pyruvic acid has been researched along with Necrosis in 16 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The combination of ethanol with CCK (2 hours) caused necrosis of approximately 40% acinar cells in medium with glucose, but not with pyruvate and/or glutamine." | 8.02 | Pyruvate and Glutamine Define the Effects of Cholecystokinin and Ethanol on Mitochondrial Oxidation, Necrosis, and Morphology of Rat Pancreatic Acini. ( Bilonoha, OO; Ivasechko, II; Manko, BO; Manko, VV; Voloshyn, DM; Zub, AM, 2021) |
| " Surprisingly, we show that replacing glucose with galactose prevented or markedly reduced the loss of ATP and any subsequent necrosis." | 7.88 | Galactose protects against cell damage in mouse models of acute pancreatitis. ( Gerasimenko, JV; Gerasimenko, OV; Gryshchenko, O; Peng, S; Petersen, OH; Samarasinghe, S; Tsugorka, TM, 2018) |
| "Exposure of U937 cells to tert-butylhydroperoxide (tB-OOH) led to cyclosporin A-sensitive mitochondrial membrane permeability transition and necrosis." | 7.70 | Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate. ( Brambilla, L; Cantoni, O; Sestili, P, 1999) |
| " The combination of ethanol with CCK (2 hours) caused necrosis of approximately 40% acinar cells in medium with glucose, but not with pyruvate and/or glutamine." | 4.02 | Pyruvate and Glutamine Define the Effects of Cholecystokinin and Ethanol on Mitochondrial Oxidation, Necrosis, and Morphology of Rat Pancreatic Acini. ( Bilonoha, OO; Ivasechko, II; Manko, BO; Manko, VV; Voloshyn, DM; Zub, AM, 2021) |
| " Surprisingly, we show that replacing glucose with galactose prevented or markedly reduced the loss of ATP and any subsequent necrosis." | 3.88 | Galactose protects against cell damage in mouse models of acute pancreatitis. ( Gerasimenko, JV; Gerasimenko, OV; Gryshchenko, O; Peng, S; Petersen, OH; Samarasinghe, S; Tsugorka, TM, 2018) |
| " The technique was extended to polarize four 13C labelled substrates potentially providing information on pH, metabolism, necrosis and perfusion, namely [1-(13)C]pyruvic acid, 13C sodium bicarbonate, [1,4-(13)C]fumaric acid, and 13C urea with high levels of solution polarization (17." | 3.76 | Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. ( Bok, R; Chen, AP; Hu, S; Keshari, KR; Kurhanewicz, J; Larson, PE; Macdonald, JM; Nelson, SJ; Van Criekinge, M; Vigneron, DB; Wilson, DM, 2010) |
| " d-Serine injures the rat kidney, causing selective necrosis of the proximal straight tubules." | 3.72 | 1H NMR pattern recognition and 31P NMR studies with d-Serine in rat urine and kidney, time- and dose-related metabolic effects. ( Jacobsen, M; Lock, EA; Williams, RE, 2003) |
| "Exposure of U937 cells to tert-butylhydroperoxide (tB-OOH) led to cyclosporin A-sensitive mitochondrial membrane permeability transition and necrosis." | 3.70 | Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate. ( Brambilla, L; Cantoni, O; Sestili, P, 1999) |
| "We have examined the effect of L- and D-2-chloropropionic acid (L-CPA and D-CPA) on the concentrations of pyruvate, lactate, glucose and beta-hydroxybutyrate in the blood at various times after doses which produce cerebellar granule cell necrosis." | 3.69 | Chloropropionic acid-induced alterations in glucose metabolic status: possible relevance to cerebellar granule cell necrosis. ( Gyte, A; Lock, EA; Simpson, M; Widdowson, P; Wyatt, I, 1995) |
| "Spheroids derived from the human bladder cancer cell line MGH-U1 were initiated in spinner culture and then transferred to multiwell plates which contained medium with varying concentrations of glucose and pyruvate." | 1.27 | Influence of glucose concentration on growth and formation of necrosis in spheroids derived from a human bladder cancer cell line. ( Kopelyan, I; Tannock, IF, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Manko, BO | 1 |
| Bilonoha, OO | 1 |
| Voloshyn, DM | 1 |
| Zub, AM | 1 |
| Ivasechko, II | 1 |
| Manko, VV | 1 |
| Peng, S | 1 |
| Gerasimenko, JV | 1 |
| Tsugorka, TM | 1 |
| Gryshchenko, O | 1 |
| Samarasinghe, S | 1 |
| Petersen, OH | 1 |
| Gerasimenko, OV | 1 |
| Huang, CY | 2 |
| Kuo, WT | 1 |
| Lee, TC | 1 |
| Chen, CT | 1 |
| Peng, WH | 1 |
| Lu, KS | 1 |
| Yang, CY | 1 |
| Yu, LC | 1 |
| Wilson, DM | 1 |
| Keshari, KR | 1 |
