vallesiachotamine: antiproliferative, from the leaves of Palicourea rigida (Rubiaceae) collected in the Brazilian Cerrado; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Palicourea | genus | A plant genus. Members contain palicourein.[MeSH] | Rubiaceae | The Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH] |
| Palicourea rigida | species | [no description available] | Rubiaceae | The Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 5384527 |
| CHEMBL ID | 454571 |
| SCHEMBL ID | 20943621 |
| MeSH ID | M0575800 |
| Synonym |
|---|
| 5523-37-5 |
| nsc338699 |
| vallesiachotamine |
| vallesiachotamine k106 |
| nsc-338699 |
| CHEMBL454571 |
| (2s,12betas)-methyl 2-[(1e)-1-formyl-1-propenyl]-1,2,6,7,12,12b-hexahydroindolo[2,3-alpha]quinolizine- 3-carboxylic acid |
| SCHEMBL20943621 |
| FS-7866 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID356162 | DNA damaging activity in yeast RS 188N mutant assessed as drug level required to produce 12 mm zone of inhibition | 2003 | Journal of natural products, Jul, Volume: 66, Issue:7 | Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids. |
| AID464435 | Cytotoxic activity against human SK-BR-3 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID464432 | Cytotoxic activity against human HL60 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID464433 | Cytotoxic activity against human SMMC7721 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID399471 | Cytotoxicity against mouse P388 cells | |||
| AID464434 | Cytotoxic activity against human A549 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jan, Volume: 73, Issue:1 | Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi. |
| AID399470 | Cytotoxicity against human KB cells | |||
| AID356161 | DNA damaging activity in yeast RS 322YK mutant assessed as drug level required to produce 12 mm zone of inhibition | 2003 | Journal of natural products, Jul, Volume: 66, Issue:7 | Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.72) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||