Page last updated: 2024-08-07 12:54:33
Corticosteroid-binding globulin
A corticosteroid-binding globulin that is encoded in the genome of human. [PRO:CNA, UniProtKB:P08185]
Synonyms
CBG;
Serpin A6;
Transcortin
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| hydrocortisone acetate | Homo sapiens (human) | Ki | 0.0282 | 1 | 1 |
| corticosterone | Homo sapiens (human) | Ki | 0.0381 | 1 | 2 |
| prednisolone | Homo sapiens (human) | Ki | 0.0309 | 1 | 1 |
| estriol | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| aldosterone | Homo sapiens (human) | Ki | 0.5248 | 1 | 1 |
| estrone | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| androsterone | Homo sapiens (human) | Ki | 2.4547 | 1 | 1 |
| etiocholanolone | Homo sapiens (human) | Ki | 5.8884 | 1 | 1 |
| dehydroepiandrosterone | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| androstenedione | Homo sapiens (human) | Ki | 1.7378 | 1 | 1 |
| desoxycorticosterone | Homo sapiens (human) | Ki | 0.0224 | 1 | 1 |
| 17-alpha-hydroxyprogesterone | Homo sapiens (human) | Ki | 0.0182 | 1 | 1 |
| pregnenolone | Homo sapiens (human) | Ki | 5.8884 | 1 | 1 |
| nandrolone | Homo sapiens (human) | Ki | 0.7244 | 1 | 1 |
| androstenediol | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| dihydrotestosterone | Homo sapiens (human) | Ki | 1.2023 | 1 | 1 |
| algestone | Homo sapiens (human) | Ki | 0.5623 | 1 | 1 |
| 11-ketoprogesterone | Homo sapiens (human) | Ki | 0.1660 | 1 | 1 |
| 2 alpha-methyl-9 alpha-fluorocortisol | Homo sapiens (human) | Ki | 1.5849 | 1 | 1 |
| 3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| cortisone | Homo sapiens (human) | Ki | 0.1288 | 1 | 1 |
| 19-norprogesterone | Homo sapiens (human) | Ki | 0.1514 | 1 | 1 |
| 5 alpha-androstane-3 beta,17 beta-diol | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| cortodoxone | Homo sapiens (human) | Ki | 0.0132 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| androstenediol | Homo sapiens (human) | Log Ki | 5,000.0000 | 1 | 1 |
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| steroid binding | molecular function | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732] |
| serine-type endopeptidase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| glucocorticoid metabolic process | biological process | The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [ISBN:0198506732] |
| negative regulation of endopeptidase activity | biological process | Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb] |