Page last updated: 2024-08-07 12:49:31
Beta-lactamase
A protein that is a translation product of any of the plasmid-encoded copies of the blaZ gene in Staphylococcus aureus. [PRO:DAN, UniProtKB:P00807]
Synonyms
EC 3.5.2.6;
Penicillinase
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| boric acid | Staphylococcus aureus | Ki | 2,150.0000 | 1 | 2 |
| 3-aminobenzeneboronic acid | Staphylococcus aureus | Ki | 7.3000 | 1 | 1 |
| tazobactam | Staphylococcus aureus | IC50 | 0.5000 | 1 | 1 |
| sulbactam | Staphylococcus aureus | IC50 | 6.5000 | 1 | 1 |
| methaneboronic acid | Staphylococcus aureus | Ki | 1,750.0000 | 1 | 2 |
| clavulanic acid | Staphylococcus aureus | IC50 | 0.0800 | 1 | 1 |
| tazobactam sodium | Staphylococcus aureus | IC50 | 10.0712 | 6 | 6 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cephaloridine | Staphylococcus aureus | Km | 110.0000 | 1 | 1 |
| penicillin g | Staphylococcus aureus | Km | 7.7000 | 2 | 2 |
| cephalothin | Staphylococcus aureus | Km | 1.0000 | 1 | 1 |
| cefepime | Staphylococcus aureus | Km | 61.0000 | 1 | 1 |
| ceftazidime | Staphylococcus aureus | Km | 29.0000 | 1 | 1 |
| ceftobiprole | Staphylococcus aureus | Km | 78.0000 | 1 | 1 |