobial activity against ampD, ampDh1, ampDh2 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID531082 | Antimicrobial activity against CTX-M-14, TEM-1 beta-lactamase producing Escherichia coli isolate CUMC174 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID532200 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae WH42T harboring qnrA gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID534169 | Antimicrobial activity against armB positive Escherichia coli COP producing beta lactamase CTX-M-14 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID555213 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 195 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID155832 | The compound was evaluated for the inhibition of [14C]- Pen G binding to Escherichia coli UB1005 penicillin-binding protein 1b 90 kDa. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID523041 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID529659 | Activity of Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID498822 | Antimicrobial activity against Klebsiella pneumoniae WH77 expressing IMP-4, TEM-1, SHV-14, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519657 | Antimicrobial activity against Escherichia coli EPI300 Irk1224 type 1 mutant harboring beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID519641 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID544494 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase KPC-5 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID285265 | Antimicrobial activity against Escherichia coli DH5-alpha isolate expressing pBK-CMV by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID523489 | Antimicrobial activity against Pseudomonas aeruginosa R20 Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID429082 | Antibacterial activity against penicillin-intermediate resistant Neisseria meningitidis clinical isolates harbouring altered penA gene after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Combined real-time PCR and pyrosequencing strategy for objective, sensitive, specific, and high-throughput identification of reduced susceptibility to penicillins in Neisseria meningitidis. |
| AID495632 | Antimicrobial activity against Pseudomonas luteola expressing blaLUT-2 to blaLUT-6 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID495509 | Antibacterial activity against Acinetobacter baumannii BM4587 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID567272 | Ratio of Kcat to Ki for Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID495804 | Antimicrobial activity against Klebsiella pneumoniae 2878 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID555215 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 14 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID205978 | In Vitro minimal inhibitory concentration against Staphylococcus aureus (FDA 209P) | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24 | Syntheses of new isodethiaazacephems as potent antibacterial agents. |
| AID559901 | Antimicrobial activity against Klebsiella pneumoniae 278sp by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID564530 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid with entire blaAmpC gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID535675 | Antimicrobial activity against beta-lactamase positive Haemophilus influenzae expressing fst1 gene assessed as resistant isolates by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID535695 | Antimicrobial activity against Azide-resistant Escherichia coli J53 transconjugant harboring Escherichia coli DH5alpha-5825 qnrB2 gene by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID585445 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 harboring pZY0908 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID530505 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype II isolate 3776-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID535721 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-A | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID555227 | Activity of Acinetobacter genomosp. 3 isolate 195 ADC-18 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID522390 | Activity of Escherichia coli K-12 Beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID68854 | In vitro minimum inhibitory concentration was measured against Escherichia coli 257 strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID1295319 | Antimicrobial activity against Candida albicans ATCC 14154 incubated for 24 hrs by CLSI/NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID33699 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Alcaligenes | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID587962 | Activity of Escherichia coli beta-lactamase Toho-1 N104A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID612540 | Binding affinity to human PepT2 in SKTP cells | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. |
| AID499070 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae GZ84 deficient in SHV-11, aac(6')-Ib-cr, ompK35 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID510509 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate MC4AC9-30 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID396031 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID657436 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID561316 | Antimicrobial activity against Enterobacter cloacae isolate 101 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID520382 | Antimicrobial activity Escherichia coli DH5alpha harboring bacteriophage T4 plasmid alpha omega by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID520639 | Antimicrobial activity against Escherichia coli MRY05-3283 expressing qepA and rmtB gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID70597 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Escherichia coli DC 2 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID544493 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase KPC-4 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID547765 | Antimicrobial activity against Escherichia coli DH10B harboring plasmid pBR322-catI carrying beta-lactamase KPC-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID535342 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID206117 | In vitro antibacterial activity against Staphylococcus aureus 95(MR) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID44047 | Minimum protective concentration against beta-lactamase in Staphylococcus aureus (95 strain) | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID560705 | Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-30 using cephalothin as reporter substrate | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID555210 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 103 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID499055 | Antimicrobial activity against Escherichia coli PU101T expressing CMY-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID64387 | In vitro evaluation of antimicrobial activity against Escherichia coli EC14 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID528530 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B40 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID544514 | Metabolic stability in Escherichia coli TOP10 harboring beta-lactamase KPC-4 assessed as hydrolysis rate per mg of extracts at 100 uM after 5 mins by spectrophotometric analysis | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID561105 | Antibacterial activity against Pasteurella multocida BB1039 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID522025 | Antimicrobial activity against Escherichia coli isolate A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID561314 | Antimicrobial activity against Enterobacter cloacae isolate 37 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1056857 | Antibacterial activity against Clostridium perfringens FNSST 4999 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID543798 | Antimicrobial activity against Streptococcus pyogenes VT 59 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID373753 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab4 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID562736 | Antimicrobial activity against Klebsiella pneumoniae AH24-270 expressing blaCTX-M-71 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID608253 | Antibacterial activity against 1 x 10'4 cfu/mL Escherichia coli ATCC 11303 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID558332 | Antibacterial activity against Campylobacter jejuni isolate P338 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1321399 | Bactericidal activity against amoxicillin-resistant Escherichia coli isolate G28 harboring beta-lactamase by broth microdilution method | 2016 | Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19 | The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases. |
| AID528531 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B60 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID524257 | Ratio of Kcat to Km in Escherichia coli beta-lactamase SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID1056836 | Antibacterial activity against CTX-15 expressing Escherichia coli isolate 235 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID535677 | Antimicrobial activity against beta-lactamase positive Haemophilus influenzae expressing fst1 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID422493 | Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID531086 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC203 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID200862 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Salmonella Typhimurium | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID521298 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype B by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID557095 | Binding affinity to first site on human serum albumin by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID567305 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2203 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID405318 | Antibacterial activity against Haemophilus influenzae group III-like isolates with ftsI gene mutation by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID523033 | Antimicrobial activity against Enterococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID205895 | Minimum inhibitory concentration against Staphylococcus epidermidis (222) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID535673 | Antimicrobial activity against beta-lactamase negative, ampicillin-resistant Haemophilus influenzae expressing fst1 mutant gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID573526 | Antibacterial activity against Klebsiella pneumoniae isolate Kp204 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID279812 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZR01 from patient sputum by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID534082 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID68367 | In vitro minimum inhibitory concentration was measured against Enterobacter cloacae 5699 strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID209878 | tested for its efficacy against systemic murine infection caused by Streptococcus pneumoniae 6301. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID576299 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 25008 by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID330969 | Antimicrobial activity against wild type Escherichia coli transfected with pCF1 by agar diffusion assay | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID667375 | Antibacterial activity against Bacillus subtilis ATCC 33712 after 24 hrs by microtiter broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives. |
| AID587971 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 A237A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID573520 | Antibacterial activity against Klebsiella pneumoniae isolate Kp266 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID498818 | Antimicrobial activity against Klebsiella pneumoniae GZ64 expressing IMP-4, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID531535 | Antibacterial activity against extended-spectrum beta-lactamase-producing Klebsiella pneumoniae | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Extended-spectrum beta-lactamase production is associated with an increase in cell invasion and expression of fimbrial adhesins in Klebsiella pneumoniae. |
| AID573499 | Antibacterial activity against Citrobacter amalonaticus isolate Ca38009 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID325443 | Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID585196 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-6 K104, S170 mutant by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID532176 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae SH39T harboring qnrA gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID495332 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Ser311Pro, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID559688 | Antibacterial activity against ESBL-positive and OmpF and OmpC porin-deficient Escherichia coli HB4 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID535691 | Antimicrobial activity against beta-lactamase CTX-M-15-producing fluoroquinolone-resistant Escherichia coli FMV5825 expressing qnrB2 and aac(6')-Ib-cr and harboring gyrA Ser83Ile and Asp87Asn mutant gene and ParC Ser80Ile and Glu84Val mutant gene obtained | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID542623 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338P mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID584493 | Antibacterial activity against porin deficient OmpA positive extended-spectrum beta-lactamase producing Klebsiella pneumoniae KPBj1 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID1543305 | Antimicrobial activity against Escherichia coli ATCC 35218 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID564529 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID373987 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr deficient Escherichia coli J53 qnrA1 bearing pHS4 transconjugant from Enterobacter cloacae 91 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID573533 | Antibacterial activity against Enterobacter cloacae El3518 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID520327 | Antimicrobial activity against Acinetobacter baumannii isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Outbreak of Acinetobacter baumannii with chromosomally encoded VIM-1 undetectable by imipenem-EDTA synergy tests. |
| AID532166 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii PU55 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB, qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID567460 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080048Ty transconjugant harboring bla CTX-M-15 gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID524031 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 1564 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID285269 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM28 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID520798 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype F by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID528602 | Antimicrobial activity against blaKPC-2, blaKLUC-2 and blaTEM-1 producing Enterobacter cloacae 7506 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID542613 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338A mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID447071 | Antibacterial activity against Escherichia coli ATCC 11230 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID681344 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | 2002 | Life sciences, Mar-08, Volume: 70, Issue:16 | Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. |
| AID535727 | Antibacterial activity against Klebsiella pneumoniae urine isolate A28011 PFGE pattern A expressing KPC-2 CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID535698 | Antimicrobial activity against Azide-resistant Escherichia coli J53 by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID584838 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID207355 | In vitro minimum inhibitory concentration was measured against Staphylococcus aureus 67-0 (Methicillin resistant) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID285157 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent susceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID545425 | Antimicrobial activity against Enterobacter aerogenes obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID205699 | Minimum inhibitory concentration for prevention of visible growth of Staphylococcus aureus (FDA 209P strain) | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID534760 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 03-286 harboring glpT gene with 405[5-bp duplication]411 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID585182 | Ratio of Kcat to Km for Beta-lactamase GES-7 K104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID524216 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID542058 | Antibacterial activity against Klebsiella pneumoniae C expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID518522 | Antimicrobial activity against Capnocytophaga sputigena CIP 104301T after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID203622 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Staphylococcus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID528606 | Activity of Escherichia coli 2138 beta-lactamase KPC-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID471357 | Antibacterial activity against Candida albicans CECT 170 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID701874 | Antibacterial activity against multidrug resistant ESBL producing Escherichia coli isolate after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID535882 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID544423 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID269449 | Antibacterial activity against TEM1 beta-lactamase Escherichia coli IV-3-2 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID368500 | Ratio of Kcat to Km of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID535716 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-B2 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID519010 | Activity of Beta-lactamase TEM-149 T182M mutant expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID585443 | Antimicrobial activity against ampG, ampGh1 deficient Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID530522 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607-03 expressing pbp2x Q557E mutant and harboring plasmid expressing wild-type pbp2x by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID495792 | Antimicrobial activity against Escherichia coli DH10B harbouring recombinant plasmid pSau1 expressing beta-lactamase BIC-1 from Pseudomonas fluorescens PF-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID340736 | Activity of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID764529 | Chemical stability of the compound in simulated gastric fluid assessed as compound remaining at 10 uM after 60 mins at pH 1.2 | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis. |
| AID573721 | Antibacterial activity against Escherichia coli Ec221 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID597605 | Antibacterial activity against Streptococcus pyogenes CIP 104226 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID535645 | Antimicrobial activity against Group B Streptococcus serotype Ia N1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID558318 | Antibacterial activity against Campylobacter jejuni by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID678819 | TP_TRANSPORTER: inhibition of PGF2alpha in OAT2-S2 cells | 2003 | European journal of pharmacology, Mar-28, Volume: 465, Issue:1-2 | Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. |
| AID520698 | Antimicrobial activity against Escherichia coli isolate DH10B by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID544428 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID95554 | Minimum inhibitory concentration against Klebsiella (KAE beta-lactamase containing) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID495335 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Ser357Asp, Ser385Thr, Leu389Phe, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID498816 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae FZ49 deficient in IMP-8, TEM-1, SHV-11, CTX-M-14, qnrB2, aac(6')-Ib, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519645 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2320 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID372608 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-12 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID584555 | Antimicrobial activity against Acinetobacter lwoffii isolate B expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID285443 | Ratio of kcat to Km of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID68666 | In vitro antibacterial activity was determined against Escherichia coli ATCC 25922 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID1309044 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate SDSM1503 after 24 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis of riccardin D derivatives as potent antimicrobial agents. |
| AID587979 | Antibacterial activity against Escherichia coli AS226 carrying pBSDN104D mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID661606 | Antibacterial activity against Escherichia coli expressing CTX-M-14 beta-lactamase | 2012 | Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5 | Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase. |
| AID567308 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2206 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID523492 | Antimicrobial activity against Pseudomonas aeruginosa 2779-con by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID524199 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID559702 | Antimicrobial activity against Staphylococcus aureus AB94004 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID587528 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 1 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID531647 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC180 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID425863 | Antimicrobial activity against Carnobacterium divergens CIP101029 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID521347 | Antimicrobial activity against Streptococcus pneumoniae isolate k-598 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID562813 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pEK516 plasmid encoding CTX-M extended-spectrum beta-lactamases | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID368740 | Antimicrobial activity against Escherichia coli Ec2 containing pEc1-D plasmid expressing CTX-M-15 TEM-1 OXA-1gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID534388 | Antibacterial activity against Escherichia coli JM109 harboring recombinant pKHM-1 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID64082 | Minimum inhibitory concentration against Escherichia coli A8 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID295120 | Antibacterial activity against Micrococcus luteus La 2971 at 30 ug by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID559278 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Providencia stuartii Ps5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID499063 | Antimicrobial activity against Escherichia coli HX74T expressing CTX-M-3 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID542056 | Antibacterial activity against Klebsiella pneumoniae expressing CTX-M group 1 beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID1592958 | Antibacterial activity against multi-drug resistant Escherichia coli NMI 3898/15 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID542720 | Antimicrobial activity against ESBL-producing Klebsiella pneumoniae clinical isolate assessed as susceptible isolates | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID584557 | Antimicrobial activity against Acinetobacter lwoffii isolate D expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID573509 | Antibacterial activity against Citrobacter amalonaticus isolate Ca1614 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID532205 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID530518 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 4857-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID330965 | Antimicrobial activity against ampD deficient Escherichia coli by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID585678 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID555226 | Ratio of Kcat to Km for Acinetobacter genomosp. 3 isolate 103 ADC-16 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID544950 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID543278 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and Streptococcus pneumoniae 72521 pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID499050 | Antimicrobial activity against Klebsiella pneumoniae PU104T expressing TEM-1, CTX-M-15 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID542759 | Antimicrobial activity against Escherichia coli Du19 expressing qnrB6 and CTX-M-9G genes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID575944 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID520383 | Antimicrobial activity Escherichia coli DH5alpha expressing metallo-beta-lactamase VIM-11 by agar macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID495848 | Antimicrobial activity against Escherichia coli DH10B transfected with pBK-L3 expressing blaLUT-1 by Etest method in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID535876 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JN1T by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID495914 | Hydrolytic activity of beta-lactamase VIM-1 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID585450 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampG deficient Pseudomonas aeruginosa PAO1 harboring pUCP24 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID519407 | Antibacterial activity against 16S rRNA methylase rmtB and CTX-M-65 ESBL producing rifampin resistant Escherichia coli isolate ECRB1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United States. |
| AID499048 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae GZ83 deficient in SHV-11, CTX-M-14, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID151370 | Minimum inhibitory concentration against Proteus mirabilis A18 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID567470 | Antimicrobial activity against gBLNAS Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID1309045 | Antifungal activity against clinical isolates of Candida albicans SC5314 after 48 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis of riccardin D derivatives as potent antimicrobial agents. |
| AID543809 | Bactericidal activity against Escherichia coli ATCC 25922 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID613260 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by NCCLS M38-P broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. |
| AID524056 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID522392 | Ratio of Kcat Km for Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID531071 | Antimicrobial activity against CMY-2,CTX-M-14,TEM-2-like beta-lactamase producing Klebsiella pneumoniae isolate CUMCK2 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID322322 | Antibacterial activity against Escherichia coli INSRA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID549337 | Antimicrobial activity against Escherichia coli ATCC 25922 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID1127077 | Antibacterial activity against Bacillus subtilis assessed as growth inhibition after 18 hrs by agar diffusion method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Absolute configuration of (13R)- and (13S)-labdane diterpenes coexisting in Ageratina jocotepecana. |
| AID322314 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID530817 | Antibacterial activity against Escherichia coli J53 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID562339 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-5 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID562473 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 transconjugant expressing beta-lactamase KPC-2/TEM-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID530511 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 7507-03 expressing pbp2x Q557E mutant and multilocus sequence type ST19 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID95555 | Minimum inhibitory concentration against Klebsiella (X26) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID203306 | The compound was tested in vitro for minimum inhibitory concentration against Serratia marcescens 1071 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID524046 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID528524 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID542062 | Antibacterial activity against Klebsiella pneumoniae D expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID429077 | Antibacterial activity against Escherichia coli J53 by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID511291 | Activity of Pseudomonas aeruginosa GES-13 beta lactamase assessed as hydrolysis by spectrometry | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID535648 | Antimicrobial activity against aac(6')-Ib-cr-positive Escherichia coli FJ3 harboring GyrA S83L, ParC S80R mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID587524 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 4 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID543275 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID523505 | Antimicrobial activity against Pseudomonas aeruginosa isolate 12142c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID573507 | Antibacterial activity against Klebsiella oxytoca isolate Ko0426 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID562338 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID520385 | Activity at Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 by spectrometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID562331 | Antimicrobial activity against Escherichia coli DH5alpha harboring metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID542615 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID524064 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID562749 | Antimicrobial activity against Escherichia coli K-12 transconjugant harboring blaCTX-M-71 gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID519639 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2322 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID201554 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Sarcina | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID543433 | Ratio of Kcat to km for Shigella sonnei UIH-1 CTX-M-64 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID531649 | Antimicrobial activity against CTX-M-14, TEM-1 beta-lactamase producing Escherichia coli isolate CUMC174 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID522393 | Ratio of Kcat Km for Aeromonas caviae Beta-lactamase CAV1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID1765574 | Antibacterial activity against Bacillus subtilis ATCC 23857 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID547785 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237L mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID584487 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae KPBj1 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID295108 | Antibacterial activity against Proteus vulgaris ATCC 8427 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID531064 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC203 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID535344 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID528603 | Antimicrobial activity against Escherichia coli J53 harboring blaKPC-2 and blaTEM-1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID373050 | Antimicrobial activity against Bacillus clausii NR expressing beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID521299 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype C by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID1765579 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID540966 | Activity of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID523025 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID544496 | Ratio of MIC for Escherichia coli TOP10 harboring beta-lactamase KPC-4 to MIC for Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID519738 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID522001 | Antimicrobial activity against Escherichia coli isolate J53 harboring p5A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID524201 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID372619 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-1 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID543819 | Bactericidal activity against Pseudomonas aeruginosa ATCC 27853 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID52941 | In vitro antibacterial activity against Citrobacter freundii BS 16 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID531652 | Antimicrobial activity against CMY-2,TEM-2-like beta-lactamase producing Escherichia coli isolate CUMC224 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID396028 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID535756 | Antimicrobial activity against hospital-acquired Escherichia coli obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID545655 | Antimicrobial activity against Stenotrophomonas maltophilia assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID530350 | Antimicrobial activity against Escherichia coli TOP10 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID1056876 | Antibacterial activity against Clostridium perfringens FNSST 4999 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID394492 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID573527 | Antibacterial activity against Serratia marcescens isolate Sm265 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID209443 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Streptococcus pyogenes A77 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID519648 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-3 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID521306 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype J by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID519012 | Activity of Beta-lactamase TEM-10 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID544439 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID542770 | Antimicrobial activity against Escherichia coli J53 transformed with pHND2 carrying qnrB6 and CTX-M-9G genes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID573519 | Antibacterial activity against Escherichia coli isolate Ec211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID584318 | Antimicrobial activity against Serratia marcescens ATCC 8100 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Outbreak of meropenem-resistant Serratia marcescens comediated by chromosomal AmpC beta-lactamase overproduction and outer membrane protein loss. |
| AID535871 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ51T harboring qnrA gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID86140 | Minimum inhibitory concentration against Haemophilus influenzae (C.L.) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID519656 | Antimicrobial activity against Escherichia coli Irk1224 type 1 mutant harboring beta-lactamase CTX-M-3 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID227869 | Evaluated for the in vivo activity in mice against streptococcus pyogenes 4 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID528529 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B12 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID532184 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535710 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 S287N mutant protein by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID64566 | Evaluated for the minimum inhibitory concentration against Escherichia coli UB 1005 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID528533 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B502 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID495513 | Antibacterial activity against Acinetobacter baumannii BM4467 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID564527 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID587963 | Activity of Escherichia coli beta-lactamase Toho-1 D240S mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID205698 | Minimum inhibitory concentration for prevention of visible growth of Staphylococcus aureus (95 strain) | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID524259 | Ratio of Kcat to Km in Escherichia coli beta-lactamase SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID522758 | Antimicrobial activity against AmpC producing Escherichia coli Top10 isolate 7014517 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID523031 | Antimicrobial activity against vancomycin-nonsusceptible Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID529665 | Activity of Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID576293 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 11932 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID585198 | Antimicrobial activity against Escherichia coli DH5[alpha] by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID285263 | Antimicrobial activity against Escherichia coli DH5-alpha TC1295 isolate expressing TEM-1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID535340 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID521355 | Antimicrobial activity against Streptococcus pneumoniae isolate 657 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID520795 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype C by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID584554 | Antimicrobial activity against Acinetobacter lwoffii isolate A expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID1056859 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID555450 | Antibacterial activity against Escherichia coli DH5alpha by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID495658 | Antimicrobial activity against Escherichia coli TOP10 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID532163 | Antimicrobial activity against aac(6')-Ib-cr-negative Escherichia coli PU12T harboring wild-type GyrA, GyrB, ParC and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID495656 | Antimicrobial activity against Escherichia coli TOP10 expressing recombinant beta-lactamase BEL-2 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID545452 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Proteus mirabilis assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID447077 | Antibacterial activity against Mycobacterium smegmatis CCM 2067 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID520386 | Activity at Pseudomonas aeruginosa COL-1 metallo-beta lactamase VIM-2 by spectrometry | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID548000 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237N mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID206691 | tested for its efficacy against systemic murine infection caused by Staphylococcus aureus smith. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID535646 | Antimicrobial activity against Group B Streptococcus serotype III NEM 316 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID576283 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17829 by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID564228 | Activity of Escherichia coli TOP10 beta-lactamase OXA-143 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID585675 | Antimicrobial activity against ampG, ampGh1 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID587960 | Activity of Escherichia coli beta-lactamase Toho-1 A237A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID521291 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype E by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID522018 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pPR containing beta-lactamase and TEM-101 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID535897 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JS33 harboring GyrA T83I mutant, wild-type ParC, GyrB, qnrA and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID582925 | Ratio of Kcat to Km for Escherichia coli BL21(DE3) VIM-2 W87F mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID555209 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 90 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID510514 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID208138 | In vitro minimum inhibitory concentration was measured against Streptococcus pneumoniae 6301 strain.; ( | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID533878 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID495510 | Antibacterial activity against Acinetobacter baumannii BM4454 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID530600 | Antibacterial activity against Aeromonas sp. isolate A72 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID207852 | The compound was tested in vitro for minimum inhibitory concentration against Staphylococcus aureus smith | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID667373 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 after 24 hrs by microtiter broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives. |
| AID163911 | Antimicrobial activity against Pseudomonas PS18 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID558319 | Antibacterial activity against Campylobacter coli by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID567306 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2204 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID269452 | Antibacterial activity against Escherichia coli X580 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID499056 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU102 deficient in TEM-1, CTX-M-14, CMY-2, aac(6')-Ib, ompC DEc, ompF by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID1762806 | Antibacterial activity against Escherichia coli 08 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID495514 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4668 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID531677 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid containing OXA-58-4 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID1762802 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID560132 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay relative to benzylpenicillin | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID548261 | Activity of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 T237A mutant by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID123087 | The compound was tested in vitro for minimum inhibitory concentration against Micrococcus luteus ATCC 9341 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID567307 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2205 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID521433 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene at 50 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID576290 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 6267 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID521295 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype I by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID522394 | Ratio of Kcat Km for Escherichia coli K-12 Beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID395738 | Antimicrobial activity against Haemophilus influenzae Rd transformed with ftsI gene from imipenem-resistant invasive nontypeable Haemophilus influenzae isolate 183 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID543415 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 transconjugant by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID555211 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 109 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID1329364 | Antibacterial activity against Staphylococcus aureus ATCC 25922 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID21914 | Relative hydrolysis rate (RHR) was evaluated against RTEM enzyme | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID519005 | Antimicrobial activity against Escherichia coli HB101 expressing recombinant plasmid encoded TEM-149 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID523493 | Antimicrobial activity against Pseudomonas aeruginosa 1405-con D2 by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID325156 | Antimicrobial activity against Haemophilus parasuis BB 1023 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID68368 | In vitro minimum inhibitory concentration was measured against Enterobacter cloacae p99 (beta lactamase producer) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID163109 | Minimum inhibitory concentration against Pseudomonas aeruginosa (X528) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID209454 | In vitro antibacterial activity against Streptococcus pyogenes 4 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID322325 | Antibacterial activity against Escherichia coli DH5 alpha-URA5924 isolates expressing CTX-M-32 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID543951 | Antibacterial activity against oxacillin, chloramphenicol, erythromycin-susceptible and tetracycline-resistant Staphylococcus aureus COL-S with SCCmec excised | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID597607 | Antibacterial activity against Enterococcus faecium CIP 54.32 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID1129348 | Antibacterial activity against NDM-1 producing Escherichia coli clinical isolate 74859898 after 18 hrs by microdilution broth method | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7 | Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli. |
| AID206097 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Streptococcus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID559263 | Antimicrobial activity against Providencia stuartii Ps5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID540943 | Antimicrobial activity against Klebsiella pneumoniae HP205 expressing CMY-36 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID405305 | Antibacterial activity against beta-lactamase nonproducing ampicillin susceptible Haemophilus influenzae isolate assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID519009 | Ratio of Kcat to Km for Beta-lactamase TEM-149 expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID608254 | Antibacterial activity against 1 x 10'4 cfu/mL Staphylococcus aureus ATCC 29213 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID518523 | Antimicrobial activity against Escherichia coli TOP10 after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID524244 | Antimicrobial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID524203 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID559898 | Antimicrobial activity against Klebsiella oxytoca KO281 harboring beta-lactamase OXY-1 and CMY-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID559904 | Antimicrobial activity against Escherichia coli TF-KP278 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID573514 | Antibacterial activity against Klebsiella pneumoniae isolate Kp149 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID544422 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID547761 | Antimicrobial activity against Klebsiella pneumoniae 1534 expressing beta-lactamase KPC-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID535757 | Antimicrobial activity against community-acquired Escherichia coli expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID567309 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2207 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID531683 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151T by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID531678 | Antimicrobial activity against Acinetobacter baumannii TVICU53 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID584492 | Antibacterial activity against porin, OmpA positive extended-spectrum beta-lactamase producing Klebsiella pneumoniae KPBj1 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID565332 | Antibacterial activity against Enterobacter hormaechei isolate UCN62 | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Emergence of an Enterobacter hormaechei strain with reduced susceptibility to tigecycline under tigecycline therapy. |
| AID373209 | Activity of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID525545 | Antimicrobial activity against Haemophilus influenzae Rd KW20 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID518724 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase DIM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID567303 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2201 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID528920 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-14 and CTX-M-27 and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID534086 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID544963 | Antimicrobial activity against Klebsiella pneumoniae expressing extended-spectrum beta-lactamase and beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID587982 | Antibacterial activity against Escherichia coli AS226 carrying pBSDD240A mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID205375 | tested for its efficacy against systemic murine infection caused by Serratia marcescens SM. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID394495 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID285258 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha CL1179 isolate expressing pBK-TEM-152 and CMT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID499069 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ91 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID495338 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID498361 | Antimicrobial activity against rifampin resistant Klebsiella pneumoniae 52deltaacrB containing isogenic acrB knockout assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID528599 | Antimicrobial activity against blaKPC-2 and blaTEM-1 producing Escherichia coli 2138 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID521287 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype A by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID341107 | Antibacterial activity against Escherichia coli transconjugant carrying pEC28 isolate eby Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID562769 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID535870 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ51T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID576311 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 29830 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID228959 | Evaluated for morphology; F represents filaments and L represents lysis | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID535894 | Antimicrobial activity against aac(6')-Ib-cr-negative Citrobacter freundii JN64T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID522008 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-2 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID547801 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237W mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID567461 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080049Ty by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID405084 | Activity of Citrobacter freundii PER2 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID495749 | Antimicrobial activity against Salmonella enterica serotype Virchow 3464b by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. |
| AID495906 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-4 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID521354 | Antimicrobial activity against Streptococcus pneumoniae isolate 4134 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID471359 | Antibacterial activity against Mycobacterium smegmatis ATCC 19420 after 48 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID585442 | Antimicrobial activity against ampGh1 deficient Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID269446 | Antibacterial activity against VRE Enterococcus faecalis 1528 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID542625 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene, disruption in PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID131716 | Effective dose against mouse infected with Staphylococcus aureus 753 (MR) (LDs-6) | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID524745 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, P167S mutation in beta lactamase CTX-M-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID530345 | Antimicrobial activity against Escherichia coli BicA expressing blaTEM-1, blaCTX-M-15 and qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID583094 | Activity of Escherichia coli XL1-Blue wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID405086 | Ratio of Kcat to Km of Citrobacter freundii PER2 beta lactamase relative to cephalothin | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID163238 | Evaluated for the minimum inhibitory concentration against Proteus vulgaris 1028 BC (Class Ic beta-lactamase overproducer | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID529662 | Ratio of Kcat to Km for Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID583097 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 A64W mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID221946 | Geometrical average of minimum inhibitory concentration in isosensitest broth against, gram-negative strains. | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID519735 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID531656 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC190 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID567463 | Antimicrobial activity against Escherichia coli W3110 transformant harboring bla CTX-M-15 gene by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID543802 | Bactericidal activity against Escherichia coli ATCC 25922 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID534084 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID567304 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2202 isolated from burn patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID681114 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID561109 | Antibacterial activity against Pasteurella multocida BB1043 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID529575 | Activity of Erwinia carotovora subsp. atroseptica DSM 30184 beta-lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID496592 | Antimicrobial activity against Escherichia coli DH10B by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. |
| AID573518 | Antibacterial activity against Klebsiella pneumoniae isolate Kp211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID524055 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID68822 | In vivo activity in murine against Escherichia coli 257 infection after sc administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID447078 | Antibacterial activity against Listeria monocytogenes ATCC 15313 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID530501 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 6649-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID524058 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1295313 | Antimicrobial activity against Candida albicans ATCC 14154 at 1 mg/ml incubated for 24 hrs by cup diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID269454 | Antibacterial activity against Salmonella enterica ATCC 13311 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID543484 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID531657 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC181 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID70740 | Minimum inhibitory concentration against Escherichia coli TEM-1 (TEM-1 (class IIIa) beta-lactamase producer) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID532208 | Antimicrobial activity against Escherichia coli J53 harboring wild-type GyrA, ParC, GyrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID523502 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1333c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID522565 | Antimicrobial activity against Escherichia coli isolate 7008211 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID587965 | Activity of Escherichia coli beta-lactamase Toho-1 C69A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID521286 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype J by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID583085 | Activity of Escherichia coli BL21(DE3) wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID545440 | Antimicrobial activity against Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID584501 | Antibacterial activity against porin deficient OmpA positive Klebsiella pneumoniae KPBj5 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID499061 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU43 deficient in TEM-1, CTX-M-14, aac(6')-Ib, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID529666 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID323042 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Proteus mirabilis assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID520977 | Antibacterial activity against Escherichia coli DH10B expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID423752 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate J4 having blaSHV promoter sequence with IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID523035 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID562757 | Ratio of Kcat to Km for Klebsiella pneumoniae AH27 CTX-M-15 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID372618 | Ratio of Kcat to Km for Escherichia coli CF0042 beta-lactamase TEM-35 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID542620 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene and Janus disruption at PBP1a after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID532199 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae WH42T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1765576 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID324359 | Antibacterial activity against Escherichia coli DH10B by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID558799 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Klebsiella oxytoca assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID471358 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID576277 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17834 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID556338 | Antimicrobial activity against Escherichia coli ATCC 25922 by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID531077 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC214 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID395356 | Antibacterial activity against Listeria monocytogenes ATCC 15313 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID560554 | Antimicrobial activity against Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID524571 | Antimicrobial activity against Shigella isolate DH-22855 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID529462 | Antimicrobial activity against Klebsiella pneumoniae isolate 11 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID541023 | Ratio of Kcat to Km for Burkholderia cenocepacia 07-34 beta-lactamase PenB1 expressed in Escherichia coli Top10 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID1592959 | Antibacterial activity against multi-drug resistant Klebsiella pneumoniae NMI 2697/14 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID534753 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 08-555 harboring glpT gene with 981[227-bp deletion]1209 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID524193 | Clearance in infant weighing 2 to 6.2 kg weight during extracorporeal membrane oxygenation at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID563976 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase VIM2 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID495798 | Ratio of Kcat to Km of Pseudomonas fluorescens PF-1 beta-lactamase BIC-1 expressed in Escherichia coli DH10B using nitrocefin hydrolysis | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID519014 | Antimicrobial activity against Enterobacter aerogenes isolate SS-13 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID535641 | Antimicrobial activity against Group B streptococcus serotype V C1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID519472 | Antimicrobial activity against Stenotrophomonas maltophilia K279a harboring -121 frameshift mutation in ampR gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator. |
| AID295114 | Antibacterial activity against Mycobacterium smegmatis CCM 2067 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID373985 | Antimicrobial activity Citrobacter freundii 64 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID587961 | Activity of Escherichia coli wild type beta-lactamase Toho-1 assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID522569 | Antimicrobial activity against Escherichia coli isolate 5000869 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID562741 | Antimicrobial activity against Escherichia coli DH5[alpha] by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID585437 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 harboring pZY0901 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID534757 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 05-690 harboring uhpA stop at amino acid at 144 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID535704 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A S287N mutant protein by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID519471 | Antimicrobial activity against Stenotrophomonas maltophilia K279a expressing beta-lactamase L1 and L2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator. |
| AID573529 | Antibacterial activity against Acinetobacter baumannii isolate AbN450 harboring IblaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID587973 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 D240A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID576320 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 31750 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID209449 | Minimum inhibitory concentration against Streptococcus pyogenes 4 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID495905 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID201950 | In vitro antimicrobial activity against Streptococcus pneumoniae PARK strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID495326 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Gly490Glu, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID498872 | Antimicrobial activity against Acinetobacter baumannii B9 containing carbapenemase blaOXA-23 gene assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate. |
| AID374141 | Antimicrobial activity against non-CTX-M ESBL producing isolate of Escherichia coli by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system. |
| AID535900 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JS33T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID547797 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237F mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID287373 | Antibacterial activity against Klebsiella pneumoniae after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID1879067 | Antibacterial activity against pET28a-NDM-1 positive Escherichia coli BL21(DE3) isolates assessed as inhibition of bacterial growth incubated for 18 to 24 hrs by CLSI based broth microdilution method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli. |
| AID374363 | Activity of Aeromonas caviae A324R metallo-beta-lactamase IMP-19 expressed in Escherichia coli DH5alpha by computerized microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID519629 | Antimicrobial activity against Escherichia coli JM83 without producing beta-lactamase OXA-63 after 3 days by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID573534 | Antibacterial activity against Citrobacter amalonaticus Ca3927 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID423771 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate 120 having upstream IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID498803 | Antimicrobial activity against Klebsiella pneumoniae ZJ18T expressing KPC-2, DHA-1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID542617 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x2349 and PBP1a2349 mutant gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID498813 | Antimicrobial activity against Escherichia coli ZJ87T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519746 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID524196 | Clearance in infant weighing 2 to 6.2 kg weight at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID549335 | Antimicrobial activity against Escherichia coli isolate Z1 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID283320 | Antimicrobial activity against Klebsiella pneumoniae KPN15-NL | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID543656 | Elimination rate constant in extracorporeal membrane oxygenation-treated human neonatal plasma treatment at 50 mg/kg BID by UPLC-MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. |
| AID582965 | Antimicrobial activity against Yersinia enterocolitica Biovar 1B 8081 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID524936 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, N106S and P167S mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID528792 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID531068 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC244 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID567280 | Activity of Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID544566 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8133 expressing bla TEM-55 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID534083 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID585836 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampG deficient Pseudomonas aeruginosa PAO1 harboring pUCP24 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl- | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID524067 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID562328 | Antimicrobial activity against Chryseobacterium indologenes 597 expressing metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID323041 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Proteus mirabilis isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID543950 | Antibacterial activity against oxacillin, chloramphenicol-susceptible and erythromycin, tetracycline-resistant Staphylococcus aureus COL | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID495341 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Ser385Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID555220 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 103 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID340728 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID206865 | Antibacterial activity against penicillin G resistance Staphylococcus aureus | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID519405 | Antibacterial activity against 16S rRNA methylase RmtB and CTX-M-65 ESBL producing Escherichia coli isolate ECRB1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United States. |
| AID528739 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B516 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID533880 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID546430 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID68007 | Bacterial challenge for systemic murine infection against Enterobacter cloacae 5699 | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID573540 | Antibacterial activity against Morganella morganii Mm38009 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID535852 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ67T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID573538 | Antibacterial activity against Citrobacter amalonaticus Ca38009 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID499054 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU101 deficient in TEM-1, CTX-M-14, CMY-2, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID509867 | Antibacterial activity against Acinetobacter baumannii isolate 2824 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID95913 | Antibacterial activity against Klebsiella pneumoniae 1082E | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID701871 | Antibacterial activity against multidrug resistant KPC producing Klebsiella pneumoniae isolate after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID583653 | Antibacterial activity against Escherichia coli TOP10 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID495325 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Ser357Asp, Met377Ile, Ser385Thr, Arg517His substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID499045 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ68T deficient in CTX-M-15, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID534385 | Antibacterial activity against Escherichia coli K-12 W1895 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID368736 | Antimicrobial activity against Enterobacter aerogenes Ea2 expressing TEM-3 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID279187 | Ratio of kcat to Km of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID543177 | Antimicrobial activity against Aeromonas hydrophila assessed as susceptibility level by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activities of tigecycline against clinical isolates of Aeromonas, Vibrio, and Salmonella species in Taiwan. |
