Proteins > Mcl-1
Page last updated: 2024-08-07 12:29:59

Mcl-1

[no definition available]

Synonyms

Research

Bioassay Publications (0)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0)18.7374
1990's0 (0)18.2507
2000's0 (0)29.6817
2010's0 (0)24.3611
2020's0 (0)2.80

Compounds (135)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ro 5-4864Homo sapiens (human)IC5054.000010
5,8,11,14-eicosatetraynoic acidHomo sapiens (human)IC501.780010
benzylhydrochlorothiazideHomo sapiens (human)IC5054.000010
bisacodylHomo sapiens (human)IC5054.000010
bithionolHomo sapiens (human)IC501.784420
safingolHomo sapiens (human)IC5054.000010
gossypolHomo sapiens (human)IC501.191520
hexachloropheneHomo sapiens (human)IC507.846620
omeprazoleHomo sapiens (human)IC503.144810
phenazineHomo sapiens (human)IC5054.000010
prochlorperazineHomo sapiens (human)IC503.773310
bromobenzeneHomo sapiens (human)IC5054.000010
1-amino-4-hydroxyanthraquinoneHomo sapiens (human)IC504.345410
anthralinHomo sapiens (human)IC502.392010
hematoxylinHomo sapiens (human)IC503.439310
6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazineHomo sapiens (human)IC5018.760010
triadimenolHomo sapiens (human)IC5054.000010
N-[4-(dimethylamino)phenyl]-3,4,5-trimethoxybenzamideHomo sapiens (human)IC504.780310
chaetochrominHomo sapiens (human)IC502.148910
ticlopidine hydrochlorideHomo sapiens (human)IC5054.000010
2,3-trimethylene-4-quinazoloneHomo sapiens (human)IC500.520010
2-aminodiphenylamineHomo sapiens (human)IC5054.000010
prazosin hydrochlorideHomo sapiens (human)IC5054.000010
9-methoxyellipticineHomo sapiens (human)IC5054.000010
2,2'-((3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)diimino)bis-benzoic acidHomo sapiens (human)IC501.186320
methyl fluorone blackHomo sapiens (human)IC5023.945620
coumarin 7Homo sapiens (human)IC501.620010
sch 45752Homo sapiens (human)IC501.491910
gossypol acetic acidHomo sapiens (human)IC501.262820
PoriolHomo sapiens (human)IC503.944110
2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinoneHomo sapiens (human)IC5024.783610
6-nitro-1,3-benzodioxol-5-amineHomo sapiens (human)IC505.210010
4-[[bis(2-hydroxyethyl)amino]methyl]-2,6-ditert-butylphenolHomo sapiens (human)IC501.630010
2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(3-pyridinyl)methyl]-5,5-dimethylcyclohexane-1,3-dioneHomo sapiens (human)IC5054.000010
3-Hydroxy-1-(4-hydroxyphenyl)-1-propanoneHomo sapiens (human)IC505.157610
2-(2-ethyl-6-methyl-3-oxo-1,4-benzoxazin-4-yl)-N-[(5-methyl-2-furanyl)methyl]-N-(3-pyridinylmethyl)acetamideHomo sapiens (human)IC5054.000010
2-(2,5-dimethoxyphenyl)-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazoleHomo sapiens (human)IC5054.000010
N-[2-[2-[2-(4-methoxyanilino)-2-oxoethyl]-5-tetrazolyl]phenyl]-2-furancarboxamideHomo sapiens (human)IC506.220010
N-[2-(3-pyridinyl)-1,3-benzoxazol-5-yl]butanamideHomo sapiens (human)IC5054.000010
2-amino-4-(2-chlorophenyl)-6-(ethylthio)pyridine-3,5-dicarbonitrileHomo sapiens (human)IC500.460010
N-butyl-N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-2-pyridinecarboxamideHomo sapiens (human)IC5054.000010
9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-oneHomo sapiens (human)IC500.550010
