Proteins > Histone deacetylase 6
Page last updated: 2024-08-07 17:30:01

Histone deacetylase 6

A histone deacetylase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBN7]

Synonyms

HD6;
EC 3.5.1.98;
Tubulin-lysine deacetylase HDAC6;
3.5.1.-

Research

Bioassay Publications (484)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.21)18.2507
2000's77 (15.91)29.6817
2010's280 (57.85)24.3611
2020's126 (26.03)2.80

Compounds (106)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC502,000.000011
butyric acidHomo sapiens (human)Ki136.000011
celecoxibHomo sapiens (human)IC501.140022
ci 994Homo sapiens (human)IC5031.21241017
ci 994Homo sapiens (human)Ki0.095013
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC502,290.002055
valproic acidHomo sapiens (human)Ki564.000011
ebselenHomo sapiens (human)IC506.533333
fluconazoleHomo sapiens (human)IC5040.000011
beta-thujaplicinHomo sapiens (human)Ki2.500011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC500.805333
entinostatHomo sapiens (human)IC5016.43994462
4-phenylbutyric acidHomo sapiens (human)IC50240.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
ppm 18Homo sapiens (human)IC505.540022
pyroxamideHomo sapiens (human)IC505.100022
pyroxamideHomo sapiens (human)Ki0.004811
suberoyl bis-hydroxamic acidHomo sapiens (human)IC502.030011
suberoyl bis-hydroxamic acidHomo sapiens (human)Ki0.014511
scriptaidHomo sapiens (human)IC500.119455
scriptaidHomo sapiens (human)Ki0.000211
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000022
fenofibrateHomo sapiens (human)Ki75.000011
imatinibHomo sapiens (human)IC50100.000011
vorinostatHomo sapiens (human)IC501.2867412450
vorinostatHomo sapiens (human)Ki0.30471416
benzohydroxamic acidHomo sapiens (human)IC501.276033
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
daunorubicinHomo sapiens (human)IC500.020011
lovastatinHomo sapiens (human)IC5016.285011
atorvastatinHomo sapiens (human)IC5014.466011
bendamustineHomo sapiens (human)IC500.010011
nicotinohydroxamic acidHomo sapiens (human)IC500.679011
osajinHomo sapiens (human)IC506.530011
8-mercaptoquinolineHomo sapiens (human)IC50200.000011
zm 241385Homo sapiens (human)IC501.000011
lapatinibHomo sapiens (human)IC5055.000022
N-hydroxy-2-phenylacetamideHomo sapiens (human)IC501.100011
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5012.744368
bortezomibHomo sapiens (human)IC5069.440011
trapoxin aHomo sapiens (human)IC500.004733
actinoninHomo sapiens (human)IC5010.000011
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.2559100120
trichostatin aHomo sapiens (human)Ki0.073077
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50360.000033
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC5010.000033
aureusidinHomo sapiens (human)IC5033.500022
romidepsinHomo sapiens (human)IC5035.45531515
romidepsinHomo sapiens (human)Ki0.106533
cinnamoylhydroxamic acidHomo sapiens (human)IC500.022011
3',4'-dihydroxyauroneHomo sapiens (human)IC5017.550022
psammaplin aHomo sapiens (human)IC500.791244
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.0545711
laq824Homo sapiens (human)Ki0.009522
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
pd 404182Homo sapiens (human)IC507.000011
tubacinHomo sapiens (human)IC500.46681616
tubacinHomo sapiens (human)Ki1.266046
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC503.90451414
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)Ki0.123411
belinostatHomo sapiens (human)IC503.94141426
belinostatHomo sapiens (human)Ki0.003644
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC500.23072230
panobinostatHomo sapiens (human)Ki0.014866
hdac-42Homo sapiens (human)IC500.011322
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC508.1611725
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.167213
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC5078.000011
bml 210Homo sapiens (human)IC5091.400055
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC50146.392977
givinostatHomo sapiens (human)IC500.098244
givinostatHomo sapiens (human)Ki0.004222
mocetinostatHomo sapiens (human)IC508.6016919
6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)-Homo sapiens (human)IC5010.000011
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.036022
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazoneHomo sapiens (human)IC505.000011
spiruchostatin aHomo sapiens (human)IC501.600011
quisinostatHomo sapiens (human)IC500.066444
quisinostatHomo sapiens (human)Ki0.183422
resminostatHomo sapiens (human)IC500.072022
abexinostatHomo sapiens (human)IC500.012011
abexinostatHomo sapiens (human)Ki0.049038
dactolisibHomo sapiens (human)IC500.002011
chidamideHomo sapiens (human)IC505.789032
hc toxinHomo sapiens (human)IC500.430011
hc toxinHomo sapiens (human)Ki0.350011
azumamide eHomo sapiens (human)IC5031.000022
azumamide eHomo sapiens (human)Ki5.000011
cnf 2024Homo sapiens (human)IC501.000022
N-(2-aminophenyl)-2-pyrazinecarboxamideHomo sapiens (human)IC5011.707522
pci 34051Homo sapiens (human)IC5019.15921313
cudc 101Homo sapiens (human)IC500.155574
largazoleHomo sapiens (human)IC504.220877
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.021377
trichostatin rkHomo sapiens (human)IC50100.000011
incb-018424Homo sapiens (human)IC500.015011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC503.17667281
tubastatin aHomo sapiens (human)Ki0.005755
pracinostatHomo sapiens (human)IC500.109522
pracinostatHomo sapiens (human)Ki0.247011
acy-1215Homo sapiens (human)IC500.08403434
acy-1215Homo sapiens (human)Ki0.001011
cudc-907Homo sapiens (human)IC500.103988
rgfp966Homo sapiens (human)IC501.000011
mi-192Homo sapiens (human)IC5010.000011
acy-738Homo sapiens (human)IC500.001888
2-((1-(3-fluorophenyl)cyclohexyl)amino)-n-hydroxypyrimidine-5-carboxamideHomo sapiens (human)IC500.007544
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC500.15361515
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)Ki0.030011
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC501.955523

