Proteins > Muscarinic acetylcholine receptor M2
Page last updated: 2024-08-07 15:53:48
Muscarinic acetylcholine receptor M2
A muscarinic acetylcholine receptor M2 that is encoded in the genome of rat. [OMA:P10980, PRO:DNx]
Synonyms
Research
Bioassay Publications (92)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 18 (19.57) | 18.7374 |
| 1990's | 51 (55.43) | 18.2507 |
| 2000's | 13 (14.13) | 29.6817 |
| 2010's | 10 (10.87) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (197)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quinacrine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane | Rattus norvegicus (Norway rat) | Ki | 0.0620 | 1 | 2 |
| ro 5-4864 | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 5,8,11,14-eicosatetraynoic acid | Rattus norvegicus (Norway rat) | IC50 | 1.7800 | 1 | 0 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| aceclidine | Rattus norvegicus (Norway rat) | IC50 | 0.5100 | 1 | 1 |
| aceclidine | Rattus norvegicus (Norway rat) | Ki | 8.2600 | 1 | 1 |
| methacholine | Rattus norvegicus (Norway rat) | IC50 | 3.5933 | 2 | 3 |
| methacholine | Rattus norvegicus (Norway rat) | Ki | 0.0590 | 1 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 3 |
| arecoline | Rattus norvegicus (Norway rat) | IC50 | 17.1331 | 8 | 13 |
| arecoline | Rattus norvegicus (Norway rat) | Ki | 1.8327 | 5 | 6 |
| benzylhydrochlorothiazide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| bisacodyl | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| bithionol | Rattus norvegicus (Norway rat) | IC50 | 1.6700 | 1 | 0 |
| carbetapentane | Rattus norvegicus (Norway rat) | Ki | 0.0760 | 1 | 1 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0603 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| safingol | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| profenamine | Rattus norvegicus (Norway rat) | IC50 | 0.7200 | 1 | 1 |
| gossypol | Rattus norvegicus (Norway rat) | IC50 | 0.8600 | 1 | 0 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 5.2542 | 5 | 5 |
| hexachlorophene | Rattus norvegicus (Norway rat) | IC50 | 0.8600 | 1 | 0 |
| methoctramine | Rattus norvegicus (Norway rat) | Ki | 0.0173 | 3 | 4 |
| 5-methylfurtrethonium | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 1 |
| methixene | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| oxotremorine | Rattus norvegicus (Norway rat) | IC50 | 2.7261 | 8 | 13 |
| oxotremorine | Rattus norvegicus (Norway rat) | Ki | 334,124,666,674.4914 | 11 | 15 |
| oxybutynin | Rattus norvegicus (Norway rat) | Ki | 0.0105 | 2 | 2 |
| periciazine | Rattus norvegicus (Norway rat) | IC50 | 0.2300 | 1 | 1 |
| phenazine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| pirenzepine | Rattus norvegicus (Norway rat) | IC50 | 0.6281 | 35 | 45 |
| pirenzepine | Rattus norvegicus (Norway rat) | Ki | 4.8286 | 3 | 4 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 1 |
| triflupromazine | Rattus norvegicus (Norway rat) | IC50 | 7.4000 | 1 | 1 |
| carbachol | Rattus norvegicus (Norway rat) | IC50 | 10.9373 | 8 | 11 |
| carbachol | Rattus norvegicus (Norway rat) | Ki | 25.4284 | 10 | 13 |
| pilocarpine | Rattus norvegicus (Norway rat) | IC50 | 3.8400 | 2 | 2 |
| pilocarpine | Rattus norvegicus (Norway rat) | Ki | 3.6700 | 1 | 1 |
| physostigmine | Rattus norvegicus (Norway rat) | IC50 | 160.0000 | 1 | 1 |
| caramiphen | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 1 | 3 |
| 1,3-ditolylguanidine | Rattus norvegicus (Norway rat) | Ki | 2.9600 | 1 | 1 |
| bromobenzene | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| muscarine | Rattus norvegicus (Norway rat) | IC50 | 2.0755 | 3 | 4 |
| muscarine | Rattus norvegicus (Norway rat) | Ki | 1.7795 | 4 | 5 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0209 | 1 | 1 |
| clothiapine | Rattus norvegicus (Norway rat) | Ki | 0.1349 | 1 | 1 |
| 6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazine | Rattus norvegicus (Norway rat) | IC50 | 18.7600 | 1 | 0 |
| quinuclidinyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 5.2000 | 1 | 1 |
| triadimenol | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| fluperlapine | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| 1-(3,4-dihydroxyphenyl)-2-(1-imidazolyl)ethanone | Rattus norvegicus (Norway rat) | IC50 | 30.2000 | 1 | 0 |
| n-methyl-n-(1-methyl-4-pyrrolidino-2-butynyl)acetamide | Rattus norvegicus (Norway rat) | Ki | 0.1709 | 7 | 10 |
| besipirdine | Rattus norvegicus (Norway rat) | IC50 | 2.3133 | 4 | 6 |
| n-methyl-3-piperidyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 1 |
