buthionine sulfoximine has been researched along with Necrosis in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 14 (53.85) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukami, T; Iida, A; Matsuo, K; Nakajima, M; Sasaki, E; Tsuneyama, K; Yokoi, T | 1 |
| Barbero-Farran, A; Boix, J; Mattiolo, P; Ribas, J; Yuste, VJ | 1 |
| Han, BR; Kim, SH; Park, WH; Shin, HR; You, BR | 1 |
| Fletcher, EV; Knudson, CM; Love-Homan, L; Martin, SM; Parsons, AD; Simons, AL; Sobhakumari, A; Spitz, DR | 1 |
| Aller, P; Bernardi, P; de Blas, E; Fernández, C; Sancho, P; Troyano, A | 1 |
| Bähr, M; Gillardon, F; Grötsch, P; Heckel, A; Kussmaul, L; Rohde, G; Romig, H; Weishaupt, JH | 1 |
| Cederbaum, AI; Gong, P; Nieto, N | 1 |
| Bertè, F; Bertone, R; Ferrigno, A; Freitas, I; Richelmi, P; Vairetti, M | 1 |
| Aller, P; Amrán, D; de Blas, E; Fernández, C; Ramos, AM; Sancho, P; Susin, SA; Yuste, VJ | 1 |
| Bagnell, R; Caldwell, SJ; Hiebert, LM; Mandal, AK; Ping, T | 1 |
| Ciralik, H; Coban, YK; Ergun, Y | 1 |
| Cederbaum, A; Lu, Y | 1 |
| Awad, JA; Burk, RF; Hill, KE; Lyons, PR; Morrow, JD | 1 |
| Gandolfi, AJ; Hall, PM; Lind, RC | 1 |
| Dettbarn, WD; Yang, ZP | 1 |
| Gyte, A; Lock, EA; Simpson, MG; Widdowson, PS; Wyatt, I | 1 |
| Gwag, BJ; Jou, I; Park, EC | 1 |
| Maher, P; Tan, S; Wood, M | 1 |
| Belcuig, M; Chopp, M; Grenier, J; Jiang, F; Li, Y; Lilge, L; Singh, G | 1 |
| Gwag, BJ; Jou, I; Ko, HW; Noh, JS; Ryu, BR | 1 |
| Kawazoe, S; Mizutani, T; Murakami, M; Shirai, M; Yoshida, K | 1 |
| Cederbaum, AI; Wu, D | 1 |
| Aller, P; de Blas, E; Fernández, C; Galán, A; García-Bermejo, L; Troyano, A; Vilaboa, NE | 1 |
| Aller, P; de Blas, E; Fernández, C; Sancho, P; Troyano, A | 1 |
| Andrikopoulos, NK; Dedoussis, GV | 1 |
| Bai, J; Cederbaum, AI; Marí, M | 1 |
26 other study(ies) available for buthionine sulfoximine and Necrosis
| Article | Year |
|---|---|
A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Female; Glutathione; Immunity, Innate; Inflammasomes; Inflammation Mediators; Liver; Mice; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Phenytoin; T-Lymphocytes, Helper-Inducer | 2013 |
2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Caspases; Cell Death; Chromatin; Gene Expression Regulation; Genes, p53; HCT116 Cells; Humans; Necrosis; Oxidative Stress; Reactive Oxygen Species; Sulfonamides | 2014 |
Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Auranofin; Buthionine Sulfoximine; Caspase Inhibitors; Cell Proliferation; Glutathione; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Necrosis; Oligopeptides; Oxidative Stress; Singlet Oxygen | 2015 |
Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Auranofin; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Catalase; Cell Line, Tumor; Cell Survival; Drug Synergism; Erlotinib Hydrochloride; Female; Gene Knockdown Techniques; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Necrosis; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Quinazolines; RNA, Small Interfering; Thioredoxin-Disulfide Reductase; Thioredoxins; Xenograft Model Antitumor Assays | 2012 |
The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells.
Topics: Adenosine Triphosphate; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzamides; Blotting, Western; Buthionine Sulfoximine; Caspase 3; Caspase 9; Caspases; Cisplatin; Cytochromes c; Electron Transport Complex III; Flow Cytometry; Glutathione; Humans; Hydrogen Peroxide; Microscopy, Fluorescence; Monocytes; Necrosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection; U937 Cells | 2003 |
Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction.
Topics: Animals; Apoptosis; Brain Ischemia; Buthionine Sulfoximine; Cell Death; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria; Necrosis; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2003 |
Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity.
Topics: Animals; Apoptosis; Arachidonic Acid; Buthionine Sulfoximine; Cell Line; Cytochrome P-450 CYP2E1; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Humans; Lipid Peroxidation; Membrane Potentials; Membrane Proteins; Mesoporphyrins; Mitochondria; Necrosis; Protective Agents; Rats; Reactive Oxygen Species | 2004 |
Apoptosis vs. necrosis: glutathione-mediated cell death during rewarming of rat hepatocytes.
Topics: Analysis of Variance; Animals; Annexin A5; Apoptosis; Buthionine Sulfoximine; Cell Count; Deferoxamine; Glutathione; Hepatocytes; L-Lactate Dehydrogenase; Male; Maleates; Necrosis; Propidium; Rats; Rats, Wistar; Reactive Oxygen Species; Rewarming; Thiobarbituric Acid Reactive Substances; Time Factors | 2005 |
Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress.
Topics: Acetylcysteine; Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; Buthionine Sulfoximine; Cadmium; Caspase 3; Caspase 9; Caspases; Drug Interactions; Glutathione; Humans; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Monocytes; Necrosis; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transfection; U937 Cells | 2006 |
Electron microscopic analysis of glucose-induced endothelial damage in primary culture: possible mechanism and prevention.
Topics: Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Glucose; Glutathione; Heparin; Insulin; Microscopy, Electron, Transmission; Necrosis; Swine | 2006 |
Depletion of glutathione by buthionine sulfoximine decreases random-pattern skin flap viability in rats.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Dermatologic Surgical Procedures; Enzyme Inhibitors; Female; Glutathione; Ischemia; Necrosis; Postoperative Complications; Rats; Rats, Wistar; Skin; Surgical Flaps | 2007 |
The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Caspases; Cell Death; Cisplatin; Cytochrome P-450 CYP2E1; Extracellular Signal-Regulated MAP Kinases; Glutathione; Humans; Liver Neoplasms; Necrosis; Reactive Oxygen Species; Thioredoxins; Tumor Cells, Cultured | 2007 |
Liver and kidney necrosis in selenium-deficient rats depleted of glutathione.
Topics: Animals; Buthionine Sulfoximine; Dinoprost; Glutathione; Ketones; Kidney; Lipid Peroxides; Liver; Male; Maleates; Methionine Sulfoximine; Necrosis; Osmolar Concentration; Proteins; Rats; Rats, Sprague-Dawley; Selenium; Selenoprotein P; Selenoproteins | 1995 |
A model for fatal halothane hepatitis in the guinea pig.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Guinea Pigs; Halothane; Liver; Male; Methionine Sulfoximine; Necrosis | 1994 |
Diisopropylphosphorofluoridate-induced cholinergic hyperactivity and lipid peroxidation.
Topics: 3,4-Methylenedioxyamphetamine; Acetylcholinesterase; Animals; Buthionine Sulfoximine; Cholinergic Fibers; Cholinesterase Inhibitors; Chromans; Diaphragm; Free Radical Scavengers; Free Radicals; Glutathione; Isoflurophate; Lipid Peroxidation; Male; Methionine Sulfoximine; Muscle Fibers, Skeletal; Necrosis; Piperazines; Rats; Rats, Sprague-Dawley; Thiobarbiturates; Tubocurarine | 1996 |
The role of glutathione in L-2-chloropropionic acid induced cerebellar granule cell necrosis in the rat.
Topics: Administration, Oral; Animals; Buthionine Sulfoximine; Cerebellar Cortex; Cerebellum; Cytoplasmic Granules; Drug Synergism; Glutathione; Hydrocarbons, Chlorinated; Male; Necrosis; Neurons; Propionates; Rats; Rats, Inbred Strains | 1996 |
Nerve growth factor potentiates the oxidative necrosis of striatal cholinergic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholinesterase; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Buthionine Sulfoximine; Cells, Cultured; Chromans; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Drug Synergism; Fetus; Free Radicals; Iron; Necrosis; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley | 1998 |
Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aurintricarboxylic Acid; Buthionine Sulfoximine; Cell Line, Transformed; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; DNA Fragmentation; Enzyme Inhibitors; Glutamic Acid; Glutathione Synthase; Hippocampus; Mice; Microscopy, Electron; Necrosis; Neurons; Oxidative Stress; Protein Kinase C; Protein Synthesis Inhibitors; RNA; Sulfones; Trypsin Inhibitors | 1998 |
Photodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Chemistry; Brain Neoplasms; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Dihematoporphyrin Ether; Free Radicals; Gliosarcoma; Glutathione; Male; Necrosis; Oxidation-Reduction; Photochemotherapy; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Reactive Oxygen Species | 1998 |
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin | 1999 |
Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glutathione; Liver; Male; Methimazole; Mice; Mice, Inbred ICR; Necrosis; Structure-Activity Relationship; Thiourea | 2000 |
Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1.
Topics: Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspases; Cyclosporine; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Glutathione; Humans; Membrane Potentials; Mitochondria, Liver; Necrosis; Tumor Cells, Cultured | 2001 |
The role of intracellular oxidation in death induction (apoptosis and necrosis) in human promonocytic cells treated with stress inducers (cadmium, heat, X-rays).
Topics: Adenosine Triphosphate; Antimetabolites; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cadmium Chloride; Caspases; Fluoresceins; Hot Temperature; Humans; Necrosis; Oxidative Stress; Reactive Oxygen Species; U937 Cells; X-Rays | 2001 |
Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation.
Topics: Adenosine Triphosphate; Alkylating Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Buthionine Sulfoximine; Camptothecin; Cell Death; Cisplatin; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Enzyme Inhibitors; Etoposide; Flow Cytometry; Glutathione; Humans; Hydrogen Peroxide; Hypoxia; Immunoblotting; Melphalan; Membrane Potentials; Mitochondria; Monocytes; Necrosis; Nucleic Acid Synthesis Inhibitors; Oxygen; Radiation-Protective Agents; Reactive Oxygen Species; Spectrometry, Fluorescence; Time Factors; Topoisomerase I Inhibitors; U937 Cells | 2001 |
Glutathione depletion restores the susceptibility of cisplatin-resistant chronic myelogenous leukemia cell lines to Natural Killer cell-mediated cell death via necrosis rather than apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Buthionine Sulfoximine; Cell Separation; Cisplatin; Coculture Techniques; Cytotoxicity Tests, Immunologic; DNA Fragmentation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; Fluorescent Dyes; Glutathione; Humans; K562 Cells; Killer Cells, Natural; Necrosis; Proliferating Cell Nuclear Antigen | 2001 |
Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria.
Topics: Antioxidants; Apoptosis; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Catalase; Glutathione; Humans; Lipid Peroxidation; Mitochondria; Necrosis; Oxygen; Pyruvates; Sulfhydryl Compounds; Tumor Cells, Cultured | 2002 |