Guanylate cyclase soluble subunit alpha-1

A guanylate cyclase soluble subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02108]

Synonyms

GCS-alpha-1;
EC 4.6.1.2;
Guanylate cyclase soluble subunit alpha-3;
GCS-alpha-3;
Soluble guanylate cyclase large subunit

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	1 (25.00)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
6-anilino-5,8-quinolinedione	Homo sapiens (human)	IC50	1.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gemfibrozil	Homo sapiens (human)	EC50	624.0000	1	1
benzydamine	Homo sapiens (human)	EC50	1.0200	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	Homo sapiens (human)	EC10	3.3600	1	1
bay 41-8543	Homo sapiens (human)	EC10	0.0440	1	1
bay 41-8543	Homo sapiens (human)	EC20	0.0110	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
guanylate cyclase activity	molecular function	Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
GTP binding	molecular function	Binding to GTP, guanosine triphosphate. [GOC:ai]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
signaling receptor activity	molecular function	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
GABA-ergic synapse	cellular component	A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
guanylate cyclase complex, soluble	cellular component	Complex that possesses guanylate cyclase activity and is not bound to a membrane. [GOC:mah]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
cGMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732]
nitric oxide mediated signal transduction	biological process	An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. [GOC:jl, PMID:21549190]
blood circulation	biological process	The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825]
regulation of blood pressure	biological process	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
positive regulation of nitric oxide mediated signal transduction	biological process	Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]
nitric oxide-cGMP-mediated signaling	biological process	An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. [GOC:signaling, PMID:21549190, PMID:22019632]
relaxation of vascular associated smooth muscle	biological process	A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:dph, GOC:rph, GOC:TermGenie, PMID:15867178, PMID:19996365, PMID:27389411]
retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	biological process	Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. [GOC:dos]
response to oxygen levels	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:BHF, GOC:mah]
cGMP-mediated signaling	biological process	An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]