Page last updated: 2024-08-07 16:52:50
D(2) dopamine receptor
A D(2) dopamine receptor that is encoded in the genome of rat. [OMA:P61169, PRO:DNx]
Synonyms
Dopamine D2 receptor
Research
Bioassay Publications (252)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 45 (17.86) | 18.7374 |
| 1990's | 117 (46.43) | 18.2507 |
| 2000's | 59 (23.41) | 29.6817 |
| 2010's | 29 (11.51) | 24.3611 |
| 2020's | 2 (0.79) | 2.80 |
Compounds (257)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 7-hydroxy-2-n,n-dipropylaminotetralin | Rattus norvegicus (Norway rat) | Ki | 0.2218 | 6 | 6 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | IC50 | 2.8959 | 4 | 6 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 1.1602 | 8 | 9 |
| sk&f 82958 | Rattus norvegicus (Norway rat) | IC50 | 0.3360 | 1 | 1 |
| octoclothepine | Rattus norvegicus (Norway rat) | IC50 | 0.0028 | 2 | 5 |
| octoclothepine | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 2 | 7 |
| sk&f 77434 | Rattus norvegicus (Norway rat) | IC50 | 2.4250 | 1 | 1 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 720.0000 | 1 | 1 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | Ki | 6.8700 | 1 | 2 |
| 1-(1-naphthyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0830 | 1 | 1 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 1.1000 | 2 | 2 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.5160 | 2 | 2 |
| 5-carboxamidotryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 1 |
| bmy 7378 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 2 |
| bmy 7378 | Rattus norvegicus (Norway rat) | Ki | 0.0490 | 1 | 2 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 0.2055 | 5 | 6 |
| buspirone | Rattus norvegicus (Norway rat) | Ki | 0.6095 | 2 | 2 |
| verapamil | Rattus norvegicus (Norway rat) | IC50 | 200.0000 | 1 | 1 |
| celecoxib | Rattus norvegicus (Norway rat) | IC50 | 10.2150 | 2 | 2 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 0.0365 | 10 | 16 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0055 | 8 | 9 |
| cisapride | Rattus norvegicus (Norway rat) | IC50 | 0.5350 | 2 | 2 |
| cisapride | Rattus norvegicus (Norway rat) | Ki | 0.2270 | 1 | 1 |
| clebopride | Rattus norvegicus (Norway rat) | IC50 | 0.0170 | 1 | 1 |
| clebopride | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | Ki | 0.0560 | 1 | 1 |
| clonidine | Rattus norvegicus (Norway rat) | Ki | 4.0000 | 1 | 2 |
| [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2-furanyl)methanone | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| domperidone | Rattus norvegicus (Norway rat) | IC50 | 0.0052 | 1 | 1 |
| adtn | Rattus norvegicus (Norway rat) | IC50 | 0.2349 | 3 | 3 |
| fluoxetine | Rattus norvegicus (Norway rat) | IC50 | 0.1000 | 1 | 1 |
| vanoxerine | Rattus norvegicus (Norway rat) | Ki | 0.0037 | 1 | 2 |
| gbr 12935 | Rattus norvegicus (Norway rat) | Ki | 0.0037 | 1 | 2 |
| granisetron | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 0.0062 | 2 | 3 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.0129 | 20 | 25 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 35 | 58 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.8100 | 1 | 1 |
| jl 18 | Rattus norvegicus (Norway rat) | Ki | 0.5300 | 1 | 1 |
| nsc 664704 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| ketanserin | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 2 | 2 |
| ketanserin | Rattus norvegicus (Norway rat) | Ki | 0.7770 | 2 | 2 |
| methiothepin | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 2 | 2 |
| metoclopramide | Rattus norvegicus (Norway rat) | IC50 | 0.6237 | 4 | 4 |
| metoclopramide | Rattus norvegicus (Norway rat) | Ki | 0.1820 | 3 | 5 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 3.5481 | 2 | 2 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.9427 | 2 | 3 |
| mirtazapine | Rattus norvegicus (Norway rat) | Ki | 1.4600 | 1 | 2 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.5300 | 1 | 1 |
| nan 190 | Rattus norvegicus (Norway rat) | Ki | 0.0277 | 2 | 3 |
| nemonapride | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| nemonapride | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| nomifensine | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 6.2561 | 4 | 8 |
| phenoxybenzamine | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 1 | 2 |
| prazosin | Rattus norvegicus (Norway rat) | IC50 | 11.0000 | 1 | 1 |
| prazosin | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 1.0400 | 1 | 2 |
| quetiapine | Rattus norvegicus (Norway rat) | IC50 | 0.3300 | 1 | 2 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 2 |
| 3-allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine | Rattus norvegicus (Norway rat) | IC50 | 0.7010 | 1 | 1 |
| risperidone | Rattus norvegicus (Norway rat) | IC50 | 0.0154 | 3 | 5 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 11 | 16 |
| ritanserin | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 6 | 7 |
| ritanserin | Rattus norvegicus (Norway rat) | Ki | 0.0632 | 3 | 4 |
| ropinirole | Rattus norvegicus (Norway rat) | Ki | 2.6740 | 2 | 2 |
| 3-(3-cyanophenyl)-n-n-propylpiperidine | Rattus norvegicus (Norway rat) | Ki | 3.4924 | 2 | 10 |
| spiperone | Rattus norvegicus (Norway rat) | IC50 | 0.0001 | 1 | 1 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.0249 | 8 | 9 |
| spiroxatrine | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 2 |
| sulpiride | Rattus norvegicus (Norway rat) | IC50 | 0.2215 | 2 | 2 |
| sulpiride | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| sumatriptan | Rattus norvegicus (Norway rat) | Ki | 0.2180 | 1 | 1 |
| talipexole | Rattus norvegicus (Norway rat) | Ki | 1.3529 | 2 | 2 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0590 | 4 | 7 |
| thioridazine | Rattus norvegicus (Norway rat) | Ki | 0.0270 | 1 | 1 |
| trifluoperazine | Rattus norvegicus (Norway rat) | IC50 | 0.0160 | 1 | 1 |
| u 99194 | Rattus norvegicus (Norway rat) | Ki | 0.9920 | 1 | 1 |
| wb 4101 | Rattus norvegicus (Norway rat) | Ki | 0.1230 | 1 | 2 |
| zonisamide | Rattus norvegicus (Norway rat) | Ki | 6.0330 | 1 | 1 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.0813 | 16 | 19 |
| apomorphine | Rattus norvegicus (Norway rat) | Ki | 0.0244 | 11 | 12 |
| caramiphen | Rattus norvegicus (Norway rat) | Ki | 0.5000 | 1 | 1 |
| phenylpiperazine | Rattus norvegicus (Norway rat) | Ki | 3.9000 | 2 | 2 |
| yohimbine | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| apomorphine hydrochloride, anhydrous | Rattus norvegicus (Norway rat) | Ki | 0.0092 | 2 | 4 |
| liriodenine | Rattus norvegicus (Norway rat) | IC50 | 59.0000 | 1 | 1 |
| boldine | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| boldine | Rattus norvegicus (Norway rat) | Ki | 0.3700 | 1 | 1 |
| 2-bromolysergic acid diethylamide | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| triethylenephosphoramide | Rattus norvegicus (Norway rat) | IC50 | 0.2200 | 1 | 1 |
| bulbocapnine | Rattus norvegicus (Norway rat) | IC50 | 14.0235 | 2 | 2 |
| apocodeine | Rattus norvegicus (Norway rat) | IC50 | 4.8267 | 3 | 3 |
| fluanisone | Rattus norvegicus (Norway rat) | Ki | 0.0027 | 3 | 3 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | IC50 | 0.3855 | 2 | 2 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| perlapine | Rattus norvegicus (Norway rat) | IC50 | 2.7000 | 1 | 2 |
| clothiapine | Rattus norvegicus (Norway rat) | Ki | 0.0045 | 1 | 1 |
| pimozide | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 4 |
| pimozide | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| glaucine | Rattus norvegicus (Norway rat) | Ki | 2.8000 | 1 | 1 |
| laurolitsine | Rattus norvegicus (Norway rat) | IC50 | 6.8000 | 1 | 1 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| penfluridol | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 2 |
| w-a 335 | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0034 | 4 | 5 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0053 | 2 | 3 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 0.0016 | 4 | 5 |
| 2-amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 2 | 3 |
| pergolide | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| fluperlapine | Rattus norvegicus (Norway rat) | Ki | 0.1318 | 1 | 1 |
| flutroline | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 2 |
| rimcazole | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 2 |
| remoxipride | Rattus norvegicus (Norway rat) | IC50 | 1.5700 | 2 | 2 |
| quinpirole | Rattus norvegicus (Norway rat) | IC50 | 0.1000 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 2 |
| gepirone | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 0.4954 | 3 | 5 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 2 | 10 |
| tiospirone | Rattus norvegicus (Norway rat) | IC50 | 0.0084 | 1 | 1 |
| tiospirone | Rattus norvegicus (Norway rat) | Ki | 0.0021 | 2 | 4 |
| ipsapirone | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| quinelorane | Rattus norvegicus (Norway rat) | IC50 | 0.1510 | 1 | 1 |
| eticlopride | Rattus norvegicus (Norway rat) | IC50 | 0.0009 | 3 | 5 |
| eticlopride | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 4 | 10 |
| flesinoxan | Rattus norvegicus (Norway rat) | Ki | 0.1400 | 1 | 1 |
| mk 458 | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| batanopride | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| sertindole | Rattus norvegicus (Norway rat) | IC50 | 0.0041 | 5 | 5 |
| fananserin | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| aripiprazole | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 3 | 3 |
| ziprasidone | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 2 | 4 |
| zanamivir | Rattus norvegicus (Norway rat) | IC50 | 0.0074 | 1 | 1 |
| sertraline hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 1 |
| dopamine hydrochloride | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 2 | 2 |
| irindalone | Rattus norvegicus (Norway rat) | IC50 | 1.4500 | 3 | 4 |
| eltoprazine | Rattus norvegicus (Norway rat) | Ki | 1.1000 | 1 | 1 |
| lerisetron | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| lerisetron | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| setoperone | Rattus norvegicus (Norway rat) | Ki | 0.0240 | 1 | 1 |
| sertraline | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 2 |
| mezilamine | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 2 | 3 |
| ch 29717 | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 1 | 1 |
| tefludazine | Rattus norvegicus (Norway rat) | IC50 | 0.0136 | 5 | 5 |
| hp 873 | Rattus norvegicus (Norway rat) | IC50 | 0.1100 | 1 | 1 |
| epidepride | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 3 | 4 |
| fla 797 | Rattus norvegicus (Norway rat) | IC50 | 0.0131 | 5 | 8 |
| fla 797 | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 6 |
| atherospermine | Rattus norvegicus (Norway rat) | Ki | 0.3218 | 1 | 2 |
| ecopipam | Rattus norvegicus (Norway rat) | Ki | 0.5140 | 1 | 1 |
| 6-chloro-2-(1-piperazinyl)pyrazine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide | Rattus norvegicus (Norway rat) | IC50 | 0.0034 | 1 | 1 |
| 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | IC50 | 5.7380 | 3 | 5 |
| pd 128907 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 2 |
| 3-n-methylspiperone | Rattus norvegicus (Norway rat) | IC50 | 0.0002 | 1 | 1 |
| 3-n-methylspiperone | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol | Rattus norvegicus (Norway rat) | Ki | 0.2410 | 1 | 1 |
| gr 113808 | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| pramipexole | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 1 | 1 |
| mosapride | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | IC50 | 0.1355 | 2 | 3 |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 1 | 2 |
| a 68930 | Rattus norvegicus (Norway rat) | Ki | 0.7893 | 3 | 7 |
| aj 76 | Rattus norvegicus (Norway rat) | Ki | 0.3182 | 3 | 6 |
| l 687384 | Rattus norvegicus (Norway rat) | IC50 | 3.7000 | 1 | 1 |
| mcn 5707 | Rattus norvegicus (Norway rat) | Ki | 0.4150 | 1 | 1 |
| indatraline | Rattus norvegicus (Norway rat) | Ki | 0.0230 | 1 | 1 |
| bd 1008 | Rattus norvegicus (Norway rat) | Ki | 1.1120 | 1 | 1 |
| 1,2,3,6-tetrahydro-4-phenyl-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine | Rattus norvegicus (Norway rat) | Ki | 0.0282 | 2 | 2 |
| ly 293558 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| vb 20b7 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| n 0734 | Rattus norvegicus (Norway rat) | IC50 | 0.0072 | 2 | 5 |
| 2-methoxy-n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 2 | 2 |
| 2-methoxy-n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | Ki | 0.1633 | 5 | 5 |
| 5-(dipropylamino)-5,6-dihydro-4h-imidazo-(5,1ij)quinolin-2(1h)-one | Rattus norvegicus (Norway rat) | Ki | 0.0054 | 1 | 1 |
| cyclazosin | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| sc 53116 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| u 92032 | Rattus norvegicus (Norway rat) | IC50 | 1.6900 | 1 | 1 |
| u 93385 | Rattus norvegicus (Norway rat) | Ki | 1.6290 | 1 | 1 |
| sonepiprazole | Rattus norvegicus (Norway rat) | Ki | 4.3000 | 1 | 1 |
| ciladopa | Rattus norvegicus (Norway rat) | IC50 | 2.2000 | 1 | 2 |
| 4-hydroxy-2-(di-n-propylamino)indan | Rattus norvegicus (Norway rat) | Ki | 0.0052 | 1 | 1 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 34.4300 | 1 | 1 |
| n-(2,6-dimethylergoline-8-yl)-2,2-dimethylpropanamide | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 2 | 2 |
| dexmethylphenidate hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.1235 | 2 | 2 |
| chloroethylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 5.1970 | 2 | 2 |
| anonaine | Rattus norvegicus (Norway rat) | IC50 | 19.0000 | 1 | 1 |
| stephenanthrine | Rattus norvegicus (Norway rat) | Ki | 0.0654 | 1 | 2 |
| n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.1925 | 3 | 5 |
| n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | Ki | 0.0132 | 5 | 5 |
| 5-hydroxy-2-n,n-dipropylaminotetralin | Rattus norvegicus (Norway rat) | Ki | 0.0902 | 3 | 3 |
| 8-(di-n-propylamino)-6,7,8,9-tetrahydro-3h-benz(e)indole-1-carbaldehyde | Rattus norvegicus (Norway rat) | Ki | 0.0720 | 5 | 5 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 12.0545 | 5 | 8 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 0.1890 | 1 | 1 |
| bifeprunox | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 1 | 1 |
| roxindole | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 1 |
| (R)-Roemerine | Rattus norvegicus (Norway rat) | Ki | 0.0836 | 1 | 2 |
| paullone | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| dironyl | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| gs 4071 | Rattus norvegicus (Norway rat) | IC50 | 0.0089 | 1 | 1 |
| 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| (R)-(+)-sulpiride | Rattus norvegicus (Norway rat) | Ki | 2.7000 | 1 | 2 |
| tropisetron | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| tropisetron | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 2 | 5 |
| ly382884 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| levosulpiride | Rattus norvegicus (Norway rat) | IC50 | 0.2115 | 3 | 4 |
| levosulpiride | Rattus norvegicus (Norway rat) | Ki | 0.0164 | 3 | 8 |
| flunarizine | Rattus norvegicus (Norway rat) | IC50 | 0.2280 | 1 | 1 |
| altanserin | Rattus norvegicus (Norway rat) | Ki | 0.0620 | 1 | 1 |
| raclopride | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 5 | 7 |
| raclopride | Rattus norvegicus (Norway rat) | Ki | 0.0078 | 7 | 12 |
| 4-phenyl-1-(4-phenylbutyl)piperidine | Rattus norvegicus (Norway rat) | IC50 | 0.1650 | 1 | 1 |
| mcn 5652 | Rattus norvegicus (Norway rat) | Ki | 1.0300 | 1 | 1 |
| sch 23390 | Rattus norvegicus (Norway rat) | IC50 | 5.0003 | 3 | 4 |
| sch 23390 | Rattus norvegicus (Norway rat) | Ki | 0.6246 | 6 | 8 |
| ro 60-0175 | Rattus norvegicus (Norway rat) | Ki | 0.0051 | 1 | 1 |
| pm 1000 | Rattus norvegicus (Norway rat) | Ki | 6.2850 | 2 | 2 |
| 3-[(3-fluorophenyl)methyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 1 | 1 |
| 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | Rattus norvegicus (Norway rat) | Ki | 13.2000 | 1 | 1 |
| 2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-6,7,8,8a-tetrahydro-5H-imidazo[1,5-a]pyridine-1,3-dione | Rattus norvegicus (Norway rat) | Ki | 0.2460 | 1 | 1 |
| le 300 | Rattus norvegicus (Norway rat) | Ki | 0.0060 | 1 | 1 |
| flupenthixol | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| topiramate | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| sb 277011 | Rattus norvegicus (Norway rat) | Ki | 2.8200 | 1 | 1 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 2.0703 | 4 | 7 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 0.1991 | 4 | 5 |
| l 745870 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| ml 10302 | Rattus norvegicus (Norway rat) | Ki | 0.0056 | 1 | 1 |
| pd 128907 | Rattus norvegicus (Norway rat) | IC50 | 0.4773 | 2 | 6 |
| pd 166285 | Rattus norvegicus (Norway rat) | IC50 | 0.0790 | 1 | 1 |
| ro 63-0563 | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 2 |
| ro 4-6790 | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 2 |
| sb 258719 | Rattus norvegicus (Norway rat) | Ki | 3.9811 | 1 | 1 |
| sb 271046 | Rattus norvegicus (Norway rat) | Ki | 0.6289 | 3 | 4 |
| fluvoxamine | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 1 |
| pd-173952 | Rattus norvegicus (Norway rat) | IC50 | 0.6400 | 1 | 1 |
| romidepsin | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| zimeldine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| morphine chloride | Rattus norvegicus (Norway rat) | IC50 | 0.0340 | 2 | 4 |
| 7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.2650 | 1 | 1 |
| a 77636 | Rattus norvegicus (Norway rat) | Ki | 1.8000 | 1 | 1 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 2.2050 | 2 | 2 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 0.1563 | 4 | 4 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 2 | 2 |
| dihydrexidine | Rattus norvegicus (Norway rat) | IC50 | 0.0448 | 2 | 3 |
| dihydrexidine | Rattus norvegicus (Norway rat) | Ki | 1.4000 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.8260 | 1 | 1 |
| uh 232 | Rattus norvegicus (Norway rat) | Ki | 0.0820 | 3 | 6 |
| sb 269970 | Rattus norvegicus (Norway rat) | Ki | 0.0650 | 1 | 2 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 6.8750 | 2 | 2 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | Ki | 5.8750 | 3 | 4 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 3 | 5 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 0.6660 | 1 | 1 |
| sarizotan | Rattus norvegicus (Norway rat) | Ki | 0.0190 | 1 | 1 |
| ms-245 | Rattus norvegicus (Norway rat) | Ki | 1.9000 | 1 | 2 |
| 3-(diphenylmethylene)-1-[4-(4-phenyl-1-piperazinyl)butyl]pyrrolidine-2,5-dione | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 2 |
| osu 6162 | Rattus norvegicus (Norway rat) | Ki | 6.2700 | 1 | 1 |
| dinapsoline | Rattus norvegicus (Norway rat) | IC50 | 0.0380 | 1 | 1 |
| n-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide | Rattus norvegicus (Norway rat) | Ki | 0.0579 | 2 | 2 |
| lu 28-179 | Rattus norvegicus (Norway rat) | IC50 | 0.8000 | 1 | 1 |
| 2-propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-azacyclopent-1-ena(c)phenanthrene-9,10-diol | Rattus norvegicus (Norway rat) | Ki | 0.8000 | 1 | 1 |
| l 772405 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 6 |
| sun n8075 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| sb-505124 | Rattus norvegicus (Norway rat) | IC50 | 0.6680 | 1 | 1 |
| [2-[[2-[(dimethylamino)methyl]phenyl]thio]-5-iodophenyl]methanol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| slv 313 | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| ngb 2904 | Rattus norvegicus (Norway rat) | Ki | 0.5640 | 3 | 4 |
| u 92016a | Rattus norvegicus (Norway rat) | Ki | 0.5380 | 1 | 1 |
| flb 457 | Rattus norvegicus (Norway rat) | IC50 | 0.0012 | 2 | 4 |
| flb 457 | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 3 | 4 |
| pnu 96415e | Rattus norvegicus (Norway rat) | Ki | 0.1600 | 1 | 1 |
| (2S,3S)-nemonapride | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| (2S,3S)-nemonapride | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 2 | 2 |
| ly-2157299 | Rattus norvegicus (Norway rat) | IC50 | 0.4050 | 1 | 1 |
| pik 75 | Rattus norvegicus (Norway rat) | IC50 | 0.3400 | 1 | 1 |
| fauc 365 | Rattus norvegicus (Norway rat) | Ki | 3.6000 | 1 | 2 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.3680 | 2 | 2 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.1920 | 8 | 8 |
| (5R)-9-bromo-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol | Rattus norvegicus (Norway rat) | IC50 | 0.5110 | 1 | 1 |
| 5-hydroxy-2-n,n-dipropylaminotetralin, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0824 | 4 | 4 |
| lassbio-579 | Rattus norvegicus (Norway rat) | Ki | 2.4900 | 1 | 1 |
| octoclothepine, (s)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.0018 | 5 | 6 |
| octoclothepine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 2 | 7 |
| ncq 298 | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 1 | 1 |
| niraparib | Rattus norvegicus (Norway rat) | IC50 | 0.0021 | 1 | 1 |
| niraparib | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| ew-7197 | Rattus norvegicus (Norway rat) | IC50 | 2.1800 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.6759 | 19 | 25 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.1693 | 25 | 37 |
| olanzapine | Rattus norvegicus (Norway rat) | IC50 | 0.1580 | 1 | 2 |
| olanzapine | Rattus norvegicus (Norway rat) | Ki | 0.0562 | 8 | 13 |
| flumezapine | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.Bioorganic & medicinal chemistry, , Jun-01, Volume: 17, Issue:11, 2009
Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.Journal of medicinal chemistry, , May-22, Volume: 51, Issue:10, 2008
6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.Journal of medicinal chemistry, , Volume: 32, Issue:10, 1989
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Piperazinylalkyl heterocycles as potential antipsychotic agents.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.Bioorganic & medicinal chemistry letters, , May-15, Volume: 22, Issue:10, 2012
Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine.Journal of medicinal chemistry, , Jul-04, Volume: 40, Issue:14, 1997
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.Journal of medicinal chemistry, , Jan-20, Volume: 38, Issue:2, 1995
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.Journal of medicinal chemistry, , Apr-16, Volume: 36, Issue:8, 1993
Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
Psychotropic agents: synthesis and antipsychotic activity of substituted beta-carbolines.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Charged analogues of chlorpromazine as dopamine antagonists.Journal of medicinal chemistry, , Volume: 30, Issue:9, 1987
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.Journal of medicinal chemistry, , Volume: 26, Issue:4, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.Journal of medicinal chemistry, , Volume: 23, Issue:8, 1980
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.Journal of medicinal chemistry, , Apr-29, Volume: 37, Issue:9, 1994
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.Journal of medicinal chemistry, , 01-11, Volume: 61, Issue:1, 2018
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.European journal of medicinal chemistry, , Jan-27, Volume: 90, 2015
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.Journal of medicinal chemistry, , Jan-13, Volume: 48, Issue:1, 2005
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.Journal of medicinal chemistry, , May-24, Volume: 44, Issue:11, 2001
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical anJournal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.Bioorganic & medicinal chemistry letters, , Apr-21, Volume: 8, Issue:8, 1998
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 8, Issue:24, 1998
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.Journal of medicinal chemistry, , Dec-05, Volume: 40, Issue:25, 1997
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
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[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
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[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
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[no title available]Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
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Molecular similarity, quantitative chirality, and QSAR for chiral drugs.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
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Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
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Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.Journal of medicinal chemistry, , Jan-22, Volume: 36, Issue:2, 1993
Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
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Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
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Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002
New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Molecular similarity, quantitative chirality, and QSAR for chiral drugs.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.Journal of medicinal chemistry, , Volume: 33, Issue:3, 1990
N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).Journal of medicinal chemistry, , Jul-27, Volume: 43, Issue:15, 2000
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Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
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CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.Journal of medicinal chemistry, , Aug-10, Volume: 43, Issue:16, 2000
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine.Journal of medicinal chemistry, , Jul-04, Volume: 40, Issue:14, 1997
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Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors.Journal of medicinal chemistry, , Aug-04, Volume: 38, Issue:16, 1995
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Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.Journal of medicinal chemistry, , Mar-27, Volume: 57, Issue:6, 2014
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
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Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
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