Proteins > Cysteine proteinase falcipain 2a
Page last updated: 2024-08-07 17:27:42
Cysteine proteinase falcipain 2a
[no definition available]
Synonyms
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chloroquine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0200 | 1 | 1 |
| leupeptin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0636 | 3 | 3 |
| e 64 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0828 | 6 | 6 |
| e 64 | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 13.6267 | 3 | 3 |
| isatin beta-thiosemicarbazone | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 38.8000 | 1 | 1 |
| 5-Nitroisatin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 42.6000 | 1 | 1 |
| 2-acetylpyridine thiosemicarbazone | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 20.0000 | 1 | 1 |
| calpain inhibitor iii | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.0000 | 1 | 1 |
| gallinamide a | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0085 | 2 | 2 |
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).Journal of medicinal chemistry, , 08-24, Volume: 60, Issue:16, 2017
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.European journal of medicinal chemistry, , Volume: 46, Issue:3, 2011
Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 20, Issue:3, 2010
Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.European journal of medicinal chemistry, , Volume: 45, Issue:7, 2010
Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004