phenobarbital has been researched along with Necrosis in 109 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 8.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 7.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 5.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| "Pretreatment with phenobarbital (PB, 3 x 80 mg/kg i." | 5.28 | Shifting necrosis: butylated hydroxytoluene (BHT) and phenobarbital move cocaine-induced hepatic necrosis across the lobule. ( Charles, SJ; Connolly, AK; Powell, CJ, 1991) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 5.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| "5 or 23 mmol/kg) and sacrificed 24 h after dosing exhibited liver toxicity." | 5.26 | A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. ( Rao, GS, 1977) |
| "Phenobarbital pretreatment potentiated the hepatic necrosis produced by both thioacetamide and thioacetamide sulfine." | 5.26 | Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. ( Holscher, MA; Hunter, AL; Neal, RA, 1977) |
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 4.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| " This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn." | 3.73 | The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn. ( Donatucci, CF; Erdmann, D; Kukies, S; Levin, LS; Schäfer, T; Stokes, TH, 2005) |
| " However, hepatic HGF levels were decreased despite an increased number of mitotic hepatocytes and increased or unchanged plasma HGF levels in rats given phenobarbital and in rats after dimethylnitrosamine intoxication, which can induce hepatic necrosis after apoptosis of hepatic stellate cells." | 3.70 | Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration. ( Fujiwara, K; Ogata, I; Tomiya, T, 1998) |
| " Hepatotoxic compounds such as CCl4, galactosamine and thioacetamide that cause hepatic necrosis and compounds such as hydrazine and ethionine that cause fatty liver all result in elevated urinary taurine levels in rats." | 3.69 | Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro. ( Timbrell, JA; Waterfield, CJ, 1996) |
| "Hyperplasia of the rat liver can be induced by cyproterone acetate (CPA)." | 3.67 | Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. ( Bursch, W; Lauer, B; Schulte-Hermann, R; Taper, HS, 1985) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 3.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture." | 3.65 | Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977) |
| "Treatment of rats with phenobarbital, which stimulates the activity of the drug-metabolizing enzymes in the liver, potentiates hepatic necrosis elicited by bromobenzene and a number of other chemically inert halogenated aromatic hydrocarbons." | 3.65 | Possible mechanism of liver necrosis caused by aromatic organic compounds. ( Brodie, BB; Cho, AK; Gillette, JR; Krishna, G; Reid, WD; Sipes, G, 1971) |
| "A single 6-hr exposure to vinyl chloride monomer (5%) produces extensive vacuolization of centrolobular liver parenchyma and focal midzonal necrosis in the hepatic lobuole in phenobarbital-pretreated rats." | 3.65 | Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats. ( Jaeger, RJ; Murphy, SD; Reynolds, ES, 1975) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 1.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| "Phenobarbital pretreatment potentiated thioacetamide necrogenicity, and this potentiation was parallel to the induction of the microsomal FAD monooxygenase system, both by phenobarbital and by thioacetamide itself." | 1.31 | Potentiation of thioacetamide hepatotoxicity by phenobarbital pretreatment in rats. Inducibility of FAD monooxygenase system and age effect. ( Andrés, D; Cascales, M; Sarrión, D; Zaragoza, A, 2000) |
| "Phenobarbital pretreatment also caused a shift in the morphologic site of necrosis from midzonal to peripheral lobular (zone 1) regions." | 1.28 | Cocaethylene hepatotoxicity in mice. ( Harbison, RD; James, RC; Roberts, SM; Roth, L, 1992) |
| " Although the exact sequence of its hepatotoxic factors is unproven, it seems likely that lipid peroxidation through the dysfunction of antioxidant defence factors and a toxic metabolite contribute to the formation of this liver injury." | 1.28 | Hepatotoxicity of diethyldithiocarbamate in rats. ( Hobara, T; Ishiyama, H; Kanbe, T; Ogino, K; Shimomura, Y, 1990) |
| "Pretreatment with phenobarbital (PB, 3 x 80 mg/kg i." | 1.28 | Shifting necrosis: butylated hydroxytoluene (BHT) and phenobarbital move cocaine-induced hepatic necrosis across the lobule. ( Charles, SJ; Connolly, AK; Powell, CJ, 1991) |
| " The different toxic effects were related to the structure and metabolism of the compounds." | 1.27 | The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids. ( Driver, HE; Mattocks, AR, 1984) |
| "Acetylhydrazine did not produce detectable lesions in organs other than the liver, despite the occurrence of covalent binding to protein in those organs." | 1.27 | Acetylhydrazine hepatotoxicity: the role of covalent binding. ( Timbrell, JA; Woodward, KN, 1984) |
| "Chlorobenzene (CB) was less hepatotoxic to trout than to rats." | 1.27 | A comparative study of the hepatotoxicity of monochlorobenzene in the rainbow trout (Salmo gairdnerii) and the Sprague-Dawley rat. ( Dalich, GM; Larson, RE, 1985) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| "This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h." | 1.27 | A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 1.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| " These LAAM-induced changes demonstrated dose- and time-dependence within that dosage range producing mortality." | 1.27 | L-alpha-acetylmethadol-induced tissue alterations in mice. ( Freeman, RW; Harbison, RD; James, RC, 1984) |
| "5 or 23 mmol/kg) and sacrificed 24 h after dosing exhibited liver toxicity." | 1.26 | A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. ( Rao, GS, 1977) |
| "Phenobarbital pretreatment provided little or no protection." | 1.26 | Iodipamide hepatotoxicity in the rat. ( Barnhart, JL; Burk, RF, 1979) |
| "Phenobarbital pretreatment potentiated the hepatic necrosis produced by both thioacetamide and thioacetamide sulfine." | 1.26 | Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. ( Holscher, MA; Hunter, AL; Neal, RA, 1977) |
| " Prior dosing with phenobarbitone augments CCl4 toxicity only in the adult and the newborn but the foetus continues to be resistant." | 1.25 | Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine. ( Chopra, P; Das, PK; Dhar, A; Nayak, NC, 1975) |
