A sodium- and chloride-dependent glycine transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y345]
GlyT-2;
GlyT2;
Solute carrier family 6 member 5
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| glycine | Homo sapiens (human) | IC50 | 128.0000 | 1 | 0 |
| n-arachidonylglycine | Homo sapiens (human) | IC50 | 6.0000 | 2 | 2 |
| n-oleoylglycine | Homo sapiens (human) | IC50 | 0.5000 | 2 | 2 |
| alx 5407 | Homo sapiens (human) | IC50 | 15.9000 | 2 | 2 |
| palmitoylcarnitine | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| alx 1393 | Homo sapiens (human) | IC50 | 0.0753 | 3 | 3 |
| n-arachidonoylalanine | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| oleoylcarnitine | Homo sapiens (human) | IC50 | 0.3400 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| glycine:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). [GOC:ai] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| endosome | cellular component | A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| dense core granule | cellular component | Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. [NIF_Subcellular:sao772007592, PMID:14690495] |
| presynaptic membrane | cellular component | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194] |
| glycinergic synapse | cellular component | A synapse that uses glycine as a neurotransmitter. [GOC:dos] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| neurotransmitter transport | biological process | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| synaptic transmission, glycinergic | biological process | The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos] |
| glycine import across plasma membrane | biological process | The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |