A malate dehydrogenase, cytoplasmic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40925]
EC 1.1.1.37;
Cytosolic malate dehydrogenase;
Diiodophenylpyruvate reductase;
1.1.1.96
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzyl benzoate | Homo sapiens (human) | IC50 | 125.0000 | 1 | 1 |
| clotrimazole | Homo sapiens (human) | IC50 | 35.0000 | 1 | 1 |
| econazole | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| fluconazole | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| glyburide | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| ketoconazole | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| mefenamic acid | Homo sapiens (human) | IC50 | 225.0000 | 1 | 1 |
| miconazole | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| nicardipine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| oxaprozin | Homo sapiens (human) | IC50 | 175.0000 | 1 | 1 |
| sulconazole | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| delavirdine | Homo sapiens (human) | IC50 | 85.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| malic enzyme activity | molecular function | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. [ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| L-malate dehydrogenase activity | molecular function | Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. [EC:1.1.1.37] |
| diiodophenylpyruvate reductase activity | molecular function | Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH. [EC:1.1.1.96, RHEA:20293] |
| hydroxyphenylpyruvate reductase activity | molecular function | Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN, RHEA:10780] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| centrosome | cellular component | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| gluconeogenesis | biological process | The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [MetaCyc:GLUCONEO-PWY] |
| NADH metabolic process | biological process | The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153] |
| NADP metabolic process | biological process | The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. [GOC:mah] |
| malate metabolic process | biological process | The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. [ISBN:0198506732] |
| oxaloacetate metabolic process | biological process | The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. [ISBN:0198506732] |
| tricarboxylic acid cycle | biological process | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. [ISBN:0198506732] |