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bufexamacHomo sapiens (human)Kd10.700011
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000011
suberoyl bis-hydroxamic acidHomo sapiens (human)EC501.100011
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC502.13281111
vorinostatHomo sapiens (human)Kd0.300011
trichostatin aHomo sapiens (human)EC500.005211
romidepsinHomo sapiens (human)EC5014,000.000011
tubacinHomo sapiens (human)EC502.900022
belinostatHomo sapiens (human)EC500.056022
panobinostatHomo sapiens (human)EC500.150711
kd 5170Homo sapiens (human)EC500.045011
gdc 0941Homo sapiens (human)EC5030.000011
tubastatin aHomo sapiens (human)EC501.090011
cudc-907Homo sapiens (human)EC500.221811

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
largazoleHomo sapiens (human)INH0.572011
tubastatin aHomo sapiens (human)Km29.100011

Enables

This protein enables 22 target(s):

TargetCategoryDefinition
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
transcription corepressor bindingmolecular functionBinding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]
actin bindingmolecular functionBinding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
beta-catenin bindingmolecular functionBinding to a catenin beta subunit. [GOC:bf]
microtubule bindingmolecular functionBinding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
polyubiquitin modification-dependent protein bindingmolecular functionBinding to a protein upon poly-ubiquitination of the target protein. [GOC:pg]
ubiquitin protein ligase bindingmolecular functionBinding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
tubulin deacetylase activitymolecular functionCatalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. [PMID:12024216, PMID:12486003]
alpha-tubulin bindingmolecular functionBinding to the microtubule constituent protein alpha-tubulin. [GOC:jl]
ubiquitin bindingmolecular functionBinding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]
tau protein bindingmolecular functionBinding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]
beta-tubulin bindingmolecular functionBinding to the microtubule constituent protein beta-tubulin. [GOC:krc]
misfolded protein bindingmolecular functionBinding to a misfolded protein. [GOC:ai]
Hsp90 protein bindingmolecular functionBinding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai]
dynein complex bindingmolecular functionBinding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. [GOC:bf, GOC:BHF, GOC:mah]
transcription factor bindingmolecular functionBinding to a transcription factor, a protein required to initiate or regulate transcription. [ISBN:0198506732]

Located In

This protein is located in 17 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
multivesicular bodycellular componentA type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [PMID:11566881, PMID:16533950]
centrosomecellular componentA structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
microtubulecellular componentAny of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]
caveolacellular componentA membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]
inclusion bodycellular componentA discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744]
aggresomecellular componentAn inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. [PMID:11121744]
axoncellular componentThe long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
dendritecellular componentA neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
cell leading edgecellular componentThe area of a motile cell closest to the direction of movement. [GOC:pg]
ciliary basal bodycellular componentA membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. [GOC:cilia, GOC:clt, PMID:21750193]
perikaryoncellular componentThe portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
perinuclear region of cytoplasmcellular componentCytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
axon cytoplasmcellular componentAny cytoplasm that is part of a axon. [GO_REF:0000064, GOC:TermGenie, PMID:18667152]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
histone deacetylase complexcellular componentA protein complex that possesses histone deacetylase activity. [GOC:mah]
microtubule associated complexcellular componentAny multimeric complex connected to a microtubule. [GOC:jl]