| "The influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (CCl4) was investigated in a group of rhesus monkeys." | 1.25 | Protein deficiency in carbon tetrachloride-induced hepatic lesions. ( Deo, MG; Ramalingaswami, V; Roy, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (79.82) | 18.7374 |
| 1990's | 15 (13.76) | 18.2507 |
| 2000's | 6 (5.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (0.92) | 2.80 |
| Authors | Studies |
|---|---|
| Zombori, L | 1 |
| Bacon, M | 1 |
| Wood, H | 1 |
| Chatterjee, F | 1 |
| Venkateswaran, R | 1 |
| Lampariello, S | 1 |
| Yoong, M | 1 |
| Das, BK | 1 |
| Bepary, S | 1 |
| Datta, BK | 1 |
| Chowdhury, AA | 1 |
| Ali, MS | 1 |
| Rouf, AS | 1 |
| Schäfer, T | 1 |
| Kukies, S | 1 |
| Stokes, TH | 1 |
| Levin, LS | 1 |
| Donatucci, CF | 1 |
| Erdmann, D | 1 |
| Guo, D | 1 |
| Sarkar, J | 1 |
| Ahmed, MR | 1 |
| Viswakarma, N | 1 |
| Jia, Y | 1 |
| Yu, S | 1 |
| Sambasiva Rao, M | 1 |
| Reddy, JK | 1 |
| Di Mizio, G | 1 |
| Gambardella, A | 1 |
| Labate, A | 1 |
| Perna, A | 1 |
| Ricci, P | 1 |
| Quattrone, A | 1 |
| Driver, HE | 1 |
| Mattocks, AR | 1 |
| Rubenchik, BL | 1 |
| Tsapenko, VF | 1 |
| Boĭm, TM | 1 |
| Woodward, KN | 1 |
| Timbrell, JA | 3 |
| James, RC | 3 |
| Freeman, RW | 1 |
| Harbison, RD | 3 |
| Shingu, K | 1 |
| Eger, EI | 1 |
| Johnson, BH | 1 |
| Van Dyke, RA | 1 |
| Lurz, FW | 1 |
| Harper, MH | 1 |
| Cheng, A | 1 |
| Buckpitt, AR | 1 |
| Warren, DL | 1 |
| Evans, MA | 1 |
| McMartin, DN | 1 |
| O'Connor, JA | 1 |
| Kaminsky, LS | 1 |
| Smith, MT | 1 |
| Wills, ED | 1 |
| Bahri, AK | 1 |
| Chiang, CS | 1 |
| Puri, AS | 1 |
| Sharma, BC | 1 |
| Khan, EM | 1 |
| Saraswat, VA | 1 |
| Cascales, M | 2 |
| Alvarez, A | 1 |
| Gascó, P | 1 |
| Fernández-Simón, L | 1 |
| Sanz, N | 1 |
| Boscá, L | 1 |
| Zakharova, MV | 1 |
| Shkurupiĭ, VA | 1 |
| Grek, OR | 1 |
| Ozaki, M | 1 |
| Masuda, Y | 1 |
| Lake, BG | 2 |
| Evans, JG | 2 |
| Waterfield, CJ | 1 |
| Tomiya, T | 1 |
| Ogata, I | 1 |
| Fujiwara, K | 2 |
| Martin, FL | 1 |
| McLean, AE | 2 |
| Okamiya, H | 1 |
| Mitsumori, K | 1 |
| Onodera, H | 1 |
| Ito, S | 1 |
| Imazawa, T | 1 |
| Yasuhara, K | 1 |
| Takahashi, M | 1 |
| Zaragoza, A | 1 |
| Andrés, D | 1 |
| Sarrión, D | 1 |
| Cantile, C | 1 |
| Chianini, F | 1 |
| Arispici, M | 1 |
| Fatzer, R | 1 |
| Ford, EJ | 2 |
| Rivera, R | 1 |
| Deo, MG | 1 |
| Roy, H | 1 |
| Ramalingaswami, V | 2 |
| Nayak, NC | 2 |
| Chopra, P | 2 |
| Dhar, A | 1 |
| Das, PK | 1 |
| Rao, GS | 2 |
| Grumley, JO | 1 |
| Willson, RA | 1 |
| Hart, FE | 1 |
| Burk, RF | 1 |
| Barnhart, JL | 1 |
| McLain, GE | 1 |
| Sipes, IG | 2 |
| Brown, BR | 2 |
| Ross, WT | 1 |
| Daggy, BP | 1 |
| Cardell, RR | 1 |
| Thompson, ML | 1 |
| Shuster, L | 1 |
| Shaw, K | 1 |
| Mallov, S | 1 |
| Giri, SN | 1 |
| Barger, AE | 1 |
| Bickford, AA | 1 |
| Peoples, SA | 1 |
| Hunter, AL | 1 |
| Holscher, MA | 1 |
| Neal, RA | 2 |
| Gopinath, G | 1 |
| Day, PA | 1 |
| Reynolds, ES | 2 |
| Jaeger, RJ | 1 |
| Murphy, SD | 1 |
| Mgbodile, MU | 1 |
| Holscher, M | 1 |
| Aoki, N | 1 |
| Roth, L | 2 |
| Tobin, T | 1 |
| Roberts, SM | 2 |
| Denda, A | 1 |
| Sai, KM | 1 |
| Tang, Q | 1 |
| Tsujiuchi, T | 1 |
| Tsutsumi, M | 1 |
| Amanuma, T | 1 |
| Murata, Y | 1 |
| Nakae, D | 1 |
