Sodium-dependent phosphate transport protein 2B

A sodium-dependent phosphate transport protein 2B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95436]

Synonyms

Sodium-phosphate transport protein 2B;
Na(+)-dependent phosphate cotransporter 2B;
NaPi3b;
Sodium/phosphate cotransporter 2B;
Na(+)/Pi cotransporter 2B;
NaPi-2b;
Solute carrier family 34 member 2

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
crizotinib	Homo sapiens (human)	IC50	0.0510	1	1
pf-06463922	Homo sapiens (human)	IC50	0.0002	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
sodium:phosphate symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). [TC:2.A.1.14.6]
sodium ion binding	molecular function	Binding to a sodium ion (Na+). [GOC:mah]
phosphate ion binding	molecular function	Binding to a phosphate ion. [GOC:jl]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
brush border membrane	cellular component	The portion of the plasma membrane surrounding the brush border. [GOC:mah]
vesicle	cellular component	Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
brush border	cellular component	The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. [GOC:sl, ISBN:0815316194]
vesicle	cellular component	Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
in utero embryonic development	biological process	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
phosphate ion transport	biological process	The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
protein metabolic process	biological process	The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma]
intracellular phosphate ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. [GOC:mah]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
response to estrogen	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732]
sodium-dependent phosphate transport	biological process	The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. [GOC:BHF, GOC:jl]

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