Proteins > Vascular endothelial growth factor receptor 1
Page last updated: 2024-08-07 16:04:17

Vascular endothelial growth factor receptor 1

A vascular endothelial growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA]

Synonyms

VEGFR-1;
EC 2.7.10.1;
Fms-like tyrosine kinase 1;
FLT-1;
Tyrosine-protein kinase FRT;
Tyrosine-protein kinase receptor FLT;
FLT;
Vascular permeability factor receptor

Research

Bioassay Publications (107)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.93)18.2507
2000's44 (41.12)29.6817
2010's54 (50.47)24.3611
2020's8 (7.48)2.80

Compounds (118)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pd 173074Homo sapiens (human)IC500.190011
papaverineHomo sapiens (human)IC5024.330011
whi p180Homo sapiens (human)IC502.330035
galantamineHomo sapiens (human)IC500.590011
2,3,7,8-tetrachlorodibenzodioxineHomo sapiens (human)IC500.002710
2,3,7,8-tetrachlorodibenzodioxineHomo sapiens (human)Ki0.000710
staurosporineHomo sapiens (human)IC500.014977
ptk 787Homo sapiens (human)IC500.093522
vatalanibHomo sapiens (human)IC500.11921720
birb 796Homo sapiens (human)IC500.625022
erlotinibHomo sapiens (human)IC500.250011
sorafenibHomo sapiens (human)IC500.060044
papaverinolHomo sapiens (human)IC5010.730011
hematoxylinHomo sapiens (human)IC502.900011
zd 6474Homo sapiens (human)IC500.54711317
cb676475Homo sapiens (human)IC509.50771113
semaxinibHomo sapiens (human)IC500.764844
orantinibHomo sapiens (human)IC500.028011
su 11248Homo sapiens (human)IC500.045822
su 11248Homo sapiens (human)Ki0.002011
n,n'-dimethyl-n,n'-bis(mercaptoacetyl)hydrazineHomo sapiens (human)IC500.032011
6-(4-methoxyphenyl)-3-(3-thiophenyl)pyrazolo[1,5-a]pyrimidineHomo sapiens (human)IC500.387022
m475271Homo sapiens (human)IC500.010011
2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-oneHomo sapiens (human)IC501.520011
2-((4-pyridyl)methyl)amino-n-(3-(trifluoromethyl)phenyl)benzamideHomo sapiens (human)IC500.13651213
axitinibHomo sapiens (human)IC500.000122
gdp 366Homo sapiens (human)IC500.002022
krn 633Homo sapiens (human)IC500.085522
jnj 10198409Homo sapiens (human)IC503.100011
lenvatinibHomo sapiens (human)IC500.022033
tivozanibHomo sapiens (human)IC500.003222
3,9-bis((ethylthio)methyl)-k-252aHomo sapiens (human)IC500.209011
cediranibHomo sapiens (human)IC500.005022
chir 99021Homo sapiens (human)IC505.000011
pazopanibHomo sapiens (human)IC500.032044
bibw 2992Homo sapiens (human)IC5010.000011
aee 788Homo sapiens (human)IC500.059011
saracatinibHomo sapiens (human)IC50100.000011
exel-7647Homo sapiens (human)IC500.050010
regorafenibHomo sapiens (human)IC500.009233
brivanibHomo sapiens (human)IC500.380011
brivanibHomo sapiens (human)Ki0.060011
abt 869Homo sapiens (human)IC500.0364510
dorsomorphinHomo sapiens (human)IC500.011011
tak 285Homo sapiens (human)IC5010.000011
crizotinibHomo sapiens (human)IC501.000011
chir-265Homo sapiens (human)IC500.020011
motesanibHomo sapiens (human)IC500.8553414
nvp-tae684Homo sapiens (human)IC500.872011
tak 593Homo sapiens (human)IC500.003222
ponatinibHomo sapiens (human)IC500.012322
quizartinibHomo sapiens (human)IC5010.000011
lucitanibHomo sapiens (human)IC500.007033
cabozantinibHomo sapiens (human)IC500.012022
defactinibHomo sapiens (human)IC502.500010
gsk 1363089Homo sapiens (human)IC500.2541512
mk 2461Homo sapiens (human)IC500.010011
abt-348Homo sapiens (human)IC500.032011
3-((4-(6-methylpyridin-2-yl)-5-(quinolin-6-yl)-1h-imidazol-2-yl)methyl)benzamideHomo sapiens (human)IC502.100011
gsk 1070916Homo sapiens (human)IC500.042021
chir 98014Homo sapiens (human)IC505.000011
urmc-099Homo sapiens (human)IC500.039011
pf-543Homo sapiens (human)IC5010.000011
at 9283Homo sapiens (human)IC500.010011
chir 258Homo sapiens (human)IC500.006522
nintedanibHomo sapiens (human)IC500.039555