| Maruyama, H | 1 |
| Kurokawa, Y | 1 |
| Ishiyama, H | 1 |
| Ogino, K | 1 |
| Shimomura, Y | 1 |
| Kanbe, T | 1 |
| Hobara, T | 1 |
| Powell, CJ | 1 |
| Connolly, AK | 1 |
| Charles, SJ | 1 |
| Mockli, G | 1 |
| Crowley, M | 1 |
| Stern, R | 1 |
| Warnock, ML | 1 |
| Dalich, GM | 1 |
| Larson, RE | 1 |
| Bursch, W | 1 |
| Taper, HS | 1 |
| Lauer, B | 1 |
| Schulte-Hermann, R | 1 |
| Marzella, L | 1 |
| Muhvich, K | 1 |
| Myers, RA | 1 |
| Qazi, FM | 1 |
| Alam, SM | 1 |
| Knights, KM | 1 |
| Gourlay, GK | 1 |
| Gibson, RA | 1 |
| Cousins, MJ | 1 |
| Xian, M | 1 |
| Inoue, S | 1 |
| Matsunuma, N | 1 |
| Goto, N | 1 |
| Collins, MA | 1 |
| Savage, SA | 1 |
| Butler, WH | 3 |
| Hickman, R | 2 |
| Alp, MH | 1 |
| Poulsen, HE | 1 |
| Lerche, A | 1 |
| Pedersen, NT | 1 |
| Wheatley, DN | 1 |
| Sims, P | 1 |
| Somogyi, A | 1 |
| Kovacs, K | 1 |
| Solymoss, B | 1 |
| Kuntzman, R | 1 |
| Conney, AH | 1 |
| Jellinck, PH | 1 |
| Smith, G | 1 |
| Smith, JS | 2 |
| Harrison, GG | 2 |
| Potter, WZ | 5 |
| Davis, DC | 3 |
| Mitchell, JR | 8 |
| Jollow, DJ | 7 |
| Gillette, JR | 7 |
| Brodie, BB | 7 |
| Dhar, GJ | 1 |
| Pierach, CA | 1 |
| Ahamed, PN | 1 |
| Howard, RB | 1 |
| Koff, RS | 1 |
| Davidson, LJ | 1 |
| Gordon, G | 1 |
| Sabesin, SM | 1 |
| Vedeneyeva, ZI | 1 |
| Reid, WD | 9 |
| Cho, AK | 2 |
| Sipes, G | 1 |
| Krishna, G | 7 |
| Vandam, LD | 1 |
| Butcher, RG | 1 |
| Roy, S | 1 |
| Thorgeirsson, SS | 2 |
| Hashimoto, M | 1 |
| Barth, ML | 1 |
| Cornish, HH | 1 |
| Ilett, KF | 2 |
| Glick, JM | 1 |
| Wrights, N | 1 |
| Prescott, LF | 1 |
| Grivaux, M | 1 |
| Soulié, J | 1 |
| Diallo, A | 1 |
| Renard, C | 1 |
| Chevalley, J | 1 |
| D'Acosta, N | 1 |
| Castro, JA | 1 |
| Díaz Gòmez, MI | 1 |
| de Ferreyra, EC | 1 |
| de Castro, CR | 1 |
| de Fenos, OM | 1 |
| Zampaglione, N | 2 |
| Stripp, B | 1 |
| Hamrick, M | 1 |
| Gillette, R | 1 |
| Blinder, LV | 1 |
| Gasparian, SA | 1 |
| Maliugin, EF | 1 |
| Kliuchnikova, ZhI | 1 |
| Archakov, AI | 1 |
| Caroli, J | 1 |
| Nusinovici, V | 1 |
| Amar, AB | 1 |
| Lévy, VG | 1 |
| Walker, BE | 1 |
| Kelleher, J | 1 |
| Dixon, MF | 1 |
| Losowsky, MS | 1 |
| van Leenhoff, JA | 1 |
| Saunders, SJ | 1 |
| Terblanche, J | 1 |
| Torrielli, MV | 1 |
| Ugazio, G | 1 |
| Gabriel, L | 1 |
| Burdino, E | 1 |
| Grohme, S | 1 |
| Schneider, H | 1 |
| Masshoff, W | 1 |
| Stenger, RJ | 5 |
| Johnson, EA | 3 |
| Seawright, AA | 1 |
| Hrdlicka, J | 1 |
| Chandra, SV | 1 |
| Magos, L | 1 |
| Christie, B | 1 |
| Moskowitz, J | 1 |
| Bond, EJ | 1 |
| De Matteis, F | 1 |
| Barnes, JM | 1 |
| Scholler, KL | 3 |
| Müller, E | 1 |
| von Plehwe, U | 1 |
| Miller, RA | 1 |
| Williamson, JN | 1 |
| Clark, JG | 1 |
| Sumerling, MD | 1 |
2 reviews available for phenobarbital and Necrosis
| Article | Year |
|---|---|
Massive hepatic necrosis in a child after administration of phenobarbital.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Hypersensitivity; Humans; Liver Disea | 1989 |
Organelle pathology of the liver. The endoplasmic reticulum.
Topics: Animals; Chlordan; DDT; Endoplasmic Reticulum; Ethanol; Glycogen; Lipid Metabolism; Liver; Liver Dis | 1970 |
107 other studies available for phenobarbital and Necrosis
| Article | Year |
|---|---|
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn.