| n-ethyl-3-piperidyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 1 | 1 |
| ticlopidine hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2,3-trimethylene-4-quinazolone | Rattus norvegicus (Norway rat) | IC50 | 0.5200 | 1 | 0 |
| 2-aminodiphenylamine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| prazosin hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| n-methylscopolamine | Rattus norvegicus (Norway rat) | Ki | 6,309,570,000,000,000.0000 | 1 | 1 |
| 2,2'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)diimino)bis-benzoic acid | Rattus norvegicus (Norway rat) | IC50 | 0.8500 | 1 | 0 |
| methyl fluorone black | Rattus norvegicus (Norway rat) | IC50 | 12.4600 | 1 | 0 |
| tetrandrine | Rattus norvegicus (Norway rat) | Ki | 0.0730 | 1 | 1 |
| enpiperate | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| nicotine | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| coumarin 7 | Rattus norvegicus (Norway rat) | IC50 | 1.6200 | 1 | 0 |
| afdx 116 | Rattus norvegicus (Norway rat) | IC50 | 2.5994 | 33 | 50 |
| 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole | Rattus norvegicus (Norway rat) | Ki | 50.0000 | 1 | 1 |
| l 670548 | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 2 |
| aq-ra 741 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 1 |
| tripitramine | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 2 | 3 |
| solifenacin | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 1 | 1 |
| hyoscyamine | Rattus norvegicus (Norway rat) | Ki | 0.0027 | 1 | 1 |
| guvacoline | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| atropine | Rattus norvegicus (Norway rat) | IC50 | 0.0010 | 2 | 3 |
| atropine | Rattus norvegicus (Norway rat) | Ki | 17,609,888,888,888.8900 | 6 | 9 |
| roxifiban | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 1 |
| dizocilpine | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| sdz ens 163 | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 1 |
| br 100 | Rattus norvegicus (Norway rat) | Ki | 1.1454 | 4 | 6 |
| gossypol acetic acid | Rattus norvegicus (Norway rat) | IC50 | 1.1700 | 1 | 0 |
| berbamine | Rattus norvegicus (Norway rat) | Ki | 0.1900 | 1 | 1 |
| 5-((4-(4-(diethylamino)butyl)-1-piperidinyl)acetyl)-10,11-dihydrobenzo(b,e)(1,4)diazepine-11-one | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| enkephalin, methionine | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| tolterodine | Rattus norvegicus (Norway rat) | Ki | 0.0069 | 1 | 1 |
| darifenacin | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| 4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-ditert-butylphenol | Rattus norvegicus (Norway rat) | IC50 | 1.6300 | 1 | 0 |
| 2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(3-pyridinyl)methyl]-5,5-dimethylcyclohexane-1,3-dione | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(2-ethyl-6-methyl-3-oxo-1,4-benzoxazin-4-yl)-N-[(5-methyl-2-furanyl)methyl]-N-(3-pyridinylmethyl)acetamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(2,5-dimethoxyphenyl)-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[2-[2-[2-(4-methoxyanilino)-2-oxoethyl]-5-tetrazolyl]phenyl]-2-furancarboxamide | Rattus norvegicus (Norway rat) | IC50 | 6.2200 | 1 | 0 |
| N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]butanamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| ipratropium bromide anhydrous | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| 2-amino-4-(2-chlorophenyl)-6-(ethylthio)pyridine-3,5-dicarbonitrile | Rattus norvegicus (Norway rat) | IC50 | 0.4600 | 1 | 0 |
| N-butyl-N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-2-pyridinecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 1-(3,4-dihydroxyphenyl)-2-[[5-(2-methoxyphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]ethanone | Rattus norvegicus (Norway rat) | IC50 | 13.4750 | 1 | 0 |
| 9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | Rattus norvegicus (Norway rat) | IC50 | 0.5500 | 1 | 0 |
| 4-(1-benzotriazolyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| quinuclidinyl benzilate | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 1 | 1 |
| 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone | Rattus norvegicus (Norway rat) | IC50 | 49.5000 | 1 | 0 |
| 3-cyclohexyl-1,1-bis(2-methylpropyl)thiourea | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 4-[oxo-(pyridin-4-ylamino)methyl]-1H-imidazole-5-carboxylic acid ethyl ester | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| [3-amino-6-(4-methoxyphenyl)-2-thieno[2,3-b]pyridinyl]-(3,4-dimethoxyphenyl)methanone | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 0 |
