Ubiquitin carboxyl-terminal hydrolase 1

A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94782]

Synonyms

EC 3.4.19.12;
Deubiquitinating enzyme 1;
hUBP;
Ubiquitin thioesterase 1;
Ubiquitin-specific-processing protease 1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
trifluoperazine	Homo sapiens (human)	IC50	8.0000	1	1
pimozide	Homo sapiens (human)	IC50	2.0000	2	2
nih-12848	Homo sapiens (human)	IC50	7.9000	1	1
gw 7647	Homo sapiens (human)	IC50	5.0000	2	2
rottlerin	Homo sapiens (human)	IC50	8.0000	1	1
flupenthixol	Homo sapiens (human)	IC50	7.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
cysteine-type deubiquitinase activity	molecular function	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
skeletal system development	biological process	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb]
DNA repair	biological process	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
regulation of DNA repair	biological process	Any process that modulates the frequency, rate or extent of DNA repair. [GOC:go_curators]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
response to UV	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb]
protein deubiquitination	biological process	The removal of one or more ubiquitin groups from a protein. [GOC:ai]
monoubiquitinated protein deubiquitination	biological process	The removal of the ubiquitin group from a monoubiquitinated protein. [GOC:bf]
positive regulation of receptor signaling pathway via JAK-STAT	biological process	Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. [GOC:bf]
positive regulation of error-prone translesion synthesis	biological process	Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]