Proteins > Transient receptor potential cation channel subfamily M member 8
Page last updated: 2024-08-07 18:45:17

Transient receptor potential cation channel subfamily M member 8

A transient receptor potential cation channel TRPM8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q7Z2W7]

Synonyms

Long transient receptor potential channel 6;
LTrpC-6;
LTrpC6;
Transient receptor potential p8;
Trp-p8

Research

Bioassay Publications (13)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (15.38)29.6817
2010's8 (61.54)24.3611
2020's3 (23.08)2.80

Compounds (19)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
mentholHomo sapiens (human)IC50210.333333
5-methoxytryptamineHomo sapiens (human)IC5012.000022
cannabichromeneHomo sapiens (human)IC5040.700011
5-chlorotryptamineHomo sapiens (human)IC5026.850022
5-benzyloxytryptamineHomo sapiens (human)IC500.500022
(6ar-trans)-isomer of tetrahydrocannabivarin 9Homo sapiens (human)IC500.020011
5-fluorotryptamineHomo sapiens (human)IC5012.700022
sb 366791Homo sapiens (human)IC5010.000011
hc 030031Homo sapiens (human)IC5030.000011
capsazepineHomo sapiens (human)IC5018.000011
cannabigerolHomo sapiens (human)IC500.160011
4-amylcinnamoylanthranilic acidHomo sapiens (human)IC503.900022
sb 705498Homo sapiens (human)IC501.600011
n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamideHomo sapiens (human)IC500.637522
cannabidivarinHomo sapiens (human)IC500.900011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
mentholHomo sapiens (human)EC50122.366799
mentholHomo sapiens (human)Kd14.400011
mentholHomo sapiens (human)EC5010.100011
ag 3-5Homo sapiens (human)EC500.180022
geraniolHomo sapiens (human)EC505,900.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
mentholHomo sapiens (human)Activity10.000011
eucalyptolHomo sapiens (human)Activity100.000011
ag 3-5Homo sapiens (human)Activity0.099011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
calcium channel activitymolecular functionEnables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
ligand-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:dos]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membranecellular componentThe leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
membrane raftcellular componentAny of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 6 target(s):

TargetCategoryDefinition
intracellular calcium ion homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
response to coldbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]
calcium-mediated signalingbiological processAny intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
thermoceptionbiological processThe series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). [GOC:ai, Wikipedia:Thermoception]
calcium ion transmembrane transportbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
positive regulation of cold-induced thermogenesisbiological processAny process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]