A calpain-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14815]
EC 3.4.22.-;
Digestive tract-specific calpain;
New calpain 4;
nCL-4;
Protein CG36
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0) | 18.7374 |
| 1990's | 0 (0) | 18.2507 |
| 2000's | 0 (0) | 29.6817 |
| 2010's | 0 (0) | 24.3611 |
| 2020's | 0 (0) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| calpeptin | Homo sapiens (human) | IC50 | 2.8400 | 1 | 0 |
| calpain inhibitor 2 | Homo sapiens (human) | IC50 | 3.3200 | 1 | 0 |
| n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine | Homo sapiens (human) | IC50 | 35.8300 | 1 | 0 |
| e 64 | Homo sapiens (human) | IC50 | 11.5800 | 1 | 0 |
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | Homo sapiens (human) | IC50 | 9.8800 | 1 | 0 |
| 5-Nitroisatin | Homo sapiens (human) | IC50 | 42.2900 | 1 | 0 |
| benzyloxycarbonyl-phe-ala-fluormethylketone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 0 |
| z-val-ala-asp(ome)-fluoromethylketone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 0 |
| sja 6017 | Homo sapiens (human) | IC50 | 2.2300 | 1 | 0 |
| calpain inhibitor iii | Homo sapiens (human) | IC50 | 1.6100 | 1 | 0 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| calcium-dependent cysteine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. [GOC:mah] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cellular_component | cellular component | A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |