Proteins > Thyroid hormone receptor beta
Page last updated: 2024-08-07 15:53:35

Thyroid hormone receptor beta

A thyroid hormone receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10828]

Synonyms

Nuclear receptor subfamily 1 group A member 2;
c-erbA-2;
c-erbA-beta

Research

Bioassay Publications (29)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (3.45)18.2507
2000's19 (65.52)29.6817
2010's6 (20.69)24.3611
2020's3 (10.34)2.80

Compounds (17)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
amiodaroneHomo sapiens (human)IC500.600011
3,3',5-triiodothyroacetic acidHomo sapiens (human)IC500.000044
3,3',5-triiodothyropropionic acidHomo sapiens (human)IC500.000044
triiodothyronineHomo sapiens (human)IC500.000689
triiodothyronineHomo sapiens (human)Ki0.001255
mifepristoneHomo sapiens (human)Ki2.250011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC50100.000011
gc 1 compoundHomo sapiens (human)Ki0.000311
kb 141Homo sapiens (human)IC500.0035910
kb 141Homo sapiens (human)Ki0.000333
kb 130015Homo sapiens (human)IC504.857244
cgs 23425Homo sapiens (human)Ki0.000511
3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acidHomo sapiens (human)IC500.000378
kb 2115Homo sapiens (human)Ki0.000411

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
thyroxineHomo sapiens (human)EC500.240011
triiodothyronineHomo sapiens (human)EC500.00811012
triiodothyronineHomo sapiens (human)Kd0.000168
tetraiodothyroacetic acidHomo sapiens (human)EC500.020011
3,5-dimethyl-3'-isopropyl-l-thyronineHomo sapiens (human)Kd0.008623
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC50100.000011
gc 1 compoundHomo sapiens (human)EC500.012522
gc 1 compoundHomo sapiens (human)Kd0.000245
kb 141Homo sapiens (human)EC500.009233
3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acidHomo sapiens (human)EC500.000211
fg-4592Homo sapiens (human)EC500.012911
mgl-3196Homo sapiens (human)EC500.188622

Enables

This protein enables 12 target(s):

TargetCategoryDefinition
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
transcription coactivator bindingmolecular functionBinding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. [GOC:krc]
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
DNA-binding transcription factor activitymolecular functionA transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
chromatin DNA bindingmolecular functionBinding to DNA that is assembled into chromatin. [GOC:mah]
thyroid hormone bindingmolecular functionBinding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. [GOC:rph]
sequence-specific double-stranded DNA bindingmolecular functionBinding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nuclear bodycellular componentExtra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulator complexcellular componentA transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 16 target(s):

TargetCategoryDefinition
positive regulation of thyroid hormone mediated signaling pathwaybiological processAny process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway. [GOC:hjd]
DNA-templated transcriptionbiological processThe synthesis of an RNA transcript from a DNA template. [GOC:jl, GOC:txnOH]
sensory perception of soundbiological processThe series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai]
negative regulation of female receptivitybiological processAny process that stops, prevents or reduces the receptiveness of a female to male advances. [GOC:bf, PMID:11092827]
regulation of heart contractionbiological processAny process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph, GOC:go_curators, GOC:tb]
female courtship behaviorbiological processThe behavior of a female, for the purpose of attracting a sexual partner. [GOC:bf, GOC:pr]
mRNA transcription by RNA polymerase IIbiological processThe cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:jl, ISBN:0321000382]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
retinal cone cell developmentbiological processDevelopment of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. [ISBN:0198506732]
type I pneumocyte differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. [GOC:dph, GOC:mtg_lung, ISBN:0721662544]
cellular response to thyroid hormone stimulusbiological processA change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]
retinal cone cell apoptotic processbiological processAny apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. [CL:0000573, GOC:jc]
retinoic acid receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
thyroid hormone mediated signaling pathwaybiological processThe series of molecular signals mediated by the detection of a thyroid hormone. [GOC:hjd]
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]