| AID559902 | Antimicrobial activity against Escherichia coli TF-KO279 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID544558 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 7668 expressing bla SHV-48 gene by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID373211 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID499052 | Antimicrobial activity against Escherichia coli PU60T expressing CMY-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID520797 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype E by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID558796 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Escherichia coli assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID438297 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID543428 | Antimicrobial activity against Escherichia coli XL-1 Blue harboring plasmid CL1920 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID396027 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID567279 | Activity of Acinetobacter baumannii ADC-33 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID535751 | Antimicrobial activity against community-acquired Klebsiella pneumoniae obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID69484 | Minimum inhibitory concentration against Escherichia coli (EC14) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID423768 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 115 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID522383 | Inhibition of Beta-lactamase KPC-2 in Klebsiella pneumoniae isolates assessed as reduction in antimicrobial MIC of beta-lactams by agar dilution method relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID531079 | Antimicrobial activity against CMY-2,TEM-2-like beta-lactamase producing Escherichia coli isolate CUMC224 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID567326 | Antimicrobial activity against Escherichia coli ML4901 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID425866 | Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID524034 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 24 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID374140 | Antimicrobial activity against CTX-M ESBL producing isolate of Klebsiella oxytoca at 30 ug by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system. |
| AID559701 | Antimicrobial activity against Bacillus subtilis AB91021 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID521833 | Antimicrobial activity against Streptococcus pneumoniae isolated from non-meningitis patient assessed as percent resistant isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID529901 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID657437 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID164866 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Pseudomonas aeruginosa 1771 M | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID534085 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID542066 | Antibacterial activity against Escherichia coli TrC C expressing Klebsiella pneumoniae C blaCTX-M beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID495793 | Antimicrobial activity against Escherichia coli DH10B by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID534768 | Antimicrobial activity against Escherichia coli DH10B transformant containing Sac2 fragment with fosA3 gene from 08-607 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID604021 | Unbound volume of distribution in Sprague-Dawley rat brain measured per gram of brain tissue administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr b | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID68049 | The compound was tested in vitro for minimum inhibitory concentration against Enterococcus faecalis ATCC 29212 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID559900 | Antimicrobial activity against Klebsiella pneumoniae 278 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID549346 | Antimicrobial activity against Escherichia coli isolate 16 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID562811 | Antimicrobial activity against Escherichia coli J53 harboring pEK204 plasmid encoding CTX-M extended-spectrum beta-lactamases | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID373774 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh39 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID340735 | Antimicrobial activity against Escherichia coli HB101 harboring pBC-IND-5 plasmid containing metallo-beta-lactamase IND5 assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID584494 | Antibacterial activity against porin deficient OmpA positive extended-spectrum beta-lactamase producing Klebsiella pneumoniae KPBj1 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID524749 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, N114D, A140S, P167T, D288N mutations in beta lactamase CTX-M-1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID573521 | Antibacterial activity against Serratia marcescens isolate Sm211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID395352 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID544430 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID498808 | Antimicrobial activity against Klebsiella pneumoniae ZJ99 expressing KPC-2, CTX-M-3, qnrS1, ompK35 DE by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID323038 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Escherichia coli assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID531646 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC192 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID521999 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp6A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID519743 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID548258 | Ratio of Kcat/Km for Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID163394 | In vitro minimum inhibitory concentration was measured against Proteus vulgaris 1028BC (beta lactamase producer) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID558539 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P1826 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID209892 | Antibacterial activity against Streptococcus pneumoniae | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID373053 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID522380 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates in presence of 4 ug/ml by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID529459 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase Oxa-48 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID573333 | Antibacterial activity against Enterobacter cloacae isolate El3280 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID544438 | Antimicrobial activity against Escherichia coli MC4100A expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID585672 | Antimicrobial activity against ampD, ampDh2, ampDh3 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID701872 | Antibacterial activity against multidrug resistant Amp-C producing Escherichia coli isolate after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID279184 | Antibacterial activity against Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID285268 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM152 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID325157 | Antimicrobial activity against Haemophilus parasuis BB 1024 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID529657 | Activity of Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID582966 | Antimicrobial activity against beta-lactamase A-deficient Yersinia enterocolitica GY5717 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID325449 | Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID542622 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338A mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID269456 | Antifungal activity against Candida albicans BMSY 212 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID522017 | Antimicrobial activity against Providencia rettgeri isolate expressing beta-lactamase OXA-48 and TEM-101 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID560117 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID587733 | Ratio of Kcat to Km for Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID405310 | Antibacterial activity against beta-lactamase nonproducing ampicillin resistant Haemophilus influenzae isolate assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID544537 | Antimicrobial activity against Escherichia coli ATCC 25922 by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID394487 | Activity of Escherichia coli beta-lactamase ACC4 by UV spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID554989 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 60 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID559697 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. |
| AID368733 | Antimicrobial activity against Enterobacter aerogenes Ea1 expressing TEM-24b AmpC +/- TEM-1 or TEM-2 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID535636 | Antimicrobial activity against Group B streptococcus serotype VI R4 harboring Q557E mutation in PBP 2X and T567I, Y262N mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID531081 | Antimicrobial activity against CTX-M-15,OXA-30 beta-lactamase producing Escherichia coli isolate CUMC245 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID85972 | Evaluated for its antibacterial activity against Haemophilus influenzae 30063 | 2001 | Bioorganic & medicinal chemistry letters, Nov-19, Volume: 11, Issue:22 | Enols as potent antibacterial agents. |
| AID564528 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-50 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID495323 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID546432 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID519638 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2320 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID576267 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18918 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID597668 | Antibacterial activity against Haemophilus influenzae ATCC 49766 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID1661700 | Antimicrobial activity against Escherichia coli ATCC 8739 assessed as inhibition of microbial growth measured after 8 passes in presence of sublethal compound concentration concentrations | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Tailoring the Physicochemical Properties of Antimicrobial Peptides onto a Thiazole-Based γ-Peptide Foldamer. |
| AID555685 | Antimicrobial activity against Escherichia coli DH10B by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID524068 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID287377 | Antibacterial activity against Mycobacterium smegmatis after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID531315 | Activity of Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID322319 | Antibacterial activity against Escherichia coli DH5 alpha isolates by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID509865 | Antibacterial activity against Acinetobacter baumannii ATCC 17978 isolated from human CSF | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID534174 | Antimicrobial activity against armA positive Enterobacter cloacae BEH producing beta lactamase CTX-M-3 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID524059 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID583096 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 W87F mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID529661 | Activity of Pseudomonas aeruginosa 9551 beta-lactamase VIM-15 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID521356 | Antimicrobial activity against Streptococcus pneumoniae isolate 2907 obtained from sinusitis of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID575285 | Antimicrobial activity against Haemophilus influenzae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID405091 | Antimicrobial activity against non-integron carrying Enterobacteriaceae assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Enterobacteriaceae bloodstream infections: presence of integrons, risk factors, and outcome. |
| AID374139 | Antimicrobial activity against CTX-M ESBL producing isolate of Klebsiella pneumoniae at 30 ug by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a U.S. health care system. |
| AID535888 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID555680 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring phagemid pBK-CMV by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID567473 | Antimicrobial activity against gBLPAR-TEM1 Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID1363870 | Antibiofilm activity against Staphylococcus aureus ATCC 29213 at 128 ug/ml after 18 hrs by XTT-menadione assay relative to control | 2018 | Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22 | Bile Acid Oligomers and Their Combination with Antibiotics To Combat Bacterial Infections. |
| AID524195 | Elimination half life in infant weighing 2 to 6.2 kg weight during extracorporeal membrane oxygenation assessed as desacetylcefotaxime at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID523500 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1681c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID519894 | Antimicrobial activity against Escherichia coli Irk1224 harboring beta-lactamase CTX-M-3 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID524567 | Antimicrobial activity against Shigella isolate DH-20369 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID368499 | Ratio of Kcat to Km of Klebsiella oxytoca beta-lactamase K1 assessed as drug hydrolysis by spectrophotometry | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID524212 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID535858 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40T harboring qnrB gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID587959 | Activity of Escherichia coli beta-lactamase Toho-1 N104D mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID573536 | Antibacterial activity against Serratia marcescens Sm2723 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID521346 | Antimicrobial activity against Streptococcus pneumoniae isolate 2904 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID340731 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase SHV-ES by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID529647 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-15 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID205950 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Staphylococcus aureus 503 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID498360 | Antimicrobial activity against rifampin resistant Klebsiella pneumoniae 52145R assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. |
| AID530327 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pUCP carrying VIM-13 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID530325 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID528740 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 harboring PBP-2X Q557E mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID522022 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc2 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID535362 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as susceptible isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID358855 | Antibacterial activity against Bacillus subtilis by microdilution assay | 2001 | Journal of natural products, Mar, Volume: 64, Issue:3 | Isoterchebulin and 4,6-O-isoterchebuloyl-D-glucose, novel hydrolyzable tannins from Terminalia macroptera. |
| AID582763 | Antimicrobial activity against eaeA positive verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID495340 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID471599 | Antibacterial activity against Salmonella CECT 4569 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID93999 | Minimum inhibitory concentration against Klebsiella pneumoniae A24 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID561322 | Antimicrobial activity against Escherichia coli isolate 48 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID1056844 | Antibacterial activity against TEM-1/CTX-M-15 expressing Enterobacter cloacae isolate 62 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID396033 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID534391 | Antibacterial activity against Escherichia coli JM109 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID155828 | Evaluated for concentration required for 90 % inhibition of [14C]- penicillin G binding to PBP's of Escherichia coli UB 1005 as penicillin-binding protein 4 49 kDa | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID563969 | Antibacterial activity against Escherichia coli J53 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID279816 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID560128 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID573528 | Antibacterial activity against Acinetobacter isolate A74510 harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID522012 | Antimicrobial activity against Escherichia coli isolate J53 harboring pE containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID532196 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae WH42 harboring wild-type GyrA, ParC, GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID563974 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase IMP1 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID573332 | Antibacterial activity against Klebsiella pneumoniae isolate Kp2730 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 and dfrA12-orfF-aadA2 arrays by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID565337 | Antibacterial activity against Enterobacter hormaechei isolate UCN63 after 3 weeks of treatment | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Emergence of an Enterobacter hormaechei strain with reduced susceptibility to tigecycline under tigecycline therapy. |
| AID524256 | Activity at Escherichia coli beta-lactamase SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID542768 | Antimicrobial activity against Escherichia coli J53 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID520877 | Antibacterial activity against Achromobacter xylosoxidans MER by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID519659 | Antimicrobial activity against Escherichia coli EPI300 Irk1224 type 3 mutant harboring CTX-M-3 beta-lactamase Lys136 mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID330967 | Antimicrobial activity against ampD deficient Escherichia coli transfected with pCF1 by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID530500 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 5662-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID597606 | Antibacterial activity against Streptococcus mitis CIP 103335 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID520811 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype E by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID546431 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID585177 | Activity of Beta-lactamase GES-2 E104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1543304 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID543483 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a and Streptococcus pneumoniae 72521 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID524750 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, D240G mutations in beta lactamase CTX-M-15 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID544436 | Antimicrobial activity against Escherichia coli CU164A harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1056854 | Antibacterial activity against Pseudomonas aeruginosa FNSST 982 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID543427 | Antimicrobial activity against Escherichia coli XL-1 Blue harboring plasmid CL1920 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID96244 | In vitro antibacterial activity against Klebsiella pneumoniae A | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID67535 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Enterobacter | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID498824 | Antimicrobial activity against Citrobacter freundii SZ62 expressing IMP-4, TEM-1, CMY-2, qnrS1, aac(6')-Ib-cr by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID554986 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 21 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID510505 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-4 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID425864 | Antimicrobial activity against Carnobacterium divergens CIP101029 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID531066 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC233 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID498827 | Antimicrobial activity against Citrobacter freundii SZ63T expressing IMP-4, qnrS1by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID555554 | Antimicrobial activity against Pseudomonas aeruginosa isolate M136074 expressing IMP-22 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID519646 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2322 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID585441 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID498811 | Antimicrobial activity against Escherichia coli ZJ86T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID524191 | Clearance in infant during extracorporeal membrane oxygenation assessed as desacetylcefotaxime at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID531606 | Ratio of Kcat to Km for Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID521351 | Antimicrobial activity against Streptococcus pneumoniae isolate k-585 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID523497 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1529c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID522000 | Antimicrobial activity against Escherichia coli isolate J53 harboring p4A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID557093 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID373206 | Antimicrobial activity against Bacillus clausii OC by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID558790 | Antimicrobial activity against Enterobacter cloacae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID562818 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pEK516 plasmid encoding CTX-M extended-spectrum beta-lactamases in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID573497 | Antibacterial activity against Serratia marcescens isolate Sm2723 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID64224 | Minimum inhibitory concentration against Escherichia coli DC2 (inoculum, 10e4 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID585451 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampGh1 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID562737 | Antimicrobial activity against Escherichia coli K-12 transconjugant harboring blaCTX-M-71 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID1126588 | Antibacterial activity against Staphylococcus aureus at 30 ug/disc at 37 degC after 24 hrs by agar well diffusion assay | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis, structure-activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives. |
| AID584563 | Antimicrobial activity against Acinetobacter lwoffii isolate J expressing beta-lactamase OXA-58 isolated from bedsore by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID532181 | Antimicrobial activity against aac(6')-Ib-cr-negative Klebsiella pneumoniae SY22T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID372617 | Activity of Escherichia coli CF0042 beta-lactamase TEM-35 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID561447 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID1505214 | Antibacterial activity in Escherichia coli clinical isolates endogenously expressing NDM1 incubated at 37 degC for 18 hrs by spectrophotometry | 2018 | ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1 | Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1. |
| AID64217 | The compound was tested in vitro for minimum inhibitory concentration against Escherichia coli ATCC 25922 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID368737 | Antimicrobial activity against Escherichia coli Ec1 containing pEc1-A plasmid expressing CTX-M-15 TEM-1 OXA-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID495631 | Antimicrobial activity against Pseudomonas luteola LAM expressing blaLUT-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID567317 | Antimicrobial activity against Proteus mirabilis TUM4660 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID587732 | Activity of Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID535649 | Antimicrobial activity against aac(6')-Ib-cr-positive Escherichia coli FJ3 harboring GyrA S83L, ParC S80R mutant, wild-type GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID681377 | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3 | Interaction of human organic anion transporters with various cephalosporin antibiotics. |
| AID529903 | Antimicrobial activity against Leptospira kirschneri serovar Grippotyphosa isolate 13 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID520876 | Antibacterial activity against Achromobacter xylosoxidans CIP69598 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID573722 | Antibacterial activity against Klebsiella oxytoca Ko238 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID531076 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC201 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID535722 | Activity of Escherichia coli TOP10 beta-lactamase AmpC-A S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID522027 | Antimicrobial activity against Escherichia coli isolate J53 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID162720 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Proteus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID322315 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID524569 | Antimicrobial activity against Shigella isolate DH-22451 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID322321 | Antibacterial activity against Escherichia coli DH5 alpha-URA5776 isolates expressing CTX-M-14 enzyme by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID1056855 | Antibacterial activity against Klebsiella pneumoniae FNSST 011 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID524206 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID471597 | Antibacterial activity against Proteus mirabilis CECT 170 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID561107 | Antibacterial activity against Pasteurella multocida BB1041 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID521829 | Antimicrobial activity against Streptococcus pneumoniae in non-meningitis patients by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID340730 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase TEM-ES by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID584837 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID374021 | Ratio of Kcat to Km for Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGE | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. |
| AID1325282 | Induction of defects in chromosomal segregation in Escherichia coli SH3210 assessed as generation of anucleate cells at MIC after 2.5 hrs using beta-galactosidase substrate DDAOG by fluorescence assay | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | 5-Alkyloxytryptamines are membrane-targeting, broad-spectrum antibiotics. |
| AID64248 | The compound was tested in vitro for minimum inhibitory concentration against Escherichia coli TEM-1 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID583087 | Ratio of Kcat to Km for Escherichia coli XL1-Blue VIM-2 A64W mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID576296 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 16830 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID559275 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID1762801 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID524061 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID285261 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-36 and IRT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID529896 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 4 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID509868 | Antibacterial activity against Acinetobacter baumannii isolate 2898 isolated from human ankle | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID528791 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID252634 | Bacterial susceptibility induced by D113 mutation in Escherichia coli OmpF | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID373754 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab8 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID542735 | Antimicrobial activity against Klebsiella pneumoniae D10 expressing aac(6')-Ib-cr, qnrB4, CTX-M-1G and DHA-1 genes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID534759 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 03-285 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID657434 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID532197 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae WH42 harboring wild-type GyrA, ParC, GyrB and qnrA genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID523496 | Antimicrobial activity against Pseudomonas aeruginosa isolate 17145c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID519662 | Antimicrobial activity against Escherichia coli EPI300 harboring GM2995 pCC1-1224 carrying CTX-M-3 beta-lactamase gene from by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID543800 | Bactericidal activity against Haemophilus influenzae VT450-2006 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID544976 | Antimicrobial activity against Klebsiella pneumoniae 52145 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. |
| AID201402 | In vitro antimicrobial activity against Staphylococcus aureus S13E strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID584559 | Antimicrobial activity against Acinetobacter lwoffii isolate F expressing beta-lactamase OXA-164 isolated from tracheostoma of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID587984 | Antibacterial activity against Escherichia coli AS226 carrying pBSDF160T mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID558334 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1093 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID325152 | Antimicrobial activity against Haemophilus parasuis BB 1019 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID203134 | Evaluated for the minimum inhibitory concentration against Serratia marcescens 1071 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID156119 | Affinity for penicillin binding protein 1b of Escherichia coli UB1005 (DC0) was evaluated. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID1543301 | Antimicrobial activity against Candida albicans ATCC 90028 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID549348 | Antimicrobial activity against Escherichia coli isolate 86 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID585449 | Antimicrobial activity against Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID585630 | Antimicrobial activity against gentamycin resistant Escherichia coli SNO301-1 harboring pEC1C carrying ampC, ampR from Enterobacter cloacae after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID1543302 | Antimicrobial activity against Aspergillus fumigatus ATCC 90906 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID519655 | Antimicrobial activity against Escherichia coli GM2995 harboring plasmid pCC1 carrying beta-lactamase CTX-M-3 Ser167 mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID562738 | Antimicrobial activity against Escherichia coli K-12 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID520803 | Antimicrobial activity against Escherichia coli str. K-12 substr. DH10B harboring plasmid CTX-M-2 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID96236 | Evaluated for its antibacterial activity against Klebsiella pneumoniae UC 12081 | 2001 | Bioorganic & medicinal chemistry letters, Nov-19, Volume: 11, Issue:22 | Enols as potent antibacterial agents. |
| AID1295309 | Antimicrobial activity against Escherichia coli ATCC 25922 at 1 mg/ml incubated for 24 hrs by cup diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID573505 | Antibacterial activity against Enterobacter cloacae isolate El3799 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID528521 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC BAA-611 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID561319 | Antimicrobial activity against Escherichia coli isolate 17 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID542106 | Antibacterial activity against Escherichia coli TrC C expressing Klebsiella pneumoniae C blaCTX-M beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID283322 | Antimicrobial activity against Escherichia coli XL10/pSHV-31 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID1295315 | Antimicrobial activity against Escherichia coli ATCC 25922 incubated for 24 hrs by CLSI/NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID520975 | Antibacterial activity against Pseudomonas aeruginosa 2404 plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID582924 | Ratio of Kcat to Km for Escherichia coli BL21(DE3) VIM-2 W87A mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID201556 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Sarcina | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID1295311 | Antimicrobial activity against Streptococcus lactis ATCC 14591 at 1 mg/ml incubated for 24 hrs by cup diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID667376 | Antibacterial activity against Escherichia coli ATCC 11303 after 24 hrs by microtiter broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives. |
