1,2-diacetylbenzene profile

1,2-Diacetylbenzene, also known as o-diacetylbenzene, is an organic compound with the formula C10H10O2. It is a colorless liquid with a pungent odor. The compound is an aromatic ketone with two acetyl groups attached to the benzene ring at the 1 and 2 positions. 1,2-diacetylbenzene is a versatile building block for the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and polymers. It can be synthesized by Friedel-Crafts acylation of benzene with acetyl chloride in the presence of aluminum chloride. The compound has been studied for its potential biological activity, particularly as a potential anti-inflammatory and analgesic agent. It has also been investigated for its ability to inhibit the growth of certain types of cancer cells.'

ID Source	ID
PubMed CID	35459
SCHEMBL ID	279655
MeSH ID	M0140187

Synonym
1-(2-acetylphenyl)ethanon
AKOS015837774
ethanone, 1,1'-(1,2-phenylene)bis-
1,1'-(1,2-phenylene)bisethanone
benzene-1,2-bis(acetyl)
o-diacetylbenzene
einecs 211-877-6
1,2-diacetylbenzene, 99%
1,2-diacetylbenzene
704-00-7
1-(2-acetylphenyl)ethanone
inchi=1/c10h10o2/c1-7(11)9-5-3-4-6-10(9)8(2)12/h3-6h,1-2h3
lvqfkrxrtxcqcz-uhfffaoysa-
A836873
1-(2-acetylphenyl)ethan-1-one
ortho-diacetylbenzene
benzene, o-diacetyl-
FT-0610968
SCHEMBL279655
DTXSID20220667
diacetylbenzene
mfcd00008733
o-diacetylbenzol
CS-0261352
Q63409546
1,1'-(1,2-phenylene)diethanone
EN300-7826947

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (4.35)	18.7374
1990's	2 (8.70)	18.2507
2000's	11 (47.83)	29.6817
2010's	3 (13.04)	24.3611
2020's	6 (26.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
risperidone Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.. risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.	3.01	2	1,2-benzoxazoles; heteroarylpiperidine; organofluorine compound; pyridopyrimidine	alpha-adrenergic antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; psychotropic drug; second generation antipsychotic; serotonergic antagonist
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	1.96	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
1,4-diethylbenzene [no description available]	1.98	1	benzenes
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.47	2	alkane
2,5-hexanedione 2,5-hexanedione: metabolite of methyl-n-butyl ketone. 2,5-hexanedione : A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone	7.75	3	diketone; methyl ketone	human xenobiotic metabolite; neurotoxin
n-hexane hexane : An unbranched alkane containing six carbon atoms.	2.47	2	alkane; volatile organic compound	neurotoxin; non-polar solvent
1,2-diethylbenzene [no description available]	3.12	5
ninhydrin Ninhydrin: 2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.. ninhydrin : A member of the class of indanones that is indane-1,3-dione bearing two additional hydroxy substituents at position 2.	2.41	2	aromatic ketone; beta-diketone; indanones; ketone hydrate	colour indicator; human metabolite
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.04	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
biocytin biocytin : A monocarboxylic acid amide that results from the formal condensation of the carboxylic acid group of biotin with the N(6)-amino group of L-lysine.	1.96	1	azabicycloalkane; L-alpha-amino acid zwitterion; L-lysine derivative; monocarboxylic acid amide; non-proteinogenic L-alpha-amino acid; thiabicycloalkane; ureas	mouse metabolite

Condition	Relationship Strength	Studies
Cognitive Decline [description not available]	2.9	2
Acute Confusional Senile Dementia [description not available]	2.41	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.41	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	7.52	2
Cognitive Dysfunction Diminished or impaired mental and/or intellectual function.	2.9	2
Age-Related Memory Disorders [description not available]	2.96	3
Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.	2.96	3
Liver Dysfunction [description not available]	7.6	1
Liver Diseases Pathological processes of the LIVER.	2.6	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.47	2
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	7.1	1
Encephalopathy, Toxic [description not available]	2.72	3
Myelopathy [description not available]	2.05	1
Spinal Cord Diseases Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.	2.05	1
ALS - Amyotrophic Lateral Sclerosis [description not available]	2.02	1
Amyotrophic Lateral Sclerosis A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)	2.02	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.04	1
Nervous System Disorders [description not available]	2.69	3
Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	2.69	3
Central Nervous System Disease [description not available]	1.98	1
Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	1.98	1

1,2-diacetylbenzene

Cross-References

Synonyms (27)

Research

Studies (23)

Market Indicators

Research Demand Index: 21.51

Study Types