Page last updated: 2024-09-27

cadmium metallothionein

Description

cadmium-binding protein: metallothionein which serves in a metal-sequestering mechanism [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID198548
MeSH IDM0045189

Synonyms (7)

Synonym
cadmium-thionein
cadmium-metallothionen
cadmium-binding protein
73419-42-8
DTXSID90994141
cadmium bis[3-(2-sulfido-1h-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate]
cadmium(2+);3-(2-sulfido-1h-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate

Research

Studies (292)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990132 (45.21)18.7374
1990's105 (35.96)18.2507
2000's28 (9.59)29.6817
2010's22 (7.53)24.3611
2020's5 (1.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews7 (2.31%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other296 (97.69%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (38)

ArticleYear
Role of metallothionein-like cadmium-binding protein (MTLCdBP) in the protective mechanism against cadmium toxicity in the testis.
Industrial health, Sep-26, Volume: 57, Issue: 5
2019
Metal subcellular partitioning determines excretion pathways and sensitivity to cadmium toxicity in two marine fish species.
Chemosphere, Volume: 217
2019
Expression of basolateral organic anion and cation transporters in experimental cadmium nephrotoxicity in rat kidney.
Archives of toxicology, Volume: 90, Issue: 3
2016
The effect of multiwalled carbon nanotubes on hepatotoxicity of Cd2+ in accumulated cadmium-metallothione in mice.
BioMed research international, Volume: 2014
2014
Differential transcytosis and toxicity of the hNGAL receptor ligands cadmium-metallothionein and cadmium-phytochelatin in colon-like Caco-2 cells: implications for in vivo cadmium toxicity.
Toxicology letters, Apr-21, Volume: 226, Issue: 2
2014
Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo.
Toxicology letters, Jul-20, Volume: 212, Issue: 2
2012
Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells.
The Journal of pharmacology and experimental therapeutics, Volume: 318, Issue: 2
2006
Nephrotoxicity of cadmium-metallothionein: protection by zinc and role of glutathione.
Toxicology and applied pharmacology, Volume: 151, Issue: 2
1998
Cadmium toxicity and distribution in metallothionein-I and -II deficient transgenic mice.
Journal of toxicology and environmental health, Dec-26, Volume: 52, Issue: 6
1997
Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity.
Toxicology and applied pharmacology, Volume: 137, Issue: 2
1996
Protection against cadmium-metallothionein nephrotoxicity in streptozotocin-induced diabetic rats: role of increased metallothionein synthesis induced by streptozotocin.
Toxicology, Jan-08, Volume: 106, Issue: 1-3
1996
Nephrotoxicity of repeated injections of cadmium-metallothionein in rats.
Toxicology and applied pharmacology, Volume: 119, Issue: 1
1993
Protective effects of selenium on cadmium toxicity in rats: role of altered toxicokinetics and metallothionein.
Journal of toxicology and environmental health, Volume: 38, Issue: 2
1993
Effect of progesterone pretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat.
Toxicology and applied pharmacology, Volume: 118, Issue: 1
1993
Effect of L-ascorbic acid pretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat.
Toxicology, Dec-31, Volume: 85, Issue: 2-3
1993
The nephrotoxicity of intravenously administered cadmium-metallothionein: effect of dose, mode of administration, and preexisting renal cadmium burden.
Toxicology and applied pharmacology, Volume: 126, Issue: 2
1994
The susceptibility of spontaneously diabetic mice to cadmium-metallothionein nephrotoxicity.
Toxicology, Apr-18, Volume: 89, Issue: 2
1994
Influence of zinc and copper administration on metal disposition in rats with cadmium-metallothionein-induced nephrotoxicity.
Toxicology and applied pharmacology, Volume: 126, Issue: 1
1994
Nephrotoxicity of CdCl2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells.
Toxicology and applied pharmacology, Volume: 128, Issue: 2
1994
Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 23, Issue: 4
1994
Protection by zinc-metallothionein (ZnMT) against cadmium-metallothionein-induced nephrotoxicity.
Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 26, Issue: 1
1995
Role of ultrastructural techniques in understanding mechanisms of metal-induced nephrotoxicity.
Federation proceedings, Volume: 42, Issue: 13
1983
Rat kidney epithelial cell culture for metal toxicity studies.
In vitro cellular & developmental biology : journal of the Tissue Culture Association, Volume: 21, Issue: 9
1985
Cadmium-metallothionein nephrotoxicity in the rat: transient calcuria and proteinuria.
Toxicology, Volume: 45, Issue: 3
1987
Influence of cadmium-metallothionein pretreatment on tolerance of rat kidney cortical cells to cadmium toxicity in vitro and in vivo.
Pharmacology & toxicology, Volume: 60, Issue: 5
1987
Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance.
Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 10, Issue: 1
1988
On the role of metallothionein in cadmium induced renal toxicity.
Experientia. Supplementum, Volume: 52
1987
Renal toxicity of cadmium-metallothionein and enzymuria in rats.
The Journal of pharmacology and experimental therapeutics, Volume: 240, Issue: 1
1987
Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats.
Toxicology and applied pharmacology, Volume: 98, Issue: 3
1989
Comparisons of the toxicity of CdCl2 and Cd-metallothionein in isolated rat hepatocytes.
Toxicology, Volume: 55, Issue: 1-2
1989
Effect of N-benzyl-D-glucamine dithiocarbamate on renal toxicity induced by cadmium-metallothionein in rats.
Archives of toxicology, Volume: 64, Issue: 2
1990
Pregnancy-associated changes in renal toxicity of cadmium-metallothionein: possible role of intracellular metallothionein.
Toxicology, Dec-17, Volume: 65, Issue: 1-2
1990
Comparison of the toxicity of inorganic and liver-incorporated cadmium: a 4-wk feeding study in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume: 28, Issue: 6
1990
A multivariate study of protective effects of Zn and Cu against nephrotoxicity induced by cadmium metallothionein in rats.
Toxicology and applied pharmacology, Volume: 114, Issue: 2
1992
Cd-metallothionein nephrotoxicity in inbred strains of mice.
Journal of toxicology and environmental health, Volume: 35, Issue: 2
1992
Modulation of calciuria by cadmium pretreatment in rats with cadmium-metallothionein-induced nephrotoxicity.
Toxicology, Volume: 75, Issue: 1
1992
Cadmium, metallothionein and renal tubular toxicity.
IARC scientific publications, Issue: 118
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (2)