Topics: Anticonvulsants; Circumcision, Male; Foot Injuries; Humans; Infant, Newborn; Infusions, Intravenous; | 2005 |
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Topics: Acetaminophen; Active Transport, Cell Nucleus; Adenoviridae; Animals; Blotting, Northern; Cell Nucle | 2006 |
Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients.
Topics: Adult; Anticonvulsants; Autopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Chromatography | 2007 |
The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids.
Topics: Alkaloids; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 1984 |
[Possibility of N-dimethylnitrosamine formation after parenteral administration of amidopyrine and nitrite to rats].
Topics: Aminopyrine; Animals; Ascorbic Acid; Dimethylnitrosamine; Injections, Intraperitoneal; Injections, I | 1984 |
Acetylhydrazine hepatotoxicity: the role of covalent binding.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Hydrazines; Liv | 1984 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Met | 1984 |
Hepatic injury induced by anesthetic agents in rats.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Necrosis; Oxygen; Phenoba | 1983 |
Evidence for hepatic formation, export and covalent binding of reactive naphthalene metabolites in extrahepatic tissues in vivo.
Topics: Animals; Binding Sites; Biological Transport; Cytochrome P-450 Enzyme System; Glutathione; Kidney; L | 1983 |
Role of protein binding in cocaine-induced hepatic necrosis.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cricetinae; Esterase | 1983 |
Effects of differential changes in rat hepatic and renal cytochrome P-450 concentrations on hepatotoxicity and nephrotoxicity of chloroform.
Topics: Animals; Cadmium; Chloroform; Cytochrome P-450 Enzyme System; Fasting; Kidney; Liver; Male; Necrosis | 1981 |
The mechanism of phenobarbitone potentiation of centrilobular hepatic necrosis.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Synergism; Drug-Related Side Effects and Adverse React | 1981 |
Factors affecting acetylhydrazine hepatotoxicity.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydrazines; Isoniazid; Liver; Male; Necrosis; Phenobarbital | 1981 |
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans | 1994 |
Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Division; Cells, Cultured; Cocaine; Cytochrome P-45 | 1994 |
[Effect of preliminary phenobarbital and ziksorin administration on reparative processes in the liver parenchyma after ischemic damage].
Topics: Acute Disease; Animals; Benzhydryl Compounds; Ischemia; Liver; Liver Regeneration; Male; Microscopy, | 1994 |
Carbon tetrachloride-induced cell death in perfused livers from phenobarbital-pretreated rats under hypoxic conditions and various ionic milieu. Further evidence for calcium-dependent irreversible changes.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Death; Cell Hypoxia; Cytochrome P-450 Enzyme System; El | 1993 |
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; Coumarins; Dose-Response Relat | 1993 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbute | 1996 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal | 1998 |
Comparison of paracetamol-induced hepatotoxicity in the rat in vivo with progression of cell injury in vitro in rat liver slices.
Topics: Acetaminophen; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cytochrome P-450 Enzyme Syste | 1998 |
Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Connexins; Cytochrome P-450 CYP2B1; Eating; Gap Ju | 1998 |
Potentiation of thioacetamide hepatotoxicity by phenobarbital pretreatment in rats. Inducibility of FAD monooxygenase system and age effect.
Topics: Age Factors; Animals; Aspartate Aminotransferases; Bilirubin; Biotransformation; Drug Synergism; Enz | 2000 |
Necrotizing meningoencephalitis associated with cortical hippocampal hamartia in a Pekingese dog.
Topics: Amoxicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dexamethasone; Dogs; | 2001 |
The modification of the dehydromyodesmone-induced hepatic lesion in cattle by microsomal drug metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Bilirubin; Cattle; Chemical and Drug Induced Liver Injury; Enzym | 1978 |
Protein deficiency in carbon tetrachloride-induced hepatic lesions.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Glucos | 1975 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1975 |
Extrahepatic tissue distribution, covalent binding, and toxicity of halothane in control and phenobarbital-pretreated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Lung; Male; Necrosis; Phe | 1978 |
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li | 1977 |
Iodipamide hepatotoxicity in the rat.
Topics: Age Factors; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dos | 1979 |
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc | 1979 |
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys | 1979 |
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine | 1979 |
Calcium and the protective effect of ethanol in epinephrine-induced cardiac necrosis in the rat.