4-(1-benzotriazolyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidineHomo sapiens (human)IC5054.000010
3-cyclohexyl-1,1-bis(2-methylpropyl)thioureaHomo sapiens (human)IC5054.000010
3-[1-(4-acetylphenyl)-5-thiophen-2-yl-2-pyrrolyl]propanoic acidHomo sapiens (human)IC509.230010
4-[oxo-(pyridin-4-ylamino)methyl]-1H-imidazole-5-carboxylic acid ethyl esterHomo sapiens (human)IC5054.000010
2,4-dimethyl-N-[4-(1-pyrrolidinyl)phenyl]benzamideHomo sapiens (human)IC507.063310
[3-amino-6-(4-methoxyphenyl)-2-thieno[2,3-b]pyridinyl]-(3,4-dimethoxyphenyl)methanoneHomo sapiens (human)IC500.485020
1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)ureaHomo sapiens (human)IC509.895220
4-morpholinyl-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanoneHomo sapiens (human)IC5054.000010
N-[4-(1-pyrrolidinyl)phenyl]-2-naphthalenecarboxamideHomo sapiens (human)IC505.138810
N-(2,6-dimethylphenyl)-2-[(6-methoxy-2-methyl-4-quinolinyl)thio]acetamideHomo sapiens (human)IC5010.470010
(E)-4-Phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acidHomo sapiens (human)IC500.540010
2-(3-methylphenyl)-N-[4-(4-morpholinyl)phenyl]-4-quinazolinamineHomo sapiens (human)IC5054.000010
5-(3,4-dimethoxyphenyl)-2-(4-methylphenyl)-4-thieno[2,3-d][1,3]oxazinoneHomo sapiens (human)IC501.980010
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamideHomo sapiens (human)IC504.013710
3-[[[[[5-(4-chlorophenyl)-2-furanyl]-oxomethyl]amino]-sulfanylidenemethyl]amino]-4-methoxybenzoic acidHomo sapiens (human)IC507.126910
N-(6-chloro-1,3-benzothiazol-2-yl)-2-diphenylphosphorylacetamideHomo sapiens (human)IC5054.000010
2-(benzenesulfonylmethyl)-5-(4-chlorophenyl)cyclohexane-1,3-dioneHomo sapiens (human)IC502.310010
N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamideHomo sapiens (human)IC5054.000010
5-[(2-cyanoethylthio)methyl]-2-benzofurancarboxylic acidHomo sapiens (human)IC5016.390010
3-amino-N-(2-fluorophenyl)-6-(2-furanyl)-2-thieno[2,3-b]pyridinecarboxamideHomo sapiens (human)IC502.284010
N-[5-methyl-2-(4-methylphenyl)-3-pyrazolyl]-2-[(7-methyl-4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-9-yl)oxy]acetamideHomo sapiens (human)IC500.400010
3-(4-methylphenyl)sulfonylpropanoic acid [2-[(3,5-dichloro-2-pyridinyl)amino]-2-oxoethyl] esterHomo sapiens (human)IC5054.000010
2-(2-furanyl)-4-quinolinecarboxylic acid [2-[4-amino-1-methyl-3-(2-methylpropyl)-2,6-dioxo-5-pyrimidinyl]-2-oxoethyl] esterHomo sapiens (human)IC502.591210
1-[1-(phenylmethyl)-4-piperidinyl]-3-(2,4,4-trimethylpentan-2-yl)thioureaHomo sapiens (human)IC5054.000010
5-bromo-N-(4,7-dimethoxy-1,3-benzothiazol-2-yl)-2-thiophenecarboxamideHomo sapiens (human)IC501.000010
3-[4-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]-3-(2-oxo-1-benzopyran-3-yl)-1-pyrazolyl]propanoic acidHomo sapiens (human)IC503.422610
4E2RCatHomo sapiens (human)IC501.574620
1-[(7-chloro-4-quinolinyl)amino]-3-(2,4-dichlorophenyl)thioureaHomo sapiens (human)IC504.378120
1-(2-chlorophenyl)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-3-methyl-5-thieno[2,3-c]pyrazolecarboxamideHomo sapiens (human)IC501.620010
