Eukaryotic initiation factor 4A-I

A eukaryotic initiation factor 4A-I that is encoded in the genome of human. [PRO:DNx]

Synonyms

eIF-4A-I;
eIF4A-I;
EC 3.6.4.13;
ATP-dependent RNA helicase eIF4A-1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cycloheximide	Homo sapiens (human)	IC50	0.1390	4	4
rocaglamide	Homo sapiens (human)	IC50	0.1044	4	4
hippuristanol	Homo sapiens (human)	IC50	0.8618	5	5

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rocaglamide	Homo sapiens (human)	Kd	0.1560	1	1
aglafoline	Homo sapiens (human)	EC50	0.0500	2	2
silvestrol	Homo sapiens (human)	EC50	0.0039	2	2

Enables

This protein enables 11 target(s):

Target	Category	Definition
RNA cap binding	molecular function	Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. [GOC:krc]
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
RNA helicase activity	molecular function	Unwinding of an RNA helix, driven by ATP hydrolysis. [GOC:jl, PMID:19158098]
double-stranded RNA binding	molecular function	Binding to double-stranded RNA. [GOC:jl]
mRNA binding	molecular function	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]
translation initiation factor activity	molecular function	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]
helicase activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
translation factor activity, RNA binding	molecular function	Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. [GOC:ai, GOC:vw]
ATP hydrolysis activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
eukaryotic translation initiation factor 4F complex	cellular component	The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. [GOC:hb, PMID:32883864, PMID:8449919]

Involved In

This protein is involved in 2 target(s):

Target	Category	Definition
cytoplasmic translational initiation	biological process	The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [GOC:hjd]
translational initiation	biological process	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [ISBN:019879276X]