| 1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | Rattus norvegicus (Norway rat) | IC50 | 1.0500 | 1 | 0 |
| 4-morpholinyl-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-(2,6-dimethylphenyl)-2-[(6-methoxy-2-methyl-4-quinolinyl)thio]acetamide | Rattus norvegicus (Norway rat) | IC50 | 10.4700 | 1 | 0 |
| (E)-4-Phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acid | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 0 |
| benztropine | Rattus norvegicus (Norway rat) | Ki | 0.0026 | 1 | 1 |
| 5-(3,4-dimethoxyphenyl)-2-(4-methylphenyl)-4-thieno[2,3-d][1,3]oxazinone | Rattus norvegicus (Norway rat) | IC50 | 1.9800 | 1 | 0 |
| N-(6-chloro-1,3-benzothiazol-2-yl)-2-diphenylphosphorylacetamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 1-(3,4-dihydroxyphenyl)-2-[[5-(3-methoxyphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]ethanone | Rattus norvegicus (Norway rat) | IC50 | 13.1000 | 1 | 0 |
| 2-(benzenesulfonylmethyl)-5-(4-chlorophenyl)cyclohexane-1,3-dione | Rattus norvegicus (Norway rat) | IC50 | 2.3100 | 1 | 0 |
| N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 5-[(2-cyanoethylthio)methyl]-2-benzofurancarboxylic acid | Rattus norvegicus (Norway rat) | IC50 | 16.3900 | 1 | 0 |
| 3-(4-methylphenyl)sulfonylpropanoic acid [2-[(3,5-dichloro-2-pyridinyl)amino]-2-oxoethyl] ester | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 1-[1-(phenylmethyl)-4-piperidinyl]-3-(2,4,4-trimethylpentan-2-yl)thiourea | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-[[5-[(1,3-benzothiazol-2-ylthio)methyl]-4-ethyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanone | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 0 |
| 5-bromo-N-(4,7-dimethoxy-1,3-benzothiazol-2-yl)-2-thiophenecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 0 |
| 4E2RCat | Rattus norvegicus (Norway rat) | IC50 | 1.7000 | 1 | 0 |
| 1-[(7-chloro-4-quinolinyl)amino]-3-(2,4-dichlorophenyl)thiourea | Rattus norvegicus (Norway rat) | IC50 | 2.2200 | 1 | 0 |
| 1-(2-chlorophenyl)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 1.6200 | 1 | 0 |
| 3-methyl-N-[(4-methylphenyl)methyl]-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 3-methyl-2-thiophenecarboxylic acid [2-(4-morpholinyl)-2-oxoethyl] ester | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(2,3-dihydro-1H-inden-5-yloxy)-1-(2,3-dihydroindol-1-yl)ethanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 7-[(4-acetylphenoxy)methyl]-5-thiazolo[3,2-a]pyrimidinone | Rattus norvegicus (Norway rat) | IC50 | 1.0400 | 1 | 0 |
| N-[4-methyl-5-[2-(3-nitroanilino)-4-thiazolyl]-2-thiazolyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 1.2800 | 1 | 0 |
| 2,5-dimethoxy-n-(quinolin-3-yl)benzenesulfonamide | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 0 |
| 2-(5-phenyl-1H-1,2,4-triazol-3-yl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione | Rattus norvegicus (Norway rat) | IC50 | 0.1335 | 1 | 0 |
| cb 7969312 | Rattus norvegicus (Norway rat) | IC50 | 0.5100 | 1 | 0 |
| 1-[2-furanyl(oxo)methyl]-6-(1-pyrrolidinylsulfonyl)-2-benzo[cd]indolone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 3-(4-chlorophenyl)sulfonyl-N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]propanamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[4-[[2-(4-acetamidoanilino)-5-nitro-4-pyrimidinyl]amino]phenyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 10.8800 | 1 | 0 |
| 4-methyl-2-[3-methyl-4-(3-methylphenyl)azo-5-oxo-4H-pyrazol-1-yl]-5-thiazolecarboxylic acid ethyl ester | Rattus norvegicus (Norway rat) | IC50 | 1.4200 | 1 | 0 |
| N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]-4-pyrazolyl]-2-[[4-(trifluoromethyl)-5,6-dihydrobenzo[h]quinazolin-2-yl]thio]acetamide | Rattus norvegicus (Norway rat) | IC50 | 1.9100 | 1 | 0 |
| 1-(3,5-dimethyl-1-piperidinyl)-2-[[2-(thiophen-2-ylmethyl)-4-quinazolinyl]thio]ethanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-(3-chlorophenyl)-4-[4-(3-methoxyphenyl)-2-thiazolyl]-1-piperazinecarbothioamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-(6-benzimidazolo[1,2-c]quinazolinylthio)-N-(2-furanylmethyl)acetamide | Rattus norvegicus (Norway rat) | IC50 | 2.5000 | 1 | 0 |
| 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid methyl ester | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 0 |
| N,N-diethyl-4-[[5-oxo-6-(phenylmethyl)-7H-pyrrolo[3,4-b]pyridin-7-yl]amino]benzenesulfonamide | Rattus norvegicus (Norway rat) | IC50 | 1.5200 | 1 | 0 |