3-methyl-N-[(4-methylphenyl)methyl]-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amineHomo sapiens (human)IC5054.000010
2-pyridin-4-yl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamideHomo sapiens (human)IC501.638410
3-methyl-2-thiophenecarboxylic acid [2-(4-morpholinyl)-2-oxoethyl] esterHomo sapiens (human)IC5054.000010
2-(2,3-dihydro-1H-inden-5-yloxy)-1-(2,3-dihydroindol-1-yl)ethanoneHomo sapiens (human)IC5054.000010
7-[(4-acetylphenoxy)methyl]-5-thiazolo[3,2-a]pyrimidinoneHomo sapiens (human)IC501.040010
2-[[4-amino-5-[4-(difluoromethoxy)phenyl]-1,2,4-triazol-3-yl]thio]-N-[(2-furanylmethylamino)-oxomethyl]acetamideHomo sapiens (human)IC509.191110
1H-benzimidazole-5,6-diamineHomo sapiens (human)IC5054.000010
N-[4-methyl-5-[2-(3-nitroanilino)-4-thiazolyl]-2-thiazolyl]acetamideHomo sapiens (human)IC501.091220
1-[4-(4-morpholinyl)-2,1,3-benzoxadiazol-7-yl]-3-(4-nitrophenyl)ureaHomo sapiens (human)IC504.451610
1-[3-[4-(2-chloro-5-methoxyphenyl)-1-piperazinyl]propyl]-3-(4-methylphenyl)ureaHomo sapiens (human)IC506.559810
cb 7969312Homo sapiens (human)IC501.929420
1-[2-furanyl(oxo)methyl]-6-(1-pyrrolidinylsulfonyl)-2-benzo[cd]indoloneHomo sapiens (human)IC5054.000010
3-(4-chlorophenyl)sulfonyl-N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]propanamideHomo sapiens (human)IC5054.000010
asterric acidHomo sapiens (human)IC502.419810
N-[4-[[2-(4-acetamidoanilino)-5-nitro-4-pyrimidinyl]amino]phenyl]acetamideHomo sapiens (human)IC509.280820
4-methyl-2-[3-methyl-4-(3-methylphenyl)azo-5-oxo-4H-pyrazol-1-yl]-5-thiazolecarboxylic acid ethyl esterHomo sapiens (human)IC501.420010
2-[(4-chlorophenyl)-[2-[5-(4-chlorophenyl)-2-thiazolyl]-5-methyl-3-oxo-1H-pyrazol-4-yl]methyl]propanedinitrileHomo sapiens (human)IC501.704410
N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]-4-pyrazolyl]-2-[[4-(trifluoromethyl)-5,6-dihydrobenzo[h]quinazolin-2-yl]thio]acetamideHomo sapiens (human)IC501.910010
1-(3,5-dimethyl-1-piperidinyl)-2-[[2-(thiophen-2-ylmethyl)-4-quinazolinyl]thio]ethanoneHomo sapiens (human)IC5054.000010
N-(3-chlorophenyl)-4-[4-(3-methoxyphenyl)-2-thiazolyl]-1-piperazinecarbothioamideHomo sapiens (human)IC5054.000010
N-[[1-(4-methoxyphenyl)-3-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzenesulfonamideHomo sapiens (human)IC5054.000010
2-(6-benzimidazolo[1,2-c]quinazolinylthio)-N-(2-furanylmethyl)acetamideHomo sapiens (human)IC502.500010
N,N-diethyl-4-[[5-oxo-6-(phenylmethyl)-7H-pyrrolo[3,4-b]pyridin-7-yl]amino]benzenesulfonamideHomo sapiens (human)IC501.520010
2-(2-methoxyethyl)-9-methyl-4-[(4-methyl-1-piperidinyl)-oxomethyl]-1-pyrido[3,4-b]indoloneHomo sapiens (human)IC5053.020010
7-(5-chloro-2-methoxyanilino)-6-[(4-methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-oneHomo sapiens (human)IC500.530010
N-[4-(dimethylamino)phenyl]-2-(1-oxo-[1,2,4]triazino[4,5-a]indol-2-yl)acetamideHomo sapiens (human)IC503.143410
N-[(4-methylphenyl)methyl]-4-(1-pyrrolyl)benzamideHomo sapiens (human)IC503.274710
N-[5-ethyl-3-[(4-fluorophenyl)-(4-morpholinyl)methyl]-2-thiophenyl]benzamideHomo sapiens (human)IC5054.000010
4-(4-chlorophenyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]-4-oxobutanamideHomo sapiens (human)IC5054.000010