| AID542612 | Antimicrobial activity against Streptococcus pneumoniae R6 after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID585677 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 harboring pZY0901 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID561442 | Antibacterial activity against Escherichia coli YD006 harboring beta-lactamase CMY-33 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID521826 | Antimicrobial activity against Streptococcus pneumoniae isolated from patient with bacterial infection by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID535885 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID587728 | Antimicrobial activity against Escherichia coli DH5alpha carrying Pseudomonas aeruginosa strain PS 297 IMP-1-pLBII after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID521294 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype H by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID573498 | Antibacterial activity against Klebsiella pneumoniae isolate Kp7564 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID544508 | Metabolic stability in Escherichia coli TOP10 harboring beta-lactamase KPC-2 assessed as hydrolysis rate per mg of extracts at 100 uM after 5 mins by spectrophotometric analysis in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID544425 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID576305 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 287942 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID447073 | Antibacterial activity against Klebsiella pneumoniae UC57 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID522579 | Antimicrobial activity against AmpC producing Escherichia coli Top10 isolate 8009162 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID520882 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID524746 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, P167S mutation in beta lactamase CTX-M-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID252618 | Mean lysis diameter of wild type Enterobacter aerogenes EA289 with OmpF by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID521995 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp3A expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID530521 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 8607-03 expressing pbp2x Q557E mutant and harboring empty vector by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID66244 | Minimum inhibitory concentration against Enterobacter cloacae P99 (Class Ia beta-lactamase overproducer) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID542624 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene, disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID548004 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237P mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID582968 | Antimicrobial activity against beta-lactamase A and B-deficient Yersinia enterocolitica GY5718 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID406623 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID522005 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-1 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID534394 | Activity of Beta-lactamase KHM-1 in Escherichia coli JM109 harboring recombinant pKHM-1 assessed as compound hydrolysis by UV-visible spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID567311 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2202 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID565200 | Antimicrobial activity against Klebsiella pneumoniae isolate A-1760 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID560489 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-2 producing Escherichia coli MC4100 harboring plasmid AC-cmy2 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID495664 | Ratio of Kcat to Km for Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID322318 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID68815 | Evaluated for the in vivo activity in mice against Escherichia coli 257 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID535655 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ61 harboring GyrA S83I, GyrA D87A, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID373770 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh26 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID531976 | Antibacterial activity against Escherichia coli DH10B expressing KPC-2 CTX-M-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID495839 | Ratio of Kcat to Km for Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID535891 | Antimicrobial activity against aac(6')-Ib-cr-negative Citrobacter freundii JN64 harboring GyrA T83I, wild-type ParC, GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID559262 | Antimicrobial activity against Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID613256 | Antibacterial activity against Staphylococcus aureus ATCC 10832 after 24 hrs by NCCLS M7-A6 broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. |
| AID522004 | Antimicrobial activity against Escherichia coli isolate J53 harboring p7A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID428295 | Antimicrobial activity against Acinetobacter baumannii BM4579 expressing adeIJK genes with pAT807 isolated from patient with urinary tract infection by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID657432 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID558813 | Antimicrobial activity against Pseudomonas aeruginosa assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID495806 | Antimicrobial activity against Providencia stuartii 6858 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID530507 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype III isolate 3444-99 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID604020 | Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID498804 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ70 deficient in KPC-2, SHV-11, CTX-M-14, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID523509 | Antimicrobial activity against Pseudomonas aeruginosa isolate 15107 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID657435 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID531650 | Antimicrobial activity against CTX-M-15,OXA-30 beta-lactamase producing Escherichia coli isolate CUMC245 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID528526 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B7 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID521352 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-612 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID374136 | Antimicrobial activity Enterobacter cloacae 91 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID1056872 | Antibacterial activity against Aeromonas hydrophila FNSST 014 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID510510 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate N2AC9-18 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID524593 | Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae isolate Kpn-DK2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. |
| AID208021 | Minimum inhibitory concentration against Streptococcus pneumoniae 6301 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID548032 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237R mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID520982 | Antibacterial activity against Escherichia coli harboring pRYC plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID544960 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID544421 | Antimicrobial activity against Escherichia coli CU164A expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID521297 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype A by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID549332 | Antimicrobial activity against Escherichia coli isolate 86 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID524060 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543273 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID279815 | Antimicrobial activity against Escherichia coli DH5-alpha with pGEM-T EASY expressing TEM1 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID564525 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID495903 | Antimicrobial activity in Escherichia coli DIH-1 expressing beta-lactamase VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID325159 | Antimicrobial activity against Escherichia coli | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID535855 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID543812 | Bactericidal activity against Streptococcus pyogenes VT 59 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID543280 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID499072 | Antimicrobial activity against Citrobacter freundii RJ78 expressing CMY-2, qnrA1, aac(6')-Ib-cr, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID573508 | Antibacterial activity against Klebsiella oxytoca isolate Ko1156 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID565201 | Antimicrobial activity against Klebsiella pneumoniae isolate T-1504 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID495828 | Antimicrobial activity against Escherichia coli C600 2878 transconjugate expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID278604 | Inhibitory activity against azide-resistant Escherichia coli J53 T12-1502 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID529573 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid pLBII carrying beta-lactamase CAR-1 gene after 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID587968 | Ratio of Kcat to Km for Escherichia coli wild type beta-lactamase Toho-1 assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID544977 | Antimicrobial activity against Klebsiella pneumoniae 52OmpA2Com | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. |
| AID534173 | Antimicrobial activity against armA positive Escherichia coli TOP10 producing beta lactamase CTX-M-3 with plasmid MEZ by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID563966 | Antibacterial activity against Klebsiella pneumoniae 05-560 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID330972 | Antimicrobial activity against ampD deficient Escherichia coli transfected with pCF1 in medium containing EtbuPUG by agar diffusion assay | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID368747 | Antimicrobial activity against Escherichia coli Ec10 expressing TEM-24b gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID561102 | Antibacterial activity against Pasteurella multocida BB1036 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID68010 | Antibacterial activity against Enterobacter cloacae 265A | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID520978 | Antibacterial activity against Escherichia coli harboring pCOL plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID26428 | Serum T1/2 in marmosets (IV dose) | 1992 | Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14 | Pharmacokinetics of catechol cephalosporins. The effect of incorporating substituents into the catechol moiety on pharmacokinetics in a marmoset model. |
| AID535644 | Antimicrobial activity against Group B streptococcus serotype Ib N2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID535658 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ61T harboring qnrS gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID584498 | Antibacterial activity against porin deficient OmpA positive Klebsiella pneumoniae KPBj3 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID198311 | Minimum inhibitory concentration against Streptococcus pyogenes (inoculum, 10e5 cfu per spot) A1 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID70599 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Escherichia coli TEM | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID164246 | Antibacterial activity against Pseudomonas aeruginosa X528 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID518728 | Activity of Pseudomonas stutzeri beta-lactamase DIM-1 by UV-spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID533875 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID587530 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 4 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID585834 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampG deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID374026 | Ratio of Kcat to Km for Klebsiella pneumoniae KPC-1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. |
| AID395351 | Antibacterial activity against Klebsiella pneumoniae UC57 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID523503 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1248c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID547793 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237V mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID93996 | Minimum inhibitory concentration against Klebsiella aerogenes X5L (inoculum, 10e4 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID544424 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID557090 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 0.1% alpha-1-acid glycoprotein | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID322326 | Antimicrobial activity against Streptococcus pneumoniae WB4 by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. |
| AID285257 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha CL1295 isolate expressing pBK-TEM-151 and CMT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1765573 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID52809 | The compound was tested in vitro for minimum inhibitory concentration against Citrobacter Freundii BS-16 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID200338 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Salmonella | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID495648 | Antimicrobial activity against Escherichia coli DH10B by Etest method in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID543655 | Volume of distribution in extracorporeal membrane oxygenation-treated human neonatal plasma at 50 mg/kg BID by UPLC-MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. |
| AID543794 | Antimicrobial activity against Klebsiella pneumoniae VT 1367 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID561328 | Antimicrobial activity against Klebsiella pneumoniae isolate 202 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID520794 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype B by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID542628 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene and Janus disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID546428 | Activity at Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID325445 | Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID546427 | Activity at Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID498820 | Antimicrobial activity against Klebsiella pneumoniae WH76 expressing IMP-4, TEM-1, SHV-14, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID587966 | Activity of Escherichia coli beta-lactamase Toho-1 F160T mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID495805 | Antimicrobial activity against Klebsiella pneumoniae 6828 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID499068 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae NJ90 deficient in CTX-M-14, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535666 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ67 harboring wild-type GyrA S83I and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535664 | Antimicrobial activity against aac(6')-Ib-cr-positive Enterobacter cloacae FJ63T harboring qnrS gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535642 | Antimicrobial activity against Group B streptococcus serotype VI N4 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID531314 | Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID532173 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae SH39 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrA genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID557094 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 1.6% gamma globulin | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID528528 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID326265 | Antibacterial activity against Escherichia coli 3521r carrying pR352 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID531681 | Antimicrobial activity against Acinetobacter baumannii Ab290 containing plasmid harboring OXA-58-3 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID559265 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID1762805 | Antibacterial activity against against Escherichia coli 06 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID555225 | Activity of Acinetobacter genomosp. 3 isolate 103 ADC-16 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID524436 | Antimicrobial activity against Shigella flexneri isolate AM19035 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID558324 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P835 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID585181 | Ratio of Kcat to Km for Beta-lactamase GES-1 E104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID322323 | Antibacterial activity against Escherichia coli DH5 alpha-URA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID373983 | Antimicrobial activity Escherichia coli 633 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID546621 | Antimicrobial activity against Escherichia coli harboring plasmid pPCRScript by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID562816 | Antimicrobial activity against Escherichia coli J53 harboring pEK204 plasmid encoding CTX-M extended-spectrum beta-lactamases in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID396026 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID373982 | Antimicrobial activity Enterobacter cloacae 641 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID208789 | The compound was tested in vitro for minimum inhibitory concentration against Streptococcus pneumoniae 6301 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID563973 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase NDM-1 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID373757 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab1308 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID520968 | Antibacterial activity against Escherichia coli harboring pRYC plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1056852 | Antibacterial activity against CTX-15 expressing Stenotrophomonas maltophilia isolate 125 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID535862 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ47 harboring qnrB and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID524037 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae 1076 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID374362 | Ratio of Kcat to Km of Aeromonas caviae A324R metallo-beta-lactamase IMP-19 expressed in Escherichia coli DH5alpha by computerized microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID573517 | Antibacterial activity against Serratia marcescens isolate Sm203 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID524246 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID560702 | Activity of Escherichia coli MC4100 Beta-Lactamase CMY-2 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID368743 | Antimicrobial activity against Escherichia coli Ec5 expressing CTX-M-2 TEM-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID520969 | Antibacterial activity against Klebsiella pneumoniae GR by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID587964 | Activity of Escherichia coli beta-lactamase Toho-1 D240A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID543797 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID584565 | Antimicrobial activity against Acinetobacter lwoffii isolate L expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID524329 | Clearance in infant weighing 2 to 6.2 kg weight after extracorporeal membrane oxygenation assessed as desacetylcefotaxime at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose measured after 72 hrs | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID523507 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1495c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID164050 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Pseudomonas | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID520878 | Antibacterial activity against Achromobacter xylosoxidans LOL by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID368754 | Antimicrobial activity against Proteus mirabilis Pm1-Pm3 expressing TEM-24b gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID535892 | Antimicrobial activity against aac(6')-Ib-cr-negative Citrobacter freundii JN64 harboring GyrA T83I, wild-type ParC, GyrB and qnrA genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID269450 | Antibacterial activity against ampC beta-lactamase Enterobacter cloacae P99 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID567316 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2207 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID564526 | Antimicrobial activity against Acinetobacter baumannii AYE expressing VEB-1 gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID373765 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh13 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID519011 | Ratio of Kcat to Km for Beta-lactamase TEM-149 T182M mutant expressed in Escherichia coli HB101 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID373772 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh36 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID561101 | Antibacterial activity against Pasteurella multocida BB1035 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID520776 | Antibacterial activity against beta-lactamase KPC-2 producing Serratia marcescens isolate S1 to S21 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID535661 | Antimicrobial activity against aac(6')-Ib-cr-positive Enterobacter cloacae FJ63 harboring GyrA S83I, GyrA D87A, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID521830 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent susceptible isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID597603 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID205374 | tested for its efficacy against systemic murine infection caused by Pseudomonas aeruginosa 8780. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID555670 | Antimicrobial activity against Escherichia coli DH10B harboring natural plasmid pWES-1 carrying CTX-M-53 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID495516 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii AYE by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID423753 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate J5 having blaSHV promoter sequence with IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID543807 | Bactericidal activity against Haemophilus influenzae VT450-2006 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID562810 | Antimicrobial activity against Escherichia coli J53 harboring pEK499 plasmid encoding CTX-M extended-spectrum beta-lactamases | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID544560 | Antimicrobial activity against Escherichia coli DH5[alpha] by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID519981 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID567322 | Antimicrobial activity against Proteus mirabilis TUM4660 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID558331 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P338 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID164229 | Bacterial challenge for systemic murine infection against Pseudomonas aeruginosa 8780 | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID520974 | Antibacterial activity against Escherichia coli harboring pBC2303 expressing blaKPC gene plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID525549 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1052 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID544568 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8128 expressing bla SHV-105 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID535634 | Antimicrobial activity against Group B streptococcus serotype VI R6 harboring F395L, V405A, R433H, H438Y, A374V and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID495636 | Ratio of kcat/Km for Pseudomonas luteola LAM Beta-lactamase LUT-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID521293 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype G by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID530341 | Ratio of Kcat to Km for Pseudomonas aeruginosa VIM-1 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID535707 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID583091 | Activity of Escherichia coli XL1-Blue wild-type IMP-1 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID498836 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU5 deficient in SHV-12, DHA-1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID531680 | Antimicrobial activity against Acinetobacter baumannii Ab290 harboring TVICU53 plasmid by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID522028 | Antimicrobial activity against Escherichia coli isolate TOP10 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID295102 | Antibacterial activity against Klebsiella pneumoniae UC57 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID423754 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate K2 having blaSHV promoter sequence with IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID543271 | Antimicrobial activity against Streptococcus pneumoniae 3191 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID510502 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate C1AC9-24 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID520696 | Antimicrobial activity against Escherichia coli DH10B harboring p041060 carrying qepA gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID534087 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID543805 | Bactericidal activity against Streptococcus pyogenes VT 59 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID548044 | Activity of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID548028 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237K mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID559684 | Antibacterial activity against Acinetobacter baumannii BM4652 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID584556 | Antimicrobial activity against Acinetobacter lwoffii isolate C expressing beta-lactamase OXA-164 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID543955 | Antibacterial activity against chloramphenicol, tetracycline-resistant Staphylococcus aureus COL-S carrying SAmecA/mecI-mecR1 plasmid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID374111 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr deficient Escherichia coli J53 qnrA1 bearing pHS5 transconjugant from Enterobacter cloacae 641 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID521283 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype G by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID495342 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Ala502Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID544515 | Metabolic stability in Escherichia coli TOP10 harboring beta-lactamase KPC-4 assessed as hydrolysis rate per mg of extracts at 100 uM after 5 mins by spectrophotometric analysis in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID529898 | Antimicrobial activity against Leptospira weilii isolate 6 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID524747 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, N114D, A140S, D288N mutations in beta lactamase CTX-M-1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID524433 | Antimicrobial activity against Shigella isolate DH10B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID555556 | Antimicrobial activity against Pseudomonas aeruginosa isolate 22843 expressing VIM-2 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID534171 | Antimicrobial activity against beta lactamase CTX-M-14 producing Escherichia coli TOP10 harboring plasmid COP2 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID530339 | Activity of Pseudomonas aeruginosa VIM-13 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID583082 | Ratio of Kcat to Km for Escherichia coli BL21(DE3) wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID573531 | Antibacterial activity against Klebsiella pneumoniae Kp1239 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID531065 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC204 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID544429 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID531083 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC176 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID573530 | Antibacterial activity against Citrobacter youngae isolate CyB38 harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID164737 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Pseudomonas aeruginosa 1592 E | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID524933 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, A77V mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID372620 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID325151 | Antimicrobial activity against Haemophilus parasuis BB 1018 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID587532 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 4 ug/ml cavulanate beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID557100 | Binding affinity to human serum albumin assessed as fraction of binding sites occupied by compound at 22 to 44 ug/ml by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID252616 | Mean lysis diameter of porin deficient Enterobacter aerogenes EA289 by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID543801 | Bactericidal activity against Klebsiella pneumoniae VT 1367 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID498823 | Antimicrobial activity against Klebsiella pneumoniae WH77T expressing IMP-4, TEM-1, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID518520 | Antimicrobial activity against Escherichia coli TOP10(pNOR-1) expressing CSP-1 gene after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID1129347 | Antibacterial activity against extended-spectrum beta-lactamase producing multidrug-resistant and colistin-susceptible Escherichia coli CTX-M-15 clinical isolate Aar 11 after 18 hrs by microdilution broth method | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7 | Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli. |
| AID323040 | Antimicrobial activity against extended-spectrum-beta-lactamase producing Klebsiella pneumoniae assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. |
| AID558793 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Escherichia coli assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID561315 | Antimicrobial activity against Enterobacter cloacae isolate 101 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID543804 | Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID535873 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JN1 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID524222 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID405090 | Antimicrobial activity against integron carrying Enterobacteriaceae assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Enterobacteriaceae bloodstream infections: presence of integrons, risk factors, and outcome. |
| AID523499 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1247c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID587526 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 4 ug/ml cavulanate beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID206093 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Streptococcus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID528604 | Antimicrobial activity against Escherichia coli J53 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID1295316 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 24 hrs by CLSI/NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID573723 | Antibacterial activity against Klebsiella pneumoniae Kp204 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID575418 | Antimicrobial activity against anrB-deficient Listeria monocytogenes EGD-e assessed as growth inhibition after 16 hrs by broth dilution method relative to wild type | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID521290 | Antimicrobial activity against SHV-5 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype D by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID544584 | Antimicrobial activity against Escherichia coli ATCC 25922 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID559703 | Antimicrobial activity against Escherichia coli AB94012 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID368504 | Ratio of Kcat to Km of Klebsiella pneumoniae TEM26 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495842 | Hydrolytic activity of Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID613255 | Antibacterial activity against Escherichia coli ATCC 11303 after 24 hrs by NCCLS M7-A6 broth dilution method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. |
| AID524192 | Volume of distribution in infant during extracorporeal membrane oxygenation assessed as desacetylcefotaxime at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID561100 | Antibacterial activity against Pasteurella multocida BB1034 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1001 bearing tetB gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID65229 | Minimum inhibitory concentration for inhibition of [14C]- Pen G binding to Escherichia coli UB1005 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID447079 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID423772 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate 121 having upstream IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID205968 | Minimum inhibitory concentration against Staphylococcus aureus 1059B (inducible, high level beta-lactamase producer) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID330962 | Antimicrobial activity against wild type Escherichia coli in medium containing EtbuPUG by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID269444 | Antibacterial activity against wild type Staphylococcus aureus SG 511 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID467612 | Fraction unbound in human plasma | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID1862391 | Antibacterial activity against Klebsiella pneumoniae harboring KPC-3/NMD-1 assessed as bacterial growth inhibition at 0.06 to 64 ug/ml incubated for 16 to 20 hrs by microdilution method | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. |
| AID542773 | Antimicrobial activity against Escherichia coli J53 transformed with pHNPA1 carrying qnrB6 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID597602 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID269453 | Antibacterial activity against Escherichia coli ATCC 33475 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID395733 | Antimicrobial activity against imipenem-susceptible invasive nontypeable Haemophilus influenzae isolate 244 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID522014 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBEL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID575948 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID532188 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26T harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID531074 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC181 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID560119 | Antimicrobial activity against Acinetobacter baumannii by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID395355 | Antibacterial activity against Mycobacterium smegmatis CCM 2067 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID545461 | Antimicrobial activity against Pasteurella sp. assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID528522 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID373755 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab12 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID428293 | Antimicrobial activity against Acinetobacter baumannii BM4651 expressing deltaadeIJK genes isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID524214 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID519740 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-72 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID529899 | Antimicrobial activity against Leptospira weilii isolate 8 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID522581 | Antimicrobial activity against AmpC producing Escherichia coli Top10 isolate 25922 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID423757 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 85 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID287372 | Antibacterial activity against Staphylococcus aureus after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID510504 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-2 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID584316 | Antimicrobial activity against beta-lactamase AmpC producing meropenem-resistant Serratia marcescens by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Outbreak of meropenem-resistant Serratia marcescens comediated by chromosomal AmpC beta-lactamase overproduction and outer membrane protein loss. |
