UDP-glucuronosyltransferase 1A3

A UDP-glucuronosyltransferase 1A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35503]

Synonyms

UGT1A3;
EC 2.4.1.17;
UDP-glucuronosyltransferase 1-3;
UDPGT 1-3;
UGT1*3;
UGT1-03;
UGT1.3;
UDP-glucuronosyltransferase 1-C;
UGT-1C;
UGT1C;
UDP-glucuronosyltransferase 1A isoform 3

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	1 (33.33)	24.3611
2020's	1 (33.33)	2.80

Compounds (15)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezogabine	Homo sapiens (human)	EC50	3.9000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amitriptyline	Homo sapiens (human)	Km	267.0000	1	1
cyproheptadine	Homo sapiens (human)	Km	240.0000	1	1
diclofenac	Homo sapiens (human)	Km	12.0000	1	1
flurbiprofen	Homo sapiens (human)	Km	90.0000	1	1
ibuprofen	Homo sapiens (human)	Km	230.0000	1	1
imipramine	Homo sapiens (human)	Km	472.0000	1	1
ketoprofen	Homo sapiens (human)	Km	84.0000	1	1
ketotifen	Homo sapiens (human)	Km	174.0000	1	2
clonixin	Homo sapiens (human)	Km	624.0000	1	1
norbuprenorphine	Homo sapiens (human)	Km	19.0000	1	1
ezetimibe	Homo sapiens (human)	Km	42.0000	1	1
scutellarein	Homo sapiens (human)	Km	7.3400	1	1
morphine	Homo sapiens (human)	Km	3,280.0000	1	1
morphine-3-glucuronide	Homo sapiens (human)	Km	3,200.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
retinoic acid binding	molecular function	Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]
glucuronosyltransferase activity	molecular function	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
estrogen metabolic process	biological process	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
bile acid secretion	biological process	The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. [GOC:ecd]
retinoic acid metabolic process	biological process	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
cellular glucuronidation	biological process	The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]
flavonoid glucuronidation	biological process	The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. [GOC:BHF, PMID:20056724]
xenobiotic glucuronidation	biological process	The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. [GOC:BHF, PMID:20056724]
vitamin D3 metabolic process	biological process	The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. [GOC:BHF, GOC:mah]