| 2-(2-methoxyethyl)-9-methyl-4-[(4-methyl-1-piperidinyl)-oxomethyl]-1-pyrido[3,4-b]indolone | Rattus norvegicus (Norway rat) | IC50 | 53.0200 | 1 | 0 |
| 7-(5-chloro-2-methoxyanilino)-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one | Rattus norvegicus (Norway rat) | IC50 | 0.5300 | 1 | 0 |
| N-[5-ethyl-3-[(4-fluorophenyl)-(4-morpholinyl)methyl]-2-thiophenyl]benzamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 4-(4-chlorophenyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-oxobutanamide | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane | Rattus norvegicus (Norway rat) | Ki | 0.0488 | 1 | 1 |
| N-[3-(1,3-benzothiazol-2-yl)phenyl]-4-oxo-1-benzopyran-2-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 2.3200 | 1 | 0 |
| 4-(6-methyl-4-phenyl-2-quinazolinyl)-1,3-dihydroquinoxalin-2-one | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| N-[1-[1-[2-[4-(diethylamino)anilino]-2-oxoethyl]-2-benzimidazolyl]ethyl]-4-methylbenzamide | Rattus norvegicus (Norway rat) | IC50 | 0.9000 | 1 | 0 |
| 8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione | Rattus norvegicus (Norway rat) | IC50 | 25.1700 | 1 | 0 |
| 2-nitro-4-[(6-nitro-4-quinolinyl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide | Rattus norvegicus (Norway rat) | IC50 | 1.3800 | 1 | 0 |
| ellagic acid | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 0 |
| naloxone | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| morphine | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 2 | 6 |
| (2S)-2-(3-oxo-1H-isoindol-2-yl)-3-phenylpropanoic acid | Rattus norvegicus (Norway rat) | IC50 | 22.2900 | 1 | 0 |
| beta-funaltrexamine | Rattus norvegicus (Norway rat) | IC50 | 0.0820 | 1 | 1 |
| dextromethorphan | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| N-[(2-methoxyphenyl)methyl]-6H-indolo[2,3-b]quinoxaline-2-carboxamide | Rattus norvegicus (Norway rat) | IC50 | 8.0700 | 1 | 0 |
| himbacine | Rattus norvegicus (Norway rat) | Ki | 0.0436 | 2 | 3 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| vn2222 | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| tert-butyl peroxybenzoate | Rattus norvegicus (Norway rat) | IC50 | 1.2891 | 1 | 2 |
| iperoxo | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 1 | 1 |
| calpain inhibitor iii | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 4 |
| tiotropium bromide | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| scopolamine hydrobromide | Rattus norvegicus (Norway rat) | IC50 | 0.0060 | 3 | 3 |
| scopolamine hydrobromide | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 1 | 2 |
| [4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]methanone | Rattus norvegicus (Norway rat) | IC50 | 54.0000 | 1 | 0 |
| 2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-4-pyridinecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 0.9100 | 1 | 0 |
| 7-spiroindanyloxymorphone | Rattus norvegicus (Norway rat) | Ki | 0.0106 | 1 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.0356 | 2 | 2 |
| flumezapine | Rattus norvegicus (Norway rat) | IC50 | 0.0780 | 3 | 3 |
| lomofungin | Rattus norvegicus (Norway rat) | IC50 | 3.2300 | 1 | 0 |
Drugs with Activation Measurements
Drugs with Other Measurements
In vitro muscarinic activity of spiromuscarones and related analogs.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.Journal of medicinal chemistry, , Jun-29, Volume: 43, Issue:13, 2000
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.Journal of medicinal chemistry, , Jan-01, Volume: 41, Issue:1, 1998
In vitro muscarinic activity of spiromuscarones and related analogs.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.Journal of medicinal chemistry, , Apr-03, Volume: 35, Issue:7, 1992
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and muscarinic activities of 1,2,4-thiadiazoles.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
A novel class of conformationally restricted heterocyclic muscarinic agonists.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed bJournal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.Journal of medicinal chemistry, , Jun-29, Volume: 43, Issue:13, 2000
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.Journal of medicinal chemistry, , Jan-01, Volume: 41, Issue:1, 1998
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.Journal of medicinal chemistry, , Apr-03, Volume: 35, Issue:7, 1992
Cholinergic activity of acetylenic imidazoles and related compounds.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.Journal of medicinal chemistry, , Oct-20, Volume: 48, Issue:21, 2005
Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 15, Issue:8, 2005
Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors.Bioorganic & medicinal chemistry letters, , Oct-18, Volume: 9, Issue:20, 1999
3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Feb-03, Volume: 38, Issue:3, 1995
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed bJournal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.Journal of medicinal chemistry, , Apr-03, Volume: 35, Issue:7, 1992
Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M2) antimuscarinics.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties.Journal of medicinal chemistry, , 03-28, Volume: 62, Issue:6, 2019
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.Journal of medicinal chemistry, , Jun-29, Volume: 43, Issue:13, 2000
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Synthesis and muscarinic activities of 1,2,4-thiadiazoles.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
A novel class of conformationally restricted heterocyclic muscarinic agonists.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
In vitro muscarinic activity of spiromuscarones and related analogs.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.Journal of medicinal chemistry, , Jun-29, Volume: 43, Issue:13, 2000
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Cholinergic activity of acetylenic imidazoles and related compounds.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Construction of a molecular shape analysis-three-dimensional quantitative structure-analysis relationship for an analog series of pyridobenzodiazepinone inhibitors of muscarinic 2 and 3 receptors.Journal of medicinal chemistry, , Oct-28, Volume: 37, Issue:22, 1994
Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M2) antimuscarinics.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed bJournal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed bJournal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Synthesis and muscarinic activities of 1,2,4-thiadiazoles.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
A novel class of conformationally restricted heterocyclic muscarinic agonists.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: deBioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.Nature chemical biology, , Volume: 4, Issue:1, 2008
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
Synthesis and antimuscarinic activity of some 1-cycloalkyl-1-hydroxy-1-phenyl-3-(4-substituted piperazinyl)-2-propanones and related compounds.Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Synthesis and muscarinic activities of 1,2,4-thiadiazoles.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Enantioselectivity of muscarinic antagonists. 2,2-Dicyclohexyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides and related 3-oxides.Journal of medicinal chemistry, , Volume: 31, Issue:9, 1988
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Molecular modification of anticholinergics as probes for muscarinic receptors. 1. Amino esters of alpha-substituted phenylacetic acid and related analogues.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
4-(Diphenylmethyl)-1-[(imino)methyl]piperidines as gastric antisecretory agents.Journal of medicinal chemistry, , Volume: 26, Issue:4, 1983
Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.Journal of medicinal chemistry, , Sep-16, Volume: 37, Issue:19, 1994
Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.Journal of medicinal chemistry, , Sep-16, Volume: 37, Issue:19, 1994
Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Synthesis and muscarinic M2 subtype antagonistic activity of unnatural ent-himbacine and an enantiomeric pair of (2'S,6'R)-diepihimbacine.Bioorganic & medicinal chemistry letters, , Oct-21, Volume: 12, Issue:20, 2002
Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 9, Issue:6, 1999
Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways.Journal of medicinal chemistry, , Jan-03, Volume: 40, Issue:1, 1997
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics.Journal of medicinal chemistry, , Volume: 32, Issue:12, 1989
Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity.Journal of medicinal chemistry, , Volume: 32, Issue:10, 1989
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity.Journal of medicinal chemistry, , Volume: 32, Issue:10, 1989
Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics.Journal of medicinal chemistry, , Volume: 32, Issue:12, 1989
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982