| AID585193 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-1 E104, G170 mutant by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID542621 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring wild type PBP2x, disruption in PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID558333 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P790 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID543423 | Antimicrobial activity against Escherichia coli XL-1 Blue transconjugant harboring beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID576289 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 16855 harboring porin OmpK36 and OmpK35 genes by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID604026 | Unbound CSF to plasma concentration ratio in human | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID1056873 | Antibacterial activity against Pseudomonas aeruginosa FNSST 982 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID584848 | Ratio of Kcat to Km for Aeromonas allosaccharophila AL-1 beta-lactamase PER2 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID519628 | Antimicrobial activity against beta-lactamase OXA-63 producing Brachyspira pilosicoli isolate BM4442 isolated from feces of patient with diarrhea by disc diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID94305 | Minimum inhibitory concentration was determined against Klebsiella pneumoniae 102 with an inoculum size-0.5 mL of 10 E5 CFU/mL of suspension | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID340737 | Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID528535 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae B513 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID564219 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID573537 | Antibacterial activity against Klebsiella pneumoniae Kp7564 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID583089 | Ratio of Kcat to Km for Escherichia coli XL1-Blue wild-type VIM-2 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID497694 | Antimicrobial activity against colistin-resistant Klebsiella pneumoniae isolated from bacteremia patient assessed as percentage of resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. |
| AID562572 | Antimicrobial activity against TEM-10 ESBL producing Escherichia coli clinical isolate by CLSI disk diffusion assay | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western Pennsylvania. |
| AID522580 | Antimicrobial activity against wild-type AmpC producing Escherichia coli ATCC 25922 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID524743 | Antimicrobial activity against Escherichia coli GB20 harboring D240G mutation in beta lactamase CTX-M-10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID69614 | Antibacterial activity against Escherichia coli DC-O | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID522575 | Antimicrobial activity against Escherichia coli isolate 8009989 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID423759 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 104 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID510507 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate M3AC9-7 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID428294 | Antimicrobial activity against Acinetobacter baumannii BM4652 expressing adeIJK genes with pAT807 isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID325446 | Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID495515 | Antibacterial activity against Acinetobacter baumannii CIP70-10 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID546429 | Activity at Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID545431 | Antimicrobial activity against Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID657440 | Antibacterial activity against Escherichia coli clinical isolate after 16 hrs by 2-fold microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID405312 | Antibacterial activity against beta-lactamase producing amoxicillin-clavulanic acid-resistant Haemophilus influenzae isolate assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID530515 | Antimicrobial activity against group B Streptococcus sp. 'group B' isolate 6149-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID548263 | Selectivity index, Ratio of Kcat/Km for Klebsiella pneumoniae 1534 beta-lactamase KPC-2 T237S mutant to ratio of Kcat/Km for Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID521491 | Antibacterial activity against Pseudomonas aeruginosa KG2505 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID562748 | Antimicrobial activity against Klebsiella pneumoniae AH24-270 expressing blaCTX-M-71 gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID561099 | Antibacterial activity against Pasteurella multocida ATCC 43137 by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID518729 | Ratio of Kcat to Km for Pseudomonas stutzeri beta-lactamase DIM-1by UV-spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID561318 | Antimicrobial activity against Enterobacter cloacae isolate 153 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID163912 | In vitro antimicrobial activity against Pseudomonas X239 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID562740 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBC-CTX-M-15 plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID535758 | Antimicrobial activity against hospital-acquired Escherichia coli expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID523490 | Antimicrobial activity against Pseudomonas aeruginosa AHP Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID1209736 | Inhibition of human OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID405081 | Antimicrobial activity against Escherichia coli CAG12177 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID521486 | Antibacterial activity against Escherichia coli harboring pBC2303 expressing blaKPC gene plasmid by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID532172 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae SH39 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrA genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535853 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ67T harboring qnrS gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID162920 | Minimum inhibitory concentration against Proteus morganii (PR 15) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID522007 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-1 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1543306 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID583090 | Activity of Escherichia coli XL1-Blue IMP-1 W64A mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID544434 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID562575 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID660263 | Ratio of MIC for wild type Salmonella typhimurium SH5014 to MIC for Salmonella typhimurium SH7616 harboring missense mutation in acrA/acrB gene by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID498831 | Antimicrobial activity against Escherichia coli C600 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID545455 | Antimicrobial activity against Pseudomonas aeruginosa assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID562752 | Antimicrobial activity against Escherichia coli DH5alpha harboring pBC-CTX-M-15 plasmid by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID65051 | Minimum inhibitory concentration was determined against Escherichia coli ISM with an inoculum size-0.5 mL of 10 E6 CFU/mL of suspension | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID523512 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1240 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID523518 | Antimicrobial activity against Pseudomonas aeruginosa isolate 17112 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID573506 | Antibacterial activity against Klebsiella pneumoniae isolate Kp3799 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID522574 | Antimicrobial activity against Escherichia coli isolate 8009389 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID163565 | The compound was tested in vitro for minimum inhibitory concentration against Proteus vulgaris 1028 BC | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID340733 | Antimicrobial activity against Chryseobacterium indologenes NF16 isolate assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID559705 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus P1386 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID269448 | Antibacterial activity against wild type Escherichia coli DC0 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID521993 | Antimicrobial activity against Klebsiella pneumoniae isolate KpB expressing OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID556759 | Antimicrobial activity against extended spectrum beta-lactamase CTX-M-2-producing Pseudomonas aeruginosa isolate P6208 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Further identification of CTX-M-2 extended-spectrum beta-lactamase in Pseudomonas aeruginosa. |
| AID495910 | Antimicrobial activity in Escherichia coli TOP10 strain | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID524937 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, N106S and D240G mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID543277 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID429062 | Antimicrobial activity against Proteus mirabilis JIE273 expressing 16S rRNA methyltransferase RmtC | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | RmtC 16S rRNA methyltransferase in Australia. |
| AID587978 | Antibacterial activity against Escherichia coli AS226 carrying pBSDN104A mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID543810 | Bactericidal activity against Pseudomonas aeruginosa ATCC 27853 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID1762809 | Antibacterial activity against Carbapenem-resistant Pseudomonas aeruginosa assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID373773 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh37 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID531684 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151T containing plasmid harboring OXA-58-3 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID374024 | Ratio of Kcat to Km for Enterobacter cloacae IMI1 beta lactamase Escherichia coli DH5alpha by SDS-PAGE | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase. |
| AID279814 | Antimicrobial activity against Escherichia coli DH5-alpha with pYW2 expressing KPC2 and TEM1 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID1329362 | Antibacterial activity against Enterococcus faecalis ATCC 10541 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID499053 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU96 deficient in TEM-1, CTX-M-14, CMY-2, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID560706 | Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-2 using cephalothin as reporter substrate | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID576302 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 26077 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID368493 | Activity of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID495831 | Antimicrobial activity against Escherichia coli DH5alpha 2878 transformant expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID395350 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 1 ug after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. |
| AID522024 | Antimicrobial activity against Escherichia coli isolate J53 harboring pCF containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID498830 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae WH103 deficient in IMP-4, TEM-1, CTX-M-3, qnrS1, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID197863 | The compound was tested in vitro for minimum inhibitory concentration against Staphylococcus aureus 67-0 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID583028 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli pGLK-1 plasmid carrying FOX-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID524219 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID530348 | Antimicrobial activity against azide-resistant Escherichia coli J53 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID64558 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Escherichia coli | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID558335 | Antibacterial activity against Campylobacter jejuni isolate P1093 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID531092 | Antimicrobial activity against SHV-12-like, SHV-1-like beta-lactamase producing Klebsiella pneumoniae isolate CUMCK9 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID534766 | Antimicrobial activity against rifampin-, nalidixic acid resistant Escherichia coli CSH-2 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID287376 | Antibacterial activity against Proteus vulgaris after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID561445 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK carrying beta-lactamase CMY-44 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID1309043 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate SDS15016 after 24 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | Synthesis of riccardin D derivatives as potent antimicrobial agents. |
| AID374137 | Antimicrobial activity Enterobacter cloacae 113 expressing plasmid-mediated quinolone resistance qnr A gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID394497 | Antimicrobial activity against Escherichia coli MC4100 harboring pBCSK plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID559704 | Antimicrobial activity against Pseudomonas aeruginosa AB92037 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID425865 | Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID532185 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID528601 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID529894 | Antimicrobial activity against Leptospira interrogans serovar Grippotyphosa isolate 2 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID498806 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ71 deficient in KPC-2, TEM-1, SHV-11, CTX-M-14, ompK35 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID562756 | Ratio of Kcat to Km for Klebsiella pneumoniae AH24-270 CTX-M-71 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID200333 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Salmonella | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID373760 | Antibacterial activity against imipenem-intermediate Acinetobacter baumannii ab1297 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID544488 | Antibacterial activity against Pseudomonas aeruginosa PR100 harboring beta-lactamase KPC-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID533876 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID423764 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 109 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID543416 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 transconjugant by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID559896 | Antimicrobial activity against Klebsiella oxytoca KO279 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID542043 | Antibacterial activity against Escherichia coli TrC B expressing Klebsiella pneumoniae B blaCTX-M beta-lactamase by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID66232 | The compound was tested in vitro for minimum inhibitory concentration against Enterobacter cloacae P99 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID585438 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID325160 | Antimicrobial activity against Escherichia coli pB1000 expressing ROB1 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID524053 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID163924 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Pseudomonas | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID535692 | Antimicrobial activity against beta-lactamase CTX-M-15-producing fluoroquinolone-resistant Escherichia coli FMV5825 expressing qnrB2 and aac(6')-Ib-cr and harboring gyrA Ser83Ile and Asp87Asn mutant gene and ParC Ser80Ile and Glu84Val mutant gene obtained | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID368742 | Antimicrobial activity against Escherichia coli Ec4 expressing CTX-M-1 AmpC gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID123062 | In vitro minimum inhibitory concentration was measured against Micrococcus luteus ATCC 9341 strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID209765 | Minimum inhibitory concentration against Streptococcus pyogenes (C203) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID495809 | Antimicrobial activity against Escherichia coli DH5alpha harbouring plasmid BK-VIM-19 expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID561324 | Antimicrobial activity against Klebsiella pneumoniae isolate 132 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID283321 | Antimicrobial activity against Escherichia coli XL10/vector | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID535637 | Antimicrobial activity against Group B streptococcus serotype Ib R3 harboring Q557E, A400V mutations in PBP 2X and T567I, G539E mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID585180 | Activity of Beta-lactamase GES-13 K104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID495799 | Ratio of Kcat to Km of KPC-2 using nitrocefin hydrolysis | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID530324 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring pUCP carrying VIM-13 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID201412 | In vitro antimicrobial activity against Staphylococcus aureus X400 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID523495 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1693c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID368741 | Antimicrobial activity against Escherichia coli Ec3 expressing CTX-M-15 TEM-1 OXA-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID150913 | Minimum inhibitory concentration against Pseudomonas aeruginosa A21 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID535702 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID563968 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase NDM-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID585444 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 harboring pUCP24 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID1209733 | Binding affinity to mouse OAT3 expressed in CHO cells at 10 to 1000 uM measured over 20 mins | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4 | Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. |
| AID562221 | Antimicrobial activity against Desulfovibrio fairfieldensis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID531089 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC241 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID562766 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID573524 | Antibacterial activity against Escherichia coli isolate Ec221 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID544518 | Metabolic stability in Escherichia coli TOP10 harboring beta-lactamase KPC-5 assessed as hydrolysis rate per mg of extracts at 100 uM after 5 mins by spectrophotometric analysis in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID559689 | Antibacterial activity against ESBL-positive and OmpF and OmpC porin-deficient Escherichia coli HB4 harboring plasmid AT517 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID560701 | Ratio of Kcat to Km for Escherichia coli MC4100 Beta-Lactamase CMY-30 harboring Val211?Gly211 mutation | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID535639 | Antimicrobial activity against Group B streptococcus serotype VI R1 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID559922 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-V49 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID405306 | Antibacterial activity against beta-lactamase nonproducing ampicillin susceptible Haemophilus influenzae isolate assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID524930 | Antimicrobial activity against Escherichia coli MI1443 harboring N106S and D240G mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID585670 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID558807 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Klebsiella pneumoniae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID163116 | Minimum inhibitory concentration for prevention of visible growth of Pseudomonas aeruginosa (18S-H strain) | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID524052 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID534177 | Antimicrobial activity against armA positive Escherichia coli TOP10 producing beta lactamase CTX-M-3 with plasmid DU by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID561108 | Antibacterial activity against Pasteurella multocida BB1042 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID368746 | Antimicrobial activity against Escherichia coli Ec9 expressing TEM-24b TEM-26 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID498807 | Antimicrobial activity against Klebsiella pneumoniae ZJ71T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID529660 | Ratio of Kcat to Km for Pseudomonas aeruginosa COL-1 beta-lactamase VIM-2 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID564225 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID423766 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 113 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID205199 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Serratia | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID535358 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as susceptible isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID495663 | Activity at Pseudomonas aeruginosa 51170 beta-lactamase BEL-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID520638 | Antimicrobial activity against Escherichia coli MRY04-1060 expressing qepA gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID1592960 | Antibacterial activity against multi-drug resistant Klebsiella pneumoniae NMI 3081/09 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID524258 | Activity at Escherichia coli beta-lactamase SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID532164 | Antimicrobial activity against aac(6')-Ib-cr-negative Escherichia coli PU12T harboring wild-type GyrA, GyrB, ParC and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID522582 | Antimicrobial activity against Escherichia coli Top10 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID95544 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Klebsiella | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID324358 | Antibacterial activity against Escherichia coli DH10B expressing SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID558330 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P316 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID584489 | Antibacterial activity against porin deficient OmpA positive Klebsiella pneumoniae KPBj1 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID495838 | Hydrolytic activity of Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID520387 | Ratio of Kcat to Km for Pseudomonas aeruginosa M5109 metallo-beta-lactamase VIM-11 | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain. |
| AID522384 | Antimicrobial activity against Aeromonas enteropelogenes ATCC 49803 producing endogenous class C beta-lactamase TRU-1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID68060 | Antibacterial activity against Enterococcus faecium | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID518726 | Antimicrobial activity against Escherichia coli TOP10 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID532209 | Antimicrobial activity against Escherichia coli J53 harboring wild-type GyrA, ParC, GyrB genes by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID534168 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid VOG2 expressing CTX-M-14 and AAC(6 )-Ib gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID584499 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae KPBj5 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID203462 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Staphylococcus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID544427 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID535346 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by PK/PD technique | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1056860 | Antibacterial activity against Bacillus cereus ATCC 11778 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID522009 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBIC expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID521426 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID524205 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524327 | Clearance in infant weighing 2 to 6.2 kg weight after extracorporeal membrane oxygenation assessed as desacetylcefotaxime at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID532676 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID529892 | Antimicrobial activity against Leptospira interrogans isolate 7 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID278599 | Inhibitory activity against azide-resistant Escherichia coli J53 T35 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID531651 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC225 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID330964 | Antimicrobial activity against wild type EtbuPUG treated Escherichia coli transfected with pCF1 by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID565198 | Antimicrobial activity against Klebsiella pneumoniae isolate A-1797 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID563977 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase VIM2 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID498810 | Antimicrobial activity against carbapenem-resistant Escherichia coli ZJ86 deficient in KPC-2, TEM-1, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID156275 | Concentration required for 90% inhibition against 90 kDa penicillin-binding protein 1b binding using [14C]-Pen G as the radioligand. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID567457 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080049Ty by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID10721 | Serum AUC in marmosets (IV dose) | 1992 | Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14 | Pharmacokinetics of catechol cephalosporins. The effect of incorporating substituents into the catechol moiety on pharmacokinetics in a marmoset model. |
| AID587981 | Antibacterial activity against Escherichia coli AS226 carrying pBSDD240S mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID585183 | Ratio of Kcat to Km for Beta-lactamase GES-2 E104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1295310 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 1 mg/ml incubated for 24 hrs by cup diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID549350 | Antimicrobial activity against Escherichia coli isolate 100 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID405455 | Antibacterial activity against Escherichia coli 1540 isolate by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID573725 | Antibacterial activity against Citrobacter youngae CyB38 transconjugant harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID340734 | Antimicrobial activity against Escherichia coli HB101 harboring pBC-SK plasmid assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID559905 | Antimicrobial activity against Escherichia coli DH5alpha by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID519983 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID1435411 | Anti-fungal activity against Candida albicans ATCC 10231 measured after 24 hrs by microtiter broth dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives. |
| AID342020 | Antibacterial activity against Escherichia coli J53 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID423770 | Antibacterial activity against ESBL-positive Klebsiella pneumoniae isolate 119 having blaSHV promoter sequence with IS26 insertion by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID520881 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant p6S3 expressing beta lactamase OXA-114a by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID522016 | Antimicrobial activity against Escherichia coli isolate J53 harboring pL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID524568 | Antimicrobial activity against Shigella sonnei isolate AM22451 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID93997 | Minimum inhibitory concentration against Klebsiella aerogenes X6 (inoculum, 10e4 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID369228 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID524032 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 2688 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524209 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID557096 | Binding affinity to human alpha-1-acid glycoprotein assessed as compound binding sites level by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID510508 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate MC1AC9-26 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID520796 | Antimicrobial activity against SHV-5 producing Klebsiella pneumoniae with PFGE pulsotype D by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID542629 | Antimicrobial activity against streptomycin-resistant Streptococcus pneumoniae R6 harboring PBP2x T338G mutant gene, Janus disruption at PBP1a and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID524202 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID529643 | Antimicrobial activity against Pseudomonas aeruginosa 9551 expressing beta-lactamase VIM-15 obtained from urine of patient by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID544585 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8133 expressing bla TEM-55 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID498833 | Antimicrobial activity against Klebsiella pneumoniae CY1T expressing SHV-11, DHA-1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID519744 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID535754 | Antimicrobial activity against hospital-acquired Klebsiella pneumoniae expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID534382 | Antibacterial activity against Escherichia coli K-12 W1895 transconjugant harboring pCF243 by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID542044 | Antibacterial activity against Escherichia coli TrC B expressing Klebsiella pneumoniae B blaCTX-M beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID548020 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237E mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID524036 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 2527 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID496590 | Antimicrobial activity against Klebsiella pneumoniae 1534 harboring beta lactamase KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. |
| AID543282 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b genes and Streptococcus pneumoniae 3191 genomic DNA by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID587523 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 2 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID531648 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC176 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID531069 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC248 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID322324 | Antibacterial activity against Escherichia coli INSRA5924 isolates expressing CTX-M-32 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID567315 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2206 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID372609 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-35 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID562777 | Antimicrobial activity against Escherichia coli DH10B by Etest | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID340738 | Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis relative to control | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID532170 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii PU55T harboring wild-type GyrA, ParC, GyrB and qnrA genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID546620 | Antimicrobial activity against Escherichia coli harboring beta-lactamase VIM-2 by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID201438 | In vitro antimicrobial activity against Staphylococcus epidermidis 270 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID205377 | Bacterial challenge for systemic murine infection against Serratia marcescens SM | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID519651 | Antimicrobial activity against Escherichia coli Irk1224 type 2 mutant harboring beta-lactamase CTX-M-3 Ser167 mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID555216 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 20 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID222088 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against, gram-positive strains. | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID535654 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ61 harboring GyrA S83I, GyrA D87A, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID585837 | Antimicrobial activity against ampD, ampDh2, ampDh3 and ampG deficient Pseudomonas aeruginosa PAO1 harboring pZY0901 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID495334 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Ser357Asp, Met377Ile, Ser385Thr, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID528921 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-14 and CTX-M-27 gene and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID531605 | Activity of Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID535867 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ51 harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID499057 | Antimicrobial activity against Escherichia coli PU102T expressing TEM-1, CTX-M-14, CMY-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID520799 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype G by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID529897 | Antimicrobial activity against Leptospira interrogans serovar Pyrogenes isolate 5 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID573542 | Antibacterial activity against Escherichia coli Ec9381 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID497692 | Antimicrobial activity against Klebsiella pneumoniae isolated from bacteremia patient assessed as percentage of resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. |
| AID531080 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC225 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID521485 | Antibacterial activity against Klebsiella pneumoniae KN2303 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID543272 | Antimicrobial activity against Streptococcus pneumoniae 72521 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID562767 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID524434 | Antimicrobial activity against Shigella flexneri isolate AM13291 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID534754 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 08-642 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID447074 | Antibacterial activity against Bacillus cereus ATCC 7064 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID561313 | Antimicrobial activity against Enterobacter cloacae isolate 37 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID547789 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237M mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID544531 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 7668 expressing bla SHV-48 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID529645 | Antimicrobial activity against Pseudomonas aeruginosa 166301 expressing beta-lactamase VIM-16 obtained from urine of patient by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID549336 | Antimicrobial activity against Escherichia coli isolate 49 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID285690 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA4036 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID495837 | Antimicrobial activity against Escherichia coli harbouring plasmidBK-CMV expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID495347 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID535667 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ67 harboring wild-type GyrA S83I and qnrS genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID564544 | Ratio of Kcat to Ki for Acinetobacter baumannii ADC-33 beta-lactamase to Kcat to Ki for Acinetobacter baumannii ADC-11 beta-lactamase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID532190 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii TJ15 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB, qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID567325 | Antimicrobial activity against Escherichia coli ML4909 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID549353 | Antimicrobial activity against Escherichia coli ATCC 25922 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID562751 | Antimicrobial activity against Escherichia coli DH5alpha harboring pBC-CTX-M-71 plasmid by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID532175 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae SH39T harboring qnrA gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID535874 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JN1 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB and qnrA genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID573720 | Antibacterial activity against Citrobacter koseri Ck211 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1295320 | Antimicrobial activity against Aspergillus flavus ATCC 23554 incubated for 24 hrs by CLSI/NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID95719 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Klebsiella aerogenes 1522 E | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID1230845 | Antimicrobial activity against wild type Escherichia coli DH10B producing beta-lactamase PDC3 by agar dilution method | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14 | Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors. |
| AID394488 | Activity of Hafnia alvei beta-lactamase ACC-1 assessed as nmol of compound hydrolysis per ug of protein | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID524197 | Clearance in infant weighing 2 to 6.2 kg weight assessed as desacetylcefotaxime at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID524039 | Antibacterial activity against methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID323690 | Antibacterial activity against TEM92 ESBL-producing Acinetobacter baumannii by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. |
| AID524042 | Antibacterial activity against methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID701870 | Antibacterial activity against multidrug resistant NDM-1 producing Klebsiella pneumoniae isolate after 16 to 20 hrs by broth microdilution assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16 | Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones. |
| AID21913 | Relative hydrolysis rate (RHR) was evaluated against K1 enzyme | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | Dependence of beta-lactamase stability on substructures within beta-lactam antibiotics. |
| AID535647 | Antimicrobial activity against Group B Streptococcus serotype V 2603 V/R harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID372607 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-158 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID549351 | Antimicrobial activity against Escherichia coli isolate Z1 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID1056841 | Antibacterial activity against TEM-1/SHV-12 expressing Aeromonas hydrophila isolate 268 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID209442 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Streptococcus pyogenes A 308 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID563972 | Activity of Klebsiella pneumoniae 05-560 beta-lactamase NDM-1 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID79571 | In vitro antimicrobial activity against Haemophilus influenzae C.L. strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID499051 | Antimicrobial activity against carbapenem-resistant Escherichia coli PU60 deficient in TEM-1, CMY-2, ompC/F by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID511292 | Ratio of Kcat/Km for Pseudomonas aeruginosa GES-13 beta lactamase assessed as hydrolysis by spectrometry | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID285264 | Antimicrobial activity against Escherichia coli DH5-alpha TC1179 isolate expressing TEM-1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID523517 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1665 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID549352 | Antimicrobial activity against Escherichia coli isolate 49 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID567318 | Antimicrobial activity against Escherichia coli TUM4670 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID561443 | Antibacterial activity against Escherichia coli 34943 harboring beta-lactamase CMY-44 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID495333 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Ile449Val, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID395732 | Antimicrobial activity against imipenem-susceptible invasive nontypeable Haemophilus influenzae isolate 187 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID471354 | Antibacterial activity against Staphylococcus epidermidis ATCC 14990 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID205969 | Minimum inhibitory concentration against Staphylococcus aureus 95 (Methicillin-resistant, high-level beta-lactamase producer) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID575946 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID529461 | Antimicrobial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID1435414 | Anti-bacterial activity against Staphylococcus aureus ATCC 10832 measured after 24 hrs by microtiter broth dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives. |
| AID583651 | Antibacterial activity against Escherichia coli isolate 271 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID531601 | Antimicrobial activity against Escherichia coli JM109 harboring pSC1 plasmid expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID587729 | Antimicrobial activity against Escherichia coli DH5alpha carrying empty pBC-SK after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID597604 | Antibacterial activity against Streptococcus agalactiae ATCC 12400 after 18 hrs by broth microdilution method | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10 | Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. |
| AID1127078 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition after 18 hrs by agar diffusion method | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4 | Absolute configuration of (13R)- and (13S)-labdane diterpenes coexisting in Ageratina jocotepecana. |
| AID1321386 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2016 | Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19 | The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases. |
| AID584562 | Antimicrobial activity against Acinetobacter lwoffii isolate I expressing beta-lactamase OXA-58 isolated from tracheal secretion of patient by vitek 2 system | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. |
| AID495657 | Antimicrobial activity against Escherichia coli TOP10 expressing recombinant beta-lactamase BEL-1 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID528608 | Ratio of Kcat to Km for Escherichia coli 2138 beta-lactamase KPC-2 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID155941 | Concentration required for 90% inhibition of [14C]-pen G binding | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID535753 | Antimicrobial activity against community-acquired Klebsiella pneumoniae expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID524043 | Antibacterial activity against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID95904 | tested for its efficacy against systemic murine infection caused by Klebsiella pneumoniae A | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID524211 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID585679 | Antimicrobial activity against ampGh1 deficient Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID524926 | Antimicrobial activity against Escherichia coli MI1443 harboring A77V and P167S mutations in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID587980 | Antibacterial activity against Escherichia coli AS226 carrying pBSDS237A mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID561325 | Antimicrobial activity against Klebsiella pneumoniae isolate 135 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID519652 | Antimicrobial activity against Escherichia coli Irk1224 type 3 mutant harboring beta-lactamase CTX-M-3 Lys136 mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID583019 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli DH10B plasmid carrying DHA-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID523498 | Antimicrobial activity against Pseudomonas aeruginosa isolate 14169c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID530504 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IB isolate 5436-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID510513 | Antibacterial activity against Escherichia coli ATCC 25922 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID287375 | Antibacterial activity against Micrococcus luteus after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID540942 | Antimicrobial activity against Salmonella enterica serotype Newport AM17274 expressing CMY-31 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID520802 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype J by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID529579 | Ratio of Kcat to Km for Legionella gormanii ATCC 33297T beta-Lactamase FEZ-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID163774 | Evaluated for the minimum inhibitory concentration against Pseudomonas aeruginosa 18S/H (Class Id beta-lactamase overproducer) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID573523 | Antibacterial activity against Enterobacter cloacae isolate El216 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1862390 | Antibacterial activity against Klebsiella pneumoniae harboring OXA-48 assessed as bacterial growth inhibition incubated for 16 to 20 hrs by microdilution method | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. |
| AID559700 | Antimicrobial activity against Bacillus thuringiensis AB93066 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. |
| AID162718 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Proteus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID562576 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID285259 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-29 and ESBL by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID524215 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1056874 | Antibacterial activity against Klebsiella pneumoniae FNSST 011 assessed as diameter of zone of inhibition at 30 ug/disc after 24 hrs by disc diffusion method | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID330963 | Antimicrobial activity against wild type Escherichia coli transfected with pCF1 by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID530506 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype II isolate 9051-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID528788 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID524033 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 1394 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID156422 | Evaluated for concentration required for 90 % inhibition of [14C]- penicillin G binding to PBP's of Escherichia coli UB 1005 as Penicillin-binding protein 5/6 40 kDa | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID543411 | Antimicrobial activity against Shigella sonnei UIH-1 expressing beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1762804 | Antibacterial activity against against Escherichia coli 04 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID372611 | Antibacterial activity against Escherichia coli DH5alpha by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID584835 | Antimicrobial activity against Aeromonas allosaccharophila AL-1 expressing beta-lactamase PER6 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID467611 | Dissociation constant, pKa of the compound | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID67230 | Evaluated for the minimum inhibitory concentration against Enterococcus faecalis ATCC 29212 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID562472 | Antimicrobial activity against Klebsiella pneumoniae isolate 2641/08 obtained from urine of patient with ischemic cardiomyopathy and several comorbidities by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID368757 | Antimicrobial activity against Morganella morganii expressing TEM-24b AmpC gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID519067 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 assessed as resistant strains by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID543419 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID495337 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Ser357Asp, Met377Ile, Ser385Thr, Leu389Phe, substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID510511 | Antibacterial activity against Acinetobacter calcoaceticus/baumannii complex isolate N2AC9-19 expressing KPC beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Detection of KPC in Acinetobacter spp. in Puerto Rico. |
| AID528787 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID573539 | Antibacterial activity against Klebsiella pneumoniae Kp38009 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID495646 | Antimicrobial activity against Pseudomonas luteola expressing blaLUT-2 to blaLUT-6 by Etest method in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID524938 | Antimicrobial activity against Escherichia coli MI1443 harboring V27A, Q38R, P167S and D240G mutations in beta lactamase CTX-M-3 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID554985 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 20 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID520966 | Antibacterial activity against Klebsiella pneumoniae YC by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID534176 | Antimicrobial activity against armA positive Klebsiella pneumoniae DU producing beta lactamase CTX-M-3 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID522187 | Antimicrobial activity against Klebsiella pneumoniae isolate KpL expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID557091 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 4% human serum albumin | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID585184 | Ratio of Kcat to Km for Beta-lactamase GES-5 E104, S170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID498839 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae GZ66 deficient in SHV-11, DHA-1, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID585195 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-2 E104, N170 mutant by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID64249 | Minimum inhibitory concentration against Escherichia coli X4 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID524213 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID530502 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 7490-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID576065 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 69928 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID63907 | Minimum inhibitory concentration against Enterobacter cloacae A13 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID667372 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microtiter broth dilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives. |
| AID531675 | Antimicrobial activity against Escherichia coli DH5alpha by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID496594 | Ratio of Kcat to Km for Escherichia coli DH10B beta-lactamase KPC-2 | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. |
| AID541013 | Antimicrobial activity against Burkholderia cenocepacia 5007902 expressing beta-lactamase PenB4 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID530349 | Antimicrobial activity against Escherichia coli TOP10 harboring pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID585440 | Antimicrobial activity against ampG, ampGh1 deficient Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID555557 | Antimicrobial activity against Pseudomonas aeruginosa isolate 27135 expressing VIM-2 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID520883 | Activity of Achromobacter xylosoxidans CIP69598 beta-lactamase OXA-114a expressed in Escherichia coli TOP10 assessed as compound hydrolysis | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID509869 | Antibacterial activity against Acinetobacter baumannii isolate 4860 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID524048 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543953 | Antibacterial activity against tetracycline-resistant Staphylococcus aureus COL-S carrying SSpbpD plasmid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID524066 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID162759 | In vitro minimum inhibitory concentration was measured against Proteus mirabilis 90 strain.; ( | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID498821 | Antimicrobial activity against Klebsiella pneumoniae WH76T expressing IMP-4, TEM-1, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID205210 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Serratia | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID520398 | Antibacterial activity against mef-positive Streptococcus pneumoniae isolates assessed as resistance incidence by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID561441 | Antibacterial activity against Escherichia coli 1285 harboring beta-lactamase CMY-33 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID576062 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 71697 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID368756 | Antimicrobial activity against Enterobacter cloacae Ecl1 expressing TEM-24b AmpC TEM-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID285689 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA4012 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID269445 | Antibacterial activity against MRSA Staphylococcus aureus 134/93 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID471355 | Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID64567 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Escherichia coli | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID285271 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM1 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID520777 | Antibacterial activity against beta-lactamase KPC-2 producing Klebsiella pneumoniae isolate K10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID535889 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41T harboring qnrB gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID1435416 | Anti-bacterial activity against Bacillus subtilis ATCC 33712 measured after 24 hrs by microtiter broth dilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives. |
| AID542737 | Antimicrobial activity against Klebsiella pneumoniae D24 expressing aac(6')-Ib-cr and CTX-M-9G genes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID559271 | Antimicrobial activity against Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID542721 | Antimicrobial activity against ESBL-producing Klebsiella pneumoniae clinical isolate assessed as resistant isolates | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases. |
| AID583095 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 W87A mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID521489 | Antibacterial activity against Escherichia coli DH10B expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID561106 | Antibacterial activity against Pasteurella multocida BB1040 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID585175 | Activity of Beta-lactamase GES-1 E104, G170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID529463 | Antimicrobial activity against Klebsiella pneumoniae isolate 21 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID531091 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC248 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID535877 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii JN1T by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID498837 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU8 deficient in SHV-11, DHA-1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535717 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-B2 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID555675 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring recombinant plasmid carrying CTX-M-53 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID498809 | Antimicrobial activity against Klebsiella pneumoniae ZJ99T expressing KPC-2, CTX-M-3, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID373762 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii ab1266 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID68181 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Enterobacter cloacae 1321 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID201411 | In vitro antimicrobial activity against Staphylococcus aureus X1.1 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID544441 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID422494 | Antimicrobial activity against Escherichia coli BL21 (DE3) by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID543412 | Antimicrobial activity against Shigella sonnei UIH-1 expressing beta-lactamase CTX-M-64 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID373208 | Antimicrobial activity against Bacillus clausii DSM 8716 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID534762 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate C316 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID559270 | Antimicrobial activity against Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID285364 | Susceptibility of qnr positive Enterobacter cloacae assessed as percentage nonsusceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. |
| AID524057 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID52940 | Evaluated for the minimum inhibitory concentration against Citrobacter freundii BS-16. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID522023 | Antimicrobial activity against Citrobacter freundii isolate expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID164081 | In vivo activity in murine against Pseudomonas aeruginosa 5712 infection after sc administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID562778 | Antimicrobial activity against Escherichia coli DH10B by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID471356 | Antibacterial activity against Bacillus cereus ATCC 21772 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID546618 | Antimicrobial activity against Pseudomonas aeruginosa isolate 243-31C expressing beta-lactamase VIM-18 isolated from sputum of patient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID544426 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID201437 | In vitro antimicrobial activity against Staphylococcus epidermidis 222 strain | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID519649 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID269447 | Antibacterial activity against wild type Mycobacterium vaccae IMET10670 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID554984 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 14 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID681115 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID531072 | Antimicrobial activity against CMY-2,CTX-M-14,TEM-2-like beta-lactamase producing Escherichia coli isolate CUMC215 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID498826 | Antimicrobial activity against Citrobacter freundii SZ63 expressing IMP-4, qnrS1by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID524207 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID562809 | Antimicrobial activity against Escherichia coli J53 | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID205371 | In vivo activity in murine against Serratia marcescens SM infection after sc administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID560113 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69-V49 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID269455 | Antibacterial activity against Klebsiella pneumoniae ATCC 8308 by agar diffusion assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. |
| AID498844 | Antimicrobial activity against Klebsiella pneumoniae XJ81T expressing TEM-1, SHV-12, aac(6')-Ib by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID495511 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4665 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID522002 | Antimicrobial activity against Escherichia coli isolate J53 harboring p6A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID540967 | Activity of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID523504 | Antimicrobial activity against Pseudomonas aeruginosa isolate 15110c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID544517 | Metabolic stability in Escherichia coli TOP10 harboring beta-lactamase KPC-5 assessed as hydrolysis rate per mg of extracts at 100 uM after 5 mins by spectrophotometric analysis | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID1762808 | Antibacterial activity against Klebsiella pneumoniae assessed as reduction in bacterial growth incubated for 24 hrs by by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID520801 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype I by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID1659472 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as induction of changes in mass spectral profile of bacteria 1 times MIC uM by MALDI-TOF MS analysis | 2020 | Journal of medicinal chemistry, 08-27, Volume: 63, Issue:16 | Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening. |
| AID530326 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pUCP carrying VIM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID147163 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Neisseria perfl. | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID374113 | Antimicrobial activity against azide-resistant Escherichia coli J53 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID535671 | Antimicrobial activity against beta-lactamase negative, ampicillin-resistant Haemophilus influenzae expressing fst1 mutant gene assessed as resistant isolates by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID373056 | Antimicrobial activity against Bacillus clausii NR expressing beta-lactamase BCL1 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID530323 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 harboring pUCP carrying VIM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID567474 | Antimicrobial activity against gBLPACR-1 Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID661607 | Antibacterial activity against Escherichia coli expressing CTX-M-9 beta-lactamase | 2012 | Journal of medicinal chemistry, Mar-08, Volume: 55, Issue:5 | Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase. |
| AID520807 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype A by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID534178 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID549330 | Antimicrobial activity against Escherichia coli isolate 16 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID682156 | TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Cefotaxime: 2000 uM) in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2 | The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. |
| AID520397 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Spain 6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID531600 | Antimicrobial activity against Escherichia coli JM109 harboring pE1 plasmid expressing beta-lactamase SHV-11 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID373751 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ATCC 19606 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID369230 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent sensitive isolates by CLSI breakpoint method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID523491 | Antimicrobial activity against Pseudomonas aeruginosa Z799/61 by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID544490 | Antibacterial activity against Pseudomonas aeruginosa PR280 harboring beta-lactamase KPC-5 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID576317 | Antimicrobial activity against ESBL-negative Klebsiella pneumoniae 30018 harboring porin OmpK35 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID396029 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID532029 | Antimicrobial activity against Escherichia coli TOP10F' transformant harboring beta-lactamase CTX-M-78 by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID521305 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype I by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID524194 | Elimination half life in infant weighing 2 to 6.2 kg weight during extracorporeal membrane oxygenation at 50 mg/kg, iv dosed 2 to 3 times in a day bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID524071 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID373764 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh11 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID567314 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2205 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID511287 | Antibacterial activity against Pseudomonas aeruginosa NL68 expressing GES-13 beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID520972 | Antibacterial activity against Escherichia coli harboring pBC633 plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID151382 | Minimum inhibitory concentration against Proteus vulgaris Pv9 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID163115 | Minimum inhibitory concentration for prevention of visible growth of Pseudomonas aeruginosa (1101-75 strain) | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID530813 | Antibacterial activity against Escherichia coli J53 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID64247 | Minimum inhibitory concentration against Escherichia coli TEM X3 (inoculum, 10e5 cfu per spot)(TEM I type lactamase producer) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID543285 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1056839 | Antibacterial activity against TEM-1/CTX-M-15 expressing Aeromonas caviae isolate 260 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID544964 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase DHA by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID520967 | Antibacterial activity against Escherichia coli harboring pNYC plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID524204 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID520879 | Antibacterial activity against Achromobacter xylosoxidans DUC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID528523 | Antimicrobial activity against penicillin-resistant Streptococcus agalactiae ATCC 12403 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | First molecular characterization of group B streptococci with reduced penicillin susceptibility. |
| AID522381 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates assessed as susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID522026 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEcA containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID495344 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Gly490Glu, Ala502Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID529458 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID541016 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase PenB1 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID368758 | Antimicrobial activity against Klebsiella oxytoca expressing TEM-11 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID372616 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-12 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID584490 | Antibacterial activity against porin deficient OmpA positive Klebsiella pneumoniae KPBj1 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID94225 | The compound was tested in vitro for minimum inhibitory concentration against Klebsiella pneumoniae A | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID341106 | Antibacterial activity against metallo-beta-lactamase VIM12 expressing Escherichia coli 28 isolate from decubitus ulcer infection patient by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID567310 | Antimicrobial activity against SHV-12 ESBL producing Pseudomonas aeruginosa isolate 2201 isolated from burn patient by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient. |
| AID573510 | Antibacterial activity against Citrobacter freundii isolate Cf1614 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID587731 | Ratio of Kcat to Km for Pseudomonas aeruginosa strain PS 297 metallo-beta-lactamase IMP18 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis using 100 uM nitrocefin | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID563967 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID373052 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID681569 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3 | Interaction of human organic anion transporters with various cephalosporin antibiotics. |
