A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSD5]
GAT-2;
Solute carrier family 6 member 13
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gamma-aminobutyric acid | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| beta-alanine | Homo sapiens (human) | IC50 | 154.5000 | 2 | 2 |
| 2,3-diaminopropionic acid | Homo sapiens (human) | IC50 | 39.8107 | 1 | 1 |
| guvacine | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| nipecotic acid | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| n-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 2-ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| nnc 05-2090 | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| snap 5114 | Homo sapiens (human) | IC50 | 11.9000 | 2 | 2 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| amino acid:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). [GOC:ai] |
| creatine transmembrane transporter activity | molecular function | Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. [GOC:ai] |
| gamma-aminobutyric acid:sodium:chloride symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). [PMID:7589472, PMID:7861179] |
| taurine transmembrane transporter activity | molecular function | Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. [GOC:ai] |
| taurine:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). [TC:2.A.22.3.3] |
| monocarboxylic acid transmembrane transporter activity | molecular function | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai] |
| amino acid transmembrane transporter activity | molecular function | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| gamma-aminobutyric acid transmembrane transporter activity | molecular function | Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell projection | cellular component | A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| monocarboxylic acid transport | biological process | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| taurine transmembrane transport | biological process | The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| creatine transmembrane transport | biological process | The directed movement of creatine across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie] |
| gamma-aminobutyric acid reuptake | biological process | The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387] |
| gamma-aminobutyric acid import | biological process | The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. [GOC:ai] |
| nitrogen compound transport | biological process | The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| amino acid import across plasma membrane | biological process | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| amino acid transport | biological process | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |