Proteins > Sodium channel protein type 2 subunit alpha
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Sodium channel protein type 2 subunit alpha
A sodium channel protein type 2 subunit alpha that is encoded in the genome of rat. [OMA:P04775, PRO:DNx]
Synonyms
Sodium channel protein brain II subunit alpha;
Sodium channel protein type II subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.2
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (24)
Drugs with Potency Measurements
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenytoin | Rattus norvegicus (Norway rat) | IC50 | 22.0000 | 2 | 2 |
| carbamazepine | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| racemethorphan | Rattus norvegicus (Norway rat) | IC50 | 150.6500 | 2 | 2 |
| lidocaine | Rattus norvegicus (Norway rat) | IC50 | 56.0000 | 1 | 2 |
| lamotrigine | Rattus norvegicus (Norway rat) | IC50 | 63.5800 | 4 | 5 |
| lidoflazine | Rattus norvegicus (Norway rat) | Ki | 0.0770 | 1 | 1 |
| mexiletine | Rattus norvegicus (Norway rat) | IC50 | 47.0000 | 1 | 1 |
| riluzole | Rattus norvegicus (Norway rat) | IC50 | 4.7300 | 1 | 1 |
| pimozide | Rattus norvegicus (Norway rat) | IC50 | 0.3400 | 1 | 1 |
| mibefradil | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| sipatrigine | Rattus norvegicus (Norway rat) | IC50 | 10.2000 | 2 | 2 |
| lubeluzole | Rattus norvegicus (Norway rat) | IC50 | 1.5995 | 2 | 2 |
| lifarizine | Rattus norvegicus (Norway rat) | IC50 | 0.4940 | 1 | 1 |
| l 741742 | Rattus norvegicus (Norway rat) | Ki | 1.9000 | 1 | 1 |
| oxytocin | Rattus norvegicus (Norway rat) | Ki | 0.0610 | 1 | 2 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| flunarizine | Rattus norvegicus (Norway rat) | IC50 | 0.4900 | 1 | 1 |
| flunarizine | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| topiramate | Rattus norvegicus (Norway rat) | IC50 | 97.0000 | 2 | 2 |
| dextromethorphan | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| tetrodotoxin | Rattus norvegicus (Norway rat) | IC50 | 0.0093 | 3 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ezogabine | Rattus norvegicus (Norway rat) | EC50 | 0.1500 | 1 | 1 |
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 14, Issue:13, 2004
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 9, Issue:17, 1999
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers.Journal of medicinal chemistry, , Mar-29, Volume: 39, Issue:7, 1996
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.Journal of medicinal chemistry, , Jan-21, Volume: 37, Issue:2, 1994
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 9, Issue:17, 1999
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.Journal of medicinal chemistry, , Jan-21, Volume: 37, Issue:2, 1994
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