| AID330961 | Antimicrobial activity against wild type Escherichia coli by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID576280 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17830 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID525546 | Antimicrobial activity against Haemophilus influenzae Rd KW20 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID543424 | Antimicrobial activity against Escherichia coli XL-1 Blue transconjugant harboring beta-lactamase CTX-M-64 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID562776 | Antimicrobial activity against Escherichia coli DH10B by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID558336 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1618 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID96424 | In vitro minimum inhibitory concentration was measured against Klebsiella pneumoniae A strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID520800 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype H by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID162780 | In vitro minimum inhibitory concentration was measured against Pseudomonas aeruginosa 18S/H strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID279186 | Activity of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID495816 | Antimicrobial activity against Escherichia coli 2603 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID534379 | Antibacterial activity against Citrobacter freundii KHM243 clinical isolate by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate. |
| AID524573 | Antimicrobial activity against Shigella isolate DH-26336 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID557797 | Antimicrobial activity against Escherichia coli J53 transconjugated with Proteus mirabilis pHS10 carrying qnrC gene by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. |
| AID523488 | Antimicrobial activity against Pseudomonas aeruginosa R70 Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID396030 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID531085 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC192 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID63910 | Minimum inhibitory concentration against Enterobacter cloacae P99 (inoculum, 10e4 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID559269 | Antimicrobial activity against Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID340727 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-2 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID531084 | Antimicrobial activity against CTX-M-14, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC180 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID68001 | tested for its efficacy against systemic murine infection caused by Enterobacter cloacae 5699. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID423756 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 30 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID573502 | Antibacterial activity against Klebsiella pneumoniae isolate Kp38045 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1543303 | Antimicrobial activity against Cryptococcus neoformans ATCC 90113 assessed as inhibition of microbial growth by CLSI based method | 2019 | Journal of natural products, 07-26, Volume: 82, Issue:7 | Anthraquinone-Based Specialized Metabolites from Rhizomes of |
| AID544965 | Antimicrobial activity against Proteus mirabilis expressing extended-spectrum beta-lactamase by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID532191 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii TJ15 harboring GyrA T83I, ParC S80I mutant, wild-type GyrB, qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID524049 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524040 | Antibacterial activity against methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID561321 | Antimicrobial activity against Escherichia coli isolate 48 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID531318 | Ratio of Kcat to Km for Escherichia coli beta-lactamase VIM-1 by spectrophotometry | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. |
| AID524742 | Antimicrobial activity against Escherichia coli GB20 harboring P167S mutation in beta lactamase CTX-M-10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID576308 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 29459 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID587985 | Antibacterial activity against Escherichia coli AS226 carrying pBSD6 mutant after 18 hrs by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID567320 | Antimicrobial activity against Escherichia coli ML4909 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID368495 | Ratio of Kcat to Km of Escherichia coli CTX-M-15 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Interactions of ceftobiprole with beta-lactamases from molecular classes A to D. |
| AID522019 | Antimicrobial activity against Enterobacter cloacae isolate 1 expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID562222 | Antimicrobial activity against Desulfovibrio desulfuricans Essex 6 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID523511 | Antimicrobial activity against Pseudomonas aeruginosa isolate 13167 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID1056842 | Antibacterial activity against TEM-1/SHV-12/CTX-15 expressing Enterobacter intermedius isolate 243 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID534758 | Antimicrobial activity against beta-lactamase CTX-M-producing Escherichia coli isolate 03-271 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID562578 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID522570 | Antimicrobial activity against Escherichia coli isolate 7008710 with AmpC beta-lactamase S287N mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID68858 | In vitro minimum inhibitory concentration was measured against Escherichia coli TEM-1 (Beta lactamase producer) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID531088 | Antimicrobial activity against CTX-M-14-like, TEM-1-like beta-lactamase producing Escherichia coli isolate CUMC233 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID585194 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-7 K104, G170 mutant by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID585676 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAO1 harboring pUCP24 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID524190 | Volume of distribution in infant during extracorporeal membrane oxygenation at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID521353 | Antimicrobial activity against Streptococcus pneumoniae isolate k-421 obtained from ear of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID604022 | Fraction unbound in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID530517 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 3386-05 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID373051 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID585629 | Antimicrobial activity against kanamycin resistant Escherichia coli SNO301-1 harboring pEC1C carrying ampC, ampR from Enterobacter cloacae after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID94303 | In vivo protective dose was determined in infected swiss mice (120/strain) infected ip with Klebsiella pneumoniae 102 with an inoculum size-0.5 mL of 10 E5 CFU/mL of suspension. Activity value range is 1.82-7.92 | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID208312 | Minimum inhibitory concentration against Streptococcus pneumoniae (PARK) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID559272 | Antimicrobial activity against Proteus vulgaris Pv9 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID522021 | Antimicrobial activity against Enterobacter cloacae isolate 2 expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID585436 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 16 to 20 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID543795 | Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID525548 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1051 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID555555 | Antimicrobial activity against Pseudomonas aeruginosa isolate 26285 expressing IMP-13 beta lactamase gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. |
| AID529664 | Ratio of Kcat to Km for Pseudomonas aeruginosa 166301 beta-lactamase VIM-16 relative to cephaloridine | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID70596 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Escherichia coli DC 0 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID523501 | Antimicrobial activity against Pseudomonas aeruginosa isolate 1352c from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID532202 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99 harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID495345 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Ala368Thr, Ala502Thr, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID543269 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID519013 | Ratio of Kcat to Km for Beta-lactamase TEM-10 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID495834 | Antimicrobial activity against Escherichia coli DH5alpha harbouring plasmid BK-VIM-19 expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID368738 | Antimicrobial activity against Escherichia coli Ec2 containing pEc1-B plasmid expressing CTX-M-15 TEM-1 OXA-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID1505215 | Antibacterial activity in Escherichia coli BL21 (DE3) expressing pET-24a-blaNDM-1 incubated at 37 degC for 18 hrs by spectrophotometry | 2018 | ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1 | Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1. |
| AID423761 | Antibacterial activity against ESBL-negative Klebsiella pneumoniae isolate 106 by Etest | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. |
| AID496591 | Antimicrobial activity against Escherichia coli DH10B harboring beta lactamase KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. |
| AID1329361 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution method | 2016 | Journal of natural products, 09-23, Volume: 79, Issue:9 | Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. |
| AID530322 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA-SL2 harboring blaVIM-13 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID519004 | Antimicrobial activity against Serratia marcescens isolate CT-118 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID583652 | Antibacterial activity against Escherichia coli TOP10 expressing metallo-beta-lactamase NDM-1 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID498841 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae SX67 deficient in SHV-2, CTX-M-14, DHA-1, qnrB6/S1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID558537 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P321 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID519653 | Antimicrobial activity against Escherichia coli GM2995 harboring plasmid pCC1 carrying beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID559899 | Antimicrobial activity against Klebsiella pneumoniae 101A harboring beta-lactamase CMY-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID544432 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID584491 | Antibacterial activity against porin, OmpA positive extended-spectrum beta-lactamase producing Klebsiella pneumoniae KPBj1 by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID368759 | Antimicrobial activity against Escherichia coli Ec6 expressing CTX-M-14 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID499060 | Antimicrobial activity against Enterobacter aerogenes PU41T expressing CTX-M-14, DHA-1, qnrS1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID559685 | Antibacterial activity against Acinetobacter baumannii BM4652 harboring plasmid IP847 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID546619 | Antimicrobial activity against Escherichia coli harboring beta-lactamase VIM-18 by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID521304 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype H by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID562768 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID583086 | Ratio of Kcat to Km for Escherichia coli XL1-Blue IMP-1 W64A mutant beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID197865 | The compound was tested in vitro for minimum inhibitory concentration against Staphylococcus aureus 753 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID368755 | Antimicrobial activity against Proteus mirabilis Pm4 expressing TEM-21 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID582967 | Antimicrobial activity against beta-lactamase B-deficient Yersinia enterocolitica GY5542 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID521488 | Antibacterial activity against Pseudomonas aeruginosa KG2505 harboring pCOL plasmid by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID528916 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-14 and CTX-M-27 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID530816 | Antibacterial activity against Escherichia coli J53 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID509870 | Antibacterial activity against Acinetobacter baumannii isolate 5191 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID573501 | Antibacterial activity against Morganella morganii isolate Mm38009 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID657438 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium after 16 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives. |
| AID521425 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID562814 | Antimicrobial activity against Escherichia coli J53 in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID522391 | Inhibition of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID585833 | Antimicrobial activity against ampG deficient Pseudomonas aeruginosa PAK harboring pZY0901 conferring resistance to gentamycin after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID1295312 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 at 1 mg/ml incubated for 24 hrs by cup diffusion assay | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and anticancer agents. |
| AID562754 | Activity of Klebsiella pneumoniae AH24-270 CTX-M-71 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID573511 | Antibacterial activity against Morganella morganii isolate Mm1614 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID209441 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Streptococcus pyogenes 8b | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID543799 | Bactericidal activity against Acinetobacter baumannii VT 126 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID495349 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Asp350Asn, Ala437Ser substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID528917 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-14 and CTX-M-27 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID562817 | Antimicrobial activity against Escherichia coli DH5[alpha] in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID576262 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 17829 harboring pSHA2-encoded porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID498829 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae RJ94 deficient in IMP-4, TEM-1, CTX-M-3, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID540948 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c2 plasmid expressing cephalosporinase CMY-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID520396 | Antibacterial activity against mef(E) and mef(A)-positive Streptococcus pneumoniae isolate CC-6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID278594 | Inhibitory activity against azide-resistant Escherichia coli J53 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID521302 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype F by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID604024 | Unbound brain to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20 | Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. |
| AID497693 | Antimicrobial activity against colistin-susceptible Klebsiella pneumoniae isolated from bacteremia patient assessed as percentage of resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. |
| AID285255 | Antimicrobial activity against Escherichia coli DH5-alpha CF1179 isolate expressing CMT and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID520778 | Antibacterial activity against beta-lactamase KPC-2 producing Escherichia coli isolate E1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID575419 | Antimicrobial activity against Listeria monocytogenes EGD-e assessed as growth inhibition after 16 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID573330 | Antibacterial activity against Klebsiella pneumoniae isolate Kp1239 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID495791 | Antimicrobial activity against Pseudomonas fluorescens isolate PF-1 expressing beta-lactamase BIC-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID322317 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID535652 | Antimicrobial activity against aac(6')-Ib-cr-positive Escherichia coli FJ3T harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID495840 | Hydrolytic activity of beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID498815 | Antimicrobial activity against Klebsiella pneumoniae FZ47T expressing IMP-8, TEM-1, CTX-M-14, qnrB2, aac(6')-Ib by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID156120 | Affinity for penicillin binding protein 2 of Escherichia coli UB1005 (DC0) was evaluated. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID151368 | The compound was tested in vitro for minimum inhibitory concentration against Proteus mirabilis 90 | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID560555 | Antimicrobial activity against Proteus vulgaris Pv7 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID543793 | Antimicrobial activity against Haemophilus influenzae VT450-2006 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID587529 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-406 infected in sc dosed CD-1 mouse in presence of 2 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID554987 | Antibacterial activity against Acinetobacter genomosp. 3 isolate 52 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID562577 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID523514 | Antimicrobial activity against Pseudomonas aeruginosa isolate 12102 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID543179 | Antimicrobial activity against Aeromonas sobria assessed as susceptibility level by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activities of tigecycline against clinical isolates of Aeromonas, Vibrio, and Salmonella species in Taiwan. |
| AID558533 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1698 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID373205 | Antimicrobial activity against Bacillus clausii T by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID561323 | Antimicrobial activity against Klebsiella pneumoniae isolate 132 expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID567324 | Antimicrobial activity against Escherichia coli TUM4672 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID429079 | Antibacterial activity against Klebsiella pneumoniae Greece producing KPC-2 beta-lactamase by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID530503 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IA isolate 9012-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID559918 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG4 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID558329 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P305 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID561446 | Antibacterial activity against Escherichia coli DH10B harboring plasmid BCSK carrying beta-lactamase CMY-2 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. |
| AID534172 | Antimicrobial activity against armA positive Escherichia coli MEZ producing beta lactamase CTX-M-3 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID542619 | Antimicrobial activity against streptomycin- resistant Streptococcus pneumoniae R6 harboring PBP2x2349 mutant gene and Janus disruption at PBP1a after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID608336 | Antibacterial activity against 1 x 10'4 cfu/mL methicillin-resistant Staphylococcus aureus ATCC 700699 after 24 hrs by NCCLS M7-A6 microtiter broth dilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis and antimicrobial evaluation of new benzofuran derivatives. |
| AID203135 | In vitro antibacterial activity against Serratia marcescens SM | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID325150 | Antimicrobial activity against Haemophilus parasuis ATCC 19417 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID495913 | Ratio of Kcat to Km for beta-lactamase VIM-19 expressed in Escherichia coli TOP10 by spectrophotometry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID522578 | Antimicrobial activity against Escherichia coli isolate 8009162 AmpC with A292V mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID542772 | Antimicrobial activity against Escherichia coli J53 transformed with pHNDU1 carrying qnrB6 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID522576 | Antimicrobial activity against Escherichia coli isolate 7014517 AmpC with LAA insertion at position 295 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID559698 | Antibacterial activity against quinolone-resistant Escherichia coli TOP10-3963 transformant harboring qnrS1 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. |
| AID1129351 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 700221 after 18 hrs by microdilution broth method | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7 | Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli. |
| AID520971 | Antibacterial activity against Klebsiella pneumoniae 633 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID535663 | Antimicrobial activity against aac(6')-Ib-cr-positive Enterobacter cloacae FJ63T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID342019 | Antibacterial activity against plasmid pK29 transconjugant Escherichia coli J53 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID1765580 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID524051 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID544491 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID495819 | Antimicrobial activity against Klebsiella pneumoniae 2878 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 0.4 mM EDTA | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID524220 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543420 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID425867 | Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID519982 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID587969 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 N104A mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID577711 | Antibacterial activity against 10'5 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a after 16 hrs by by two fold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics. |
| AID542049 | Antibacterial activity against rifampicin resistant Escherichia coli J53-2 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID543284 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, murM and Streptococcus pneumoniae 72521 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID532178 | Antimicrobial activity against aac(6')-Ib-cr-negative Klebsiella pneumoniae SY22 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID67566 | In vitro minimum inhibitory concentration was measured against Enterococcus faecalis ATCC 29212 strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID205556 | Minimum inhibitory concentration against Staphylococcus aureus (X1.1) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID530342 | Ratio of Kcat to Km for Pseudomonas aeruginosa VIM-13 beta-lactamase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID585186 | Ratio of Kcat to Km for Beta-lactamase GES-13 K104, N170 mutant | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID521427 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID325448 | Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID531603 | Antimicrobial activity against Escherichia coli JM109 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID535859 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40T harboring qnrB gene by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID1129346 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by microdilution broth method | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7 | Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli. |
| AID529159 | Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID252617 | Mean lysis diameter of Enterobacter aerogenes EA289 with D113A mutation by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID40191 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Bacillus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID422495 | Antimicrobial activity against Escherichia coli BL21 (DE3) harboring pAT514 by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID560488 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-30 producing Escherichia coli MC4100 harboring plasmid AC-cmy30 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID373204 | Antimicrobial activity against Bacillus clausii SIN by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID534770 | Antimicrobial activity against streptomycin-, chloramphenicol-resistant pBCKS positive Escherichia coli DH10B transformant | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID522573 | Antimicrobial activity against Escherichia coli isolate 8009162 with AmpC beta-lactamase A292V mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID531654 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC214 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID522566 | Antimicrobial activity against Escherichia coli isolate 7008153 with AmpC beta-lactamase H296P mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID155830 | The compound was evaluated for the inhibition of [14C]- Pen G binding to Escherichia coli UB1005 penicillin-binding protein 1a 90 kDa. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID533877 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID559897 | Antimicrobial activity against Klebsiella oxytoca KO280 harboring beta-lactamase OXY-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | First detection of plasmid-encoded blaOXY beta-lactamase. |
| AID544957 | Antimicrobial activity against Escherichia coli expressing beta-lactamase SHV by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID495512 | Antibacterial activity against multidrug-resistant Acinetobacter baumannii BM4666 by antimicrobial susceptibility assay | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. |
| AID549331 | Antimicrobial activity against Escherichia coli isolate 32 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID50531 | In vitro minimum inhibitory concentration was measured against Citrobacter freundii BS-16 (beta lactamase producer) strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID576074 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 18260 harboring pSHA2-encoded porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID531073 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC243 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID558322 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni NCTC 11168 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID368753 | Antimicrobial activity against Klebsiella pneumoniae Kp5 expressing plasmid-mediated cephalosporinase ACC-1 and TEM-1 | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID206866 | Antibacterial activity against penicillin G susceptible Staphylococcus aureus | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID541019 | Antimicrobial activity against Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID524210 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID564534 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid carrying entire blaAmpC gene with alanine residue deletion at 215 position and R210P substitution by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID532678 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as resistant isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID203621 | Geometrical average of minimum bactericidal concentration was determined in isosensitest broth against Staphylococcus | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID95549 | Geometrical average of minimum inhibitory concentration was determined in isosensitest broth against Klebsiella | 1987 | Journal of medicinal chemistry, May, Volume: 30, Issue:5 | Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins. |
| AID535861 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae GZ47 harboring qnrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID499058 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae GX24 deficient in TEM-1, DHA-1, aac(6')-Ib, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID535633 | Antimicrobial activity against Group B streptococcus serotype Ia R7 harboring T77I, F395V and S353F in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and Y470F in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID495810 | Antimicrobial activity against Escherichia coli harbouring plasmid BK-CMV expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID531063 | Antimicrobial activity against CMY-2,CTX-M-14,TEM-2-like beta-lactamase producing Escherichia coli isolate CUMC215 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID68012 | Antibacterial activity against Enterobacter cloacae EB5 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID498845 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU105 deficient TEM-1, SHV-12, CTX-M-14, DHA-1, qnrB10/B4-like, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID524054 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID530516 | Antimicrobial activity against group B Streptococcus sp. 'group B' isolate 7368-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID531972 | Antibacterial activity against Klebsiella pneumoniae blood isolate A28006 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID522110 | Antimicrobial activity against Escherichia coli isolates producing extended-spectrum beta-lactamases bla(CTX-M-1), bla(CTX-M-32) and bla(SHV-12) isolated from Italian broiler flocks by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | High diversity of extended-spectrum beta-lactamases in Escherichia coli isolates from Italian broiler flocks. |
| AID68184 | In vitro antibacterial activity against Enterobacter cloacae 5699 | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. |
| AID524928 | Antimicrobial activity against Escherichia coli MI1443 harboring N106S mutation in beta lactamase CTX-M-10 by E-test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID295096 | Antibacterial activity against Escherichia coli ATCC 11230 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID428291 | Antimicrobial activity against Acinetobacter baumannii BM4652 expressing adeABC adeIJK double mutant isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID549333 | Antimicrobial activity against Escherichia coli isolate 36 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID471598 | Antibacterial activity against Pseudomonas aeruginosa AK958 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID555665 | Antimicrobial activity against Salmonella enterica serotype Westhampton isolate 04CEB8273SAL CTX-M-53 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID576071 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 50748 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID559273 | Antimicrobial activity against Providencia stuartii Ps5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID535697 | Antimicrobial activity against Azide-resistant Escherichia coli J53 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID564222 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid PH1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID564536 | Antimicrobial activity against Escherichia coli TOP10 harboring pTOPO plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID573512 | Antibacterial activity against Klebsiella pneumoniae isolate Kp4614 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID583014 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli ECB2 plasmid carrying CMY-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID524748 | Antimicrobial activity against Escherichia coli GB20 harboring V27A, Q38R, A77V, N114D, A140S, P167S, D288N mutations in beta lactamase CTX-M-1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. |
| AID559266 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv8 expressing beta-lactamase PER-1 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID529651 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID394489 | Activity of Hafnia alvei beta-lactamase ACC-1 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID559274 | Antimicrobial activity against rifampin-resistant Escherichia coli J53 transconjugated with Proteus vulgaris Pv5 expressing beta-lactamase PER-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emergence of extended-spectrum beta-lactamase PER-1 in Proteus vulgaris and Providencia stuartii isolates from Algiers, Algeria. |
| AID557101 | Binding affinity to human serum albumin assessed as fraction of binding sites occupied by compound at 180 ug/ml by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID575340 | Antimicrobial activity against Listeria monocytogenes EGD-e at 30 ug after 16 hrs by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics. |
| AID531599 | Antimicrobial activity against Klebsiella pneumoniae Kp2792 expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID520780 | Antibacterial activity against Escherichia coli EC600 transconjugant harboring beta-lactamase KPC-2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID544533 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8130 expressing bla SHV-1 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID524326 | Clearance in infant weighing 2 to 6.2 kg weight after extracorporeal membrane oxygenation at 50 mg/kg, iv dosed 2 to 3 times per day as bolus dose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. |
| AID542050 | Antibacterial activity against rifampicin resistant Escherichia coli J53-2 by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID587525 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 4 ug/ml Tazobactam beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID524200 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524245 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID584500 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae KPBj5 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID524063 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID498805 | Antimicrobial activity against Klebsiella pneumoniae ZJ70T expressing KPC-2 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID587522 | Antimicrobial activity against carbapenemases KPC-producing Klebsiella pneumoniae VA-361 infected in sc dosed CD-1 mouse in presence of 1 ug/ml NXL104 beta-lactamase inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae. |
