Proteins > Bifunctional dihydrofolate reductase-thymidylate synthase
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Bifunctional dihydrofolate reductase-thymidylate synthase
[no definition available]
Synonyms
DHFR-TS
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.Bioorganic & medicinal chemistry, , 12-15, Volume: 25, Issue:24, 2017
Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 16, Issue:16, 2006
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.Journal of medicinal chemistry, , Aug-12, Volume: 47, Issue:17, 2004
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Insights into antifolate resistance from malarial DHFR-TS structures.Nature structural biology, , Volume: 10, Issue:5, 2003
Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors.Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.Journal of medicinal chemistry, , Apr-23, Volume: 41, Issue:9, 1998
Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.Journal of medicinal chemistry, , Jul-24, Volume: 35, Issue:15, 1992
Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 16, Issue:16, 2006
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.Journal of medicinal chemistry, , Aug-12, Volume: 47, Issue:17, 2004
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Insights into antifolate resistance from malarial DHFR-TS structures.Nature structural biology, , Volume: 10, Issue:5, 2003
Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors.Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.Journal of medicinal chemistry, , Apr-23, Volume: 41, Issue:9, 1998
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.Journal of medicinal chemistry, , Aug-12, Volume: 47, Issue:17, 2004
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.Journal of medicinal chemistry, , Aug-12, Volume: 47, Issue:17, 2004
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.Journal of medicinal chemistry, , Aug-12, Volume: 47, Issue:17, 2004
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002