2-(1,3-benzothiazol-2-ylthio)-N-[2-hydroxy-5-(4-morpholinylsulfonyl)phenyl]acetamideHomo sapiens (human)IC501.749010
1-(4-chlorophenyl)-3-[[1-(4-methoxyphenyl)-3-pyrrolidinyl]methyl]ureaHomo sapiens (human)IC5054.000010
N-[3-(1,3-benzothiazol-2-yl)phenyl]-4-oxo-1-benzopyran-2-carboxamideHomo sapiens (human)IC502.320010
4-(6-methyl-4-phenyl-2-quinazolinyl)-1,3-dihydroquinoxalin-2-oneHomo sapiens (human)IC5054.000010
3-hydroxy-6-(hydroxymethyl)-2-[(3-methoxyphenyl)-(2-pyridinylamino)methyl]-4-pyranoneHomo sapiens (human)IC500.400010
N2,N6-bis[4-(dimethylamino)phenyl]pyridine-2,6-dicarboxamideHomo sapiens (human)IC503.326110
N-[1-[1-[2-[4-(diethylamino)anilino]-2-oxoethyl]-2-benzimidazolyl]ethyl]-4-methylbenzamideHomo sapiens (human)IC500.900010
N-[5-(diethylsulfamoyl)-2-(4-morpholinyl)phenyl]-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamideHomo sapiens (human)IC505.074910
8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dioneHomo sapiens (human)IC5025.170010
2-nitro-4-[(6-nitro-4-quinolinyl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamideHomo sapiens (human)IC501.918820
sulfuretinHomo sapiens (human)IC501.534610
amentoflavoneHomo sapiens (human)IC501.634110
morinHomo sapiens (human)IC502.988310
rosmarinic acidHomo sapiens (human)IC502.025710
ellagic acidHomo sapiens (human)IC5027.285020
(2S)-2-(3-oxo-1H-isoindol-2-yl)-3-phenylpropanoic acidHomo sapiens (human)IC5022.290010
3-(dimethylamino)benzoic acid (7-hydroxy-2-oxo-1-benzopyran-4-yl)methyl esterHomo sapiens (human)IC502.982610
N-[(2-methoxyphenyl)methyl]-6H-indolo[2,3-b]quinoxaline-2-carboxamideHomo sapiens (human)IC508.070010
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-1-(4-methoxyphenyl)ethanoneHomo sapiens (human)IC506.575610
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-N-(3-methylphenyl)acetamideHomo sapiens (human)IC505.784810
altenusinHomo sapiens (human)IC504.147610
biapigeninHomo sapiens (human)IC502.725510
R-(-)-actinodaphnineHomo sapiens (human)IC505.612210
[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]methanoneHomo sapiens (human)IC5054.000010
xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-GlucopyranosideHomo sapiens (human)IC501.606110
2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-4-pyridinecarboxamideHomo sapiens (human)IC500.910010
cytomelHomo sapiens (human)IC5014.687410
4-[[2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]benzoic acid ethyl esterHomo sapiens (human)IC503.693310
lomofunginHomo sapiens (human)IC503.495120
N-[4-[2-[3-(dimethylsulfamoyl)anilino]-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamideHomo sapiens (human)IC504.195910
1-[4-[[(5-methyl-7-oxo-4H-isothiazolo[4,3-d]pyrimidin-3-yl)-oxomethyl]amino]phenyl]-3-piperidinecarboxylic acid ethyl esterHomo sapiens (human)IC505.253210
galloflavinHomo sapiens (human)IC5054.000010
5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazoleHomo sapiens (human)IC502.495210

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(4-ethoxycarbonylanilino)-2-quinazolinecarboxylic acid ethyl esterHomo sapiens (human)EC504.520010
6,7-dimethoxy-4-(2-oxolanylmethylamino)-1H-quinazoline-2-thioneHomo sapiens (human)EC501.900010