| AID522006 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-2 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID587970 | Ratio of Kcat to Km for Escherichia coli beta-lactamase Toho-1 N104D mutant assessed as compound hydrolysis by spectrophotometry | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. |
| AID576314 | Antimicrobial activity against ESBL-negative Klebsiella pneumoniae 299332 harboring porin OmpK36 gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID205835 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Staphylococcus aureus 285 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID368749 | Antimicrobial activity against Klebsiella pneumoniae Kp2 expressing TEM-15 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID521991 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp11978 expressing beta-lactamase OXA-48, SHV-2a and TEM-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID287379 | Antibacterial activity against Pseudomonas aeruginosa after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID341108 | Antibacterial activity against Escherichia coli 26R793 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID529160 | Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay in presence of 250 ug/ml polyethylenimine | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID522013 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBEL expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID368739 | Antimicrobial activity against Escherichia coli Ec2-a containing pEc1-C plasmid expressing CTX-M-15 OXA-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID529900 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 9 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID531655 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC201 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID530601 | Antibacterial activity against Escherichia coli J53 harboring plasmid pAM carrying beta-lactamase PER-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID562815 | Antimicrobial activity against Escherichia coli J53 harboring pEK499 plasmid encoding CTX-M extended-spectrum beta-lactamases in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID543178 | Antimicrobial activity against Aeromonas caviae assessed as susceptibility level by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activities of tigecycline against clinical isolates of Aeromonas, Vibrio, and Salmonella species in Taiwan. |
| AID530519 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype V isolate 5677-04 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID522388 | Activity of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID522568 | Antimicrobial activity against Escherichia coli isolate 4009273 with AmpC beta-lactamase S287N mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID567319 | Antimicrobial activity against Escherichia coli TUM4672 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID535723 | Ratio of Kcat to Km for Escherichia coli TOP10 beta-lactamase AmpC-A S287N mutant | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID544497 | Ratio of MIC for Escherichia coli TOP10 harboring beta-lactamase KPC-5 to MIC for Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID1056843 | Antibacterial activity against CTX-15 expressing Enterobacter cloacae isolate 51 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID519980 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID547781 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237I mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID573522 | Antibacterial activity against Citrobacter koseri isolate Ck211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID561329 | Antimicrobial activity against azide-resistant Escherichia coli J53 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID523513 | Antimicrobial activity against Pseudomonas aeruginosa isolate 3149 from fibrosis patient by Etest | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. |
| AID535880 | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID561112 | Antibacterial activity against Pasteurella multocida BB1046 harboring plasmid pB1003 bearing blaROB-1 gene and plasmid pB1002 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID495348 | Antimicrobial activity against Beta-lactamase-positive, ampicillin-cluvulanate-resistant Haemophilus influenzae with Ile449Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID295117 | Antibacterial activity against Listeria monocytogenes ATCC 15313 at 30 ug after 24 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. |
| AID519658 | Antimicrobial activity against Escherichia coli EPI300 Irk1224 type 2 mutant harboring beta-lactamase CTX-M-3 Ser167 mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID564524 | Antimicrobial activity against Acinetobacter baumannii KI by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID521288 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype B by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID530513 | Antimicrobial activity against group B Streptococcus sp. 'group B' serotype IV isolate 3454-03 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. |
| AID156271 | Evaluated for concentration required for 90 % inhibition of [14C]- penicillin G binding to PBP's of Escherichia coli UB 1005 as penicillin-binding protein 1a 90 kDa | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1 | Cephalosporin 3'-quinolone esters with a dual mode of action. |
| AID521432 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene at 50 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID495330 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Ala502Val, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID522567 | Antimicrobial activity against Escherichia coli isolate 7001178 with AmpC beta-lactamase S287N mutation | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital. |
| AID498812 | Antimicrobial activity against Escherichia coli ZJ87 expressing KPC-2, TEM-1, ompC by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID584497 | Antibacterial activity against porin deficient OmpA positive Klebsiella pneumoniae KPBj3 expressing efflux system by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID561103 | Antibacterial activity against Pasteurella multocida BB1037 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID278602 | Inhibitory activity against Klebsiella pneumoniae 03-222 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID535651 | Antimicrobial activity against aac(6')-Ib-cr-positive Escherichia coli FJ3T harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID544492 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase KPC-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID252619 | Mean lysis diameter was measured against Enterobacter aerogenes EA289 with D121A mutation by standard disk diffusion method on MH agar | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5 | Beta-lactam screening by specific residues of the OmpF eyelet. |
| AID522020 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID520697 | Antimicrobial activity against Escherichia coli DH10B harboring p05283 carrying qepA and rmtB gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. |
| AID520983 | Antibacterial activity against Klebsiella pneumoniae GR by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID521284 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype H by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID548260 | Ratio of Kcat/Km for Klebsiella pneumoniae 1534 beta-lactamase KPC-2 T237S mutant by spectrophotometric analysis | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID322320 | Antibacterial activity against Escherichia coli INSRA5776 isolates expressing CTX-M-14 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID521289 | Antimicrobial activity against CTX-M-59 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype C by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID573496 | Antibacterial activity against Enterobacter cloacae isolate El1573 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID584502 | Antibacterial activity against porin deficient OmpA positive Klebsiella pneumoniae KPBj5 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID520804 | Antimicrobial activity against Escherichia coli str. K-12 substr. DH10B harboring plasmid CTX-M-2 in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID524572 | Antimicrobial activity against Shigella flexneri isolate AM26336 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID534166 | Antimicrobial activity against rmtB positive Escherichia coli VOG producing beta lactamase CTX-M-14 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID559686 | Antibacterial activity against Escherichia coli Top10 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. |
| AID562773 | Antimicrobial activity against Escherichia coli DH10B by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID499047 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZJ69 deficient in SHV-28, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID543803 | Bactericidal activity against Pseudomonas aeruginosa ATCC 27853 assessed as eradication of pre-formed biofilm at 1 to 10 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID542766 | Antimicrobial activity against Escherichia coli PA11 expressing aac(6')-Ib-cr, qnrS1 and qepA genes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID522382 | Antimicrobial activity against blaKPC-possessing Klebsiella pneumoniae isolates assessed as susceptible isolates in presence of 4 ug/ml by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | In vitro activity of penem-1 in combination with beta-lactams against blaKPC-possessing Klebsiella pneumoniae isolates. |
| AID561110 | Antibacterial activity against Pasteurella multocida BB1044 harboring plasmid pB1000 bearing blaROB-1 gene, plasmid 1006 bearing tetO gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID521301 | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype E by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID562475 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 by Etest | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID563975 | Ratio of Kcat to Km for Klebsiella pneumoniae 05-560 beta-lactamase IMP1 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. |
| AID372614 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID585671 | Antimicrobial activity against Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID524437 | Antimicrobial activity against Shigella isolate DH-19035 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID519650 | Antimicrobial activity against Escherichia coli EPI300 harboring plasmid pCC1 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID540944 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pA172 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID544570 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8130 expressing bla SHV-1 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID368735 | Antimicrobial activity against Enterobacter aerogenes Ea2 expressing TEM-3 AmpC gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID164867 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Pseudomonas aeruginosa 9027 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID405085 | Ratio of Kcat to Km of Citrobacter freundii PER2 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID53622 | Minimum inhibitory concentration for DC2, a permeability mutant | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID471353 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
| AID495911 | Antimicrobial activity in Escherichia coli J53 strain | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID368751 | Antimicrobial activity against Klebsiella pneumoniae Kp3 expressing SHV-2a TEM-1 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID565199 | Antimicrobial activity against Klebsiella pneumoniae isolate T-1780 expressing VIM-1 and KPC-2 genes by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Emerging Klebsiella pneumoniae isolates coproducing KPC-2 and VIM-1 carbapenemases. |
| AID524038 | Antibacterial activity against methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID544495 | Ratio of MIC for Escherichia coli TOP10 harboring beta-lactamase KPC-2 to MIC for Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. |
| AID373986 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr expressing Escherichia coli J53 qnrA1 bearing pHS3 transconjugant from Citrobacter freundii 64 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID373061 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID534089 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID545449 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Klebsiella oxytoca assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID543279 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID585680 | Antimicrobial activity against ampG, ampGh1 deficient Pseudomonas aeruginosa PAK after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression. |
| AID544433 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID562224 | Antimicrobial activity against Desulfovibrio piger by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID278595 | Inhibitory activity against Escherichia coli 12-1502 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID529582 | Ratio of Kcat to Km for Bradyrhizobium japonicum beta-Lactamase BJP-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID495802 | Antimicrobial activity against Escherichia coli 138 expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID369229 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by CLSI breakpoint method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID519749 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-72 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID535364 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as resistant isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1592957 | Antibacterial activity against multi-drug resistant Escherichia coli NMI 3548/14 assessed as reduction in microbial growth incubated for 20 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. |
| AID562764 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID562774 | Antimicrobial activity against Escherichia coli DH10B by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID545437 | Antimicrobial activity against extended-spectrum beta-lactamase-negative Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID548008 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237Q mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID495748 | Antimicrobial activity against Escherichia coli ATCC 25922 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. |
| AID556341 | Ratio of Kcat/Km for Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID1862387 | Antibacterial activity against Escherichia coli expressing CMY-4/TEM-1 assessed as bacterial growth inhibition at 0.06 to 64 ug/ml incubated for 16 to 20 hrs by microdilution method | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. |
| AID545428 | Antimicrobial activity against Enterobacter cloacae obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID531070 | Antimicrobial activity against SHV-12-like, SHV-1-like beta-lactamase producing Klebsiella pneumoniae isolate CUMCK9 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID524566 | Antimicrobial activity against Shigella sonnei isolate AM20369 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID519654 | Antimicrobial activity against Escherichia coli GM2995 harboring plasmid pCC1 carrying beta-lactamase CTX-M-3 from by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID521282 | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype F by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID544556 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8128 expressing bla SHV-105 gene by Etest method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID532193 | Antimicrobial activity against aac(6')-Ib-cr-positive Citrobacter freundii TJ15T harboring wild-type GyrA, ParC, GyrB genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID530815 | Antibacterial activity against human urinary Klebsiella pneumoniae UCL-1 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID567321 | Antimicrobial activity against Escherichia coli ML4901 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID583016 | Antimicrobial activity against OmpC/OmpF porin deficient Escherichia coli HB4 transformed with Escherichia coli EC-6 plasmid carrying AmpC-B2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID543811 | Bactericidal activity against Staphylococcus aureus ATCC 29213 assessed as eradication of pre-formed biofilm at 50 times MIC after 24 hrs by serial dilution | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID522011 | Antimicrobial activity against Klebsiella pneumoniae isolate KpE expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID558337 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1650 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID521832 | Antimicrobial activity against Streptococcus pneumoniae isolated from non-meningitis patient assessed as percent susceptible isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID544583 | Antimicrobial activity against Escherichia coli DH5[alpha] by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID542771 | Antimicrobial activity against Escherichia coli J53 transformed with pHND3 carrying qnrB6 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. |
| AID558810 | Antimicrobial activity against Proteus mirabilis assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID531679 | Antimicrobial activity against Acinetobacter baumannii Ab290 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID534767 | Antimicrobial activity against Escherichia coli DH10B transformant containing Kpn1 fragment with fosA3 gene from 08-642 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID495327 | Antimicrobial activity against Beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae with Asp350Asn, Met377Ile, Asn526Lys substitutions in penicillin-binding protein 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. |
| AID544586 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8128 expressing bla SHV-105 gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID561104 | Antibacterial activity against Pasteurella multocida BB1038 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID1762803 | Antibacterial activity against Escherichia coli 01 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID495634 | Antimicrobial activity against Escherichia coli DH10B by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID155834 | The compound was evaluated for the inhibition of [14C]- Pen G binding to Escherichia coli UB1005 penicillin-binding protein 2 66 kDa. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID529457 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID287374 | Antibacterial activity against Bacillus cereus after 72 hrs by disk diffusion method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. |
| AID498838 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae SZ61 deficient in TEM-1, SHV-1a, CMY-2, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID543796 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Effect of DNase and antibiotics on biofilm characteristics. |
| AID534175 | Antimicrobial activity against armA positive Escherichia coli TOP10 producing beta lactamase CTX-M-3 with plasmid BEH by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
| AID498840 | Antimicrobial activity against Klebsiella pneumoniae GZ66T expressing SHV-11, DHA-1 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID529653 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID577706 | Antibacterial activity against 10'7 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a at 30 ug after 16 hrs by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics. |
| AID197871 | Minimum inhibitory concentration against Staphylococcus aureus A6 (inoculum, 10e5 cfu per spot) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle. |
| AID1056856 | Antibacterial activity against Escherichia coli FNSST 982 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID522010 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pBIC containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID285260 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-28 and ESBL by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID447072 | Antibacterial activity against Staphylococcus aureus ATCC 6538 at 30 ug after 24 hrs by agar disk diffusion assay | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. |
| AID545422 | Antimicrobial activity against Citrobacter freundii obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID549349 | Antimicrobial activity against Escherichia coli isolate 36 harboring bla CTX-M-3a gene by broth microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID1056835 | Antibacterial activity against SIM-1 expressing Acinetobacter baumannii isolate 170 after 18 to 24 hrs by two-fold broth microdilution assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23 | Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria. |
| AID555217 | Antibacterial activity against Escherichia coli DH5alpha carrying ampC gene of Acinetobacter genomosp. 3 isolate 56 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Genetic variability among ampC genes from acinetobacter genomic species 3. |
| AID373769 | Antibacterial activity against imipenem-resistant Acinetobacter baumannii abh20 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID524069 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID531078 | Antimicrobial activity against CMY-2 beta-lactamase producing Escherichia coli isolate CUMC223 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community. |
| AID573543 | Antibacterial activity against Morganella morganii Mm1229 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID428290 | Antimicrobial activity against Acinetobacter baumannii BM4454 isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID69485 | Minimum inhibitory concentration against Escherichia coli (TEM beta-lactamase containing) | 1989 | Journal of medicinal chemistry, Nov, Volume: 32, Issue:11 | 3-Sulfonyl-1-carba-1-dethiacephems. |
| AID534769 | Antimicrobial activity against Escherichia coli DH10B transformant containing Sac2 fragment with fosC2 gene from pHPA | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. |
| AID583088 | Ratio of Kcat to Km for Escherichia coli XL1-Blue wild-type IMP-1 beta-lactamase by spectrophotometer | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID561326 | Antimicrobial activity against Klebsiella pneumoniae isolate 135 transconjugant expressing aac(6')-Ib-cr gene | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. |
| AID498834 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae PU3 deficient in DHA-1, aac(6')-Ib-cr, ompK35/36 by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. |
| AID405311 | Antibacterial activity against beta-lactamase producing amoxicillin-clavulanic acid-resistant Haemophilus influenzae isolate assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. |
| AID545658 | Antimicrobial activity against Acinetobacter sp. assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID577509 | Antibacterial activity against 10'7 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a at 30 ug after 16 hrs by disk diffusion assay | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID70598 | Compound was tested in vitro for its minimum inhibitory concentration by serial 2-fold agar dilution Muller Hinton method against Escherichia coli O 55 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 | Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives. |
| AID518519 | Antimicrobial activity against Capnocytophaga sputigena isolate NOR after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID394490 | Ratio of Vmax to Km for Hafnia alvei beta-lactamase ACC-1 | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID155841 | The compound was evaluated for the inhibition of [14C]- Pen G binding to Escherichia coli UB1005 penicillin-binding protein 3 60 kDa. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9 | Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates. |
| AID521484 | Antibacterial activity against Escherichia coli harboring pBC633 plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID543952 | Antibacterial activity against tetracycline-resistant Staphylococcus aureus COL-S carrying SAmecA plasmid | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. |
| AID535657 | Antimicrobial activity against aac(6')-Ib-cr-negative Enterobacter cloacae FJ61T harboring qnrS gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID519741 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-72 by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID576265 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae 19039 harboring porin OmpK36V mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. |
| AID584488 | Antibacterial activity against porin, OmpA positive Klebsiella pneumoniae KPBj1 revertant by disk agar diffusion method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. |
| AID278600 | Inhibitory activity against Klebsiella pneumoniae 07-006 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. |
| AID342018 | Antibacterial activity against Klebsiella pneumoniae NK29 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID530321 | Antimicrobial activity against Pseudomonas aeruginosa isolate PA-SD2 harboring blaVIM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. |
| AID583029 | Antimicrobial activity against Escherichia coli TOP10 transformed with Escherichia coli DH10B plasmid carrying DHA-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases. |
| AID206725 | Bacterial challenge for systemic murine infection against Staphylococcus aureus Smith | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID162781 | In vitro minimum inhibitory concentration was measured against Pseudomonas aeruginosa 8780 strain. | 1994 | Journal of medicinal chemistry, Feb-04, Volume: 37, Issue:3 | Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone. |
| AID394496 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID547992 | Antimicrobial activity against Escherichia coli DH10B harboring beta-lactamase KPC-2 T237Y mutant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. |
| AID205379 | Antibacterial activity against Serratia marcescens SE3 | 1990 | Journal of medicinal chemistry, Aug, Volume: 33, Issue:8 | Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. |
| AID557795 | Antimicrobial activity against Proteus mirabilis 06-489 isolated from infected human urinary tract by CLSI agar dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. |
| AID495908 | Antimicrobial activity in Escherichia coli TOP10 harbouring recombinant plasmid VIM-1-N215K by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID43893 | Minimum protective concentration against beta-lactamase Pseudomonas aeruginosa (18S-H strain) | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21 | Cephalosporin 3'-phloroglucide esters and 7-(phloroglucidamido) cephalosporins as novel antibacterial agents. |
| AID368744 | Antimicrobial activity against Escherichia coli Ec7 expressing SHV-12 IRT-6 gene | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Extended-spectrum-beta-lactamase-producing Enterobacteriaceae strains in various types of private health care centers. |
| AID373759 | Antibacterial activity against imipenem-susceptible Acinetobacter baumannii ab1316 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. |
| AID535660 | Antimicrobial activity against aac(6')-Ib-cr-positive Enterobacter cloacae FJ63 harboring GyrA S83I, GyrA D87A, ParC S80I mutant, wild-type GyrB and qnrS genes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. |
| AID520793 | Antimicrobial activity against CTX-M-2 producing Klebsiella pneumoniae with PFGE pulsotype A by Etest | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. |
| AID429078 | Antibacterial activity against Escherichia coli J53 expressing Klebsiella pneumoniae Greece blaKPC-2 gene by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID519408 | Antibacterial activity against 16S rRNA methylase RmtB and CTX-M-65 ESBL producing Escherichia coli DH10B by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United States. |
| AID520399 | Antibacterial activity against mef and erm(B) positive Streptococcus pneumoniae isolates assessed as resistance incidence by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID542626 | Antimicrobial activity against Streptococcus pneumoniae R6 harboring PBP2x T338G and PBP1a2349 mutant gene and aad9 disruption in CiaR gene after 48 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. |
| AID541004 | Antimicrobial activity against Burkholderia cenocepacia 07-34 expressing beta-lactamase PenB1 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2013 | The Journal of biological chemistry, Oct-18, Volume: 288, Issue:42 | Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2343 (44.22) | 18.7374 |
| 1990's | 1236 (23.33) | 18.2507 |
| 2000's | 819 (15.46) | 29.6817 |
| 2010's | 673 (12.70) | 24.3611 |
| 2020's | 228 (4.30) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 727 (12.65%) | 5.53% |
| Reviews | 233 (4.05%) | 6.00% |
| Case Studies | 797 (13.87%) | 4.05% |
| Observational | 15 (0.26%) | 0.25% |
| Other | 3,975 (69.17%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial [NCT02800785] | 1,552 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| Impact of Cefotaxime and Ceftriaxone on the Emergence and Carrying of Multidrug-Resistant Bacteria and Relationship to Residual Antibiotic Levels in Stool [NCT03903783] | 34 participants (Actual) | Interventional | 2019-04-30 | Completed | |||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| Laparoscopic Appendectomy for Uncomplicated Appendicitis: Does Antimicrobial Prophylaxis Really Matter? Randomized Control Trial [NCT02404064] | 288 participants (Anticipated) | Interventional | 2015-03-31 | Not yet recruiting | |||
| Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study [NCT02123628] | Phase 4 | 40 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Is Combination Antibiotic Therapy Superior to Monotherapy in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease [NCT04879030] | Phase 2/Phase 3 | 170 participants (Actual) | Interventional | 2020-01-01 | Completed | ||
| Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis [NCT01265173] | Phase 4 | 261 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| Efficacy and Safety of Antibiotics in the Treatment of Early Onset Neonatal Sepsis [NCT03932123] | 500 participants (Anticipated) | Observational | 2019-05-05 | Recruiting | |||
| Effect of Administration of 3rd Generation Cephalosporin (Ceftriaxone Versus Cefotaxime) on the Digestive Carrying of 3rd Generation Cephalosporin-resistant Enterobacteriaceae (EB C3G-R) [NCT03922919] | Phase 4 | 250 participants (Anticipated) | Interventional | 2018-04-03 | Recruiting | ||
| Does Continuous Cefotaxime Administration Improve Time to Attainment and Maintenance of Target Drug Levels in Critically Ill Patients? [NCT02560207] | Phase 4 | 60 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect Surgery in Infants [NCT03198819] | 30 participants (Anticipated) | Observational | 2016-08-31 | Recruiting | |||
| Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery: a Multicentre, Double-blind, Randomized Controlled Clinical Trial [NCT05755789] | Phase 3 | 2,000 participants (Anticipated) | Interventional | 2023-06-22 | Recruiting | ||
| Application of LiveSpo Navax® in the Treatment Support of Acute Rhinosinusitis and Acute Otitis Media [NCT05804123] | 120 participants (Anticipated) | Interventional | 2021-10-28 | Recruiting | |||
| Antibiotic Effects on the Developing Microbiome, Metabolome and Morbidities in Preterm Neonates [NCT02784821] | Phase 2 | 186 participants (Actual) | Interventional | 2017-01-16 | Completed | ||
| Comparison of Two Lengths of Treatment in Early-onset Ventilated Associated Pneumonia [NCT01559753] | Phase 4 | 225 participants (Actual) | Interventional | 1998-01-31 | Completed | ||
| Translational PKPD Modeling of Anti-infective Drugs in Children Treated in Pediatric Units on the Example of Selected Antibiotics and Antifungals. [NCT05426499] | 150 participants (Anticipated) | Observational | 2021-10-01 | Active, not recruiting | |||
| [NCT01059890] | Phase 1 | 18 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| Impact of the Choice of 3rd Generation Cephalosporins on the Emergence of Resistance in the Microbiota Intestinal. [NCT02659033] | Phase 3 | 22 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Comparative Study Between the Efficacy of Oral Gemifloxacin and Intravenous Cefotaxime in Treatment of Spontaneous Bacterial Peritonitis [NCT04168099] | Phase 3 | 60 participants (Anticipated) | Interventional | 2018-12-01 | Recruiting | ||
| Randomized Study of Conservative Versus Surgical Treatment of Appendicitis; Analyses of Result and Economics [NCT00469430] | Phase 2 | 360 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| A Randomized, Controlled, Multicentre Trial of Collateral Damage on the Intestinal Microbiota Inferred by Temocillin Versus Cefotaxime in Patients Receiving Empirical Treatment for Febrile Urinary Tract Infections [NCT02959957] | Phase 4 | 157 participants (Actual) | Interventional | 2016-05-20 | Completed | ||
| Meropenem vs Cefotaxime as Empirical Treatment of Spontaneous Bacterial Peritonitis :Prospective Randomized Clinical Trial [NCT05427747] | Phase 4 | 286 participants (Anticipated) | Interventional | 2023-01-01 | Not yet recruiting | ||
| Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days of Age (Inclusive) With Clinical or Confirmed Late-onset Sepsis : a European Multicenter Randomised Phase III Trial [NCT01551394] | Phase 3 | 272 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| Bacterial Infections Associated With Healthcare (Healthcare-Associated) in Hospitalized Cirrhotic Patients: Randomized Study of Use of Traditional Empirical Antibiotic Therapy and Second-line Targeted at Multi-resistant Bacteria [NCT01820026] | Phase 4 | 96 participants (Anticipated) | Interventional | 2012-12-31 | Recruiting | ||
| A Randomized Controlled Trial to Evaluate Fibrin Glue Application in the Treatment of Low-Output Enterocutaneous Fistulas [NCT01828892] | 30 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | |||
| Effect of Genetic Variation in the Transporter, OAT3, on the Renal Secretion of Cefotaxime [NCT00187655] | Phase 1 | 24 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| A Crossover, Cluster Randomised Controlled Trial of Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU) [NCT02389036] | Phase 3 | 20,010 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins? [NCT02443285] | Phase 3 | 100 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | ||
| Cefotaxime Resistance in Treatment of Spontaneous Bacterial Peritonitis [NCT02388035] | 254 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| Efficacy and Safety of Selective Digestive Decontamination in the ICU With Rates of Antibiotic-resistant Bacteria [NCT04839653] | 60 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||