An AMP deaminase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01432]
EC 3.5.4.6;
AMP deaminase isoform E;
Erythrocyte AMP deaminase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| coformycin | Homo sapiens (human) | Ki | 3.0000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| AMP deaminase activity | molecular function | Catalysis of the reaction: AMP + H2O = IMP + NH3. [EC:3.5.4.6] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| secretory granule lumen | cellular component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| AMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. [ISBN:0198506732] |
| IMP salvage | biological process | Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah] |
| AMP metabolic process | biological process | The chemical reactions and pathways involving AMP, adenosine monophosphate. [GOC:go_curators] |
| IMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. [ISBN:0198506732] |