A neutral amino acid transporter B(0) that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15758]
ATB(0);
Baboon M7 virus receptor;
RD114/simian type D retrovirus receptor;
Sodium-dependent neutral amino acid transporter type 2;
Solute carrier family 1 member 5
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| hydroxyproline | Homo sapiens (human) | IC50 | 2,737.5000 | 2 | 0 |
| serine | Homo sapiens (human) | IC50 | 822.0000 | 1 | 0 |
| glutamine | Homo sapiens (human) | IC50 | 541.0000 | 1 | 0 |
| asparagine | Homo sapiens (human) | IC50 | 674.0000 | 1 | 0 |
| 4-hydroxyphenylglycine, (s)-isomer | Homo sapiens (human) | IC50 | 1,864.0000 | 2 | 0 |
| D-serine | Homo sapiens (human) | IC50 | 4,913.0000 | 1 | 0 |
| gamma-glutamine-4-nitroanilide | Homo sapiens (human) | IC50 | 1,247.8333 | 6 | 4 |
| proline | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 0 |
This protein enables 12 target(s):
| Target | Category | Definition |
|---|---|---|
| virus receptor activity | molecular function | Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amino acid transmembrane transporter activity | molecular function | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| L-aspartate transmembrane transporter activity | molecular function | Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] |
| L-glutamine transmembrane transporter activity | molecular function | Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| L-serine transmembrane transporter activity | molecular function | Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, RHEA:35031] |
| symporter activity | molecular function | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] |
| antiporter activity | molecular function | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] |
| ligand-gated channel activity | molecular function | Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| neutral L-amino acid transmembrane transporter activity | molecular function | Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basal plasma membrane | cellular component | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| amino acid transport | biological process | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| glutamine transport | biological process | The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| glutamine secretion | biological process | The controlled release of glutamine by a cell. [PMID:15208395] |
| neutral amino acid transport | biological process | The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| L-serine transport | biological process | The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah] |
| erythrocyte differentiation | biological process | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. [GOC:mah] |
| symbiont entry into host cell | biological process | The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl] |
| protein homotrimerization | biological process | The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. [GOC:hjd] |
| L-aspartate import across plasma membrane | biological process | The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000069, PMID:7914198] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| L-glutamine import across plasma membrane | biological process | The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341] |