Topics: Animals; Calcitonin; Calcium; Cardiomyopathies; Epinephrine; Ethanol; Injections, Intraperitoneal; I | 1979 |
Histopathological features and biochemical mechanism of 2-chloro-4-acetotoluidine toxicity in starling.
Topics: Aminopyrine N-Demethylase; Animals; Birds; Glucosephosphate Dehydrogenase; Glutathione; Glutathione | 1978 |
A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat.
Topics: Alanine Transaminase; Animals; DNA; Drug Interactions; Halothane; In Vitro Techniques; Lipid Metabol | 1977 |
Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system.
Topics: Acetamides; Aminopyrine; Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Drug In | 1977 |
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp | 1976 |
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto | 1975 |
Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Environmental Exposure; Live | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; C | 1975 |
Infantile acute encephalopathy with combined symmetrical hypodensities in the thalami and the putamen on computed tomography.
Topics: Acute Disease; Brain Diseases; Coma; Follow-Up Studies; Glycerol; Humans; Infant; Male; Necrosis; Ph | 1992 |
Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Cocaine; Liver; Male; Necrosis; N | 1992 |
Cocaethylene hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Cocaine; Diazinon; Glutathione; L | 1992 |
Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Cytochrome Reductases; Deoxyguanosine; Dicumarol; | 1991 |
Hepatotoxicity of diethyldithiocarbamate in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Deferoxamine; Ditiocarb; Gluta | 1990 |
Shifting necrosis: butylated hydroxytoluene (BHT) and phenobarbital move cocaine-induced hepatic necrosis across the lobule.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Butylated Hydroxytoluene; C | 1991 |
A comparative study of the hepatotoxicity of monochlorobenzene in the rainbow trout (Salmo gairdnerii) and the Sprague-Dawley rat.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Chlorobenzenes; Glutathione; Live | 1985 |
Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia.
Topics: Animals; Cell Survival; Cyproterone; Cyproterone Acetate; Deoxyribonucleases; DNA; Female; Hyperplas | 1985 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Potentiating effects of phenobarbitone on the induction of cirrhosis in rats by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Female; Liver; Liver Cirrhosis, Experimental; Necrosi | 1988 |
Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation.
Topics: Alanine Transaminase; Animals; Fatty Acids; Halothane; Lipid Metabolism; Lipid Peroxidation; Liver; | 1988 |
Enhancing effect of phenobarbital sodium on Tyzzer's disease in mice.
Topics: Animals; Bacillus; Bacterial Infections; Female; Liver; Liver Diseases; Mice; Mice, Inbred ICR; Necr | 1988 |
The histology and development of hepatic nodules in C3H/He mice following chronic administration of phenobarbitone.
Topics: Animals; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Necrosis; Phenobarbital; Time Factors | 1986 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep | 1986 |
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 1985 |
Comparison of the efficacy of pretreatment protection against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and by 7-methyl-12-methylbenz(a)anthracene in rats.
Topics: Adrenal Glands; Aminoglutethimide; Animals; Azo Compounds; Benz(a)Anthracenes; Chlorpromazine; Color | 1969 |
Suppression of 7,12-dimethylbenz( )anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylase.
Topics: Adrenal Gland Diseases; Androstanes; Animals; Benz(a)Anthracenes; Benzopyrenes; Betamethasone; Dexam | 1971 |
N-ethylmaleimide adduct of 7,12-dimethylbenzanthracene. Properties and metabolism by rat liver microsomes.
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Carbon Isotopes; Chromatography, Thin Layer; Enzyme Ind | 1972 |
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
Massive lethal hepatic necrosis in rats anesthetized with fluroxene, after microsomal enzyme induction.
Topics: Anesthesia, Inhalation; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 1973 |
Diphenylhydantoin--induced hepatic necrosis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female | 1974 |
D-galactosamine hepatotoxicity. 3. Normoactive smooth endoplasmic reticulum and modification by phenobarbital.
Topics: Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Endoplasmic Reti | 1973 |
Experimental myocardial necroses and their prevention by drugs.
Topics: Animals; Benactyzine; Ganglionic Blockers; Guanethidine; Heart Diseases; Myocardium; Necrosis; Pheno | 1967 |
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Topics: Animals; Autoradiography; Benzene Derivatives; Carbon Isotopes; Chemical and Drug Induced Liver Inju | 1971 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; | 1971 |
Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction?
Topics: Aged; Anesthesia, Inhalation; Anesthetics; Autopsy; Chemical and Drug Induced Liver Injury; Drug Int | 1972 |
The effect of phenobarbitone on the production of type I hydrogen from reduced nicotinamide-adenine phosphate in different regions of the liver lobule.
Topics: Animals; Benzene Derivatives; Densitometry; Hydrogen; Liver; NADP; Naphthalenes; Necrosis; Phenobarb | 1971 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 1972 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl | 1974 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass S | 1974 |
Mechanism of allyl alcohol-induced hepatic necrosis.
Topics: Alcohol Oxidoreductases; Alcoholic Intoxication; Alcohols; Allyl Compounds; Animals; Carbon Isotopes | 1972 |
The absence of effect of phenobarbital on halothane toxicity.
Topics: Aerosols; Animals; Aspartate Aminotransferases; Body Weight; Halothane; Kidney; L-Lactate Dehydrogen | 1973 |
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glu | 1973 |
Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis.
Topics: Animals; Autoradiography; Bromine; Bronchial Diseases; Carbon Isotopes; Chemical and Drug Induced Li | 1973 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
[Therapeutic hyperosmolarity].
Topics: Adult; Bicarbonates; Blood Transfusion; Brain Diseases; Chemical and Drug Induced Liver Injury; Diaz | 1973 |
Role of cytochrome P-450 in carbon tetrachloride activation and CCl 4-induced necrosis. Effect of inhibitors of heme synthesis. I. 3-Amino-1,2,4 triazole.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enz | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, | 1973 |
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver | 1973 |
Mechanism of renal necrosis induced by bromobenzene or chlorobenzene.
Topics: Animals; Benzene Derivatives; Carbon Radioisotopes; Chlorobenzenes; Cytochrome P-450 Enzyme System; | 1973 |
Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Chloroform; Cytochrome P-450 Enzyme System; Female; Hi | 1973 |
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; | 1973 |
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1973 |
[Acholangic cholestatic hepatitis evolving towards xanthomatosis and cirrhosis].
Topics: Bile Ducts; Bilirubin; Biopsy; Blood Proteins; Cholestasis; Female; Glutethimide; Hepatitis; Humans; | 1973 |
The effect of phenobarbitone pretreatment on paracetamol toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1973 |
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
Topics: Animals; Benzene Derivatives; Biotransformation; Carbon Radioisotopes; Chemical and Drug Induced Liv | 1974 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |
Effect of drug pretreatment on CBrCl3-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver | 1974 |
[Encephalopathies in vita reducta].
Topics: Adult; Aged; Brain; Brain Death; Brain Injuries; Carbon Monoxide Poisoning; Cerebellum; Cerebral Cor | 1969 |
Modifying effect of 3-amino-1,2,4-triazole on phenobarbital-induced changes in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrom | 1972 |
The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Mice; Microsomes, Li | 1972 |
Effects of phenobarbital pretreatment on the response of rat liver to halothane administration.
Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzyme Induction; | 1972 |
The effect of carbon disulphide on the myocardium of the rat.
Topics: Animals; Carbon Disulfide; Heart; Heart Diseases; Injections, Intraperitoneal; Male; Myocardium; Nec | 1972 |
Bromobenzene metabolism and hepatic necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Chemical and Drug Induced Li | 1971 |
Effects of carbon disulphide on the liver of rats.
Topics: Animals; Carbon Disulfide; Hepatomegaly; Liver; Male; Microsomes, Liver; Necrosis; Phenobarbital; Ra | 1969 |
Modification of the effects of chloroform on the rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Disulfiram; Enzyme Induction; Microsome | 1970 |
[Stimulation and depression of toxicity of chloroform for the liver by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1970 |
Effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Injections, Intraperi | 1970 |
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul | 1971 |
[Potentiation and inhibition of chloroform liver toxicity by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chloroform; Disulfiram; Drug Antagonism; | 1971 |
Muscle necrosis and calcification in acute renal failure due to barbiturate intoxication.
Topics: Acute Kidney Injury; Adult; Calcinosis; Humans; Kidneys, Artificial; Male; Muscular Diseases; Necros | 1966 |