Page last updated: 2024-08-07 15:35:26
Albumin
An albumin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P02768]
Synonyms
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 4 (19.05) | 2.80 |
Compounds (75)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| salicylic acid | Homo sapiens (human) | Ki | 5,888,440,000.0000 | 1 | 1 |
| chlorpropamide | Homo sapiens (human) | Ki | 39,810,700,000.0000 | 1 | 1 |
| diclofenac | Homo sapiens (human) | Ki | 331,131,000,000.0000 | 1 | 1 |
| diflunisal | Homo sapiens (human) | Ki | 58,884,400,000.0000 | 1 | 1 |
| flurbiprofen | Homo sapiens (human) | Ki | 331,131,000,000.0000 | 1 | 1 |
| furosemide | Homo sapiens (human) | Ki | 138,038,000,000.0000 | 1 | 1 |
| halothane | Homo sapiens (human) | IC50 | 2,900.0000 | 1 | 1 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 2,290,870,000.0000 | 1 | 1 |
| ibuprofen | Homo sapiens (human) | Ki | 165,959,000,000.0000 | 1 | 1 |
| indomethacin | Homo sapiens (human) | Ki | 15,135,600,000.0000 | 1 | 1 |
| ketoprofen | Homo sapiens (human) | Ki | 208,930,000,000.0000 | 1 | 1 |
| ketorolac | Homo sapiens (human) | Ki | 208,930,000,000.0000 | 1 | 1 |
| nimesulide | Homo sapiens (human) | Ki | 15,135,600,000.0000 | 1 | 1 |
| sotalol | Homo sapiens (human) | Ki | 354,813,000.0000 | 1 | 1 |
| vorinostat | Homo sapiens (human) | IC50 | 0.1072 | 1 | 1 |
| thioridazine | Homo sapiens (human) | IC50 | 3.5000 | 1 | 2 |
| tolazamide | Homo sapiens (human) | Ki | 53,703,200,000.0000 | 1 | 1 |
| tolbutamide | Homo sapiens (human) | Ki | 39,810,700,000.0000 | 1 | 1 |
| tolmetin | Homo sapiens (human) | Ki | 416,869,000,000.0000 | 1 | 1 |
| zomepirac | Homo sapiens (human) | Ki | 109,648,000,000.0000 | 1 | 1 |
| 4-phenylphenol | Homo sapiens (human) | Ki | 9,549,930,000.0000 | 1 | 1 |
| 5-chlorosalicylic acid | Homo sapiens (human) | Ki | 21,379,600,000.0000 | 1 | 1 |
| biphenyl-3-carboxylic acid | Homo sapiens (human) | Ki | 251,189,000,000.0000 | 1 | 1 |
| 4-phenylbenzoic acid | Homo sapiens (human) | Ki | 199,526,000,000.0000 | 1 | 1 |
| febuxostat | Homo sapiens (human) | IC50 | 0.0013 | 1 | 1 |
| sulindac | Homo sapiens (human) | Ki | 26,302,700,000.0000 | 1 | 1 |
| reparixin | Homo sapiens (human) | Ki | 1,659,590,000,000.0000 | 1 | 1 |
| 2,2,2-trifluorodiazoethane | Homo sapiens (human) | IC50 | 1,200.0000 | 1 | 1 |
| bropirimine | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Conformation selectivity in the binding of diazepam and analogues to alpha1-acid glycoprotein.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.Journal of medicinal chemistry, , 09-14, Volume: 60, Issue:17, 2017
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
"Clickable" Albumin Binders for Modulating the Tumor Uptake of Targeted Radiopharmaceuticals.Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
"Clickable" Albumin Binders for Modulating the Tumor Uptake of Targeted Radiopharmaceuticals.Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.Journal of medicinal chemistry, , 09-14, Volume: 60, Issue:17, 2017
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).Journal of medicinal chemistry, , Apr-28, Volume: 54, Issue:8, 2011
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Enables
This protein enables 11 target(s):
| Target | Category | Definition |
|---|
| DNA binding | molecular function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| fatty acid binding | molecular function | Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732] |
| copper ion binding | molecular function | Binding to a copper (Cu) ion. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| toxic substance binding | molecular function | Binding to a toxic substance, a poisonous substance that causes damage to biological systems. [GOC:bf, GOC:curators, GOC:jl, GOC:pr] |
| antioxidant activity | molecular function | Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. [ISBN:0198506732] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein-folding chaperone binding | molecular function | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443] |
| exogenous protein binding | molecular function | Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein. [PMID:28861068] |
| enterobactin binding | molecular function | Binding to enterobactin. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132] |
Located In
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| platelet alpha granule lumen | cellular component | The volume enclosed by the membrane of the platelet alpha granule. [GOC:mah, PMID:8467233] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| blood microparticle | cellular component | A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| cellular response to starvation | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl] |
| negative regulation of mitochondrial depolarization | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai] |
| cellular response to calcium ion starvation | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions. [GOC:mah] |
| cellular oxidant detoxification | biological process | Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw] |
| transport | biological process | The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. [GOC:dos, GOC:dph, GOC:jl, GOC:mah] |