ArticleYear
Renal accumulation of cadmium and nephropathy following long-term administration of cadmium-metallothionein.
Toxicology and applied pharmacology, Volume: 141, Issue: 1
1996
Cadmium accumulation and metallothionein concentrations after 4-week dietary exposure to cadmium chloride or cadmium-metallothionein in rats.
Toxicology and applied pharmacology, Volume: 111, Issue: 3
1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Clearance study for the estimation of glomerular filtration of Cd following the intravenous bolus of CdCl2 and Cd-saturated metallothionein-II in rats.
Biological & pharmaceutical bulletin, Volume: 17, Issue: 4
1994
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (13)

ArticleYear
The effect of multiwalled carbon nanotubes on hepatotoxicity of Cd2+ in accumulated cadmium-metallothione in mice.
BioMed research international, Volume: 2014
2014
Renal accumulation of cadmium and nephropathy following long-term administration of cadmium-metallothionein.
Toxicology and applied pharmacology, Volume: 141, Issue: 1
1996
Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules.
Toxicology and applied pharmacology, Volume: 130, Issue: 1
1995
Comparison of cadmium-metallothionein synthesis in parenchymal and non-parenchymal rat liver cells.
The Biochemical journal, Mar-15, Volume: 210, Issue: 3
1983
The production of cadmium-binding protein in three species of freshwater fish.
Toxicology letters, Volume: 15, Issue: 4
1983
Cadmium-metallothionein-induced nephropathy: a morphological and autoradiographic study of cadmium distribution, the development of tubular damage and subsequent cell regeneration.
Journal of applied toxicology : JAT, Volume: 3, Issue: 5
1983
The chronic toxicity of equine cadmium metallothionein in the rat.
Archives of toxicology, Volume: 57, Issue: 3
1985
Resistance to acute nephrotoxicity induced by cadmium-metallothionein dependence on pretreatment with cadmium chloride.
Pharmacology & toxicology, Volume: 61, Issue: 2
1987
Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance.
Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 10, Issue: 1
1988
Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein.
Toxicology and applied pharmacology, Volume: 92, Issue: 1
1988
Degradation and metal composition of hepatic isometallothioneins in rats.
Toxicology and applied pharmacology, Volume: 112, Issue: 1
1992
Cd-metallothionein nephrotoxicity in inbred strains of mice.
Journal of toxicology and environmental health, Volume: 35, Issue: 2
1992
Induction of metallothionein by cadmium-metallothionein in rat liver: a proposed mechanism.
Toxicology and applied pharmacology, Volume: 112, Issue: 2
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]