| Larson, PE | 1 |
| Chen, AP | 1 |
| Hu, S | 1 |
| Van Criekinge, M | 1 |
| Bok, R | 1 |
| Nelson, SJ | 1 |
| Macdonald, JM | 1 |
| Vigneron, DB | 1 |
| Kurhanewicz, J | 1 |
| Chang, I | 1 |
| Cho, N | 1 |
| Koh, JY | 1 |
| Lee, MS | 1 |
| Williams, RE | 1 |
| Jacobsen, M | 1 |
| Lock, EA | 2 |
| Frenzel, J | 1 |
| Richter, J | 1 |
| Eschrich, K | 1 |
| Hansen, TL | 1 |
| Christensen, E | 1 |
| Brandt, NJ | 1 |
| Edwin, EE | 1 |
| Jackman, R | 1 |
| Gyte, A | 1 |
| Widdowson, P | 1 |
| Simpson, M | 1 |
| Wyatt, I | 1 |
| Sestili, P | 1 |
| Brambilla, L | 1 |
| Cantoni, O | 1 |
| Klasen, HJ | 1 |
| Kim, AH | 1 |
| Sheline, CT | 1 |
| Tian, M | 1 |
| Higashi, T | 1 |
| McMahon, RJ | 1 |
| Cousins, RJ | 1 |
| Choi, DW | 1 |
| Hinoi, E | 1 |
| Fujimori, S | 1 |
| Takemori, A | 1 |
| Yoneda, Y | 1 |
| Tannock, IF | 1 |
| Kopelyan, I | 1 |
| Nutz, V | 1 |
| Sommer, JH | 1 |
| Schultze-Petzold, J | 1 |
1 review available for pyruvic acid and Necrosis
| Article | Year |
|---|---|
A review on the nonoperative removal of necrotic tissue from burn wounds.
Topics: Administration, Topical; Animals; Burns; Cicatrix; Clinical Trials as Topic; Debridement; Female; Hu | 2000 |
15 other studies available for pyruvic acid and Necrosis
| Article | Year |
|---|---|
Pyruvate and Glutamine Define the Effects of Cholecystokinin and Ethanol on Mitochondrial Oxidation, Necrosis, and Morphology of Rat Pancreatic Acini.
Topics: Acinar Cells; Amylases; Animals; Cell Survival; Cells, Cultured; Cholecystokinin; Ethanol; Glutamine | 2021 |
Galactose protects against cell damage in mouse models of acute pancreatitis.
Topics: Acinar Cells; Adenosine Triphosphate; Animals; Asparaginase; Disease Models, Animal; Ethanol; Galact | 2018 |
Distinct cytoprotective roles of pyruvate and ATP by glucose metabolism on epithelial necroptosis and crypt proliferation in ischaemic gut.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Enterocytes; Glucose; Jejunum; Liver; Male; Microscopy, | 2017 |
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.
Topics: Animals; Biomarkers, Tumor; Enzymes; Fumarates; Gadolinium; Hydrogen-Ion Concentration; Indicators a | 2010 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell | 2003 |
1H NMR pattern recognition and 31P NMR studies with d-Serine in rat urine and kidney, time- and dose-related metabolic effects.
Topics: Animals; Dose-Response Relationship, Drug; Kidney; Lactic Acid; Magnetic Resonance Spectroscopy; Mal | 2003 |
Pyruvate protects glucose-deprived Müller cells from nitric oxide-induced oxidative stress by radical scavenging.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain Ischemia; Cells, Cultured; Energ | 2005 |
Studies on pyruvate carboxylase, pyruvate decarboxylase and lipoamide dehydrogenase in subacute necrotizing encephalomyelopathy.
Topics: Alanine; Brain Diseases; Carboxy-Lyases; Cells, Cultured; Dihydrolipoamide Dehydrogenase; Female; Fi | 1982 |
Elevation of blood keto acids in cerebrocortical necrosis.
Topics: Animals; Cattle; Cattle Diseases; Cerebral Cortex; Glyoxylates; Keto Acids; Ketoglutaric Acids; Necr | 1981 |
Chloropropionic acid-induced alterations in glucose metabolic status: possible relevance to cerebellar granule cell necrosis.
Topics: Animals; Blood Glucose; Cerebellum; Cytoplasmic Granules; Glucose; Hydrocarbons, Chlorinated; Lactat | 1995 |
Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate.
Topics: Apoptosis; Cell Count; Cell Division; Cell Survival; Cyclosporine; DNA Fragmentation; Enzyme Inhibit | 1999 |
L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells.
Topics: Animals; Apoptosis; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Ca | 2000 |
Cell death by pyruvate deficiency in proliferative cultured calvarial osteoblasts.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Cult | 2002 |
Influence of glucose concentration on growth and formation of necrosis in spheroids derived from a human bladder cancer cell line.
Topics: Cell Line; Culture Media; Cytological Techniques; Dose-Response Relationship, Drug; Glucose; Humans; | 1986 |
[Hyperlactacidemia in intestinal ischemia. II. Experimental principles].
Topics: Animals; Intestines; Ischemia; Lactates; Lactic Acid; Mesenteric Vascular Occlusion; Necrosis; Pyruv | 1987 |