Page last updated: 2024-08-07 16:59:50
Squalene synthase
A squalene synthase that is encoded in the genome of rat. [OMA:Q02769, PRO:DNx]
Synonyms
SQS;
SS;
EC 2.5.1.21;
FPP:FPP farnesyltransferase;
Farnesyl-diphosphate farnesyltransferase
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 2 | 2 |
| alprenolol | Rattus norvegicus (Norway rat) | IC50 | 4.2000 | 1 | 1 |
| thiorphan | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| losartan | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| valsartan | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| cyc 202 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| resveratrol | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| farnesyl pyrophosphate | Rattus norvegicus (Norway rat) | Ki | 2.6000 | 1 | 1 |
| omapatrilat | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| squalestatin 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0062 | 2 | 2 |
| 3-(biphenyl-4-yl)-3-hydroxyquinuclidine | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 2 | 4 |
| zaragozic acid b | Rattus norvegicus (Norway rat) | IC50 | 0.0002 | 1 | 1 |
| zaragozic acid c | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| farnesyl pyrophosphate | Rattus norvegicus (Norway rat) | Km | 12.7000 | 1 | 1 |