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000022
staurosporineHomo sapiens (human)Kd0.150022
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.120022
vatalanibHomo sapiens (human)Kd0.009622
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd8.750022
birb 796Homo sapiens (human)Kd0.410022
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd4.400022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd0.031044
pd 173955Homo sapiens (human)Kd0.023011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd9.950022
tandutinibHomo sapiens (human)Kd3.100033
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd5.000022
zd 6474Homo sapiens (human)Kd0.260022
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd10.000022
bosutinibHomo sapiens (human)Kd10.000011
su 11248Homo sapiens (human)Kd0.001833
jnj-7706621Homo sapiens (human)Kd2.100011
vx680Homo sapiens (human)Kd0.100022
ekb 569Homo sapiens (human)Kd10.000011
axitinibHomo sapiens (human)Kd0.005811
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd0.450033
ki 20227Homo sapiens (human)Kd0.130011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd0.000711
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd0.014022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd0.004722
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.016011
brivanibHomo sapiens (human)Kd0.010011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.086022
kw 2449Homo sapiens (human)Kd0.073011
abt 869Homo sapiens (human)Kd0.007522
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd2.300011
chir-265Homo sapiens (human)Kd0.800022
motesanibHomo sapiens (human)Kd0.012022
mln8054Homo sapiens (human)Kd1.000022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd0.110022
nvp-tae684Homo sapiens (human)EC500.872011
nvp-tae684Homo sapiens (human)Kd0.550011
fedratinibHomo sapiens (human)Kd4.300011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd1.900011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd0.041044
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.003811
cep-32496Homo sapiens (human)Kd0.014011
chir 258Homo sapiens (human)Kd0.069022
nintedanibHomo sapiens (human)Kd0.063011
pp242Homo sapiens (human)Kd1.200011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
brivanibHomo sapiens (human)Activity0.040011

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
transmembrane receptor protein tyrosine kinase activitymolecular functionCombining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [EC:2.7.10.1, GOC:mah]
vascular endothelial growth factor receptor activitymolecular functionCombining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:19909239]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
growth factor bindingmolecular functionBinding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators]
placental growth factor receptor activitymolecular functionCombining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:uh, PMID:12871269, PMID:7929268, Wikipedia:Placental_growth_factor]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
endosomecellular componentA vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
focal adhesioncellular componentA cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
actin cytoskeletoncellular componentThe part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 24 target(s):

TargetCategoryDefinition
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
monocyte chemotaxisbiological processThe movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]
cell surface receptor protein tyrosine kinase signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
positive regulation of phospholipase C activitybiological processAny process that increases the rate of phospholipase C activity. [GOC:dph, GOC:tb]
cell migrationbiological processThe controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
peptidyl-tyrosine phosphorylationbiological processThe phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
positive regulation of cell migrationbiological processAny process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
cellular response to vascular endothelial growth factor stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, PMID:18440775]
vascular endothelial growth factor receptor-1 signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, Wikipedia:FLT1, Wikipedia:VEGF_receptors]
vascular endothelial growth factor signaling pathwaybiological processThe series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]
positive regulation of MAP kinase activitybiological processAny process that activates or increases the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]
positive regulation of MAPK cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
positive regulation of angiogenesisbiological processAny process that activates or increases angiogenesis. [GOC:go_curators]
protein autophosphorylationbiological processThe phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
vascular endothelial growth factor receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
blood vessel morphogenesisbiological processThe process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:jid]
embryonic morphogenesisbiological processThe process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. [GOC:jid, GOC:mtg_sensu]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionbiological processAny process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
negative regulation of vascular endothelial cell proliferationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
hyaloid vascular plexus regressionbiological processThe developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression. [GOC:hjd, PMID:18841878]
multicellular organism developmentbiological processThe biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
positive regulation of kinase activitybiological processAny process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]