Involved In

This protein is involved in 59 target(s):

TargetCategoryDefinition
protein polyubiquitinationbiological processAddition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [ISBN:0815316194]
response to amphetaminebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]
protein deacetylationbiological processThe removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
protein quality control for misfolded or incompletely synthesized proteinsbiological processThe chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. [GOC:jl]
intracellular protein transportbiological processThe directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]
autophagybiological processThe cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation. [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]
actin filament organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:mah]
negative regulation of microtubule depolymerizationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. [GOC:mah, ISBN:0815316194]
regulation of autophagybiological processAny process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
positive regulation of epithelial cell migrationbiological processAny process that activates or increases the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of hydrogen peroxide metabolic processbiological processAny process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [GOC:dph, GOC:hjd, GOC:tb]
regulation of macroautophagybiological processAny process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]
axonal transport of mitochondrionbiological processThe directed movement of mitochondria along microtubules in nerve cell axons. [GOC:ai]
negative regulation of protein-containing complex assemblybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. [GOC:mah]
regulation of protein stabilitybiological processAny process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb]
protein destabilizationbiological processAny process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah]
lysosome localizationbiological processAny process in which a lysosome is transported to, and/or maintained in, a specific location. [GOC:mah]
protein-containing complex disassemblybiological processThe disaggregation of a protein-containing macromolecular complex into its constituent components. [GOC:mah]
positive regulation of peptidyl-serine phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
cellular response to heatbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:mah]
peptidyl-lysine deacetylationbiological processThe removal of an acetyl group from an acetylated lysine residue in a peptide or protein. [GOC:BHF, GOC:mah]
response to immobilization stressbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]
cellular response to topologically incorrect proteinbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]
erythrocyte enucleationbiological processThe process in which nucleated precursor cells lose their nucleus during erythrocyte maturation. [GOC:hjd]
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaybiological processThe chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. [GOC:jl, PMID:11511343]
negative regulation of protein-containing complex disassemblybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]
regulation of fat cell differentiationbiological processAny process that modulates the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
negative regulation of gene expression, epigeneticbiological processAn epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
negative regulation of proteolysisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
collateral sproutingbiological processThe process in which outgrowths develop from the shafts of existing axons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
negative regulation of axon extension involved in axon guidancebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]
positive regulation of dendrite morphogenesisbiological processAny process that activates or increases the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]
negative regulation of oxidoreductase activitybiological processAny process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. [GOC:ai]
response to corticosteronebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. [PMID:15240347]
response to misfolded proteinbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. [GOC:go_curators]
positive regulation of synaptic transmission, glutamatergicbiological processAny process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
cilium assemblybiological processThe assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]
regulation of microtubule-based movementbiological processAny process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. [GOC:dph, GOC:tb]
regulation of androgen receptor signaling pathwaybiological processAny process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]
dendritic spine morphogenesisbiological processThe process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]
cilium disassemblybiological processA cellular process that results in the breakdown of a cilium. [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441]
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarizationbiological processA positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule. [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190]
regulation of establishment of protein localizationbiological processAny process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. [GOC:BHF, GOC:mah]
cellular response to hydrogen peroxidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]
aggresome assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein. [GOC:BHF, GOC:rl, PMID:14675537]
polyubiquitinated misfolded protein transportbiological processThe directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. [GOC:BHF, GOC:mah, PMID:14675537]
response to growth factorbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:BHF, GOC:mah]
cellular response to misfolded proteinbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. [GOC:mah]
cellular response to parathyroid hormone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. [GOC:mah]
response to dexamethasonebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]
tubulin deacetylationbiological processThe removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of tubulin deacetylationbiological processAny process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of cellular response to oxidative stressbiological processAny process that activates or increases the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie]
negative regulation of protein acetylationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. [GOC:TermGenie, PMID:22117195]
regulation of autophagy of mitochondrionbiological processAny process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process. [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]
positive regulation of cholangiocyte proliferationbiological processAny process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
negative regulation of aggrephagybiological processAny process that stops, prevents or reduces the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]
epigenetic regulation of gene expressionbiological processA process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]