Compounds > 2-methyl-4'-(methylthio)-2-morpholinopropiophenone
Page last updated: 2024-12-07

2-methyl-4'-(methylthio)-2-morpholinopropiophenone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-methyl-4'-(methylthio)-2-morpholinopropiophenone: a photo-initiator [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92387
CHEMBL ID1411716
SCHEMBL ID27554
MeSH IDM0550677

Synonyms (54)

Synonym
AC-16227
smr000019254
MLS000084908 ,
2-methyl-4'-(methylthio)-2-morpholinopropiophenone
EU-0035716
2-methyl-4'-(methylthio)-2-morpholinopropiophenone, 98%
1-propanone, 2-methyl-1-[4-(methylthio)phenyl]-2-(4-4-morpholinyl)-
2-methyl-1-[4-(methylsulfanyl)phenyl]-2-morpholin-4-ylpropan-1-one
71868-10-5
M2028
2-methyl-1-[4-(methylthio)phenyl]-2-morpholino-1-propanone
AKOS000520617
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
2-methyl-1-(4-methylsulfanylphenyl)-2-morpholin-4-ylpropan-1-one
caccure 907
2-methyl-4-(methylthio)-2-morpholinopropiophenone
dtxcid6018857
dtxsid8038857 ,
tox21_301664
NCGC00255462-01
cas-71868-10-5
722clj6h6k ,
1-propanone, 2-methyl-1-(4-(methylthio)phenyl)-2-(4-morpholinyl)-
unii-722clj6h6k
ec 400-600-6
c15h21no2s
HMS2360J09
FT-0641373
irgacure 907
2-methyl-1-(4-(methylthio)phenyl)-2-morpholinopropan-1-one
mmmp
irganox 907
ir-907
2-methyl-1-[4-(methylthio)phenyl]-2-morpholinopropan-1-one
2-methyl-1-[4-(methylthio)-phenyl]-2-morpholinopropan-1-one
2-methyl-1-(4-methylthiophenyl)-2-morpholino-1-propanone
SCHEMBL27554
1-propanone, 2-methyl-1-[4-(methylthio)phenyl]-2-(4-morpholinyl)-
2-methyl-1-(4-methylsulfanylphenyl)-2-morpholino-propan-1-one
mfcd00083014
2-methyl-4'-methylthio-2-morpholinopropiophenone
2-methyl-1-[4-(methylsulfanyl)phenyl]-2-(4-morpholinyl)-1-propanone #
CHEMBL1411716
2-methyl-1-[4-(methylthio)phenyl]-2-(4-morpholinyl)-1-propanone
1-phenyl-2-(tetrahydro-2h-pyran-2-yl)butane-1,3-dione
2-methyl-4/'-(methylthio)-2-morpholinopropiophenone
DS-3825
BRD-K58799690-001-07-3
D70455
2-methyl-4'-(methylthio)-2-morpholino propiophenone
Q27266008
caccure 907; mmmp; mtmp
CS-0066164
PD057059

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Therefore, we theorized that photoinitiators such as MTMP might also have adverse cellular effects."( Cytotoxicity of the polymerization agent, 2-methyl-4'-(methylthio)-2-morpholinopropiophenone on human monocytes.
Kawasaki, Y; Matsunaga, H; Sendo, T; Yamaji, K, 2012)		0.64
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
RAR-related orphan receptor gammaMus musculus (house mouse)Potency62.94170.006038.004119,952.5996AID1159521; AID1159523
AR proteinHomo sapiens (human)Potency40.43350.000221.22318,912.5098AID1259243; AID1259247; AID743042
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency8.91250.011212.4002100.0000AID1030
thyroid stimulating hormone receptorHomo sapiens (human)Potency19.95260.001318.074339.8107AID926; AID938
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency68.58960.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency27.08410.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency27.30600.000417.946075.1148AID1346795
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency43.60920.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1259401; AID1259403
pregnane X nuclear receptorHomo sapiens (human)Potency27.30600.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency33.87950.000229.305416,493.5996AID1259244; AID743075; AID743077; AID743079
thyroid stimulating hormone receptorHomo sapiens (human)Potency4.66570.001628.015177.1139AID1224843; AID1224895
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
mitogen-activated protein kinase 1Homo sapiens (human)Potency1.99530.039816.784239.8107AID995
survival motor neuron protein isoform dHomo sapiens (human)Potency0.25120.125912.234435.4813AID1458
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency48.55770.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency48.55770.001551.739315,848.9004AID1259244
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency11.22021.000010.475628.1838AID1457
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's8 (72.73)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.70 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (9.09%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-aminobenzoic acid
4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.		2.0510aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
fentanyl
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078). fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.		2.2110anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic
4-aminobenzoic acid
para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.. 4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.		2.0510aminobenzoate;
aromatic amino-acid anion		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
azobis(isobutyronitrile)
azobis(isobutyronitrile): blowing agent for elastomers & plastics; initiator for free radical reactions; structure		2.2510
butyl methacrylate
[no description available]		2.2510enoate ester
ethylene dimethacrylate
ethylene glycol dimethacrylate : The enoate ester that is the 1,2-bis(methacryloyl) derivative of ethylene glycol.		2.2510enoate esterallergen;
cross-linking reagent;
polymerisation monomer
Methyl 2-benzoylbenzoate
methyl 2-benzoylbenzoate: a photoinitiator; structure in first source		2.1710benzophenones
isopropyl thioxanthone
isopropyl thioxanthone: structure in first source		2.0510
2,2-dimethoxy-2-phenylacetophenone
[no description available]		2.2510
caseins
Caseins: A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Drug Overdose
Accidental or deliberate use of a medication or street drug in excess of normal dosage.		02.2110
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.0810