A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3]
G-protein coupled receptor 120;
G-protein coupled receptor 129;
G-protein coupled receptor GT01;
G-protein coupled receptor PGR4;
Omega-3 fatty acid receptor 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| lauric acid | Homo sapiens (human) | EC50 | 7.5858 | 1 | 1 |
| 12-hydroxy stearic acid | Homo sapiens (human) | EC50 | 1.7378 | 1 | 1 |
| 16-hydroxypalmitic acid | Homo sapiens (human) | EC50 | 1.6982 | 1 | 1 |
| 12-hydroxydodecanoic acid | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| 3-hydroxydodecanoic acid | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| ricinoleic acid | Homo sapiens (human) | EC50 | 1.3183 | 1 | 1 |
| linoleic acid | Homo sapiens (human) | EC50 | 0.3162 | 1 | 1 |
| alpha-linolenic acid | Homo sapiens (human) | EC50 | 2.9180 | 2 | 2 |
| gw9508 | Homo sapiens (human) | EC50 | 2.6916 | 3 | 3 |
| tak-875 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| tug-469 | Homo sapiens (human) | EC50 | 6.3096 | 2 | 2 |
| tug-891 | Homo sapiens (human) | EC50 | 0.1688 | 5 | 5 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| fatty acid binding | molecular function | Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732] |
| taste receptor activity | molecular function | Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph] |
| peptide binding | molecular function | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cilium | cellular component | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] |
| endosome membrane | cellular component | The lipid bilayer surrounding an endosome. [GOC:mah] |
| endocytic vesicle | cellular component | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. [GOC:go_curators, PMID:19696797] |
| ciliary membrane | cellular component | The portion of the plasma membrane surrounding a cilium. [GOC:cilia, GOC:dph, GOC:rph] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 22 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of cytokine production | biological process | Any process that stops, prevents, or reduces the rate of production of a cytokine. [GOC:add, ISBN:0781735149] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| positive regulation of cytosolic calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai] |
| regulation of glucose transmembrane transport | biological process | Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb] |
| negative regulation of interleukin-1 beta production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah] |
| ghrelin secretion | biological process | The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone. [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| positive regulation of osteoblast differentiation | biological process | Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators] |
| negative regulation of inflammatory response | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| white fat cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. [PMID:12508945] |
| brown fat cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [PMID:12588810] |
| detection of chemical stimulus involved in sensory perception of taste | biological process | The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. [GOC:ai] |
| positive regulation of glucagon secretion | biological process | Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. [GOC:BHF, GOC:mah] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| negative regulation of somatostatin secretion | biological process | Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. [GOC:BHF] |
| positive regulation of brown fat cell differentiation | biological process | Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:BHF] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |
| cellular response to hormone stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| hormone secretion | biological process | The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. [ISBN:0198506732] |