Exopolyphosphatase PRUNE1

An exopolyphosphatase PRUNE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TP1]

EC 3.6.1.1;
Drosophila-related expressed sequence 17;
DRES-17;
DRES17;
HTcD37;
Protein prune homolog 1;
hPrune

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dipyridamole	Homo sapiens (human)	IC50	0.7800	1	1

This protein enables 6 target(s):

Target	Category	Definition
inorganic diphosphate phosphatase activity	molecular function	Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. [EC:3.6.1.1, RHEA:24576]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
tubulin binding	molecular function	Binding to monomeric or multimeric forms of tubulin, including microtubules. [GOC:clt]
phosphatase activity	molecular function	Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
exopolyphosphatase activity	molecular function	Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. [EC:3.6.1.11]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
focal adhesion	cellular component	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 2 target(s):

Target	Category	Definition
regulation of microtubule polymerization	biological process	Any process that modulates the frequency, rate or extent of microtubule polymerization. [GOC:mah]
regulation of neurogenesis	biological process	Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. [GOC:ai]