Corticosteroid-binding globulin

A corticosteroid-binding globulin that is encoded in the genome of human. [PRO:CNA, UniProtKB:P08185]

CBG;
Serpin A6;
Transcortin

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
hydrocortisone acetate	Homo sapiens (human)	Ki	0.0282	1	1
corticosterone	Homo sapiens (human)	Ki	0.0381	1	2
prednisolone	Homo sapiens (human)	Ki	0.0309	1	1
estriol	Homo sapiens (human)	Ki	10.0000	1	1
aldosterone	Homo sapiens (human)	Ki	0.5248	1	1
estrone	Homo sapiens (human)	Ki	10.0000	1	1
androsterone	Homo sapiens (human)	Ki	2.4547	1	1
etiocholanolone	Homo sapiens (human)	Ki	5.8884	1	1
dehydroepiandrosterone	Homo sapiens (human)	Ki	10.0000	1	1
androstenedione	Homo sapiens (human)	Ki	1.7378	1	1
desoxycorticosterone	Homo sapiens (human)	Ki	0.0224	1	1
17-alpha-hydroxyprogesterone	Homo sapiens (human)	Ki	0.0182	1	1
pregnenolone	Homo sapiens (human)	Ki	5.8884	1	1
nandrolone	Homo sapiens (human)	Ki	0.7244	1	1
androstenediol	Homo sapiens (human)	Ki	10.0000	1	1
dihydrotestosterone	Homo sapiens (human)	Ki	1.2023	1	1
algestone	Homo sapiens (human)	Ki	0.5623	1	1
11-ketoprogesterone	Homo sapiens (human)	Ki	0.1660	1	1
2 alpha-methyl-9 alpha-fluorocortisol	Homo sapiens (human)	Ki	1.5849	1	1
3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one	Homo sapiens (human)	Ki	10.0000	1	1
cortisone	Homo sapiens (human)	Ki	0.1288	1	1
19-norprogesterone	Homo sapiens (human)	Ki	0.1514	1	1
5 alpha-androstane-3 beta,17 beta-diol	Homo sapiens (human)	Ki	10.0000	1	1
cortodoxone	Homo sapiens (human)	Ki	0.0132	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
androstenediol	Homo sapiens (human)	Log Ki	5,000.0000	1	1

This protein enables 2 target(s):

Target	Category	Definition
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
serine-type endopeptidase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

This protein is involved in 2 target(s):

Target	Category	Definition
glucocorticoid metabolic process	biological process	The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [ISBN:0198506732]
negative regulation of endopeptidase activity	biological process	Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]